ライフサイエンスコーパス: prostaglandin endoperoxide

1 ed by measuring rates of MDA production from prostaglandin endoperoxide.

2 alyze the oxygenation of arachidonic acid to prostaglandin endoperoxides.

3 to chemically unstable products, such as the prostaglandin endoperoxides and leukotriene A(4) epoxide

4 Here, we show that prostaglandin endoperoxide E(2) selectively inhibits act

5 Prostaglandin endoperoxide H synthase (COX-2) activity w

6 TPA increased prostaglandin endoperoxide H synthase (PGHS) activity an

7 dicals have been detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they a

8 Prostaglandin endoperoxide H synthase 2 (PGHS-2) catalyz

9 and increased the amount of immunodetectable prostaglandin endoperoxide H synthase 2 (PGHS-2).

10 e substrate channel leads to inactivation of prostaglandin endoperoxide H synthase, the three serine

11 inhibit the cyclooxygenase (COX) activity of prostaglandin endoperoxide H synthase, which ultimately

12 s formed by native and mutant forms of ovine prostaglandin endoperoxide H synthase-1 (oPGHS-1) have s

13 Prostaglandin endoperoxide H synthase-1 (PGHS-1) is expr

14 tudies of the crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurb

15 Increased expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) has bee

16 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also c

17 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also k

18 COX-2, formally known as prostaglandin endoperoxide H synthase-2 (PGHS-2), cataly

19 ed with dexamethasone but not by SC 58125, a prostaglandin endoperoxide H synthase-2 (PGHS-2)-selecti

20 Prostaglandin endoperoxide H synthases (PGHS)-1 and -2,

21 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2 c

22 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2,

23 (PGG(2)) by the cyclooxygenase activities of prostaglandin endoperoxide H synthases (PGHSs) 1 and 2.

24 Prostaglandin endoperoxide H synthases (PGHSs) catalyze

25 The cyclooxygenase (COX) activity of prostaglandin endoperoxide H synthases (PGHSs) converts

26 Prostaglandin endoperoxide H synthases (PGHSs), also cal

27 Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2

28 that forms the cyclooxygenase active site of prostaglandin endoperoxide H synthases (PGHSs)-1 and -2.

29 Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 a

30 Prostaglandin endoperoxide H synthases 1 and 2, also kno

31 Prostaglandin endoperoxide H synthases are targets of no

32 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1

33 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1

34 Based on the crystal structures of the prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1

35 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs)

36 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs)

37 Prostaglandin endoperoxide H synthases-1 and -2, commonl

38 The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 a

39 mega-6 fatty acid called arachidonic acid to prostaglandin endoperoxide H(2) (PGH(2)).

40 two molecules of O(2), and two electrons to prostaglandin endoperoxide H(2) (PGH(2)).

41 thesis-the conversion of arachidonic acid to prostaglandin endoperoxide H(2) Both COX isoforms are se

42 induces conformational changes in the human prostaglandin endoperoxide H(2) synthase enzyme (PGHS-2)

43 Prostaglandin Endoperoxide H(2) Synthases (PGHS-1 and PG

44 s) 1 and 2, convert arachidonic acid (AA) to prostaglandin endoperoxide H(2).

45 Prostaglandin-endoperoxide H synthase (PGHS) (EC 1.14.99

46 unctional pairs with specific members of the prostaglandin-endoperoxide H synthase (PGHS) family.

47 ramatically induces hyaluronan synthesis and prostaglandin-endoperoxide H synthase 2 in human orbital

48 erone, p23, and associates functionally with prostaglandin-endoperoxide H synthase-1 (PGHS-1), the co

49 gulation is mediated through an induction of prostaglandin-endoperoxide H synthase-2 (PGHS-2), the in

50 Prostaglandin-endoperoxide H synthases (PGHSs) have a cy

51 y pharmacological target of acetaminophen is prostaglandin endoperoxide H2 synthase (PGHS).

52 To probe for a role of P450s in prostaglandin endoperoxide metabolism, we studied the 12

53 similarities to the arachidonic acid-derived prostaglandin endoperoxide PGH(2).

54 (PGE(2)) from the cyclooxygenase metabolite prostaglandin endoperoxide (PGH(2)).

55 (COX) which converts arachidonic acid to the prostaglandin endoperoxide PGH2, from which all other pr

56 (CYP450) enzyme catalyzing the conversion of prostaglandin endoperoxide (PGH2) into thromboxane A2 (T

57 Reaction of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hy

58 (PG) D2 through utilization of constitutive prostaglandin endoperoxide synthase (PGHS) -1 and induce

59 dal antiinflammatory agents (NSAIDs) bind to prostaglandin endoperoxide synthase (PGHS) and induce a

60 Prostaglandin endoperoxide synthase (PGHS) is a heme pro

61 Prostaglandin H(2) synthesis by prostaglandin endoperoxide synthase (PGHS) requires the

62 Prostaglandin endoperoxide synthase (PGHS)-2, the induci

63 apid as well as time-dependent inhibitors of prostaglandin endoperoxide synthase (PGHS).

64 gh levels of nitric oxide synthase (NOS) and prostaglandin endoperoxide synthase (PGHS).

65 nic acid substrate was also not available to prostaglandin endoperoxide synthase 1 in the immediate p

66 nase, ephrin-A receptor 2 (EPHA2), regulates prostaglandin endoperoxide synthase 2 (PTGS2) (encodes C

67 enhanced ovarian expression of PLA(2)G4A and prostaglandin endoperoxide synthase 2 (PTGS2) in wild-ty

68 volves the activation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of

69 thout affecting the levels of NO synthase or prostaglandin endoperoxide synthase or by inhibiting the

70 One common target for these drugs is prostaglandin endoperoxide synthase, also referred to as

71 duction of prostaglandin G/H synthase (PGHS; prostaglandin endoperoxide synthase, cyclooxygenase) by

72 Cyclooxygenase (COX), also referred to as prostaglandin endoperoxide synthase, is the rate-limitin

73 Ca2+]i) elevation in regulating ET-1-induced prostaglandin endoperoxide synthase, prostaglandin G/H s

74 p-regulation of the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nu

75 r F2-isoprostanes, is a minor product of the prostaglandin endoperoxide synthase-1 (PG G/H S-1) expre

76 m of action of this drug, we expressed human prostaglandin endoperoxide synthase-1 (PGHS-1) and PGHS-

77 nation of the crystal structure of the ovine prostaglandin endoperoxide synthase-1 (PGHS-1)/S- flurbi

78 orted to inhibit arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and

79 al hypoperfusion increases the expression of prostaglandin endoperoxide synthase-2 (PGHS-2) in ovine

80 The prostaglandin endoperoxide synthase-2 (PGS-2) gene encod

81 sly, we have shown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclo

82 t the cyclooxygenase-2 (COX-2, also known as prostaglandin endoperoxide synthase-2) signaling cascade

83 repressed the mRNA and protein expression of prostaglandin endoperoxide synthase/cyclooxygenase-2 (CO

84 BACKGROUND & AIMS: Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme

85 chanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxy

86 pithelium and included IL-1 receptor like 1, prostaglandin-endoperoxide synthase 1, CCL26, and perios

87 se domain mutations, but only a single gene, prostaglandin-endoperoxide synthase 1/cyclooxgenase 1 (P

88 cyclooxygenase 2 (COX-2) gene, also known as prostaglandin-endoperoxide synthase 2 ( PTGS2), occurs i

89 s, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (also called COX2)

90 imental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also know

91 teraction) = 0.02) with a genetic variant in prostaglandin-endoperoxide synthase 2 (PTGS2) (rs1204276

92 into the nucleus.Notably, after OT challenge prostaglandin-endoperoxide synthase 2 (PTGS2) expression

93 rowth/differentiation factor 15 (GDF15), and Prostaglandin-endoperoxide synthase 2 (PTGS2) genes, pre

94 Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key r

95 s that constitutively express high levels of prostaglandin-endoperoxide synthase 2 (Ptgs2, also known

96 es a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxyge

97 We found that induction of prostaglandin-endoperoxide synthase 2 (Ptgs2/Cox-2) and

98 ionship between levels of MIC1 and levels of prostaglandin-endoperoxide synthase 2 expression (PTGS2

99 ted Myd88(-/-) (TLR signaling-deficient) and prostaglandin-endoperoxide synthase 2(-/-) (Ptgs2(-/-))

100 of transfected A549 cells showed that PTGS2 (prostaglandin-endoperoxide synthase 2) was one of the hi

101 TGS2 (also known as COX2), the gene encoding prostaglandin-endoperoxide synthase 2, allowing activate

102 Alternatively, celecoxib, an inhibitor of prostaglandin-endoperoxide synthase 2, reduced polyp num

103 The gene expressions of prostaglandin-endoperoxide synthase 2, tissue inhibitor

104 s as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox

105 umatoid arthritis to inhibit cyclooxygenase (prostaglandin-endoperoxide synthase), thereby decreasing

106 Site-directed mutants of prostaglandin-endoperoxide synthase-2 (PGHS-2) with chan

107 Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2)

108 Prostaglandin-endoperoxide synthase-2 inhibition increas

109 rleukin-8, toll-like receptor 4, cryropyrin, prostaglandin-endoperoxide synthase-2, and heparinase ge

110 din E(2) (PGE(2)) and its processing enzyme, prostaglandin-endoperoxide-synthase-2/ cyclooxygenase-2

111 Prostaglandin endoperoxide synthases (PTGS), commonly re

112 ase activities of constitutive and inducible prostaglandin endoperoxide synthases by serving as a sub

113 n G2 by the cyclooxygenase (COX) activity of prostaglandin endoperoxide synthases.

114 with its primary mode of action in mammals (prostaglandin-endoperoxide synthases) but modulated gene

115 rved in carcinogenesis, prostaglandins (PG), prostaglandin-endoperoxide synthases, and PG receptors a

116 receptor (AR) agonist and a thromboxane A(2)/prostaglandin endoperoxide (TP) receptor antagonist, whi

117 o most extensively characterized thromboxane/prostaglandin endoperoxide (TP) receptors, from human pl

118 by way of activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor.

119 Oxabicycloheptane analogs of prostaglandin endoperoxide, U-44069 and U-46619, induced

120 alyze the oxygenation of arachidonic acid to prostaglandin endoperoxides, which are the common interm