ライフサイエンスコーパス: prostaglandin synthase

1 the common precursor to all prostanoids, by prostaglandin synthase.

2 ollowed by sustained elevation in microsomal prostaglandin synthase 1 (mPGES-1) expression.

3 te phases of PGD2 generation are mediated by prostaglandin synthase 1 (PGS1) and prostaglandin syntha

4 phases, an early phase that is dependent on prostaglandin synthase 1 and a delayed phase that is dep

5 Expression of prostaglandin synthase-1 (PGHS1), prostaglandin D syntha

6 released in these contexts is unavailable to prostaglandin synthase-1 constitutively present in fibro

7 zing enzymes cyclooxygenase-2 and microsomal prostaglandin synthase-1 in brain endothelial cells, kno

8 This arachidonate is then used by prostaglandin synthase-1 present in 3T3 cells for prosta

9 hesis by activated mast cells is mediated by prostaglandin synthase-1.

10 , in distal cells, arachidonate available to prostaglandin synthase-1.

11 Prostaglandin synthase 2 (PGS2) is an immediate-early ge

12 iated by prostaglandin synthase 1 (PGS1) and prostaglandin synthase 2 (PGS2), respectively.

13 nd decreased IL-1beta-mediated expression of prostaglandin synthase 2 (PTGS2).

14 eceptor (PR) signaling, and the induction of prostaglandin synthase 2 (Ptgs2).

15 hase that is dependent on activation-induced prostaglandin synthase 2 gene expression.

16 ligand stimulation is made available only to prostaglandin synthase-2, and (ii) a transcellular pathw

17 rophages require expression of the inducible prostaglandin synthase-2; arachidonate released in these

18 Both the prostaglandin synthase and the constitutive nitric oxide

19 f AGM, exhibit lower levels of expression of prostaglandin synthases and reduced phosphorylation of t

20 Bioactive prostaglandins produced by prostaglandin synthases and secreted by the prostate int

21 The inducible prostaglandin synthase cyclooxygenase-2 (COX-2) is aberr

22 Elevated expression of the prostaglandin synthase cyclooxygenase-2 (COX-2) is commo

23 The inducible prostaglandin synthase cyclooxygenase-2 (Cox-2) is overe

24 The prostaglandin synthase cyclooxygenase-2 (COX-2) is produ

25 Expression of the inducible prostaglandin synthase cyclooxygenase-2 appears critical

26 regulation in brain of an inducible form of prostaglandin synthase/cyclooxygenase, termed COX-2.

27 INDO, a powerful inhibitor of prostaglandin synthases (cyclooxygenases 1 and 2), did n

28 ect on COX-2 in this model, but did suppress prostaglandin synthase E2 production, presumably by inhi

29 expression, which resulted in a decrease in prostaglandin synthase E2 production.

30 ygenase-2 (COX-2) gene encodes the inducible prostaglandin synthase enzyme implicated in inflammation

31 ooxygenase (COX)-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in a

32 erence for coupling with distinct downstream prostaglandin synthases in vivo.

33 lation of stress-induced pathways, including prostaglandin synthases, in mutant chondrocytes.

34 Clinical use of prostaglandin synthase-inhibiting NSAIDs is associated w

35 Cyclooxygenase (COX)-2, the inducible prostaglandin synthase, is overexpressed in cancer and c

36 also downregulated cell adhesion molecules, prostaglandin synthases, mast cell tryptases, MMP1, MMP1

37 The expression of none of the three prostaglandin synthases (microsomal PGES1, PGES2 and cys

38 results in cell-specific differential use by prostaglandin synthases of the accumulated prostaglandin

39 the common property of the NSAIDs to inhibit prostaglandin synthase (PHS) enzymes and thereby cause a

40 Further metabolism of PGH2-EA and PGH2-G by prostaglandin synthases produces a variety of prostaglan

41 factor (cornea-derived transcript 6), and a prostaglandin synthase (prostaglandin D(2) synthase).

42 y was to examine the role of cyclooxygenase (prostaglandin synthase [PTGS]) enzymes and prostaglandin

43 actions, thus combining features of both the prostaglandin synthase/squaline-hopine cyclase and the C

44 ynthase-2 (PGS-2) gene encodes an isoform of prostaglandin synthase that is transiently induced by pr

45 es similar in sequence to specific mammalian prostaglandin synthases, the cyclooxygenases.