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1 tly, how the phenotypic features could be so protean.
2 ights into the still enigmatic phenomenon of protean agonism and a rationale for the design of such c
3 y the concepts of functional selectivity and protean agonism and begin to define the first postrecept
4 ents within dualsteric compounds that elicit protean agonism at the muscarinic M2 acetylcholine recep
5                                 In addition, protean agonism is described, whereby a ligand produces
6 gand binding may be the mechanism underlying protean agonism of dualsteric ligands.
7 r, may represent a novel approach to achieve protean agonism.
8 ne the first postreceptor step in actions of protean agonist ligands.
9 gonist at the 5-HT3A receptor, it becomes a "protean agonist" (functioning as an agonist and an inver
10 nsistent with the former's designation as a "protean" agonist.
11 ant interest both in inverse agonists and in protean agonists (i.e., compounds with functional select
12                                              Protean agonists are of great pharmacological interest a
13 e and inverse agonists on the same receptor (protean agonists), and differ in the stimulus pattern th
14 w appreciation that lymphoid progenitors are protean and able to alter their differentiation potentia
15 sions of corneal immunoglobulin deposits are protean and present a diagnostic challenge.
16                                Despite their protean and transient nature, these mucocutaneous featur
17                                     Inverse, protean, and ligand-selective agonism: matters of recept
18 iggers of vasovagal syncope are likely to be protean, and many potential central and peripheral trigg
19 delayed due to its infrequent occurrence and protean appearances.
20 e upon TA binding, generating a fluctuating "protean clamp" that stably traps the substrate.
21             Coeliac disease (CD), due to its protean clinical manifestation, is still very under diag
22 ndrome is difficult, however, because of the protean clinical manifestations and associations, limita
23 a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and
24                                    Given the protean clinical manifestations and the lack of a consen
25                                              Protean clinical manifestations characterize this disord
26  chronic autoimmune disease characterized by protean clinical manifestations that are associated with
27 o non-specific symptoms, chronic and cryptic protean clinical manifestations, and lack of clinician a
28 (2) delineates the mechanisms underlying the protean clinical manifestations, and thereby, (3) points
29 hey are often considered rare disorders with protean clinical manifestations, considerable advances i
30 bital inflammatory syndrome (IOIS), may have protean clinical manifestations.
31                                          The protean clinical presentation requires individualized tr
32 anding our mechanistic understanding of this protean condition and for improving the lives of affecte
33                    IgG4-related disease is a protean condition that mimics many malignant, infectious
34 levels of analysis are required to probe the protean consequences of early-life adversity on the deve
35                             HCMV has evolved protean countermeasures for anti-HCMV cellular immunity
36 odel system for characterizing the elusively protean cross-beta conformation.
37               TGF-beta is long considered a "protean" cytokine in cancer, changing its role from anti
38 se symptoms are nonspecific, subjective, and protean, diagnosis of drug-induced lupus (DIL) requires
39 h the pathogenesis and the treatment of this protean disorder.
40 ve in similar subsets of patients with other protean disorders.
41 , a nonreceptor protein tyrosine kinase with protean downstream influences on cell cycle regulation,
42                 Finally, given the rapid and protean effects of statins on determinants of platelet r
43 oxygen species, signaling pathways that have protean effects on smooth muscle cell physiology.
44 WIST2 mutations cause AMS or BSS by inducing protean effects on the transcription factor's DNA bindin
45 ct) and cardiac fibrosis, the prototypic but protean features of HCM histopathology, are presumed tri
46                                 Symptoms are protean (flushing, sweating, diarrhea, bronchospasm), us
47 ies, including pathologic data, has led to a protean handling of IS in LT.
48 e, yet the clinical manifestations are often protean in nature and the etiology, elusive.
49 linical manifestations of celiac disease are protean in nature and vary markedly with the age of the
50        The clinical manifestations of CD are protean in nature and vary markedly with the age of the
51 of complement regulation that manifests with protean infectious, vasculitic, and neuroinflammatory sy
52 management of the multiple, progressive, and protean lesions associated with the disorder.
53 rst century's challenges to human being with protean manifestation affecting nearly all organs of our
54                                       It has protean manifestations and can affect any organ, includi
55       Thus, this important liver disease has protean manifestations but is often insidious and can le
56  celiac disease, add to our knowledge of the protean manifestations of MBP.
57                  In addition, the multiorgan protean manifestations of mycoplasma infection are discu
58 ematosus (SLE) is an autoimmune disease with protean manifestations that predominantly affects young
59                            Assertions about "protean manifestations" of B burgdorferi infection shoul
60                   The various presentations, protean manifestations, variable natural history, and at
61 he complexity of this molecular disease with protean manifestations.
62 l, complement-mediated hemolytic anemia with protean manifestations.
63 isease) is often said to be associated with "protean" manifestations, a reference to the ancient god
64  (HCMV) infection, but the virus has evolved protean mechanisms to inhibit MHC-based Ag presentation
65 The essay concludes with observations on the protean nature of physical organic chemistry.
66                                          The protean nature of speech and language disorders requires
67                                    Given the protean nature of the clinical presentation of celiac di
68  payment structures are equipped to meet the protean needs of this important population of children.
69  herpesviruses, EBV and VZV produce the most protean neurological syndromes.
70  and a specific diagnosis for a disease with protean nonspecific findings.
71                               In addition to protean roles in embryonic development, germ-line specif
72                  In this study we review the protean roles of glutamine in cancer, both in the direct
73 in nonhematopoietic cells and dissecting the protean roles of STAT3 is limited by the lethality assoc
74                 We propose that balanol is a protean structure that may be modified to produce select
75 osed precisely because of their scarcity and protean symptoms.
76                             APFs result in a protean syndrome variously combining portal hypertension
77 wn as "the internist's tumor" because it has protean systemic manifestations, suggesting that it util
78               Because these interactions are protean, there can be no health without mental health.