ライフサイエンスコーパス: protease

1 iated by specific persulfidation of the ATG4 protease.

2 appears to function both as a scaffold and a protease.

3 itors of dengue and West Nile virus NS2B-NS3 protease.

4 damage the skin by expression of a cysteine protease.

5 ible for the activation of neutrophil serine proteases.

6 s by MCs and their activation by MC-released proteases.

7 e against unwanted proteolysis by endogenous proteases.

8 esponses and increase sensitivity to inhaled proteases.

9 cognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because proteases

10 Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic trypsino

11 dies have reported that transmembrane serine protease 2 (TMPRSS2) is essential for activation of H7N9

12 ing enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2).

13 ding protein (STAMBP) and ubiquitin-specific protease 33 (USP33) as cognate deubiquitinases for the G

14 The main protease (3CL M(pro)) from SARS-CoV-2, the etiological a

15 The 3C-like (or Main) protease (3CL(pro)) and the nsp12 RNA-dependent RNA-poly

16 re known to interact with ubiquitin-specific protease 7 (USP7); interactions of vIRF-1 and vIRF-3 wit

17 TMEM79 interacts with ubiquitin-specific protease 8 (USP8), whose activating mutations underlie h

18 induce signalling through activation of the protease activated receptor (PAR)2.

19 s of pooled and recombinant human tryptases, protease activated receptor 2 agonist and antagonist pep

20 A quenched protease-activated fluorescent probe 6qcNIR, which produ

21 IHZ assay involves imaging the binding of a protease-activated monoclonal antibody prodrug, called a

22 ators and suppressed the activation of EGFR, protease-activated receptor 2, nucleotide-binding domain

23 procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflamma

24 In vitro, protease-activated receptor-2-dependent vascular permeab

25 activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage sit

26 rter (VIPER) to investigate heterogeneity of protease activation in individual, patient-derived virus

27 Here we investigated receptor binding and protease activation of SARS-CoV-2 spike using biochemica

28 tools, little spatiotemporal information on protease activities on NETs is available in a pathophysi

29 ream of DA1, DAR1 and DAR2 to restrict their protease activity and hence fine-tune plant growth and d

30 lammatory modulator in humans that regulates protease activity and NET formation and modifies efferoc

31 These results show that protease activity can be used to process biological info

32 orm for real-time, quantitative detection of protease activity in biological fluids.

33 ymography probes (AZP) detected dysregulated protease activity in human prostate cancer biopsy sample

34 Unregulated protease activity is a biomarker of several human diseas

35 o test the therapeutic hypothesis that HtrA1 protease activity is involved in the progression of AMD.

36 Protease activity is measured by imaging the activated P

37 We further demonstrate that the SUMO protease activity is required for supernumerous mitotic

38 To address the need for spatially resolved protease activity profiling in cancer, we developed a ne

39 ategy to block Streptococcus pneumoniae IgA1 protease activity to potentially prevent infection.

40 4-week trial, reduction of neutrophil serine protease activity with brensocatib in patients with bron

41 Further, we demonstrated elevated protease activity within the extracellular DNA of sputum

42 To separate the DUB activity from the protease activity, we employed a structure-guided mutage

43 d non-inflammatory CHS with increased serine protease activity.

44 nsor which monitors the single cancer cells' protease activity.

45 tion to bystander food antigen through their protease activity.

46 eport that both hormones induce the secreted protease Adamts18 in myoepithelial cells by controlling

47 CM-remodelling enzymes-in particular the ECM protease ADAMTS4-and inflammatory cytokines, damage-resp

48 increasing the BSA coverage, which prevented protease adsorption.

49 r of the catalytically competent group 1 HDM protease allergen component is demonstrated by a review

50 LR) 4 or TLR2 signalling and, in the case of protease allergens, the activation of additional pleiotr

51 t to involve off-target inhibition of serine proteases, although the precise molecular details remain

52 transition state inhibitors of norovirus 3CL protease, an enzyme essential for viral replication.

53 Enhanced protease and alpha-amylase and reduced lipase activities

54 , the molecular mechanisms behind their dual protease and ligase activities are still poorly understo

55 Because of their dual protease and ligase activity, plant legumains have becom

56 Direct-acting agents, targeting protease and polymerase functionalities, represent a mil

57 low the N-end rule and is mediated by ClpA/P protease and the ClpS adaptor.

58 ort machinery coordinates with mitochondrial proteases and chaperones to maintain the mitochondrial p

59 din is resistant to degradation by major GAS proteases and could therefore serve as a reservoir to ma

60 ins reveal unexpected homology to flavivirus proteases and enable identification of functional self-c

61 he axial channel, as observed for other AAA+ proteases and protein-remodeling machines.

62 ) natural linear cut sites, depending on the protease, and captured most of the examples previously i

63 ecifically sever titin by digestion with TEV protease, and find that the response of muscle fibers to

64 -4/5) belong to caspase-1 family of cysteine proteases, and play a role in inflammation.

65 Droplets protect bound proteins from proteases, and these interactions can be engineered to b

66 t the putative zymogens of many trypsin-like proteases are actually active proteases, explaining thei

67 rotease 1 (Alp1) of Aspergillus sp., because proteases are critical components of many allergens that

68 Proteases are key drivers in many biological processes,

69 Proteases are often used as biomarkers of many pathologi

70 Gingipains, a class of P. gingivalis proteases, are found in association with neurons, tau ta

71 ulation has been carried out using the HIV-1 protease as receptor, thus paving the way to study the p

72 y inhibition" using bacterial and human HtrA proteases as models.

73 rotein 78 (LdHSP78), a putative caseinolytic protease, as important for parasite infection of host ma

74 mproved the protein identifications of other proteases, AspN (+62%), GluC (+80%), and chymotrypsin (+

75 mediated by the autophagy-related (ATG) Cys protease AtATG4a.

76 ly review the development and application of protease-based methods for reporting and controlling cel

77 Once rates for individual protease-on-protease binding and catalysis are determined, proteolyt

78 This structure revealed a protease-binding mode for EapH1 with cathepsin-G that wa

79 ritical for drug discovery and to understand protease biology.

80 The FhKT1 inhibitors do not inhibit serine proteases but are potent inhibitors of parasite cathepsi

81 display a catalytic triad characteristic of proteases but differ in their configuration and protonat

82 ically important for the specificity of many proteases, but this balance is not yet defined for some

83 nserved region with similarity to retroviral proteases, but whether and how DDI2 functions as a prote

84 Antibodies generally inhibit proteases by blocking substrate access by binding to act

85 two discrete fragments by a clostripain-like protease called fragipain (Fpn).

86 degradation of Rb requires action by another protease, calpain, which cleaves Rb after Lys 810.

87 roteases and TMPRSS2 suggests that both host proteases can activate the S glycoprotein during the pro

88 k and cleavage of the mask by tumor-specific proteases can be applied to enhance specificity and safe

89 ast-based platform for directed evolution of protease catalytic properties.

90 ty and/or cross-reactivity with the cysteine protease cathepsin B.

91 The current study found that a cysteine protease Cathepsin B3 (CathB3), and the associated gene

92 106B physically interacts with the lysosomal protease cathepsin D and is required to maintain proper

93 We hypothesized that the protease cathepsin G (CG) may participate in degrading l

94 ost factors, including the receptor ACE2 and protease Cathepsin L.

95 160(JR-FL) precursor with alterations in the protease cleavage site (R508S/R511S) or by introducing a

96 py-C mice express a TEVp (tobacco etch virus protease) cleavage site and a SpyTag (st) between cMyBP-

97 In the inhibition reaction of serpins, a protease cleaves a peptide bond in a solvent-exposed rea

98 Thrombin, a procoagulant protease, cleaves and activates protease-activated recep

99 e study an apicoplast-localized caseinolytic-protease (Clp) system and how it regulates organelle pro

100 rest of the complex by mitochondrial matrix protease ClpXP, which selectively removes and degrades d

101 5 hinge regions in the NS2B bound in the NS3 protease complex and 5 hinges in the NS3- helicase prote

102 Some plant proteases contain a latent sequence known as the plant-s

103 on innate pulmonary inflammation induced by protease-containing fungal allergens, such as Alternaria

104 cellular desmosterol, whereby the HCV NS3-4A protease controls activity of 24-dehydrocholesterol redu

105 and 72 glycopeptides, and confirmed that the protease could cleave in all domains of lubricin, includ

106 Amebic cysteine proteases (CPs) were inhibited using an irreversible inh

107 Binding of PP2A-B56 to ADAM17 protease decreases growth factor signaling and tumor dev

108 andidate from the screens, the mitochondrial protease DegP2, lowers porphyrin levels and decreases DH

109 The purified Lon protease degraded free H-NS but not DNA-bound H-NS.

110 trates and induces allosteric effects in the protease domain of FVIIa.

111 l (approximately 40 nm), where it presents a protease domain.

112 eraction surface, and the active site of the protease domain.

113 as a potential therapeutic target to impair protease-driven tissue degradation in chronic inflammato

114 will enable new insights into the biology of protease dysregulation in cancer and accelerate the deve

115 that the RocA regulon includes the secreted protease-encoding gene speB.

116 rlaps functionally with the other heat-shock protease-encoding genes hslVU, lon, and clpXP to promote

117 spectrum of plasma proteins including serine protease/endopeptidase inhibitors, coagulation factors,

118 the effects of environmental factors such as protease enzymes of allergens, detergents, tobacco, ozon

119 of this review is on Ste24 of the "Post-CAAX-Protease Era."

120 ike 2a (SPPL2a) is an aspartyl intramembrane protease essential for degradation of the invariant chai

121 domains for lectin kinase, R gene, aspartyl protease, etc.

122 Caspase proteases execute apoptosis but also function in develop

123 y trypsin-like proteases are actually active proteases, explaining their capacity to undergo processe

124 t different, but overlapping, sets of murine proteases facilitate H3 and IBV HA cleavages.

125 ctions how the Streptococcus pneumoniae IgA1 protease facilitates IgA1 substrate recognition and how

126 e factor (TF) and the downstream coagulation proteases factor Xa and thrombin significantly attenuate

127 acylating member of the papain-like cysteine protease family and an iteratively acting ATP-grasp prot

128 protein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature.

129 Metacaspases (MCs) belong to a cysteine protease family, structurally related to metazoan caspas

130 Some have canonical pepsin-like aspartic protease features, whereas others have unusual attribute

131 Herein, a protease-focused DNA-encoded chemical library was design

132 urin, reducing its dependence on target cell proteases for entry.

133 e study was to investigate the use of serine protease from Yarrowia lipolytica yeast for reduction of

134 Here, we show that the heat-shock protease FtsH is generally required for growth arrest su

135 anulation, prostaglandin D(2) secretion, and proteases gene transcription.

136 emonstrated high selectivity against related proteases, good target engagement, and tryptase inhibiti

137 nce factors produced by EAEC, the Pic serine protease has been implicated in bacterial colonization b

138 ses, but whether and how DDI2 functions as a protease has remained unknown.

139 se herpesvirus-associated ubiquitin-specific protease (HAUSP), which stabilizes RUNX2 by diverting it

140 Our data reveal that the SUMO protease, HEARTBREAK (HTB), from Capsella rubella contro

141 ty and highlight the contribution of several proteases, heparanase, and hyaluronidase to the shedding

142 acterization with cleavage signatures of 178 proteases highlights proteolytic degeneracy wired into t

143 rine proteases (HPs) and noncatalytic serine protease homologs (SPHs) and inhibited by serpins.

144 is mediated by a network of hemolymph serine proteases (HPs) and noncatalytic serine protease homolog

145 the expression of the pneumococcal chaperone/protease HtrA.

146 er percentage of cells expressing the serine protease HtrA1.

147 n-specific and stratified epithelia-specific protease important in processing of filaggrin, a critica

148 reveal a novel function for a cathepsin-type protease in aphid saliva that elicits effective host pla

149 y requires Ddi1, another conserved predicted protease in Saccharomyces cerevisiae.

150 sight into substrate gating and trapping the protease in the active state.

151 a single site each were generated by a dual-protease in-gel digestion.

152 kgrounds, we found that the absence of these proteases in a fakA mutant reduced dermonecrosis to leve

153 rotease (TEV) is one of the most widely used proteases in biotechnology because of its exquisite sequ

154 the activities of flavivirus NS2B-NS3 serine proteases in living cells.

155 epletion of proinflammatory elastase-related proteases in neutrophils is observed in patients with Ca

156 perative/competitive degradation by multiple proteases in one system, while simultaneously incorporat

157 ability to monitor the activity of multiple proteases in parallel.

158 The effectiveness of some non-specific proteases in reducing raw peanut allergenicity was inves

159 form of PrP(C) shed from the cell surface by proteases in the A Disintegrin And Metalloprotease (ADAM

160 Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium Their funct

161 tection of the activity profiles of multiple proteases in various diseases including many forms of ca

162 ent upon cleavage by recombinant DENV-2/ZIKV proteases in vitro A version of this sensor containing t

163 e), is cleaved from membrane-bound CX3CL1 by proteases including CTSS.

164 e activity and quantity of neutrophil serine proteases, including neutrophil elastase, are increased

165 bioinformatic approaches in mouse models of protease-induced plaque rupture and in ruptured human pl

166 Proteases, inflammatory signaling molecules, as well as

167 host lysosomal cathepsin L, S and K cysteine proteases (inhibition constants < 10 nM).

168 rand transfer inhibitor (25%), and NRTI plus protease inhibitor (19%).

169 ensive Care Clinic cohort initiating INSTI-, protease inhibitor (PI)-, and nonnucleoside reverse tran

170 on of the deleted C12L gene, encoding serine protease inhibitor 1, enhances replication of MVA in hum

171 pan-genotypic hepatitis C virus (HCV) NS3/4A protease inhibitor based on a P1-P3 macrocyclic tripepti

172 obulin-like protein 1 (A2ML1) is a monomeric protease inhibitor but has the hydroxyl reactivity-conve

173 Genetic ablation of serine protease inhibitor SerpinB9 (Sb9) results in the death o

174 ng infection and to assess the efficacy of a protease inhibitor therapy targeting neutrophil elastase

175 ccumulation of the cysteine-rich Bowman-Birk protease inhibitor was several fold higher in transgenic

176 Rationale: The role of PI (protease inhibitor) type Z heterozygotes and additional

177 l small molecule that is used worldwide as a protease inhibitor.

178 nd X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran

179 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantly corre

180 imilar to controls in plasma collected using protease inhibitors cocktail (PIC), but they significant

181 S glycoprotein, we evaluated the ability of protease inhibitors to suppress S glycoprotein function.

182 rss4-deficient mice varied in sensitivity to protease inhibitors, indicating that different, but over

183 This enzyme cleaved the tripeptide aldehyde protease inhibitors, leading to the formation of "pro-py

184 d robust classification of resistance to HIV protease inhibitors.

185 everse transcriptase inhibitors (NRTIs), and protease inhibitors.

186 ly, the largest and most ubiquitous group of protease inhibitors.

187 iated with atopic dermatitis (AD) affect the protease inhibitory activity of LEKTI or its susceptibil

188 etween the ubiquitination site K644, the Ig3-protease interaction surface, and the active site of the

189 pC) variants revealed a functional chaperone-protease interaction.

190 However, the HA proteases involved in the activation of many viral strai

191 mal cleavage sites and natural substrates of proteases is critical for drug discovery and to understa

192 (HA) glycoprotein via cleavage by host cell proteases is essential for viral infectivity, and unders

193 Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically increased in

194 is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to r

195 Skin desquamation is facilitated by serine proteases KLK5 and KLK7, which are tightly regulated by

196 Here, we show that the human cysteine protease legumain exhibits a strict substrate specificit

197 The vacuolar cysteine protease legumain plays important functions in seed matu

198 stasis to occur, cancer cells must exocytose proteases, like matrix metalloproteinases (MMPs), that a

199 hondrial inner membrane, comprising the AAA+ protease, LonP1, and subunits of oxidative phosphorylati

200 The SARS-CoV-2 main protease (M(pro) ) cleaves along the two viral polypepti

201 The main protease (M(pro)) of the severe acute respiratory syndro

202 The catalytic activity of the protease MALT1 is required for adaptive immune responses

203 Our data suggest that this protease, matrix metalloprotease-9, increases branching

204 rticle, specifically the viral cysteine-like protease, might also be potent immunogens.

205 The protease neutrophil elastase (NE) has been implicated in

206 Lgmn is a cysteine protease of late endosomes and lysosomes that can be sec

207 Once rates for individual protease-on-protease binding and catalysis are determine

208 Recently, the O-protease OpeRATOR, derived from intestinal bacteria and

209 clinical features with other PPKs caused by protease overactivity, including erythema, peeling, and

210 a urinary reporter upon exposure to specific proteases overexpressed in the tumor microenvironment.

211 The IS-specific secreted proteases, ovochymase 2 (OVCH2) and A disintegrin and me

212 s incubation using just 4 nM of the cysteine protease, papain.

213 A serine protease physiologically often comes together with a cog

214 sidues not recognized by either of the known proteases plants use to macrocyclize peptides, suggestin

215 Though ubiquitin proteases play a key role in this process by cleaving po

216 FtsH, a bacterial membrane-anchored AAA+ protease, plays a vital role in membrane protein quality

217 analyses of the PIs complexed with wild-type Protease (PR(WT)) and highly-multi-PI-resistance-associa

218 179 were sequenced and subtyped in the gag, protease (PR)-reverse transcriptase (RT), integrase (IN)

219 ogens to release bradykinin and converts the protease precursor factor XII (FXII) to the enzyme FXIIa

220 We show that host protease processing during viral entry is a significant

221 Here we investigate inflammation and the protease profile in nasal tissues and plasma from contro

222 Intestinal proteases promoted the most efficient protein release bu

223 ased protein levels of the tumor-suppressive protease prostasin.

224 Human and bacterial Lon proteases regulate DNA replication by degrading replicat

225 nced resistance to degradation by intestinal proteases relative to antibodies from human or bovine se

226 s a sialic-acid rich glycocalyx also induced protease release, and this was partially abrogated by si

227 ields was sufficient to induce intracellular protease release, suggesting altered membrane integrity

228 he ER to the Golgi, where the actions of two proteases release the amino-terminal domains of SREBPs t

229 rified Fpn provided direct evidence that the protease releases at least some of these proteins from t

230 roteases, we used RNA-Seq to investigate the protease repertoire of murine lower airway tissues, prim

231 ith an engineered FRET reporter called VIral ProteasE Reporter (VIPER) to investigate heterogeneity o

232 A newly developed luciferase-based DENV-2 protease reporter system in HeLa cells (DENV2proHeLa) wa

233 emotypes known to engage conserved catalytic protease residues.

234 s revealed that ADAM17 was also the shedding protease responsible for the transactivation of EGFR by

235 d cells with siRNA against ESPL1/Separase, a protease responsible for triggering anaphase, to generat

236 e digestion of the composite when exposed to proteases results in a change of its resistivity, a quan

237 ction of the library with thrombin, a common protease, revealed a number of enriched features which u

238 We obtained 58 protease/reverse transcriptase genotypes.

239 control of the epidermal growth factor (EGF) protease Rhomboid (Rho).

240 6qcNIR, which produces a signal only in the protease-rich tumor microenvironment, was topically appl

241 l domain of Ddi1, HDD) and a retroviral-like protease (RVP) domain.

242 interaction energy, can help characterize a protease's substrate recognition, giving insights for th

243 PRSS2 and carried out by as-yet-undetermined protease(s).

244 RIP mediated by site-1 protease (S1P) and site-2 protease (S2P) is involved in

245 n factors and are subjected to RIP by site-1 protease (S1P) and site-2 protease (S2P) sequentially in

246 mediated by site-1 protease (S1P) and site-2 protease (S2P) is involved in proteolytic activation of

247 d to RIP by site-1 protease (S1P) and site-2 protease (S2P) sequentially in response to endoplasmic r

248 To overcome this, we developed a series of protease-selective lanthanide-labeled probes compatible

249 for respiratory disease by local delivery of protease-sensing nanoparticles to the lungs.

250 n when viewed from outside the cell with the protease-sensitive GRIP domains in the periphery (Noreng

251 ve efforts are devoted to the development of protease sensors.

252 nsert (PSI) that, upon release from the full protease sequence, initiates membrane fusion to defend f

253 help of another host protein, transmembrane protease serine S1 member 2.

254 converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2), are modulated by IL-13.

255 n converting enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2), their expr

256 ily of nine secretory subtilisin-like serine proteases, seven of which cleave at specific basic resid

257 epsin-G, we crystallized EapH1 bound to this protease, solved the structure at 1.6 angstrom resolutio

258 , the first deep learning-based predictor of protease-specific substrates and cleavage sites.

259 t two 20E-regulated chymotrypsin-like serine proteases specifically expressed in the reproductive tra

260 The protease SPRTN emerged as the essential enzyme for DNA-p

261 ) production but increased expression of the proteases SspAB and aureolysin in vitro, and that the De

262 assays have provided valuable insights into protease substrate recognition.

263 Neutrophil proteases such as elastase (NE) and cathepsin G (CG) att

264 ke particles by the simple addition of viral protease, suggesting that it is possible in principle to

265 lytic cleavage of precursor p66/p66 by HIV-1 protease, suggesting that it stabilizes the productive c

266 The Clp protease system destabilizes a zinc-bound form of Mpy re

267 strong genetic interactions with stromal CLP protease system mutants, resulting in reduced growth.

268 Tobacco etch virus protease (TEV) is one of the most widely used proteases

269 HIV encodes an aspartyl protease that is activated during, or shortly after, bud

270 BACE2, an aspartyl protease that is structurally related to BACE1, has been

271 ed by TMPRSS6, is a membrane-anchored serine protease that plays a key role in suppressing hepatic he

272 e pathogenic mediators such as cytokines and proteases that contribute to disease pathogenesis and pe

273 o NE, neutrophils contain three other serine proteases that could compensate if the activity of NE wa

274 e protease (TTSP) family encompasses several proteases that play critical roles in cancer progression

275 ating enzymes, or DUBs, comprise a family of proteases that regulate ubiquitination dynamics.

276 ce is not yet defined for some of the serine proteases that serve as coagulation factors.

277 Metacaspases and paracaspases are proteases that were first identified as containing a cas

278 GAS-STING evasion enzymes evolved from viral proteases through gain of secondary nuclease activity.

279 DA agonists (NMDA or glycine) and the serine protease tissue plasminogen activator, previously shown

280 Stable introduction of the Spike-activating protease TMPRSS2 further enhanced susceptibility to infe

281 ses to enter host cells, along with the host protease TMPRSS2.

282 the canonical NF-kappaB machinery and (b) a protease to cleave and inactivate specific substrates, i

283 The copiotroph could secrete extracellular proteases to degrade and then utilize the proteinaceous

284 ) and monovalent cations but is resistant to protease treatment.

285 yndrome (MERS)-like bat CoVs using exogenous protease treatment.

286 The type II transmembrane serine protease (TTSP) family encompasses several proteases tha

287 activity was identified as EcpA, a cysteine protease under quorum sensing control.

288 e ELK-1 ETS domain by the Ubiquitin Specific Protease USP17 was shown to augment ELK-1 transcriptiona

289 t the identification of a ubiquitin-specific protease, USP7, as a regulatory switch in a protein qual

290 protein half-life, whereas cleavage by ADAM proteases was not modified.

291 The mechanistic role of MC(TC) proteases was tested using inhibitors.

292 entify additional H3 IAV- and IBV-activating proteases, we used RNA-Seq to investigate the protease r

293 ed on degradation of DQ-OVA, a substrate for proteases which upon hydrolysis is fluorescent) was comp

294 arase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes

295 Activated protein C is a trypsin-like protease with anticoagulant and cytoprotective propertie

296 Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective function

297 Kallikreins (KLK), a family of serine proteases with a diverse array of homeostatic functions,

298 enzyme used for proteome digestion, although proteases with alternative specificities are required to

299 re able to identify the distribution of four proteases with different active site geometries in three

300 The unique family of DPC-specific proteases Wss1/SPRTN targets DPC protein moieties for de