ライフサイエンスコーパス: protecting group

1 acidic removal of the 2-methoxyethoxymethyl protecting group.

2 application of the methyl group as a useful protecting group.

3 based on a lipase catalyzed cleavage of the protecting group.

4 king of the peptide charge with a lipophilic protecting group.

5 G), or tert-butyldisulfanyl (G) as the 5'-S-protecting group.

6 gly affected by the electronic effects of N3 protecting group.

7 iral BP synthons incorporating a photolabile protecting group.

8 rated to be useful as a Merrifield synthesis protecting group.

9 metrizing, cascade process involving the Boc protecting group.

10 of delta-azaproline can be tuned easily by a protecting group.

11 the chain, carrying an N-terminal carbamate protecting group.

12 ect to comparable systems lacking the cyclic protecting group.

13 esized from the corresponding o- and p-nitro protecting group.

14 ation of the tetrafluoropyridyl (TFP) phenol-protecting group.

15 y virtue of changing the nature of the amine protecting group.

16 xyquinolin-2-yl)methyl (CyHQ) photoremovable protecting group.

17 observed through precise manipulation of the protecting group.

18 onic characteristics of the ligand's benzoyl protecting group.

19 without needing derivatization or the use of protecting groups.

20 ced by the presence of aromatic rings in the protecting groups.

21 zed by variation of the alpha-amino aldehyde protecting groups.

22 ings in a single operation in the absence of protecting groups.

23 ity, stereoselectivity, or the importance of protecting groups.

24 possible, streamlining or eliminating use of protecting groups.

25 placed by various sulfonyl- or urethane-like protecting groups.

26 f the glycosylation reaction and the role of protecting groups.

27 vage reactions that allow for the removal of protecting groups.

28 readily available compound without using any protecting groups.

29 e and S-acyl-2-thioethyl (SATE) phosphate as protecting groups.

30 rs directly from functional monomers without protecting groups.

31 tionalization without the use of specialized protecting groups.

32 ubstrate scope and is tolerant of a range of protecting groups.

33 al quaternary amino acids carrying carbamate protecting groups.

34 of the solvents, acyl groups, or alkylidene protecting groups.

35 ic interplay between acetate and silyl ether protecting groups.

36 only two to four steps without the need for protecting groups.

37 s compound compared with other o-nitrobenzyl protecting groups.

38 ing fragments and cleavage of the ester-type protecting groups.

39 , followed by hydrogenolysis of benzyl ether protecting groups.

40 a Suzuki coupling using tert-butyl thioether protecting groups.

41 ve handles, purification tags, and removable protecting groups.

42 uction and subsequent removal of undesirable protecting groups.

43 t needing to mask the recognition units with protecting groups.

44 and analogues on scale without the need for protecting groups.

45 iently couple amino acids featuring standard protecting groups.

46 s it represents a reactive P-amidite without protecting groups.

47 has only the 2,4-isomer emerged as a labile protecting group?

48 ng the stability of 2-Pyridinyl Thermolabile Protecting Groups (2-Py TPGs) in the "chemical switch" a

49 lly on (1) effective use of a series alkynyl protecting groups, (2) Sonogashira cross-coupling reacti

50 A new photoremovable protecting group, (6-hydroxy-3-oxo-3H-xanthen-9-yl)methy

51 rine-derived oxazolidines as another type of protecting group), a compound with the presumed structur

52 ycarbonyl (Boc) or carboxybenzyl (Cbz) imine protecting groups adds utility to the reaction by allowi

53 tablished that para-substituted benzyl ether protecting groups affect the reactivity of glycosyl dono

54 ge and removal of the acid-labile side-chain protecting groups affords the crude peptides containing

55 al repulsion was evaluated for main types of protecting groups (alkyl, silyl, and acyl) usually used

56 The three protecting groups allow independent modification of the

57 nificantly stabilized the 1,3-dioxane acetal protecting group, allowing for specific stimulus-mediate

58 s with easily removable N,N-di-Boc-carbamate protecting groups, allowing for a flexible ynimide-based

59 lfonyl moiety, which serves as a base-labile protecting group and confers crystallinity to these cycl

60 Additional features are the TMS protecting group and halo-induced ipso-desilylation tact

61 s of polyhydroxylated terpenes by minimizing protecting group and redox adjustments.

62 using a trans-fused cyclic 3,4-O-disiloxane protecting group and TsOHH2O (1 mol%) as a catalyst.

63 lysis relative to simple nitroveratryl-based protecting groups and a useful two-photon cross-section.

64 eophilic strong-base (DBU) labile nucleobase protecting groups and a UV-light cleavable linker were u

65 rate-derived lactones can be mediated by the protecting groups and applied to the total synthesis of

66 of glycosylation stereoselectivity by remote protecting groups and as a control element in enzymic pr

67 eptides, alternative orthogonality regarding protecting groups and ease of producing C-terminal thioe

68 The judicious selection of protecting groups and reaction conditions allowed the st

69 the condition required to remove base labile protecting groups and the ODNs from the solid support.

70 -known as megamolecules-without the need for protecting groups and with precisely defined nanoscale a

71 perturb the common NHBoc or toluenesulfonyl protecting groups and, as demonstrated with an estrone s

72 epending on substrate, amino acid ligand and protecting group, and reaction conditions.

73 lytic conditions tolerate common acid-labile protecting groups, and a wide variety of alpha-acyloxy a

74 aqueous media, in the absence of side chain protecting groups, and are tolerant of all proteinogenic

75 ion reaction can serve as functional groups, protecting groups, and directing groups.

76 tide in solution, cleavage of the side-chain protecting groups, and oxidization of cysteines to yield

77 ction tolerates both acid and base sensitive protecting groups, and products are afforded in 68-96% y

78 proach circumvents the need for conventional protecting groups, and therefore no formal protection an

79 ibe this process, which essentially sets the protecting groups anew.

80 Photoremovable protecting groups are important for a wide range of appl

81 nly used in oligosaccharide synthesis, these protecting groups are not relied upon to control selecti

82 With identical protecting group arrays cyclization in the glucopyranose

83 reactions and highlights the 2-OBn pyridine protecting group as a key intermediate.

84 Utilization of a common protecting group as the directing group for meta-C-H act

85 group, 2) using common functional groups or protecting groups as directing groups, and 3) attaching

86 derivatives can be useful as photocleavable protecting groups, as demonstrated through the synthesis

87 methine, alpha to the carboxy group) and the protecting groups at C17-OH and C18-OH have posed diffic

88 possessing chemically and sterically diverse protecting groups at O-3 and O-6 is described.

89 acetyl, and tert-butyldiphenylsilyl (TBDPS) protecting groups at O-3 were prepared from p-methoxyphe

90 osyl donors bearing neighboring group-active protecting groups at O2 are discussed.

91 benzyl, benzoyl, or tert-butyldimethylsilyl protecting groups at the C3-O and C4-O positions, were s

92 y been achieved by placing sterically bulky "protecting groups" at the termini, which shield the reac

93 e describe the synthesis of a new NDBF-based protecting group bearing a methoxy substituent and use i

94 ects between picoloyl and the accompanying O-protecting groups (benzoyl vs acetyl) were evaluated, as

95 The HOP group not only acts as a protecting group but also as a polar tag for simple prod

96 The electron-withdrawing ability of the protecting groups, but not bulk, impacts the electron de

97 azoles with subsequent removal of the acetyl protecting group by acid hydrolysis was developed.

98 w that a [2]catenane can act as a mechanical protecting group by diverting tensional forces away from

99 show that the 5'-O-2,7-dimethylpixyl (DMPx) protecting group can be used to limit acid exposure and

100 The amino protecting groups can be selectively unmasked by a reduc

101 Unexpectedly, also benzyl ether protecting groups can engage in remote participation and

102 The development of effective protecting group chemistry is an important driving force

103 oting that our approach does not require any protecting group chemistry.

104 rsor in aqueous solution without recourse to protecting group chemistry.

105 acid cis-dihydroxyproline (Dyp) is a typical protecting group cleavable by traces of TFA.

106 The allyl protecting group could be removed in good yield using ca

107 of the desired alpha products and the silyl protecting groups could be removed in the presence of un

108 The thiosulfonate protecting group demonstrated resistance to oxidation an

109 Photoremovable protecting groups derived from meso-substituted BODIPY d

110 novo chromatography-free furanose synthesis, protecting group-directed Vorbruggen glycosylation, and

111 When protecting groups do not contain an aromatic ring, the s

112 ell as benzylidene-, silyl-, Troc-, and Fmoc-protecting groups do not get affected during the newly i

113 By modulating the nitrogen-protecting group, either highly branched- or linear-sele

114 reactivity via negative hyperconjugation as protecting group electron withdrawal increases.

115 ues is often lengthy and requires the use of protecting groups, enzymes have the potential to synthes

116 By tuning the stability of the silyl protecting groups (ex.

117 l catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup cond

118 vation by a sulfur atom of a methylthioalkyl protecting group, followed by enzymatic hydrolysis of th

119 nt was applied to remove the oligonucleotide protecting groups, followed by a treatment with 50 mM me

120 d robust alternative to p-methoxybenzyl as a protecting group for alcohols.

121 A diazo group was introduced as a protecting group for an enolizable ketone.

122 xperiments highlight the utility of this new protecting group for SPPS and biological experiments.

123 se coupling reactions without the need for a protecting group for the alkyne-functional initiator: (1

124 cient and effective participating orthogonal protecting group for the stereoselective synthesis of 1,

125 yl)-9-fluorenyl as a temporary, safety-catch protecting group for the suppression of epimerization in

126 sclosed herein is that vinyl ethers serve as protecting groups for alcohol-containing molecules and a

127 al design for long-wavelength photoremovable protecting groups for alcohols and amines.

128 Application of tert-butyl ester protecting groups for erythro-beta-d-methylaspartic acid

129 The acid-cleavable protecting groups for secondary alcohol and uridine urei

130 thenyl group that we name MocVinyl) serve as protecting groups for the above-mentioned heterocyclic C

131 ups to serve for the first time as removable protecting groups for the boron position of 1,2-azaborin

132 spect of this approach is the utilization of protecting groups for the N-terminal Cys in the middle f

133 asily synthesized in one step and can act as protecting groups for these pharmaceutically relevant sy

134 A selection of benzyl-based protecting groups for thiouracil ((S)U) for the synthesi

135 A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framew

136 Combined with a protecting group free two-step enzymatic glycosylation o

137 on allowed us to identify conditions for the protecting group-free or minimized total synthesis of bi

138 A protecting group-free strategy is presented for diastere

139 User-friendly protocols for the protecting group-free synthesis of 2,2'-biphenols via Su

140 h thiazole-fused A-ring through an efficient protecting group-free synthetic strategy.

141 ensuing 2-alkoxyfuran hydrolysis and (ii) a protecting group-free vinylogous Knoevenagel condensatio

142 f the approach is underscored by a succinct, protecting group-free, and enantioselective total synthe

143 Here we introduce a protecting-group-free approach for the alpha-functionali

144 An efficient seven-step, protecting-group-free first total synthesis of chatenayt

145 ve assembly of various functional units in a protecting-group-free manner.

146 A low-temperature, protecting-group-free oxidation of 2-substituted aniline

147 methoxy alkynyl zinc reagents allows for the protecting-group-free syntheses of transtaganolides C an

148 The protecting-group-free synthesis is completed in four ste

149 Further, a four-step protecting-group-free synthesis of the natural product a

150 Using a concise, protecting-group-free synthesis we demonstrate the chemo

151 A protecting-group-free synthetic strategy for the synthes

152 gomers were obtained on solid support from a protecting-group-free two-step iterative protocol, based

153 The cleavage of a protecting group from a protein or drug under bioorthogo

154 able to rapidly remove propargyloxycarbonyl-protecting group from the N-terminal Cys in a similar ef

155 nature of the electron-withdrawing nitrogen protecting group has a very limited influence on the cou

156 y-5,7-dinitroindolinyl (CDNI) photocleavable protecting group in a four-step synthesis.

157 ion, and an orthogonal cleavage of the N-Boc protecting group in piperidone derivatives was carried o

158 relative configuration and nature of the C5 protecting group in the 8 starting ketones.

159 could be controlled by changing the indole N-protecting group in the reductive cyclization precursors

160 been demonstrated in the use of thiazolidine protecting group in the synthesis of over 100 proteins,

161 groups of the carbonyl moiety rather than a protecting group in this type of FeCl3.6H2O-catalyzed co

162 e reaction mechanism and the role of distant protecting groups in glycal reactivity.

163 , bromo- and chloroacetates, which are major protecting groups in glycochemistry because they are ort

164 f, which represent an unprecedent use of the protecting groups in the synthesis of a naturally occurr

165 ty and stability of 2-Pyridinyl Thermolabile Protecting Groups in thermal deprotection.

166 ycyclization occurred in the presence of the protecting group; in the absence of the protecting group

167 Removal of the TBS protecting group initiated a 7-endo-dig cyclization to y

168 y extended the methodology to regioselective protecting group installation and manipulation toward a

169 c introduction of a small-molecule-removable protecting group into the protein of interest.

170 The choice of benzoyl as N-protecting group is critical since the observed N- to O-

171 monly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation

172 The photolabile 2-nitrobenzyl protecting group is most appropriate for promotion of th

173 An ortho-alkyloxy side chain on the N-benzyl protecting group is necessary for the macrocyclization t

174 After peptide synthesis, the Hyp protecting group is orthogonally removed and Hyp selecti

175 ers and the demand for an N-(o-alkoxybenzyl) protecting group is provided on the basis of DFT calcula

176 ing groups of the o-amino group, the o-nitro protecting group is the only choice to synthesize the o-

177 The use of photolabile protecting groups is a versatile and well-established me

178 tonation of 4-amino 2-Pyridinyl Thermolabile Protecting Groups is demonstrated by (1)H-(15)N HMBC and

179 ility of the new removal conditions for both protecting groups is exemplified in the rapid and effici

180 turing the stable trimethylacetyl (pivaloyl) protecting group, is described for their preparation.

181 genic chloromethyl methyl ether to install a protecting group late in the synthesis, and an unreliabl

182 Variation of this residue and its N-terminal protecting group leads to the conclusion that maximal le

183 ns along with studying effects of the remote protecting groups led to excellent stereocontrol of alph

184 In combination with the orthogonal hydroxyl protecting groups levulinic (Lev) ester, thexyldimethyls

185 ore, which, along with judicial selection of protecting groups, made the current synthesis very effic

186 easy removal of the N-(dipehenylphosphinoyl) protecting groups makes this method practically useful f

187 Final protecting group manipulation of the (1->3) thiodisaccha

188 Minimizing stereochemical adjustments and protecting group manipulations, diacetone glucose is con

189 is required, and the route is devoid of any protecting group manipulations.

190 ediate 9, which after a series of nontrivial protecting-group manipulations affords key intermediate

191 h features a redox-economic approach free of protecting-group manipulations, assembles all four-ring

192 purifications, is high yielding, and avoids protecting-group manipulations.

193 ty, which is key for the development of free protecting group methodologies.

194 ans of oxidation and a subsequent unexpected protecting-group migration.

195 In addition, we have demonstrated that the protecting groups, namely, Ts, Fmoc, and (t)Bu, can be e

196 Photolabile chelating cages or protecting groups need complex chemical syntheses and re

197 nyl (PhF) group has been used as an N(alpha) protecting group of amino acids and their derivatives ma

198 d, which could be explored as acid-sensitive protecting group of free amines.

199 The tert-butyl protecting group of the pendant carboxylate group was re

200 uoride (HF) is used to remove the side chain protecting groups of the assembled peptide and to releas

201 Among the four protecting groups of the o-amino group, the o-nitro prot

202 ion of the hydrogen involved in the IHB by a protecting group (OMe, OAc, OBz, OBn, or OTBDMS), a high

203 ydes, incorporating a methylthiomethyl (MTM) protecting group on nitrogen, are shown to be efficient

204 ith an azetidine derivative bearing a benzyl protecting group on nitrogen.

205 hod for synthesizing bpDNA that uses a silyl protecting group on the DNA nucleobases during the solid

206 luorination was achieved using an unorthodox protecting group on the precursor, which could withstand

207 e organotrifluoroborates in the absence of a protecting group on the sulfonamide nitrogen.

208 od is demonstrated by the removal of the Nap protecting groups on highly sensitive 2,6-dideoxy-sugar

209 the removal of 2-naphthylmethyl (Nap) ether protecting groups on highly sensitive substrates.

210 It was observed that the protecting groups on one neighboring GlcNAc moiety have

211 od for the investigation of the influence of protecting groups on the anomeric equilibrium in the sia

212 reactive nucleophiles and electron-donating protecting groups on the donor favor alpha-glycosidic bo

213 s into soluble dyes by introducing transient protecting groups on the secondary amine moieties, follo

214 r protonating agent were examined as well as protecting groups on the xyloside moiety and the influen

215 with probes that require hydrolysis of toxic protecting groups or application at high concentrations

216 y chiral tertiary amino acids carrying amide protecting groups or by chiral quaternary amino acids ca

217 Typically, protecting groups or catalysts must be used to enable th

218 prepared in 7 steps (LLS) in the absence of protecting groups or chiral auxiliaries via enantioselec

219 Photolabile protecting groups (or "photocages") enable precise spati

220 the protecting group; in the absence of the protecting group, palladium- and gold-catalyzed benzannu

221 nce of the thioglycoside substituent and the protecting group pattern on the glycosyl donor was inves

222 lation strategies, elongation sequences, and protecting group patterns are discussed, but also (semi)

223 The choice of protecting groups permitted a one-step global deprotecti

224 rature and solvents; only the delta-nitrogen protecting group plays key role in the isomerization.

225 yl (DEABn) group as an effective photolabile protecting group (PPG).

226 Photocleavable protecting groups (PPGs) are extensively used in chemica

227 Photoremovable protecting groups (PPGs) are powerful tools for physiolo

228 movable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged or photoca

229 roach that involved selective removal of the protecting group present at the O-2 position of a single

230 thesis of over 100 proteins, finding optimal protecting group(s) remains a challenge.

231 This protecting group should be useful for a plethora of appl

232 r the nonparticipating azide group, but this protecting group significantly increased beta-selectivit

233 orrelation times, which increased with silyl protecting group size rather than acene size, indicating

234 Bulky protecting groups slow the rate of acetylation.

235 By installing two different photolabile protecting groups, so-called caging groups, onto two dif

236 Transition-state calculations reveal that protecting group stereoelectronics direct the reaction t

237 ite-selective modification without employing protecting group strategies.

238 Such a protecting group strategy applied to on-surface chemistr

239 s of full length Abeta, we use an orthogonal protecting group strategy during the synthesis to append

240 plished by using a 2'/3'-O-acetyl orthogonal protecting group strategy in which non-nucleophilic stro

241 -disulfide-bonded analogues using a targeted protecting group strategy to investigate the impact of t

242 oligonucleotide building block synthesis, a protecting group strategy was developed for 2'-O-proparg

243 The protecting group strategy was directed by a stability st

244 approach combined with a para-methoxybenzyl protecting group strategy, 3-azido-3-deoxy- and 4-azido-

245 Adjusting the protecting group strategy, from an alkyl ether to a bide

246 The synthesis involved a protecting-group strategy that facilitated the regiosele

247 l and amino groups are protected with simple protecting groups such as acetates (Ac, Piv) and carbama

248 methodologies include the use of reversible protecting groups such as pseudoprolines that restrict c

249 Fmoc, Cbz, and benzyl, as well as various OH protecting groups, such as (t)Bu and Bzl.

250 iodomethyl group over hydrogenolysis-labile protecting groups, such as benzyloxycarbonyl, benzyl est

251 Reactions are compatible with common N-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, a

252 Aided by a controlled protecting group switch, we were able to effectively tar

253 ty of the conventional amino acid side-chain-protecting groups, t-Bu, Boc, Trt, and Pbf, and the form

254 pend on the steric demands of the hemiaminal protecting group, tetrahydrofuran concentration, and the

255 have designed a nitroaromatic photochemical protecting group that absorbs visible light in the viole

256 an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reactio

257 oligands using cell-adhesive peptides with a protecting group that can be easily removed via transder

258 The 4-methoxybenzyl-protecting group that has found use for (S)U during Boc-

259 Here we report a sulfonate protecting group that is resistant to nucleophilic attac

260 nd characterization of new photolabile amine protecting groups that are active under visible light.

261 compatible with the acid- and base-sensitive protecting groups that are commonly used in oligosacchar

262 ides and glycosides call utilization of many protecting groups that can be installed or deprotected w

263 Photocages are light-sensitive chemical protecting groups that give investigators control over a

264 However, protecting groups that have the ability to influence rea

265 ve led to the invention of a large number of protecting groups that temper the reactivity of nitrogen

266 des, the selection of appropriate orthogonal protecting groups, the development of stereoselective gl

267 which the phosphate moiety bears a chemical protecting group, thus eliminating the negative charges

268 The use of Ns protecting group to direct C(sp(3))-H activation of alky

269 Being able to utilize a protecting group to influence remote regiocontrol offers

270 Introduction of an N-methyl protecting group to the ligand inhibits this oxidation a

271 as shown that the coordination of the remote protecting group to the palladium center is determinant

272 tely, a new application of the 4-azidobenzyl protecting group to thioamides was found to provide the

273 Diazaheptacenes need four silylethynyl protecting groups to be isolable.

274 agents by (i) incorporating gas phase-labile protecting groups to silence otherwise reactive function

275 electron-rich alkenes (glycals) with varied protecting groups to systematically elucidate the factor

276 due to the slow release of the hydroxyalkyl protecting group, together with the fast formation of th

277 benzyl ethers and the efficient and multiple protecting group transformations are applicable in gener

278 reactivity of nitrogen; however, the use of protecting groups typically introduces additional steps

279 rivatives by vinylogous elimination of the O-protecting group under mildly acidic condition.

280 in decaging a broad range of propargyl-based protecting groups used in chemical protein synthesis.

281 makes this technique extra demanding on the protecting groups used.

282 e yield of the l-ido product and the size of protecting groups used.

283 While protecting groups vulnerable to influenza is likely a us

284 BRAP with a self-immolative boronic ester protecting group was designed to scavenge H2O2 and relea

285 -step procedure with the triethylsilyl (TES) protecting group was developed to selectively expose the

286 eck methodology, the necessity for a pyrrole protecting group was discovered.

287 The protecting group was matched to the reducing agent, and

288 ion cross-section of 0.71-1.4 GM for the new protecting group was particularly notable.

289 , an L-alanine amino acid derivatized with a protecting group was used to prevent self-polymerization

290 adaption of this approach, introduction of a protecting group was used to synthesize an oligo(3-hexyl

291 ctivity of meso-methyl BODIPY photoremovable protecting groups was accomplished through systematic va

292 en failed to undergo ring-closure, several N-protecting groups were evaluated.

293 substrate scope, and various functional and protecting groups were tolerated under the reaction cond

294 ge of a photolabile nitroveratryloxycarbonyl protecting group, which is widely used as caging group,

295 -chloro (PClB) or p-cyanobenzyl ether (PCNB) protecting groups, which decreased the reactivity of the

296 ctivated analogues by replacing the N-benzyl protecting group with a N-tosyl group, rendering these a

297 actions between the aromatic ring of the C-2 protecting group with the exocyclic triple bond and the

298 ngly trivial steps of end-capping to replace protecting groups with N-terminal acetamides and C-termi

299 acidic treatment that removes the polyamide protecting groups with no harm to the cycloadduct, in co

300 biomimetic conditions, without the need for protecting groups, yielding powerful synthons in previou