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1 tion against their binding domains elicits a protective immune response.
2 re thought to be an important component of a protective immune response.
3 ctivation of CD8(+) T cells is crucial for a protective immune response.
4 ole for antibodies and CD4(+) T cells in the protective immune response.
5 infection induces an effective and long-term protective immune response.
6 have long latencies even though there is no protective immune response.
7 exposure to B. burgdorferi may not elicit a protective immune response.
8 gnize pathogen-expressed Ags and elicit host-protective immune response.
9 immunomodulation as well as the induction of protective immune response.
10 mmon mechanism of viral escape from the host protective immune response.
11 this process are important for developing a protective immune response.
12 cytokine IL-10 is essential for preventing a protective immune response.
13 enuated in pneumonic tularemia yet induced a protective immune response.
14 rus that is genetically stable and elicits a protective immune response.
15 n reflects some type of "consolidation" of a protective immune response.
16 roach is to identify products that enhance a protective immune response.
17 e also requiring a smaller dose to achieve a protective immune response.
18 n from a Gram-positive organism and induce a protective immune response.
19 based on this region could elicit a broadly protective immune response.
20 gG3), that seem to have an essential role in protective immune response.
21 virus-specific T cells, thereby eliciting a protective immune response.
22 bnAbs are considered key to elicitation of a protective immune response.
23 BALT structure is indicative of an effective protective immune response.
24 pleen when orally delivered, indicative of a protective immune response.
25 ls produce IL-10 that downregulates the host protective immune response.
26 may prove to be more capable of elliciting a protective immune response.
27 attenuated disease in mice and stimulated a protective immune response.
28 mycin inhibitors (mTOR-i) could recover this protective immune response.
29 s to suppress the tumor growth and lead to a protective immune response.
30 that sense microbial attacks and initiate a protective immune response.
31 persistent infections without development of protective immune responses.
32 ost immune system, which might contribute to protective immune responses.
33 tral to understanding immune homeostasis and protective immune responses.
34 ellular A. fumigatus and collectively induce protective immune responses.
35 and lipopolysaccharide (LPS) is a target of protective immune responses.
36 t reduce the ability of VSV to induce potent protective immune responses.
37 etion of CD4(+) T cells and dysregulation of protective immune responses.
38 )CD8(-) DCs with regard to the initiation of protective immune responses.
39 n animal model of autoimmunity while sparing protective immune responses.
40 protein antigen induced systemic and mucosal protective immune responses.
41 which affect their ability to contribute to protective immune responses.
42 tered at these locales, thereby accelerating protective immune responses.
43 face of infected red blood cells and elicits protective immune responses.
44 r bacterium that activates both Th1 and Th17 protective immune responses.
45 infection does not reliably provoke durable, protective immune responses.
46 s contain adjuvants that are used to enhance protective immune responses.
47 it required a booster immunization to prime protective immune responses.
48 more effectively generating vaccine-induced protective immune responses.
49 ts and soluble factors coordinate to disrupt protective immune responses.
50 tory infection but are capable of generating protective immune responses.
51 immunogenic protein epitopes needed to mount protective immune responses.
52 but 2 doses of vaccine are needed to elicit protective immune responses.
53 used in a cell-based vaccine model to induce protective immune responses.
54 antigen and enables the rapid initiation of protective immune responses.
55 as staphylococcal infections fail to induce protective immune responses.
56 ses on the development of vaccines to induce protective immune responses.
57 e molecules activate/recruit DCs and enhance protective immune responses.
58 erfere with complement deposition and elicit protective immune responses.
59 g Bacillus anthracis infection and eliciting protective immune responses.
60 PS but does not coincide with a reduction in protective immune responses.
61 zed influenza vaccine and investigated their protective immune responses.
62 accines are well tolerated and elicit potent protective immune responses.
63 due to reduced alloimmunity or less diverse protective immune responses.
64 vaccine systems that can generate potent and protective immune responses.
65 such as the lung, plays an important role in protective immune responses.
66 early paradigm in which IL-2 is central for protective immune responses.
67 it with the ALVAC vector could increase the protective immune responses.
68 o respond to pandemic influenza strains with protective immune responses.
69 nt immune environment to successfully elicit protective immune responses.
70 accines, and our incomplete understanding of protective immune responses.
71 and consequently inhibit the development of protective immune responses.
72 velop therapeutic interventions that promote protective immune responses.
73 disease pathology and increased Mtb-specific protective immune responses.
74 sign of optimized Gn/Gc immunogens to elicit protective immune responses.
75 varicella-zoster virus (VZV) vaccine induces protective immune responses.
76 elop strategies to enhance the durability of protective immune responses.
77 tenuated or inactivated vaccines at inducing protective immune responses.
78 immunosuppression, and with preservation of protective immune responses.
79 at elicits broadly reactive and long-lasting protective immune responses.
80 t compromising IL-6 classic signaling-driven protective immune responses.
81 exposure, where they elicit rapid and robust protective immune responses.
82 producing inhibitory substances, and priming protective immune responses.
83 barrier tissues is critical for long-lasting protective immune responses.
84 is highly variable and does not elicit cross-protective immune responses.
86 low virulence in infected mice and induced a protective immune response against a lethal infection co
87 on of mice with recombinant (r)TF elicited a protective immune response against a pneumococcal challe
88 nd are impaired in the ability to generate a protective immune response against a second infection.
90 However, emerging data indicate that the protective immune response against attenuated F. tularen
91 pted us to examine its utility in inducing a protective immune response against Bordetella bronchisep
92 been shown to play an important role in the protective immune response against Encephalitozoon cunic
94 l helper CD4(+) T cells is the hallmark of a protective immune response against hepatitis C virus (HC
96 l infection resulted in the development of a protective immune response against lethal LVS intraperit
98 o identify a marker for the development of a protective immune response against M. tuberculosis chall
101 ride analogs of labile CPS induce a specific protective immune response against native CPS using S. p
102 4(+) T cells may provide a basis to induce a protective immune response against persistent infections
103 PspA) is highly immunogenic and can induce a protective immune response against pneumococcal infectio
104 immature in young infants to induce a fully protective immune response against RSV reinfections.
105 tics, greater understanding is needed of the protective immune response against S. aureus infection i
106 noninfectious T. gondii extract enhances the protective immune response against severe H5N1 influenza
107 er, after a single vaccination, they induced protective immune response against subsequent CHIKV chal
108 bies virus-based vaccine against CDV induces protective immune responses against both pathogens.
109 In contrast, experimental studies show that protective immune responses against cryptococcosis are a
111 vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.
112 vestigation into the mechanisms that mediate protective immune responses against IAV is important to
115 a role for gammadelta Trms in orchestrating protective immune responses against intestinal pathogens
117 n is likely to help us in tailoring the host protective immune responses against M. tuberculosis.
118 oped represent a robust model for evaluating protective immune responses against P. vivax vaccines ba
120 safety profiles and proven ability to induce protective immune responses against Plasmodium falciparu
121 t vaccination with CJ9-gD elicits strong and protective immune responses against primary HSV-1 skin d
122 ic cells (DCs) is important in enhancing the protective immune responses against rabies virus (RABV).
123 s a powerful platform approach to generating protective immune responses against respiratory pathogen
124 about how the asthmatic phenotype influences protective immune responses against respiratory viral pa
125 e NP adjuvants to promote robust and durable protective immune responses against SIV in nonhuman prim
127 production), necessary for the generation of protective immune responses against the intracellular pa
128 Vs derived from V. cholerae induce long-term protective immune responses against this gastrointestina
129 simple method of vaccine delivery to elicit protective immune responses against virus infection.
131 nding protein (DBP) is a prime target of the protective immune response and a promising vaccine candi
132 ine requires knowledge of what constitutes a protective immune response and also features that might
134 ha/beta(+) T cells are sufficient to mount a protective immune response and that an IL-17A-mediated r
135 enza because HA is the primary target of the protective immune response and the main component of cur
136 ve design process necessary to identify such protective immune responses and achieve them reliably.
137 are responsible for mucus production in both protective immune responses and allergic airway inflamma
138 been extremely useful for identification of protective immune responses and in vaccine development.
139 osenescence is characterized by decreases in protective immune responses and increases in inflammatio
140 ys a critical role in both the generation of protective immune responses and maintenance of tolerance
141 these myeloid cells is critical to maintain protective immune responses and minimize the deleterious
143 nduces T helper 1 (Th1)- and Th17 cell-based protective immune responses and potently inhibits mycoba
144 n strategies has the potential for enhancing protective immune responses and suppressing systemic res
145 nasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challe
147 utinin (HA) protein is the primary target of protective immune responses and the major component in s
148 utinin (HA) protein is the primary target of protective immune responses and the major target of vacc
149 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protecte
150 Dendritic cells (DCs) are key regulators of protective immune responses and tolerance to (self-)Ags.
151 egulatory properties of IL-10 can counteract protective immune responses and, thereby, promote persis
152 n of novel antigens, better understanding of protective immune responses, and steady progress in the
153 eins in HCV vaccines might be detrimental to protective immune responses, and/or structural proteins
154 al proteins known experimentally to elicit a protective immune response are relatively depleted in pe
155 Tools that enable the rapid evaluation of protective immune responses are essential to vaccine dev
158 cine for children, but the mechanisms behind protective immune responses are unclear, and the duratio
159 response and committal to a damaging, though protective, immune response are tightly controlled at mu
160 that must be considered to achieve the most protective immune response, as occurs naturally with man
161 CD8 TRM) cells are an essential component of protective immune responses at barrier tissues, includin
162 tegies of vaccination are required to induce protective immune responses at mucosal surfaces and in t
163 resident T cells but also to promote durable protective immune responses at relevant tissue sites.
165 studies have used mass cytometry to profile protective immune responses, both postinfection and post
166 ant was able to infect the mice and induce a protective immune response but was avirulent compared to
167 ne expression is a critical component of the protective immune response, but inappropriate cytokine e
170 ain chronic infections that fail to elicit a protective immune response, characteristics that have st
171 host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine
172 cells, two essential components of the early protective immune response directed against intracellula
173 infection, indicating that activation of the protective immune response does not require platelets.
174 n important mechanism for the suppression of protective immune responses during infection with C. par
175 T cells and induction of IFN-gamma-mediated protective immune responses during the early stage of re
178 ins of microbial origin may prevent a strong protective immune response either through hindering acce
179 taompdc mutants provide new tools to examine protective immune responses elicited by vaccination with
180 ing in mice to levels sufficient to induce a protective immune response, even when the infecting dose
181 vaccination depends upon generating broadly protective immune responses following exposure to rotavi
182 monary granulomatous responses, hallmarks of protective immune responses following mycobacterial infe
184 thors show that replicating LAVs stimulate a protective immune response from a safe haven in the germ
185 ants with reduced genetic diversity elicit a protective immune response in an animal model of infecti
186 s resulted in the inability to mount a fully protective immune response in bone marrow chimeric mice.
187 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.
188 th lactic acid-producing bacteria triggers a protective immune response in GALTs and confers neuropro
190 ndidates against VL since they elicit strong protective immune response in human PBMCs from HVL, simi
192 icles of type 3 poliovirus that can induce a protective immune response in mice transgenic for the hu
198 e brain represents a significant barrier for protective immune responses in both infectious disease a
200 Because chemokines play a vital role in the protective immune responses in LTB, we postulated that c
201 uvant, could rescue some defects in inducing protective immune responses in MHC-II-deficient mice.
203 of ST-5 CPS RU induced long-term memory and protective immune responses in rabbits superior to those
204 n-specific immunotherapy is the induction of protective immune responses in the absence of anaphylact
205 ns to lymph nodes (LNs) and are required for protective immune responses in the context of inflammati
208 roteome profiles and the elicitation of host-protective immune responses indicate plausibly irreversi
209 nt calreticulin allow cancer cells to escape protective immune responses induced by chemotherapeutic
210 ken together, the ability of rTF to elicit a protective immune response, involvement of TF in bacteri
211 analyses support the view that the maternal protective immune response is influenced by initial expo
214 the central role of memory B cells (MBC) in protective immune responses, little is understood about
215 relevant M. tuberculosis targets that elicit protective immune responses may have yet to be discovere
216 ichial immunity, possibly via decreasing the protective immune response mediated by interferon-gamma
217 f the tumor microenvironment, in promoting a protective immune response mediated by T cells against c
221 erculosis organisms exhibited increased host-protective immune responses, reduced bacillary load, and
222 antigens in quantities high enough to elicit protective immune responses, remains to be validated.
223 opment needs additional knowledge about host protective immune response(s), antigen characteristics,
224 enuated whole sporozoites can induce sterile protective immune responses targeting preerythrocytic an
225 ines have been shown to provide better cross-protective immune responses than inactivated vaccines by
226 ressive signals must be overcome to elicit a protective immune response that eliminates the virus.
227 VPI 10463, C57BL/6 mice were able to mount a protective immune response that prevented diarrhea and d
228 e findings identify GM-CSF as central to the protective immune response that prevents progressive fun
229 In addition, this vaccine induced a cross-protective immune response that was able to protect 50%
230 in identifying the inflammatory pathways and protective immune responses that are elicited in the int
231 ine against influenza would ideally generate protective immune responses that are not only broadly re
232 ent febrile malaria, possibly by maintaining protective immune responses that depend on ongoing paras
233 deeper understanding of cellular and humoral protective immune responses that eliminate pre-erythrocy
234 he lungs, enhance survival, and modulate the protective immune responses that eliminate the virus whi
235 d (ii) immunomodulatory HDTs that facilitate protective immune responses that kill Mtb or reduce dele
236 or controlling maternal viremia and inducing protective immune responses that prevent severe CMV-asso
237 knowledge of the nature and specificities of protective immune responses that should be induced by su
238 ology was found to elicit broad, potent, and protective immune responses, that were comparable to a v
241 s-like particles (cVLPs), in boosting strong protective immune responses through an intranasal (i.n.)
242 lls combat viral infection and contribute to protective immune responses through multiple mechanisms,
243 also sufficiently immunocompetent to raise a protective immune response to a candidate subunit vaccin
244 ator that drives an efficient and controlled protective immune response to a sand fly-transmitted Lei
247 endritic cells can potentially influence the protective immune response to concurrent infections.
249 al immunity is an essential component of the protective immune response to flavivirus infection.
251 thy adults and children, suggesting that the protective immune response to HMPV is incomplete and sho
253 PN construct P4c-Mal conferred a long-lived, protective immune response to mice with a broad range of
254 us strains influences the ability to mount a protective immune response to novel pandemic strains.
255 the ability of the mammalian host to mount a protective immune response to pandemic strains of influe
257 kinase provides critical checkpoints for the protective immune response to the spirochete during infe
258 BTLA(+) cells, thereby interfering with the protective immune response to this intestinal parasite.
259 To determine the role of NK cells during the protective immune response to vaccination in vivo, we st
260 sotype-switched IgG antibodies and long-term protective immune responses to a T-dependent influenza v
261 approaches that target PD-1-PD-L1 to enhance protective immune responses to A. fumigatus infections.
262 e is the necessity to produce fairly uniform protective immune responses to all four dengue virus ser
263 try of virus-specific lymphocytes, promoting protective immune responses to CNS viral infections that
264 or other intracellular pathogens, successful protective immune responses to Francisella tularensis re
265 estrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematode
267 s a role as a negative regulator in inducing protective immune responses to influenza vaccination.
268 monocytes, and/or macrophages initiate host-protective immune responses to intracellular pathogens i
269 ntibody responses are critical components of protective immune responses to many pathogens, but param
270 Knowledge of the acquisition and nature of protective immune responses to P. falciparum is presentl
272 role of CCR7 signaling in the generation of protective immune responses to the intracellular protozo
273 accines require adjuvants in order to induce protective immune responses to the targeted pathogen.
274 ell expression of CCR7 for the generation of protective immune responses to Toxoplasma infection.
275 However, the roles of MHC-II in inducing protective immune responses to vaccination have not been
279 entify adjuvant strategies aimed at inducing protective immune responses to various pathogens, includ
281 -2/IFN-gamma coproduction, characteristic of protective immune responses to viral infections, was abs
282 step toward vaccine development is defining protective immune responses; toward that end, we here ch
283 riant natural killer T (iNKT) cells induce a protective immune response triggered by foreign glycolip
285 l and affordable means to elicit potentially protective immune responses upon vaccination, especially
286 Mycobacterium tuberculosis may modulate protective immune responses using diverse mechanisms, in
289 ccine to induce rapid, as well as sustained, protective immune responses was examined with two separa
292 cystis infection are incapable of mounting a protective immune response when transferred into Rag1(-/
293 une responses and counteraction of bacterial protective immune responses when developing a vaccine ag
294 of specialized immune receptors that induce protective immune responses when they detect highly cons
295 in delivery system is capable of stimulating protective immune responses where effective immunization
296 e are not associated with the development of protective immune responses, which is attributable to a
297 imulatory and inhibitory signals to maximize protective immune responses while maintaining immunologi
298 ells (Treg cells) is critical for generating protective immune responses while minimizing autoimmunit
299 bjects and reflect classical features of the protective immune response with high expression of IL-10
300 ate and adaptive immune responses can induce protective immune responses without the need for potenti