ライフサイエンスコーパス: protective role

1 CRPA colonization acquisition and/or serve a protective role.

2 tersect, potentially reflecting their common protective role.

3 f the diet, such as vitamin K1, could play a protective role.

4 eperfusion damage where CB2 receptors play a protective role.

5 ing Th1 cells, and regulatory T cells play a protective role.

6 ude of ADCC in HIV infection, abrogating its protective role.

7 lack of MDRO acquisition, consistent with a protective role.

8 nduced PD-like phenotypes and plays a neural protective role.

9 inflammation, in which Treg cells play a key protective role.

10 that the granuloma can also serve a bacteria-protective role.

11 mediated by Abs, yet T cells may also have a protective role.

12 termine whether perforin-2 plays a similarly protective role.

13 hich functions were required for its various protective roles.

14 g results, demonstrating both pathogenic and protective roles.

15 These results show clearly that iron plays a protective role against copper uptake and toxicity to C.

16 The spleen plays an integral protective role against encapsulated bacterial infection

17 viscoelasticity of ocular tissues may have a protective role against glaucoma.

18 ressive nephron loss or whether APA exerts a protective role against glomerular damage and during Ang

19 ulus fibrosus cells, however, demonstrated a protective role against key inflammatory (IL-1beta and T

20 FN-gamma signaling in MPhis, TNF-alpha has a protective role against M. avium.

21 e adiponectin-T-cadherin association plays a protective role against neointimal and atherosclerotic p

22 ernally acquired antibodies appear to play a protective role against NTS infections during early infa

23 by ROS production and that autophagy plays a protective role against PA-induced podocyte apoptosis.

24 vidence supports that antibodies also have a protective role against TB.

25 int proteins PDL1 and HLA-E that may exert a protective role against the autoimmune assault.

26 Resveratrol may play a protective role against the frailty syndrome (FS) becaus

27 suggesting that the acidic cluster serves a protective role against unwanted proteolysis by endogeno

28 Green space and vegetation may play a protective role against urban violence.

29 ggests that dietary fibers (DFs) may exert a protective role against various chronic diseases, but th

30 ted by N-linked glycans, suggesting possible protective roles against host immune responses and harsh

31 tuent of intestinal mucus and plays critical protective roles against luminal microbes and other noxi

32 . aureus infection, IL-10 plays an important protective role and is required to prevent bacterial dis

33 r from resolved, with some studies showing a protective role and others showing a pathogenic role.

34 results suggest that YAP activation exerts a protective role and represents a pharmacological target

35 consensus that this cis interaction serves a protective role, and that the disruption of this interac

36 Consistent with a redox-protective role, approximately half of the dioxygen-usin

37 HIV-1 is complex, with studies supporting a protective role as well as a role for serum IgA in block

38 s and antibodies have a variety of potential protective roles at each stage of Mtb infection and post

39 ardioprotection, which suggested a potential protective role beyond the cardiomyocyte.

40 e RV144 vaccine, suggesting that they play a protective role, but a mechanism providing such protecti

41 eliorates mitochondrial defects and exerts a protective role by improving cell survival in cells carr

42 ur findings thus indicate that IL-22 plays a protective role by limiting infection-induced gut immuno

43 ance of dead photoreceptor cell bodies has a protective role by preventing additional retinal damage

44 tively, these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating

45 ly, our results demonstrate Cl-amidine plays protective roles by significantly decreasing BM and thym

46 fective in patients with AA; and how this IP-protective role could be restored therapeutically in pat

47 tion by a negative feedback loop and plays a protective role during atherosclerosis-associated foam c

48 l pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque developmen

49 nociceptive neurons exert a significant host protective role during C rodentium infection, independen

50 oth nuclear RPA and mitochondrial SSB play a protective role during DNA replication by preventing exc

51 Thus, CD169 plays a protective role during FVC pathogenesis by reducing vira

52 indicate that endothelial EPAS1 has a global protective role during glomerular hypertensive injuries

53 e previous studies showed that IL-17 plays a protective role during infection with mucosal pathogens,

54 s, the microbiota plays a critical and often protective role during infections, both by modulating im

55 Whether IL-33 serves a pathogenic or protective role during inflammatory bowel disease is con

56 Platelets play a protective role during pneumococcal pneumonia independen

57 hat the TWEAK/Fn14 signaling complex plays a protective role during the acute stage of intestinal inf

58 erall, these findings show that Fn14 plays a protective role during the acute stages of intestinal in

59 rating that IFN-alpha and IFN-beta both have protective roles during acute chikungunya virus (CHIKV)

60 nscription factors IRF-3 and IRF-7, have key protective roles during OROV infection.

61 that alveolar macrophages may play a limited protective role early after exposure to aerosolized ANDV

62 Collectively, these data demonstrate a novel protective role for ApoA-I in colitis and CAC and unrave

63 model of genital infection, we demonstrate a protective role for both Chlamydia-specific immunoglobul

64 ts infected with SARS-CoV-2 have suggested a protective role for both humoral and cell-mediated immun

65 These results establish a protective role for both TCF21 and SMC phenotypic modula

66 These data demonstrate a protective role for capsid and suggest that antiviral ac

67 dentify a rich source of Bregs and suggest a protective role for CB-derived Bregs against cGVHD devel

68 These data suggest a hepato-protective role for CC to limit ROS and cellular TG accu

69 r, these studies demonstrate that there is a protective role for central memory CD8(+) T cells in aut

70 0.54 (95% CI, 0.31-0.96)], consistent with a protective role for CXCL5 in coronary atherosclerosis.

71 blocking the CA-CypA interaction suggests a protective role for CypA against high concentrations of

72 d impaired hemodynamic function suggesting a protective role for endogenous HA synthesis.

73 ignaling, we demonstrate a critical vascular protective role for endothelial S1P(1) in the mouse brai

74 mune setting relative to naive, as well as a protective role for epitope-specific CD8(+) T cells agai

75 reduced BTL and thus demonstrating a crucial protective role for FXR in the gut-liver axis.

76 after acute stress, which we used to test a protective role for glucocorticoids against stress.

77 = 15) (P < 0.011), which is suggestive of a protective role for HCA2 in sepsis; 3) WT mice subjected

78 of evidence has recently begun to indicate a protective role for HLA-C in HIV-1 infection, which may

79 culosis (Mtb) infection, a discriminatory or protective role for humoral immunity remains unclear.

80 7A monoclonal antibody, suggesting a disease-protective role for IL-17A in the cecum.

81 s study describes a previously unappreciated protective role for IL-17RA signaling in regulation of t

82 Thus, we demonstrate an early protective role for ILC3s in immunity to Mtb infection.

83 Animal models of infection have identified a protective role for interleukin-18 (IL-18).

84 nce Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated

85 Our data support a protective role for LANDO in microglia in neurodegenerat

86 Our results suggest a possible protective role for LL-37 in T2D pathogenesis and offer

87 milarly treated wild-type mice, suggesting a protective role for mast cells in exposure to nominal en

88 These results indicate a protective role for miR-124 through the inhibition of SM

89 This finding suggests a protective role for mucosal antibody-mediated immunity i

90 These results suggest a protective role for mucosal HIV-1 envelope-specific IgA

91 Our findings highlight a novel protective role for NEAT1 in PD and suggest a previously

92 Our results suggest polyploidy may serve a protective role for neurons and glia in adult Drosophila

93 While a protective role for neutralizing antibody responses is w

94 s in line with previous studies suggesting a protective role for neutrophils during a UTI, whereas mo

95 Our results define a previously unknown protective role for NK cells during secondary T. gondii

96 mouse model of airway inflammation reveal a protective role for NLRP1 inflammasome activation reduci

97 fibrosis after muscle overload, indicating a protective role for normal stem cell activity in reducin

98 Collectively, our study uncovers a protective role for OVOL1 in curtailing psoriasis-like i

99 These data suggest a protective role for PAFR-expressing KCs during colitis a

100 tion during female oogenesis, highlighting a protective role for Polo kinase and the pericentriolar m

101 provide different evidences of an important protective role for protein kinase A in cancer cells und

102 n.Conclusions: Here, we demonstrate a unique protective role for pulmonary endothelial HIF-2alpha and

103 Recent evidence highlights a protective role for the activating transcription factor

104 Recently, we identified a protective role for the ATRX-interacting macroH2A1.2 his

105 We demonstrate a protective role for the endocytic protein p18 in endothe

106 Consistent with a protective role for the microbiome, treatment of pDC-dep

107 ed with stress resilience that might serve a protective role for the neurovasculature.

108 aken together, our findings indicate a novel protective role for the TL1A/DR3 axis in the regulation

109 nducible NO synthase, suggesting a potential protective role for these IFN-gamma-producing cells.

110 Emerging evidence supports a protective role for this activity in acute kidney injury

111 ed acute GVHD, consistent with an additional protective role for this cytokine independent of effects

112 To further demonstrate a protective role for TNAP at endothelial barriers within

113 tissue-resident MZ and RP macrophages and a protective role for two distinct splenic neutrophil popu

114 This study implies a protective role for VD sufficiency throughout pregnancy,

115 thus elucidates a pathogenic, as opposed to protective, role for IL-17A during Gram-positive bacteri

116 ndings demonstrate a pathogenic, rather than protective, role for MAIT cells during infection.

117 In contrast, both pathogenic and protective roles have been associated with T cell-depend

118 sion, our data indicate that IL-22BP plays a protective role in acute liver damage, via controlling I

119 e biological functions it represents serve a protective role in AD.

120 Our results suggest that TERT has a protective role in AECII, unlike its pro-fibrotic activi

121 pDCs may play a protective role in asthma and are key players in the inn

122 OGG1 plays a protective role in atherogenesis by preventing excessive

123 that TERT has a previously underappreciated, protective role in buffering senescence stresses due to

124 AS-1, the TIR/BB loop mimetic, plays a protective role in cardiac ischemia/reperfusion (I/R) bu

125 e effects of DPP4 inhibition seem to exert a protective role in cardiovascular disease at least in pr

126 , a shift that results in TGFbeta losing its protective role in cartilage homeostasis.

127 We propose that annexin A5 would exert a protective role in choroid plexus and this protection is

128 redox balance and skin homeostasis playing a protective role in CHS.

129 irrhosis (n = 216), suggesting it may have a protective role in cirrhosis progression.These findings

130 vidence that eIF2alpha phosphorylation has a protective role in CMT1B Schwann cells by limiting ERK/c

131 We found that AHR plays a protective role in colitis-associated colorectal tumorig

132 Recent data also suggest a protective role in colitis.

133 We hypothesized that IL-6 plays a protective role in conditions of heat stroke.

134 t time that RAGE inhibition has an essential protective role in COPD.

135 response to heat stress) plays an important protective role in corals.

136 T cells have a pivotal protective role in defense against infection and cancer

137 CES2 plays a protective role in development of NAFLD.

138 produced in response to injury and serves a protective role in early stages of injury and is detrime

139 erial activity, Gga-AvBD11 appears to play a protective role in embryonic development.

140 Macrophages play a key protective role in heme clearance; however, the mechanis

141 logical evidence that Vitamin D might play a protective role in HL.

142 II interferons (IFN-lambdas) play a critical protective role in hMPV infection.

143 show that PBA has a previously undiscovered protective role in host mucosal defense during infection

144 Thus, CD14 plays a protective role in IBD development by enhancing intestin

145 Lcn2 exerts mostly a protective role in infectious and inflammatory bowel dis

146 Vitamin D is known to play a protective role in inflammatory diseases.

147 Its protective role in intestinal colitis and tumorigenesis

148 to its well-appreciated microbiome-dependent protective role in intestinal colitis and tumorigenesis.

149 ivity in the coronary circulation, and has a protective role in ischemia reperfusion.

150 sults suggest that gammadelta T cells play a protective role in limiting the CHIKV-induced inflammato

151 x comprising the main source of ROS, plays a protective role in many ocular conditions by inhibiting

152 indings suggest that microglial mTOR plays a protective role in mitigating neuronal loss and attenuat

153 demonstrating that CHCHD10 normally exerts a protective role in mitochondrial and synaptic integrity

154 These findings suggest that CIB1 plays a protective role in MPTP/MPP(+)-induced neurotoxicity by

155 Based on our results, PDGF-BB may play a protective role in muscular dystrophies by enhancing mus

156 r nonneutralizing Abs and is known to play a protective role in other herpesvirus infections; yet, AD

157 hypothesis that serum DBP or 25(OH)D plays a protective role in pancreatic cancer.

158 e a critical observation that H2S also has a protective role in paramyxovirus infection by modulating

159 Progesterone plays a protective role in preventing inflammation and preterm d

160 We also demonstrate that CYGB has a protective role in proliferating keratinocytes grown und

161 channel has recently been proposed to play a protective role in prostate cancer by impairing cell mot

162 adenosine by nonhematopoietic cells plays a protective role in RA and suggests that strategies able

163 These results indicate that 20-HETE has a protective role in renal IR injury by maintaining medull

164 icate that lung macrophages serve a critical protective role in respiratory F. tularensis LVS infecti

165 st that epithelial expression of NUPR1 has a protective role in response to injury after renal transp

166 parents, particularly mothers, plays a small protective role in safer sex behavior among adolescents;

167 ar whether SUMOylation plays a pathogenic or protective role in SBMA.

168 ses (neuraminidases) suggest a host-variable protective role in secreted mucus.

169 Because Ang2 is known to play a protective role in stressed endothelial cells, we tested

170 strocytes in the IC are considered to play a protective role in the auditory pathway.

171 -coding RNA that has been found to exhibit a protective role in the cellular models of Parkinson dise

172 of Alzheimer's disease, and seems to play a protective role in the clinical progression of the disea

173 Synpo plays a protective role in the context of podocyte injury throug

174 dermal barrier function and have a potential protective role in the development of atopic dermatitis-

175 changes in the gut microbiota that played a protective role in the development of cardiovascular dis

176 secretory capacity that allowed it to play a protective role in the interstitial space.

177 roglial cells play a previously unrecognized protective role in the maintenance of BBB integrity foll

178 In conclusion, Gal-3 plays a protective role in the pathways that lead to the inflamm

179 we demonstrate that the Ron receptor plays a protective role in the progression of diet-induced obesi

180 idence that the transporter also plays a key protective role in the regulation of cellular Cu via reg

181 lls (ILC2s) are a subset of ILCs that play a protective role in the response to helminth infection, b

182 n, suggesting that it may serve an important protective role in the stressed heart.

183 essary for melanin production, thus having a protective role in the UVA-induced skin response.

184 fully support embryogenesis by maintaining a protective role in TNFalpha-induced apoptosis.

185 gh the NLRC4 inflammasome is known to have a protective role in tumorigenesis, there is an increased

186 Thus, androgens play a crucial protective role in type 2 airway inflammation by negativ

187 by serving as a decoy receptor, and plays a protective role in ZIKV-mediated brain injuries.

188 Macrophages have protective roles in immunity to pathogens, tissue develo

189 Within eukaryotes they mediate protective roles in innate immunity against malignant, v

190 ur study suggests that Malat1 plays critical protective roles in ischemic stroke.SIGNIFICANCE STATEME

191 Fpn seems to play protective roles in Mn-induced cellular toxicity and oxi

192 e a novel mechanism by which n-3 PUFAs exert protective roles in reducing Abeta accumulation via medi

193 Whereas these cytokines have protective roles in response to mucosal damage or infect

194 terleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut mucosa is controversial and

195 ndin (PG) E2 is a bioactive lipid that plays protective roles in the lung, particularly during allerg

196 ntly recruited to the oral cavity, and their protective role is highlighted in cases where their numb

197 ain actively transcribed genes and that this protective role is most prominent at heterochromatin isl

198 g evidence suggests that in addition to this protective role, Leishmania mitochondrial SOD may also i

199 We define such a protective role linked to DNA damage from oxidative stre

200 Environmental effects suggesting a possible protective role of 16-OMD for adaptation, as well as gen

201 Experimental evidence supports a protective role of 25-hydroxyvitamin D [25(OH)D] in brea

202 results provide in vivo evidence for a major protective role of a properly configured intermediate fi

203 The protective role of a small tidal volume (VT) has been es

204 The study objective was to investigate the protective role of activating transcription factor 4 (AT

205 the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency.

206 The potential protective role of B cells in controlling cCMV-related d

207 dicate that Cdk5 is required to maintain the protective role of basal autophagy in the initial respon

208 y we report that ibrutinib reverses the cyto-protective role of BMSC on FLT3-ITD AML survival.

209 full-length LCs, establishing the important protective role of C(L) domains.

210 The study also reveals a unique protective role of c-Rel in autoimmune diabetes, which i

211 se progression and provides insight into the protective role of C1q in early atherosclerosis.

212 There was no evidence supporting a protective role of catechins in the development of HCC.

213 Thus, our findings show the protective role of CCR2-mediated infiltration of macroph

214 Consequently, the protective role of cell-mediated immunity in the control

215 This study showed that the protective role of CFB rs4151667 (L9H) in AMD is not sig

216 Our findings highlight the protective role of CH25H during ZIKV infection and the p

217 In this study, we examined the protective role of cornea-resident iNKT cell subsets usi

218 in vivo and compare this to the established protective role of COX2.

219 aken together, these findings demonstrated a protective role of FST in SiO2 NP-induced oxidative stre

220 related food allergy and indicate a dominant protective role of functional IgE-blocking IgG1 antibodi

221 Here, we investigated the protective role of FXR against kidney damage induced by

222 ts into the immune mechanisms underlying the protective role of GBV-C in HIV-infected patients.

223 In opposition to the protective role of HLH-30 and DAF-16/FOXO, TOR/LET-363 a

224 tivity of ATP synthase, which may render the protective role of IF1 in ischemic hearts.

225 However, the mechanisms underlying the protective role of IFN-gamma in EAE have not been fully

226 Particularly interesting findings included a protective role of IGF-1 (insulin-like growth factor 1)

227 endent atheroprotection, thus highlighting a protective role of IL-10(+) regulatory B cells in this s

228 that anticoagulant therapy might dampen the protective role of immunothrombosis.

229 A possible protective role of increased D2R levels in the striatum

230 The current study does support the protective role of influenza vaccination on CVDs events.

231 ocular herpes.IMPORTANCE We investigated the protective role of iNKT cell subsets in asymptomatic ocu

232 The protective role of IRE1alpha under genotoxic stress is c

233 e in the aralar hemizygous mice prevents the protective role of L-lactate on glutamate excitotoxiciy

234 e utilization by neurons, which prevents the protective role of lactate on excitotoxicity, but not gl

235 In order to investigate a protective role of leaf thickness to C. sublineola, leaf

236 Findings suggested that the protective role of light filtering material was more evi

237 ective vaccines, we have previously reported protective role of live attenuated centrin gene-deleted

238 To conclude, we show a protective role of MBL in the early stages of B. burgdor

239 These findings indicate a surprising protective role of MDSCs in newborns and demonstrate the

240 s provide unambiguous evidence for a general protective role of microglia in prion pathogenesis.

241 miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced

242 Ova-allergen challenge further confirmed the protective role of MNs-CIT.

243 Overall, the protective role of MTs in neurodegenerative processes is

244 Taken together, our results indicate a protective role of NLK in HD and reveal a new molecular

245 Collectively, these findings support a protective role of Nur77 in OVA-induced airway inflammat

246 n increased circulating IL-1Ra, suggesting a protective role of PDE4B inactivation in vivo.

247 Our findings suggest that the protective role of Perforin-2 against listeriosis is bas

248 al role of periostin in CKD, we discovered a protective role of periostin in AKI.

249 purpose of this study was to investigate the protective role of peroxisome proliferator-activated rec

250 To study the mechanism of the protective role of progesterone during pregnancy, we inv

251 we investigated the mechanism underlying the protective role of RdCVF in RP.

252 illisecond timescale, suggesting a potential protective role of redox-active cofactors for preventing

253 ional epistatic relationship to Parkin and a protective role of SLP-2 in neurons.

254 endothelial dysfunction, suggesting a local protective role of Sphk1 in the endothelium.

255 The findings provide novel evidence for a protective role of SSRIs on some deleterious reproductiv

256 Our study demonstrates a protective role of sTREM2 against amyloid pathology and

257 Moreover, the protective role of stress-related EVs against subsequent

258 These studies suggest an important protective role of stroma in PDA and urge caution in cli

259 Finally, we tested the protective role of SUMOylation-mediated autophagy by exp

260 ology approach may enable restoration of the protective role of TGFbeta as a potential therapy to pre

261 nflammatory monocytes, thus highlighting the protective role of TgIST against IFN-gamma-mediated kill

262 on by entomopathogenic fungi demonstrate the protective role of the biomineral layer.

263 Further studies revealed a protective role of the cholangiocyte apical glycocalyx,

264 Here, we review the genome-protective role of the mitotic DNA damage response (DDR)

265 absorption across Caco-2 cells and (ii) the protective role of the oil bioaccessible fraction (BF) a

266 ared with non-encapsulated OLE, suggesting a protective role of the polysaccharides by the formation

267 findings provide evidence for the potential protective role of the reactive immune system in colorec

268 en-challenged mice, providing evidence for a protective role of these cells in allergic inflammation.

269 The protective role of these epithelia is, in part, dependen

270 e substance, could antagonize the endogenous protective role of these receptors in cochlea and potent

271 ients and individuals, suggesting a possible protective role of this SNP against CVD.

272 se was dramatically reduced, underlining the protective role of this unique subpopulation of innate g

273 Importantly, we provide evidence of a protective role of UPR(mt) and mitochondrial clearance a

274 Our findings lend support for a protective role of VAPB in neuromuscular health.

275 doptive cell-transfer strategy to define the protective role of Vgamma2Vdelta2 T cells in a primate t

276 However, the in vivo mechano-protective roles of caveolae have only begun to be explo

277 nisms in perturbed communities, however, the protective roles of commensals are largely under recogni

278 us on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disea

279 owever, the mechanisms underlying the tissue-protective roles of IL-33 or ILC2s at surfaces such as t

280 However, proposed protective roles of MAIT cells in human infections remai

281 r and the native sequence is crucial for its protective role over the toxic N-terminus, irrespective

282 antitumor brain microenvironment with a key protective role played by the neurotrophin brain-derived

283 ivated cardiac fibroblasts play an important protective role, preserving the ECM network, suppressing

284 Thus, reactive astrocytes play a protective role, preserving visual function.

285 in graft-versus-host disease (GVHD), however protective roles remain unclear.

286 ly, two human isoenzymes that play a special protective role, safeguarding DNA from DNDGIC, display a

287 uring red blood cell stages, indicative of a protective role seen in other organisms.

288 ntifying scenarios where the UPR(mt) plays a protective role, such as during bacterial infection, hem

289 R-responsive proteins, highlighting critical protective roles that CRTC1 selectively plays against NA

290 These findings highlight physiological protective roles that MafB may play against atherosclero

291 r study suggests that infection could have a protective role through the production of antimicrobial

292 tion of DNA damage, TRF1 deficiency serves a protective role to limit induction of DNA damage induced

293 Whilst we did not examine any protective role to re-challenge, it illustrates the diff

294 nthocyanins and ellagitannins, which exert a protective role towards degenerative diseases.

295 atopoietic cells during acute injury and the protective role upon its modulation offers potential for

296 Nrf2 protective role was associated with high expression of a

297 This protective role was observed in conventional and germ-fr

298 ed with shorter hospital stay and may play a protective role, whereas Tc2 cells may play a previously

299 itively with insulin secretion, suggesting a protective role, whereas TMEM132C was upregulated in hyp

300 ically relevant fatty acid, which may have a protective role with respect to the generation of beta-s