ライフサイエンスコーパス: protein abundance

1 mitochondrial membrane potential and NDUFA9 protein abundance.

2 ssion of transcripts only partially explains protein abundance.

3 oss of enzymatic activity and/or decrease in protein abundance.

4 a and beta1 subunits, but no change in total protein abundance.

5 aSyn was causing a lowering in synapsin-I/II protein abundance.

6 he leucoplast motif usually has greater root protein abundance.

7 om the growth-dependent global modulation of protein abundance.

8 RT1 deficiency resulted in higher liver CES1 protein abundance.

9 ion of 6-d-old mice increased IL-33 and TSLP protein abundance.

10 hepatic Srebp2 mRNA level and mature Srebp2 protein abundance.

11 for oxidative phosphorylation and modulates protein abundance.

12 nces for complex formation and regulation of protein abundance.

13 s into account enables precise modulation of protein abundance.

14 therapeutic intervention by modulating PIAS4 protein abundance.

15 okinesis, suggesting a tight control of CIF2 protein abundance.

16 ing, i.e. the characteristic time scales and protein abundance.

17 critical role in the regulation of mRNA and protein abundance.

18 partially to changes in the whole cell host protein abundance.

19 culum, inhibit Cu-transport, and lower ATP7B protein abundance.

20 exogenous signals and differentially control protein abundance.

21 of CFI mRNAs is a limited indicator of their protein abundance.

22 respond to stimuli through direct changes of protein abundance.

23 s to establish assays for use in determining protein abundance.

24 housands of individuals with high versus low protein abundance.

25 oter methylation and increases Cdh1 mRNA and protein abundance.

26 ion in gene regulation, mRNA processing, and protein abundance.

27 regulatory mechanisms affecting variation in protein abundance.

28 lts in enhanced ubiquitination and decreased protein abundance.

29 deleterious effects on protein activity and protein abundance.

30 gulation of protein stability in controlling protein abundance.

31 fe was reduced accounting for decreased NHE3 protein abundance.

32 ing negatively correlated with CURT1 and RIQ protein abundance.

33 rather than by analyzing temporal changes in protein abundance.

34 genes where DNA methylation is predictive of protein abundance.

35 ence chromatin structure, as well as RNA and protein abundance.

36 h as regulating gene expression and altering protein abundance.

37 to significant divergence between mRNA- and protein-abundance.

38 40%, 11%, and 10%, respectively, of relative protein abundances.

39 have been described that are correlated with protein abundances.

40 lator CheY increases with overall chemotaxis protein abundances.

41 rved temporal relationships between mRNA and protein abundances.

42 same environment exhibit variation in their protein abundances.

43 rrespondence between their transcription and protein abundances.

44 nning DNA accessibility, gene expression and protein abundance(1-3).

45 acid analysis showed significantly decreased protein abundance (58.5%) in blanched beans compared to

46 that cell-to-cell variability, or noise, in protein abundance acts within a network of more than six

47 ssion, DNA copy numbers, DNA methylation and protein abundance, all available in The Cancer Genome At

48 pliceosome modulation is invisible to RNA or protein abundance alone.

49 ffer greatly from measures of transcripts or protein abundance alone.

50 Protein abundance along the renal tubule for many common

51 Estimates of absolute protein abundance also reveal principles for optimizing

52 ere were significant differences in mRNA and protein abundance among ages, tissues, and between males

53 iency resulted in a general decrease in PSII protein abundances, an effect that was shown to be rever

54 uperoxide; vascular leak; increased thrombin protein abundance and activity; activation of ERK; great

55 sed to caffeine (1 mM) showed increased UCP1 protein abundance and cell metabolism with enhanced oxyg

56 KB mutations resulted in marked reduction in protein abundance and chloride current, especially those

57 nduced down-regulation of claudin-5 mRNA and protein abundance and endothelial barrier dysfunction.

58 ox1 cooperatively elevates complex I subunit protein abundance and enzymatic activity, decreases reac

59 and we used bioinformatic tools to evaluate protein abundance and functional category enrichment in

60 n stores seems to potentiate skeletal muscle protein abundance and gene expression.

61 utant MPC1(R97W) resulted in increased MICU1 protein abundance and inhibition of MCU-mediated mitocho

62 r correspondence between loci that influence protein abundance and loci that influence mRNA abundance

63 perience and internal state to control Orb2A protein abundance and long-term memory formation.

64 Co-expression of barttin increased protein abundance and membrane trafficking of hClC-Kb an

65 Protein abundance and mRNA expression were measured by W

66 oss-of-function CFK1 leads to increased DRM2 protein abundance and overexpression of CFK1 showed redu

67 elled cell Subsets) approach, we now compare protein abundance and phosphorylation changes in interph

68 In addition, Tctp increases both Akt1 protein abundance and phosphorylation in vivo.

69 9) and IDOL and thereby enhance hepatic LDLR protein abundance and plasma LDL cholesterol reduction.

70 The temporal regulation of protein abundance and post-translational modifications i

71 NP-C increased levels of viral RNA splicing, protein abundance and progeny production during infectio

72 biosynthetic and degradative mechanisms to r-protein abundance and proteome remodelling in conditions

73 imbibition, increased GA levels reduce DELLA protein abundance and release ATML1/PDF2 to activate L1

74 ovides invaluable information regarding both protein abundance and subcellular localization.

75 ne residues on TULP3 by p300 increases TULP3 protein abundance and that deacetylation of these sites

76 ted with the NIK-dependent reduction in cMAF protein abundance and the enhanced activity of the aryl

77 end iqPIR cross-linked products can provide protein abundance and/or lysine site modification level

78 pHapo conveys functionality by (i) adjusting protein abundances and (ii) affecting the rheological pr

79 al mucus may enable further understanding of protein abundances and biologic processes present in CRS

80 Western blot analysis for comparison of protein abundances and glycosylation patterns did not sh

81 ber of opposing effects, such as unbalancing protein abundances and inhibiting cell growth but also a

82 s, since complex diseases like cancer change protein abundances and modifications.

83 stacks enriched with oleosin (sixfold higher protein abundance) and novel endoplasmic reticulum morph

84 protein, or phosphorylated (pS2808, pS2814) protein abundance, and [(3)H]ryanodine binding was not d

85 a concomitant decrease in green fluorescent protein abundance, and blocks primer extension by DNA po

86 e and analyzed the effect on RNA expression, protein abundance, and infectious-virus production.

87 insulin stimulated a 5-fold increase in ATF4 protein abundance, and knockdown of ATF4 expression supp

88 (rs4680) markedly affected enzyme activity, protein abundance, and protein stability.

89 mproved urine concentrating ability and AQP2 protein abundance, and reversed the lithium-induced incr

90 tion significantly reduced glycogen synthase protein abundance, and the remaining protein was predomi

91 grating the protein OS enrichment score, the protein abundance, and the retina transcriptome, the pro

92 , we find that MethylMix genes predictive of protein abundance are enriched for biological processes

93 the actin cytoskeleton, and ROCK1 and ROCK2 protein abundances are increased in early AD.

94 ssessing microbial community structure using protein abundance as a measure for biomass contributions

95 We uncovered a decrease in CAV1 protein abundance as well as endosomal fission defects r

96 Finally, visualization of changes in protein abundance associated with a particular process p

97 a suggested that outcome-related variance in protein abundance associated with profibrotic, apoptosis

98 disease were identified based on changes in protein abundance at different time periods preceding di

99 This allowed the determination of absolute protein abundances at a subcellular level.

100 are known to have significant differences in protein abundance based on bottom-up analysis.

101 Glycoprotein changes occur in not only protein abundance but also the occupancy of each glycosy

102 oss of microRNA repression of sens increased protein abundance but not sensory pattern disorder.

103 rols showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory changes in gen

104 rom TMG-treated rats did not exhibit altered protein abundance but showed overall elevated O-GlcNAcyl

105 1 substrates slower, possessed lower CYP2B11 protein abundance, but had similar or higher mRNA expres

106 st-transcriptional modifications can control protein abundance, but the extent to which these alterat

107 that mRNA abundances broadly correlate with protein abundance, but these two are often imperfectly c

108 Reduction of PIF3 protein abundance by DELLAs correlates closely with redu

109 identified posttranscriptional regulation of protein abundance by GSK-3, with approximately 47 protei

110 PR17 activation also diminishes myelin basic protein abundance by lessening stimulation of the exchan

111 Regulation of plasma membrane (PM) protein abundance by selective endocytosis is critical f

112 Control of protein abundance by the ubiquitin-proteasome system is

113 omposition by DEXA, tissue insulin signaling protein abundance by Western blotting, glucose tolerance

114 ht into how a quantitatively small change in protein abundance can produce marked changes in cell sta

115 r, because temporal changes in intracellular protein abundances cannot be measured directly in live c

116 ustering using MethylMix genes predictive of protein abundance captures cancer subtypes.

117 Previously, we analyzed protein abundance changes across a 'minimally perturbed'

118 Recently, we analysed gene expression and protein abundance changes during interphase under minima

119 insulin signaling is actively controlled by protein abundance changes in insulin-sensitive and -resi

120 We employed proteomic approaches to assess protein abundance changes in seeds from Bt-transgenic oi

121 Somatic variants displayed reduced protein abundance compared to germline variants.

122 lustering analysis showed smaller changes in protein abundance compared to mRNA abundance.

123 Thus, we suggest that SPP-mediated protein abundance control by a regulatory branch of ER-a

124 Our findings suggest that ApoE2 protein abundance, coupled with its inability to bind to

125 grative analysis of gene expression data and protein abundance data from the NCI-60 cancer cell lines

126 analysis of highly multivariate quantitative protein abundance data generated using mass-spectrometry

127 ross three cancer cohorts we find that using protein abundance data narrows candidate nominations, wh

128 tudy thus exemplifies importance of the DMET protein abundance database, and use of determined values

129 moter methylation increases and its mRNA and protein abundance decreases in epithelium giving rise to

130 Comparison of protein abundances demonstrated that NKCC1 inhibition du

131 Protein abundance did not alter with ageing, but neopept

132 duced transient rise in pHapo These elevated protein abundances did not directly arise from high tiss

133 hips, with generally increased magnitudes of protein abundance differences between brain regions comp

134 akly correlated, but IHC did not distinguish protein abundance differences detected by MS.

135 s a sensitive and rapid approach to quantify protein abundance differences in Arabidopsis for specifi

136 By contrast, protein abundances display more varied responses.

137 cellular fractionation to generate signature protein abundance distribution profiles.

138 n that integrates multi-source data--such as protein abundances, domain-domain interactions and funct

139 trategy to determine alterations in relative protein abundance due to a particular carbon source, in

140 ere would be fluctuations of rumen microbial protein abundances due to feed intake-mediated nutrient

141 d degradative mechanisms to the control of r-protein abundance during acute stress responses is poorl

142 ws cells to differentially regulate specific protein abundance during cellular stress.

143 dance of each peptide and the fold change in protein abundance during growth.

144 rotein production, supported by steady-state protein abundance estimates.

145 Ribosome occupancy measurements enable protein abundance estimation and infer mechanisms of tra

146 m the hollow fiber system and in independent protein abundance experiments, minocycline demonstrated

147 lization, which is facilitated by changes in protein abundances for substrate uptake and initial cata

148 In silico estimates of protein abundances from publicly available protein spect

149 neural network (cTP-net), to impute surface protein abundances from scRNA-seq data by learning from

150 ional models have been developed to estimate protein abundances from transcript perturbations of mono

151 rect influences on transgenic transcript and protein abundances, identifying putative indirect regula

152 show enrichment for variants with increased protein abundance in a manner that does not compromise c

153 genotype can provide accurate predictions of protein abundance in an independent cohort of collaborat

154 Here, we show that EBP1 expression and protein abundance in Arabidopsis (Arabidopsis thaliana)

155 Thus, ATRAP likely mediates SIRT1 protein abundance in ciRPTEC.

156 The global change in protein abundance in colorectal cancer (CRC) and its con

157 two- to threefold, respectively, as well as protein abundance in culture supernatants by five- and t

158 5a/16-1 deletion enhanced claudin-5 mRNA and protein abundance in ischemic mouse brains.

159 ives precise and objective quantification of protein abundance in large numbers of individual muscle

160 Experimental manipulation of protein abundance in living cells or organisms is an ess

161 , and reliable method to quantify changes in protein abundance in meat samples.

162 expression of AtNDB2 led to increased AtNDB2 protein abundance in mitochondria but did not enhance ex

163 Investigations of MECP2 mRNA and protein abundance in patient-derived lymphoblastoid cell

164 Here, we demonstrate enhanced phytochrome B protein abundance in red light-grown MEcPP-accumulating

165 Though endocytic protein abundance in S. pombe and S. cerevisiae is more

166 PIF protein abundance in SDs oscillates as a balance between

167 Crucially, protein abundance in single cells can vary significantly

168 ociated with adverse impacts on cytoskeletal protein abundance in situ, the coexposure of embryos to

169 cotinamide phosphoribosyltransferase (NAMPT) protein abundance in skeletal muscle.

170 In accordance, NKCC1 (and gammaENaC) protein abundance in the colon of the Nedd4L knock-out a

171 ected pigs had a 70% reduction in dystrophin protein abundance in the diaphragm, psoas major, and lon

172 hypocotyl growth by promoting PIF4 and PIF5 protein abundance in the light, thus providing insights

173 In addition, omeprazole reduced tyrosinase protein abundance in the presence of cycloheximide, sugg

174 They can also be used to measure protein abundance in thousands to millions of cells usin

175 were then applied to examine changes in 6869 protein abundances in developing TA muscles.

176 ction-based microproteomics to determine the protein abundances in different regions and layers of th

177 mate the resulting monolignol transcript and protein abundances in transgenic Populus trichocarpa bas

178 The protein abundances in vernix, and particularly that of p

179 del more accurately estimated transcript and protein abundances, in comparison to previous models, wh

180 Additionally, UBR5 protein abundance increased following functional overloa

181 amic variation in ribosome occupancy affects protein abundance independent of RNA levels.

182 An analysis of protein abundance indicated that both r-proteins are und

183 act coffee quality are related to changes in protein abundance, indicating that proteomic analysis ma

184 ion of synthesis and breakdown to changes in protein abundance induced by REX differ on a protein-by-

185 g and dementia, it was hypothesised that DBN protein abundance instructs the integrity and function o

186 Alterations in protein abundances, interactions, posttranslational modi

187 classified the stimulus-dependent changes in protein abundance into two sources: global changes due t

188 Moreover, ELF3 protein abundance inversely correlates with BBX19 expres

189 Simultaneously, the decrease in r-protein abundance is compensated for by a reduced diluti

190 Here, we found FIT2 protein abundance is lower in subcutaneous and omental A

191 The model suggests that protein abundance is primarily determined by the transcr

192 Protein abundance is quantified coincident with changes

193 Here we show that PD-L1 protein abundance is regulated by cyclin D-CDK4 and the

194 d-specific gene expression and variations in protein abundance, isoform expression and phosphorylatio

195 Increased FoxO3 protein abundance leads to alterations in tubular epithe

196 ASSO, and fuzzy logic approaches can predict protein abundance levels with median ground truth-predic

197 ) and continuous data (e.g. gene expression, protein abundance, metabolite levels).

198 ation and glycation and changes in cytosolic protein abundances, MG modification and proteotoxic resp

199 of several genes were consistent with their protein abundance models.

200 ndependent genetic control of transcript and protein abundance: More than half of the expression QTLs

201 Protein abundance must be precisely regulated throughout

202 Due to their limited protein abundance, neither antibodies against literature

203 ors explaining 66% of the total variation of protein abundance observed in >800 genes in Escherichia

204 articular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA redu

205 ficantly improved the accuracy in predicting protein abundance of a portion of the total modeled mRNA

206 uction not by altering ER quality control or protein abundance of BRI1; instead, TWD1 appears to be c

207 alian target of rapamycin signaling; reduced protein abundance of caveolin-1, dystrophin, epidermal g

208 The protein abundance of CLC-1 was notably enhanced in the p

209 the pawh1 pawh2 double mutation reduces the protein abundance of EBS7 and Hrd1 and inhibits degradat

210 uncovered which consisted of an imbalance in protein abundance of inhibitory and activating regulator

211 ectory, showing that quantitative changes in protein abundance of LS-TFs in progenitors can determine

212 relative quantitation showed differences in protein abundance of major allergen proteins such as Len

213 tion characterized by reduced transcript and protein abundance of MHC class II on tumor B cells, in l

214 ux, tight junction protein distribution, and protein abundance of necroptosis related signals were de

215 ation of these proteins, mRNA expression and protein abundance of nonheme and heme Fe transport prote

216 mine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the

217 NAD(+) levels as well as gene expression and protein abundance of other NAD(+) biosynthetic enzymes r

218 We show that CBF1 increases the protein abundance of PIF4 and PIF5, two phytochrome-inte

219 The protein abundance of PRR5 is strongly increased in spy m

220 By contrast, the protein abundance of specific nuclear-encoded subunits i

221 ion of Fbxl7 in lung epithelia decreases the protein abundance of survivin, a member of the inhibitor

222 Protein abundance of TfR1 was related to midgestation ma

223 The protein abundance of the auxin efflux carrier PIN2 is re

224 Protein abundance of the heme importer, proton-coupled f

225 We found that the protein abundance of the kinesin-1 light chain (KLC1) wa

226 sociated increase in the transcriptional and protein abundance of uncoupling proteins that mediates t

227 signalling posttranslationally controls the protein abundance of vacuolar SNARE components.

228 of AAOs, as well as increased expression and protein abundance of versatile peroxidase 1, which direc

229 Unsupervised hierarchical clustering of protein abundance on nascent DNA is sufficient to identi

230 IP approach that reveals differences between protein abundance on nascent leading and lagging strands

231 e correlation of both ribosome densities and protein abundance on transcript length, the importance o

232 ogists' long-held desire to measure absolute protein abundances on a genome-wide scale.

233 mRNA correlated with protein abundance only for PD-1, PD-L1, and IDO1 and tum

234 is not an upstream cause of increased CAMKII protein abundance or activation.

235 -renewal, by enabling the dynamic control of protein abundance or isoforms or through the regulation

236 connect changes observed in gene expression, protein abundance or other global assays to proteins tha

237 CC4 eliminate this activity without changing protein abundance or surface localization.

238 osomal tubulation defects, reduction in CAV1 protein abundance, or integrin-mediated cell adhesion in

239 Changes in protein abundance partially predicted the metabolic flux

240 utophagic capacity, and higher intracellular protein abundance phenotypes of aged and SSc cells.

241 d with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs).

242 arly events in IGF1R signaling depend on the protein abundance profile of a cell.

243 man blood proteome is frequently assessed by protein abundance profiling using a combination of liqui

244 changes in gene expression and corresponding protein abundance provided by interlinked analysis revea

245 Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumo

246 agreement between changes in transcript and protein abundance (R(2) = 0.24), many proteins, includin

247 ring end-stage PAH significant changes in RV proteins abundance related to the increased myocardial s

248 rovide the first a proteome-wide analysis of protein abundance remodeling between prophase, prometaph

249 ndance are well-developed, those that assess protein abundance require tailoring to penetrate to low-

250 CRY1 and/or CRY2 decreases or enhances TLK2 protein abundance, respectively.

251 reased renal type I collagen and fibronectin protein abundance resulting from experimentally induced

252 A ~1.2- to 1.3-fold increase in NOD1 protein abundance resulting from loss of regulation by t

253 new protein abundance score, the normalized protein abundance scale (NPAS), expands on the number of

254 A new protein abundance score, the normalized protein abundanc

255 mRNA and protein abundance showed significant positive correlatio

256 e miR-326 and antisense miR-9 increased DRD2 protein abundance, suggesting an endogenous repression o

257 tes, and that these have a greater impact on protein abundance than mRNA structure or codon usage.

258 gene expression noise causes fluctuations in protein abundances that may compromise repair.

259 understand biofilm differences, we compared protein abundances that were statistically enriched in b

260 We measure single-cell protein abundance through the use of green fluorescent p

261 Nongenetic variation in protein abundances thus leads to genetic heterogeneity i

262 ages estimates of unprocessed transcript and protein abundances to extrapolate cell states.

263 mporal correlations within and among RNA and protein abundances to identify systematic trends in gene

264 f sinus node biopsies, we attribute measured protein abundances to specific cell types.

265 te, systematic measurements of both mRNA and protein abundances under a wide range of different condi

266 rotein approach provides highly reproducible protein abundance values.

267 mRNA abundance changes explain only ~10% of protein abundance variability.

268 ecision, suitable for the detection of small protein abundance variations between complex biological

269 Oncogenic RAS increased CK1alpha protein abundance via activation of the PI3K/AKT/mTOR pa

270 itatively confirmed by direct measurement of protein abundances via quantitative mass spectrometry.

271 Protein abundance was compared between different treatme

272 Consistent with these results, LYK5 protein abundance was higher in pub13 mutants compared w

273 Emc10 protein abundance was increased in the infarcted region

274 CaMKII protein abundance was increased only in sarcomere-mutati

275 We found liver ENPP1 protein abundance was lower in individuals with T2DM tha

276 e mass-spectrometry, a significant change in protein abundance was noted, of which 200 were proteins

277 d receptor; however, glucocorticoid receptor protein abundance was unaffected in miR-433 decoy cells.

278 A significant pattern of changes in protein abundance was uncovered which consisted of an im

279 The proteins' abundance was computed using a spectral matchi

280 d on our cell lines with accurately measured protein abundances, we report a method to conveniently d

281 nd the expected changes in Luciferin Binding Protein abundance were arrested in L. polyedrum cysts.

282 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were determined and compared with clin

283 esses which displayed the largest changes in protein abundance were peptidoglycan and fatty acid (FA)

284 mber (increased in 84% of tumors), mRNA, and protein abundance were significantly higher in stage 4 c

285 +)/K(+) alpha1-subunit transcript levels and protein abundance were significantly lower in ChAc neuro

286 Differences in protein abundance were validated by quantitative immunoh

287 tandem-mass-spectrometry and differences in protein abundances were assessed.

288 Immunoblotting revealed a decrease of AQP5 protein abundance when each of these miRNAs was transfec

289 eneficial to use genomic features to predict protein abundances when matching proteomic samples or me

290 reanalytical factors may affect the measured protein abundances which in turn influence the outcome o

291 HT represses the PILS6 protein abundance, which impacts on PILS6-dependent auxi

292 yed higher RvD1 levels and 15-lipoxygenase-1 protein abundance, which were prevented by incubation wi

293 the established tool for measuring cellular protein abundances will advance a more quantitative unde

294 e identified a class of cis QTLs that affect protein abundance with little or no effect on messenger

295 (-/-) mice had reduced renal Npt2a and Npt2c protein abundance, with approximately 80% of Npt2a resid

296 ul means of precisely controlling individual protein abundance within cells and is largely mediated b

297 Here, we report that large variability in protein abundance within individual herpesvirus virion p

298 y were accompanied by comparable deficits in protein abundance without changes in mRNA expression, im

299 aggregates and robustly decreased polyQ-Htt protein abundance without concomitant cellular toxicity.

300 Measurement of protein abundance, yeast complementation assays, and ass