ライフサイエンスコーパス: protein antigen

1 ncluded either one or two equivalents of the protein antigen.

2 cluded either two or four equivalents of the protein antigen.

3 tivation but activated T cells normally with protein antigen.

4 after intravenous administration of soluble protein antigen.

5 ific CD8(+) T cells when loaded with soluble protein antigen.

6 repeat boosting with soluble and particulate protein antigen.

7 antigen-specific IgM antibody response to a protein antigen.

8 gating polysaccharides to a T-cell-dependent protein antigen.

9 cells during a primary immune response to a protein antigen.

10 the immunogenicity of a genetically coupled protein antigen.

11 rsibly decorating VLPs simply by mixing with protein antigen.

12 late responses to other epitopes in the same protein antigen.

13 paired responses to cutaneous challenge with protein antigen.

14 odeoxynucleotides, which can bind His-tagged protein antigens.

15 and then immunized and boosted with relevant protein antigens.

16 ked immunospot assay using 3 recombinant HCV protein antigens.

17 the germinal center after immunization with protein antigens.

18 es to gp41 linear peptide and conformational protein antigens.

19 candidate S. pneumoniae and 3 H. influenzae protein antigens.

20 ecule mimetics of conformational epitopes on protein antigens.

21 ma cytokine secretion to tetanus and Candida protein antigens.

22 sponses to intracellular pathogens and model protein antigens.

23 ch tool for identifying antibody epitopes in protein antigens.

24 e an alternative route for immunization with protein antigens.

25 ssociated with autoimmunity to citrullinated protein antigens.

26 it nanomolar range against a wide variety of protein antigens.

27 ractions of monoclonal antibodies (mAbs) and protein antigens.

28 ripping results in dominant Th2 responses to protein antigens.

29 identified proteins and three other putative protein antigens.

30 enotypically distinct from those elicited by protein antigens.

31 have been devoted to identifying protective protein antigens.

32 th facilitate and modulate the processing of protein antigens.

33 ls to initiate an immune response to foreign protein antigens.

34 gands generated by proteasome degradation of protein antigens.

35 and well characterized P. falciparum-derived protein antigens.

36 n be recognized independently of the Sm core protein antigens.

37 lection of scFv clones against six different protein antigens.

38 tion of antibodies directed against parasite protein antigens.

39 ates for a novel S. pneumoniae vaccine using protein antigens.

40 of complement C3 when coupled to T-dependent protein antigens.

41 distinguish between a variety of hapten and protein antigens.

42 by using a biomaterial scaffold loaded with protein antigens.

43 ar locations, including 18 integral membrane protein antigens.

44 press underlying strong immunity to ingested protein antigens.

45 part of the physiological B-cell response to protein antigens.

46 ope residues; and predict epitope patches on protein antigens.

47 enter B cells and antibody responses against protein antigens.

48 ly enhanced immune response to two different protein antigens.

49 ll differentiation and antibody responses to protein antigens.

50 ectrostatic adsorption of negatively charged protein antigens.

51 oad-based antibody and T cell responses with protein antigens.

52 unogens by chemically coupling to a "carrier protein" antigen.

53 sotype, consistent with a T-dependent (i.e., protein) antigen.

54 on of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of

55 the CAP superfamily (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins

56 n, also known as the cysteine-rich secretory proteins/antigen 5/pathogenesis-related 1 proteins (CAP)

57 olar affinity for Mycobacterium tuberculosis proteins (antigens 85A, 85B, 85C, GroES, GroEL2, DnaK, C

58 acterium tuberculosis 30 kDa major secretory protein (antigen 85B) is the most abundant protein expor

59 s the M. tuberculosis 30-kDa major secretory protein antigen 85B, which is 85% homologous with the M.

60 n, we immunized mice through the skin with a protein antigen, a chemical hapten, or a non-replicating

61 phasis on cross-priming, the presentation of protein antigens acquired by dendritic cells from their

62 en protein as model antigens, we showed that protein antigens adsorbed on the aluminum hydroxide nano

63 gen-specific antibody response than the same protein antigens adsorbed on the traditional aluminum hy

64 Immune responses to several viral protein antigens after EPI were studied in mice.

65 we examined whether M-cell targeting using a protein antigen (Ag) delivery system would induce oral t

66 ag.) or intranasally (i.n.) with a bacterial protein antigen (AgI/II of Streptococcus mutans) coupled

67 These viral protein antigens (Ags) were rationally selected for thei

68 umin do not accurately reflect the effect of protein antigen alone on animal physiology.

69 Surface-localized protein antigens (alpha, beta, R1, and R4) serve as addi

70 ry GC responses to vaccine immunization with protein antigen and adjuvant: B7 was required on DCs but

71 Our findings show that exosomes loaded with protein antigen and alphaGC will activate adaptive immun

72 In contrast, control viral CD4 protein antigen and CD8 peptide antigen-specific IFN-gam

73 aneous delivery and activity presentation of protein antigen and nucleic acid ligands critically limi

74 icient (IL-2(-/-)) mice to take up a complex protein antigen and present peptides via MHC molecules t

75 mococcal immunoglobulin G to 27 pneumococcal protein antigens and 30 serotype polysaccharides was mea

76 Nanoparticle vaccines designed to co-deliver protein antigens and adjuvants can promote their deliver

77 erved between B- and T-cell epitopes in many protein antigens and autoantigens.

78 ibodies directed against both B. burgdorferi protein antigens and borrelial diacylglycerols; the latt

79 CD4(+) T cells to HCV, Candida, and tetanus protein antigens and by HLA-A2/HCV 1406-1415-specific CD

80 his extends the results reported for soluble protein antigens and demonstrates a surprisingly marked

81 The library was tested against a panel of 13 protein antigens and high-affinity Fabs were obtained fo

82 otypic typing (based on cell surface T and M protein antigens and opacity factor [OF] production) and

83 tivation and clonal expansion in response to protein antigens and pathogen challenge, whereas CD8(+)

84 by the combination of T cell-dependent (TD) protein antigens and proinflammatory costimulation.

85 ure of immune responses generated to inhaled protein antigens and the mechanisms used to establish to

86 ILC3s can take up latex beads, process protein antigen, and consequently prime CD4(+) T-cell re

87 educing its interactions with the particular protein antigen, and thus allowing for the increase in t

88 ting in vivo T cell responses to peptide and protein antigens, and a better understanding of their ac

89 simultaneously capturing DNA, DNA-conjugated protein antigens, and DNA-conjugated antibodies.

90 of clinical laboratory assays using purified protein antigens, and the identification of antigen spec

91 produced with the formation of citrullinated protein antigen-antibody complexes or other forms of ICs

92 HSP70 protein, antigen-antibody complexes, and complement were

93 n BCR stimulation; however, B cell anergy to protein antigen appeared to be impaired.

94 The combination of antibodies or protein antigens appears to provide enhanced protection

95 uted serum or CSF, antibodies bound to the E protein antigen are detected with fluorescently labeled

96 CD4(+) T-cell responses to immunization with protein antigen are strongly reduced in mice lacking the

97 vivo immunization studies revealed that when protein antigens are conjugated with DNA, the humoral im

98 ering technology, whereby polysaccharide and protein antigens are enzymatically linked in a simple E.

99 Although soluble protein antigens are generally presented by macrophages

100 Overall, the data indicate that protein antigens are important stimulators of WC1(+) gam

101 Antibodies that bind protein antigens are indispensable in biochemical resear

102 While IgG responses against Pneumocystis protein antigens are markedly CD4(+) T cell dependent, C

103 nction of the adaptive immune system in that protein antigens are not microbial in nature and should

104 Soluble extracellular protein antigens are notoriously poor stimulators of CD8

105 Leptospiral protein antigens are of interest as potential virulence

106 e development of a modular approach in which protein antigens are site-specifically linked to tempera

107 T cells recognize protein antigens as short peptides processed and display

108 on of specific antibodies using the relevant protein antigens as the receptor.

109 ly regulate antibody responses to haptenated protein antigens at multiple checkpoints, including germ

110 ated with over 100,000 antibodies binding to protein antigens attached to flat surfaces.

111 eted mycobacterial protein, Ag85 and PstS-1 (protein antigen B, p38 antigen) were quantified in sera

112 responses, particularly to T cell-dependent protein antigens, because they elicit T cell help.

113 rmational heterogeneity and slow dynamics at protein antigen binding sites appears to be a conserved

114 cells (DCs) were immunized with a haptenated protein antigen bound to a TLR9 ligand.

115 T-cell and T-dependent antibody responses to protein antigens, but it has been unclear whether CpG OD

116 s noncovalently bound to a recombinant tumor protein antigen by heat shock.

117 itic cells efficiently internalize exogenous protein antigens by fluid-phase uptake and receptor-medi

118 Single-cell staining patterns of 61 protein antigens by MxIF in 747 colorectal cancer subjec

119 njugated capture antibodies on paper, detect protein antigens by sandwich ELISAs.

120 We identified leptospiral protein antigens by screening a genomic expression libra

121 red for vaccine development as virtually any protein antigen can be engineered for delivery by these

122 The ingestion of protein antigen can induce oral tolerance, which is medi

123 To evaluate whether large protein antigens can be used with this system, recombina

124 and to a lesser extent PorB are noncapsular protein antigens capable of inducing protective bacteric

125 ormulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is d

126 lity of antibody OKT3, which binds the large protein antigen CD3.

127 RA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-

128 in response to TCR-mediated stimulation and protein antigen challenge.

129 An effective docking algorithm for antibody-protein antigen complex prediction is an important first

130 Analysis of antibody-protein antigen complexes has revealed an inherent asymm

131 oves the performance of docking for antibody-protein antigen complexes, even without any sequence inf

132 Protein antigen conjugation to OMPC or other protein car

133 presentation to antigen-specific T cells of protein antigens containing disulfide bonds.

134 at shock step showed no clear differences in protein antigen content and antigenicity, suggesting tha

135 ped by PEGylated phospholipid bilayers, with protein antigens covalently anchored to the lipid surfac

136 This study demonstrated that protein antigens delivered by a simple patch could induc

137 ms, antibody probe hybridization to a target protein antigen depends on the interplay of dilution, th

138 pH of the phagosomal compartment can enhance protein-antigen entry into the cytoplasmic major histoco

139 cobacterium tuberculosis complex recombinant protein antigens ESAT-6, CFP-10, MPB70, and MPB83 elicit

140 serve and present conformational epitopes of protein antigens for induction of neutralizing antibody

141 d variants can recognize seemingly unlimited protein antigens foreign to the host immune system.

142 in fact suppressed, the immune response to a protein antigen from cariogenic streptococci, potentiall

143 lysis of the retinoblastoma tumor suppressor protein antigen from keratinocytes and skin established

144 al-time resonance effect on sensing specific protein antigen from the extracted protein mixtures of t

145 In addition, depletion of intact protein antigen from these cell fractions eliminated the

146 thway mediates a very fast transfer of large protein antigens from the periphery to LN-resident DCs a

147 Cells use a variety of mechanisms to acquire protein antigens, from translation in the cytosol to var

148 m of the CT A subunit consisting of a target protein antigen fused with the A2 polypeptide of CT.

149 nization with the TLR9 agonist CpG linked to protein antigen gave rise to enhanced production of anti

150 t (44.5%) of the isolates contained a single protein antigen gene (bca, bac, rib, alp1, or alp3), and

151 haracterize E. phagocytophila group-specific protein antigen genes, we prepared and screened HGE agen

152 p3), and the remaining isolates had multiple protein antigen genes.

153 hogens, the development of vaccines based on protein antigens has had limited success because of deli

154 e learned that autoimmunity to citrullinated protein antigens has specificity for rheumatoid arthriti

155 directed against peripheral nerve glycan and protein antigens have been described.

156 Although numerous protein antigens have been identified that can generate

157 zed glycoprotein 340 (GP340) via the surface protein antigen I/II (AgI/II) and its homologs as the fi

158 A protein antigen identified by repertoire selection made

159 Screening for Th17-stimulating protein antigens identified PopB as a novel and promisin

160 ude the response of naive T cells to nominal protein antigen if antigen was present at high concentra

161 dy that forms an irreversible complex with a protein antigen in a metal-dependent reaction.

162 otential of SIgA to serve as a carrier for a protein antigen in a mucosal vaccine approach targeting

163 lineage B220(+)IgG(+) B(MEM) toward cognate protein antigen in comparison to bystander inflammatory

164 ection of the viral nonstructural N-terminal protein antigen in enterocytes confirmed translation.

165 ntigens, and the presence of M. tuberculosis protein antigen in RA synovial fluid, a definite causal

166 Epicutaneous application of protein antigen in the presence of adjuvant could be an

167 -derived DCs will be easier to load by using protein antigen in vitro than CD34-derived DCs, and that

168 CD11c(+)DEC205(-) DCs captured far more protein antigen in vivo, produced higher amounts of inte

169 Fv libraries to be selected against membrane protein antigens in a Chinese hamster ovary cell system.

170 lymph nodes shortly after immunization with protein antigens in adjuvants, starting during the first

171 on, we studied the generation of immunity to protein antigens in both TACI-deficient and TACI-profici

172 d analogues that compete effectively against protein antigens in cellular assays, resulting in inhibi

173 induced robust antigen-specific tolerance to protein antigens in mice, preventing subsequent immune r

174 consistent with highly efficient capture of protein antigens in solution by the MP-Ab(2) and explain

175 igh-level expression of genes encoding major protein antigens in the bovine subspecies of Mycobacteri

176 ventional T cells exist, which recognise non-protein antigens in the context of monomorphic MHC class

177 onent of skin immunity, capable of capturing protein antigens in the epidermis and presenting them to

178 n of gold nanoparticles that are coated with protein antigens in the presence of their corresponding

179 ilayer-crosslinked vesicles stably entrapped protein antigens in the vesicle core and lipid-based imm

180 However, in contrast to protein antigens in which hFcgammaRIIIA engagement was b

181 such as nanobodies (Nbs) can target untagged proteins (antigens) in the intracellular environment.

182 f memory B cells by a DNA vaccine encoding a protein antigen, in the presence of the protein itself,

183 ch as bacterial peptidoglycan and orally fed protein antigens, in the lumen and transport them to imm

184 CD8(+) T cells to coadministered peptide or protein antigens, including a peptide encoding the clini

185 and contained several recognized protective protein antigens, including pneumococcal surface protein

186 flammatory conditions, T cell-dependent (TD) protein antigens induce proinflammatory T- and B-cell re

187 mmunization via a physiological route with a protein antigen induced systemic and mucosal protective

188 ice being immunized with cellular or soluble protein antigens induced long-term anergy of antigen-spe

189 that in adult animals, codelivery of soluble protein antigens induces robust humoral, cellular, and m

190 t to the complex environment in the antibody-protein antigen interface.

191 itic cells in lymphoid tissue by engineering protein antigen into an antibody to DEC-205, a receptor

192 Injection of soluble protein antigen into animals causes abortive proliferati

193 rough a colloid osmotic mechanism, releasing protein antigens into the APC cytoplasm for class I anti

194 A recombinant WN virus envelope (E) protein antigen is covalently coupled to fluorescent pol

195 sensor for real-time detection of label-free protein antigen is feasible and sensitive based on the d

196 e association of an antibody with its target protein antigen is studied.

197 Oral administration of protein antigens is a preferred method for tolerance ind

198 nsgenic plants to express orally immunogenic protein antigens is an emerging strategy for vaccine bio

199 The humoral immune response to protein antigens is composed of a rapid low-affinity IgM

200 Although orally introducing nominal protein antigens is known to induce such pTreg cells, wh

201 ence of antibodies against SV40 viral capsid protein antigens is significantly higher (26%, P = 0.043

202 s a well-characterized immunodominant 10-kDa protein antigen known to elicit a very potent early gamm

203 thymus and the ability to respond to soluble protein antigens, lampreys seem to have evolved a B cell

204 her direction, first examining responses to protein antigens, later examining viruses as she turned

205 Recognition of specific protein antigens leads to immunological memory of antige

206 romal fibroblasts, a recent study found XMRV protein antigens mainly in malignant prostate epithelial

207 Some protein antigens may also prime for mucosal IgA memory.

208 osylation affects immunodominance on complex protein antigens may help decipher underlying B cell bio

209 mapping conformational epitopes on complete protein antigen molecules.

210 hagocytophila's major immunodominant surface protein antigen, Msp2 (P44, 44-kDa antigen), is encoded

211 study, we used PCR for all CPSs and selected protein antigens, multilocus sequencing typing (MLST), a

212 luble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells b

213 specific IgG(1) binding to HRV viral capsid protein antigens of HRV-A, -B, and -C were tested in the

214 n this study, the hsp60 and hsp70 heat shock protein antigens of Mycobacterium tuberculosis were test

215 ive means of enhancing the immunogenicity of protein antigens of potential use in pneumococcal vaccin

216 ribe a strategy to identify Th17-stimulating protein antigens of Pseudomonas aeruginosa to assess the

217 at consisted of the same protruding or spike protein antigens of the three viruses in two formats, a

218 One of the protein antigens of this species, the conserved 47-kDa p

219 rhesus recipients were inoculated with GP120 protein antigen on day -28 and -1 and grafted with heter

220 aortic DCs could cross-present two different protein antigens on MHC class I to CD8(+) TCR transgenic

221 The presentation of protein antigens on the cell surface by major histocompa

222 ccine candidates, using purified recombinant protein antigens or antigens encoded in the form of a DN

223 ficiency in T- and B-lymphocyte responses to protein antigens or during viral infection.

224 iver hydrophilic vaccine components, such as protein antigens or ligands for immune receptors.

225 ated through their T cell receptors (TCR) by protein antigens orchestrate immune responses.

226 splenocytes loaded with small amounts of the protein antigen, ovalbumin (OVA).

227 mice) is associated with increased uptake of protein antigens painted on the skin by dendritic cells

228 t is much less accurate for docking antibody-protein antigen pairs than other types of complexes, in

229 ercentages of memory B cells to pneumococcal protein antigens PhtD, LytB, PcpA, PhtE, and Ply were co

230 centages of memory B cells to 3 pneumococcal protein antigens (PhtD, PhtE, and Ply) and reduced antig

231 of data that can now be analyzed to identify protein antigens, potential targets for vaccine developm

232 a post-translationally modified Mtb-derived protein antigen presented in the context of an HLA-E spe

233 with early exposure to STm or cross-reactive protein antigens priming this T-cell development.

234 In contrast to protein antigens, processing of glycoproteins by dendrit

235 humoral reactivity to a subset of M. leprae protein antigens produced in recombinant form.

236 al growth factor (VEGF), are regulated by Hu protein antigen R (HuR), an mRNA binding protein that we

237 orm is used with a model immunoassay where a protein antigen, rabbit immunoglobulin G, was immobilize

238 Inhalation of protein antigen reactivated these Ag-specific Th2 donor

239 e evolutionary relationships of CD28-related proteins, antigen receptors and adhesion molecules and a

240 the porcine erythrocyte membrane as a major protein antigen recognized by human anti-nonalphaGal.

241 Immune recognition of protein antigens relies on the combined interaction of m

242 on of immunodominant epitopes within complex protein antigens remain elusive.

243 ly, the differences in the immunogenicity of protein antigens remain largely unpredictable and diffic

244 form natural chaperone complexes with large protein antigens represents a new and powerful approach

245 Effective humoral responses to protein antigens require the precise execution of carefu

246 ess in antibodies targeting tumor-associated protein antigens resulted in an impressive array of ther

247 response against GPI1 with that against the protein antigen SAG1, a common component of commercial s

248 of B-cell epitope prediction approaches from protein antigen sequences.

249 ing for the P41 and P101 human herpesvirus 6 protein antigens showed numerous immunoreactive astrocyt

250 mice stimulated with PSA in comparison with protein antigen simulation and non-immunized controls an

251 hat between most antibodies and conventional protein antigens since the heavy chain complementarity-d

252 In this work, we focused on protein antigens, since they induce the largest antibody

253 taAntibody) and then docking the antibody to protein antigens (SnugDock).

254 As demonstrated for protein antigens, specific antibodies may aid in RNA cry

255 tive antibody development is to direct virus protein antigens specifically to dendritic cells, which

256 redict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal

257 form natural chaperone complexes with tumor protein antigens such as gp100 represents a powerful app

258 is and gastric damage and are in contrast to protein antigens, such as urease and cag products which

259 culation with attenuated virus vs. a nominal protein antigen supports the use of the salivary as an a

260 Unlike T-dependent immune responses against protein antigens, T-independent responses against polysa

261 identifies a greatly broadened repertoire of protein antigens targeted by T cells involved in allergy

262 When challenged in vivo with protein antigen, TCCR-deficient mice had impaired Th1 re

263 n permitted identification and ranking of 94 protein antigens, ten of which were reproducibly identif

264 Recall responses to the T cell-dependent protein antigen tetanus toxoid as well as DTH responses

265 (LCs) induce type 2 antibodies reactive with protein antigens that are applied to murine skin in the

266 design of novel vaccines containing membrane protein antigens that are otherwise difficult to present

267 Human tumors express a number of protein antigens that can be recognized by T cells, thus

268 ass-II-restricted CD4(+) T-cell responses to protein antigens that contain disulphide bonds.

269 When DR6(-/-) mice were challenged with protein antigen, their T cells hyperproliferate and disp

270 -based memory responses against pneumococcal protein antigens, thereby providing significant protecti

271 teresting function of delivering recombinant protein antigens through the classical major histocompat

272 tion of recombinant 1918 haemagglutinin (HA) protein antigen to characterize at the clonal level neut

273 ep, facilitated-delivery of small amounts of protein antigen to dendritic cells in vivo can give very

274 ugmenting DC presentation of exogenous whole-protein antigen to MHC class I- and class II-restricted

275 We have previously shown that conjugation of protein antigen to the iron transport molecule, transfer

276 combinations of TLR ligands to cross-present protein antigens to CD8(+) T cells.

277 ppressive T cells in vivo by targeting whole protein antigens to DCs via DC-ASGPR.

278 his paper we show that the susceptibility of protein antigens to lysosomal proteolysis plays an impor

279 and presentation of various forms of foreign protein antigens to naive CD4 T cells.

280 In summary, EPI directly delivers protein antigens to the cytosol of the LCs in the skin a

281 hen added to dying tumor cells or with whole protein antigen, UA increased IgG1-based humoral immunit

282 gG1 and IgG2a isotypes was observed when the protein antigen was administered with anti-IL-10R mAb; h

283 Specific immunoglobulin against protein antigen was immobilized onto an optical fiber su

284 A limited set of P. falciparum protein antigens was associated with the development of

285 Expression of MUC5AC and MUC1 mucin protein antigens was quantitated by Western blot analysi

286 n the structure and stability of three model protein antigens was studied using fluorescence and Four

287 ngineered to express group A streptococcal M protein antigens, we characterized the responses of 150

288 fection and showed that the DNA replicon and protein antigen were potent vaccine candidates, particul

289 Twenty-four potential protein antigens were identified and one of them (MC001)

290 noglobulin G (IgG) titers to 28 pneumococcal protein antigens were measured among 242 individuals age

291 Vaccination responses to protein antigens were normal, but the response to pneumo

292 Protein antigens were produced by in vitro transcription

293 munoglobulin (Ig) G responses to the studied protein antigens were reduced, which suggests that antig

294 ponse to immunization with several unrelated protein antigens were remarkably similar.

295 Unlike protein antigens, which are presented on MHC class I and

296 s of lacZalpha and 74 challenging Drosophila protein antigens, which were then screened for expressio

297 These variants share a unique 153-kDa protein antigen with ankyrin repeat motifs encoded by th

298 ligate the Group B Streptococcus (GBS) GBS67 protein antigen with the CpGODN TLR9 agonist.

299 omplex recognition, ability to recognize non-protein antigens) with the persistence, trafficking, and

300 g the immunogenicity of a low-immunogenicity protein antigen without added adjuvants.