ライフサイエンスコーパス: protein coding region

1 tion (single nucleotide polymorphisms in the protein coding region).

2 er binding site through a portion of the gag protein coding region.

3 the T-DNA is present just downstream of the protein coding region.

4 ed to synonymous substitutions in the mature protein coding region.

5 r 4-kb mRNA (AGS3-LONG) in the middle of the protein coding region.

6 n that is sometimes found on the 5' end of a protein coding region.

7 the deletion of two small regions within the protein coding region.

8 eukaryotic gene contains 3.7 introns per kb protein coding region.

9 ne (containing 17 cDNAs) with no significant protein-coding region.

10 he 3' untranslated region rather than in the protein-coding region.

11 anywhere within the first few codons of the protein-coding region.

12 alization sequences are contained within the protein-coding region.

13 f expression and specific alterations in the protein-coding region.

14 ced the number of ribosomes on the principal protein-coding region.

15 ns in cloned genes, 83% were upstream of the protein-coding region.

16 ragments are generated within or near to the protein-coding region.

17 ulatory region and cannot be detected in the protein-coding region.

18 viviral recombination sites inside the viral protein-coding region.

19 poly(A) sites at their introns, 5'-UTRs, or protein coding regions.

20 he relative under-characterization of 90% of protein coding regions.

21 hem lie outside of functionally well-defined protein coding regions.

22 a design universe consisting exclusively of protein coding regions.

23 ional and translational), whilst others form protein coding regions.

24 transcription control or even become part of protein coding regions.

25 a powerful predictor of the reading frame of protein coding regions.

26 irly accurate inhomogeneous Markov models of protein coding regions.

27 ed in open reading frames that are predicted protein coding regions.

28 subject to purifying selection within their protein coding regions.

29 vestigated with the attention focused on the protein coding regions.

30 loci, the majority of which fall outside of protein coding regions.

31 ciation studies are located outside of known protein coding regions.

32 enes using patient sequence data from within protein coding-regions.

33 s of the affected transcripts but rather the protein-coding regions.

34 otide-level motifs of unusual copy number in protein-coding regions.

35 xhibiting levels of constraint comparable to protein-coding regions.

36 fying well-supported, identically-annotated, protein-coding regions.

37 f magnitude of genomic substitution rate for protein-coding regions.

38 s in gene regulation, rather than changes to protein-coding regions.

39 Hoxb1 in mouse development by swapping their protein-coding regions.

40 e than expected (7%) lie within nuclear gene protein-coding regions.

41 o accurately predict all or even most of the protein-coding regions.

42 , to be a powerful criterion for identifying protein-coding regions.

43 rojects identify amino acid substitutions in protein-coding regions.

44 se with unknown function and located outside protein-coding regions.

45 d 533 (approximately 4%) cases of TEs within protein-coding regions.

46 on the basis of the presence of mutations in protein-coding regions.

47 Other clones were polyadenylated within protein-coding regions.

48 echanism(s) for reducing misincorporation in protein-coding regions.

49 5'-untranslated regions (UTRs), introns, and protein-coding regions.

50 er of mutations and genomic polymorphisms in protein-coding regions.

51 n much more difficult to study compared with protein-coding regions.

52 y disease-risk variants that fall outside of protein-coding regions.

53 r efficient detection of genomic variants in protein-coding regions.

54 sequencing errors or indel mutations inside protein-coding regions.

55 -coding regions of the genome in addition to protein-coding regions.

56 that the element preferentially inserts into protein-coding regions.

57 association (GWA) studies are located at non-protein-coding regions.

58 e, in particular outside of the well-studied protein-coding regions.

59 ' nontranslated region and the nonstructural protein-coding regions 3 and 5A) were more sensitive but

60 f adaptations in both regulatory regions and protein-coding regions after gene duplication.

61 ure of the genes is identical throughout the protein coding region, although the Fugu gene is five ti

62 ant variants in regulatory DNA compared with protein-coding regions, although they are likely to have

63 e analysis of simple sequence repeats within protein coding regions among 25 insect genomes.

64 transformed cells contained the full-length protein coding region and detected an abundant transcrip

65 ch sequence located 130 bp upstream of the X protein coding region and showed that there was a cellul

66 h the first intron interrupts the C-terminal protein coding region and the second intron interrupts t

67 enome is 622,952 bp long and consists of 581 protein coding regions and 627 genes of putative functio

68 The protein coding regions and intron-exon boundaries of the

69 rm of single nucleotide variations (SNVs) in protein coding regions and one SNV in the 5' untranslate

70 notation errors and identify potential novel protein coding regions and sRNA.

71 evolutionary conserved frame transitions in protein coding regions and to uncover an underlying func

72 e redundant instability elements, two in the protein-coding region and one in the 3' UTR.

73 te cells, RTC4 transcription begins near the protein-coding region and the resulting short transcript

74 for the evolutionary signatures specific to protein-coding regions and applied them genome-wide, res

75 phenotype-associated variants lie distal to protein-coding regions and are likely involved in regula

76 s of information that can be inferred (e.g., protein-coding regions and cis-regulatory elements) depe

77 homology-based method, AlignFS, to identify protein-coding regions and correct erroneous frame-shift

78 machine learning to predict novel conserved protein-coding regions and efficiently guide their manua

79 , between frequencies of oligonucleotides in protein-coding regions and genome nucleotide composition

80 m A. thaliana in both the cis-regulatory and protein-coding regions and imply that molecular coevolut

81 RNAs with 3' ends within protein-coding regions and introns were less stable than

82 selection in viruses is acting primarily in protein-coding regions and is rare or absent in noncodin

83 Most RA GWAS loci reside outside of protein-coding regions and likely affect distal transcri

84 Prediction of protein-coding regions and other features of primary DNA

85 Notably, the majority reside in protein-coding regions and primarily result from rapid a

86 Most of these variants map to non-protein-coding regions and several map to gene deserts,

87 identify conserved regulatory motifs within protein-coding regions and use it to estimate the number

88 indicated a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions of gene

89 ) the accuracy of GeneMarkS-T in identifying protein-coding regions and, particularly, in predicting

90 s effect held true only for exons within the protein coding region, and not the untranslated region.

91 ound in conserved non-coding regions than in protein-coding regions, and that mutations at a large pr

92 e association studies are located outside of protein-coding regions, and their significance and mode

93 transcription initiation sites within 6% of protein-coding regions, and these sites were concentrate

94 Single nucleotide substitutions within protein coding regions are of particular importance owin

95 region for a given genome, several models of protein-coding region are automatically obtained by Gene

96 nucleotide changes that alter amino acids in protein-coding regions are one of the major causes of hu

97 However, because protein-coding regions are under high selective constrai

98 rts of the genome, including the replication protein coding region, are not required for high infecti

99 Exome sequences, which comprise all protein-coding regions, are promising data sets for stud

100 n map enabled the identification of 14 novel protein coding regions as well as 44 potential novel sRN

101 We sought to identify genetic variants in protein-coding regions associated with subclinical ather

102 hether it is likely to represent a conserved protein-coding region, based on a formal statistical com

103 computational methods for reliably detecting protein-coding regions become even more important.

104 shows extensive variation in expression and protein coding regions but has managed to elude loss fro

105 moter-proximal regions of genes, upstream of protein coding regions by 100 to 400 nucleotides.

106 ogresses being made in the identification of protein coding regions by computational methods during t

107 on comparative genomics metric for detecting protein-coding regions, comparative sequence information

108 The protein coding region consists of eight exons, with two

109 and we found that mRNA containing the Cited2 protein-coding region controlled by a heterologous promo

110 while the second site is located within the protein coding region corresponding to nt 434-634.

111 Moreover, Fpr-rs5 has a stop codon in the protein-coding region corresponding to transmembrane dom

112 Substitution of another YABBY protein coding region (CRABS CLAW) for INO overcomes thi

113 s-acting replication element (CRE) in the 2C protein-coding region [CRE(2C)] templates the addition o

114 ation in the Dhn gene were identified in the protein-coding region, deletion of one Phi-segment from

115 On the other hand, the RNA-binding protein coding region determinant-binding protein, shown

116 senger RNA decay mediated by the c-fos major protein coding-region determinant of instability (mCRD)

117 Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-

118 Conversely, the RNA-binding protein, coding region determinant-binding protein, was

119 similarity with AREs, the purine-rich c-fos protein-coding region determinant of instability.

120 mRNA turnover mediated by the major protein-coding-region determinant of instability (mCRD)

121 regation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 indi

122 ely sensitive to cytoplasmic Ca2+, yet their protein-coding regions do not contain consensus Ca2+-bin

123 large portion of these organisms' predicted protein coding regions encode polypeptides of unknown bi

124 g non-synonymous and synonymous positions in protein coding regions, especially in eukaryotes.

125 A hierarchical Bayesian analysis of protein-coding region evolution within and between speci

126 ation methods for targeted sequencing of all protein-coding regions ('exomes'), to reduce costs while

127 an increasing demand to accurately identify protein coding regions (exons) from genomic sequences.

128 tic elements, the morons, which consist of a protein-coding region flanked by a putative delta 70 pro

129 ll DNA, the viral genome was inserted in the protein-coding region for the surfactant protein A (SP-A

130 , CCR5 delta32 and CCR2-641, which alter the protein-coding regions for the HIV-1 coreceptors/chemoki

131 ce comparisons of the predicted EPSPS mature protein coding regions from both biotypes revealed four

132 e system uses a relational database to store protein coding regions from different genomes, and to st

133 and a Bantu from southern Africa, as well as protein-coding regions from an additional three hunter-g

134 whole-genome sequences and large numbers of protein-coding regions from high-throughput cDNA analysi

135 of the Smcp promoter, the green fluorescent protein coding region (Gfp) and various combination of t

136 have come to light in which mutations in non-protein-coding regions give rise to a deleterious gain-o

137 In native populations, SNPs in protein-coding regions had significantly higher F(ST) es

138 rinciple, any genetic alteration affecting a protein-coding region has the potential to generate muta

139 % of the proteins derived from the predicted protein coding regions have a significant relationship t

140 Although variants in protein-coding regions have received the most attention,

141 hisms are potentially functional variants in protein coding regions, have large effects, and are not

142 g the molecular consequences of mutations in protein coding regions, however nearly all approaches ha

143 e sequences is preferentially located within protein coding regions immediately upstream of the termi

144 SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA eleme

145 Automated methods for identifying protein coding regions in genomic DNA have progressed si

146 ns, one amplification, and nine mutations in protein coding regions in the initial iPS cell clone.

147 gy, we have identified a number of potential protein coding regions in these putative 'non-coding' re

148 new testes-specific promoter derived from a protein-coding region in a gene encoding the cell-adhesi

149 en Markov model to improve the prediction of protein-coding region in short reads.

150 eage-specific increase in copy number of any protein-coding region in the human genome and map primar

151 d comparative genomics evidence to recognize protein-coding regions in 12 species of Drosophila and s

152 We detected somatic mutations in protein-coding regions in 140 benign tissue samples repr

153 nsposable elements (TEs) have contributed to protein-coding regions in Arabidopsis thaliana.

154 Unfortunately, the use of mitochondrial protein-coding regions in deep arthropod phylogenetics a

155 Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 th

156 rie have proposed a clustering algorithm for protein-coding regions in microbial genomes.

157 9-nucleotide spliced leader (SL) upstream of protein-coding regions in polycistronic RNA precursors t

158 GeneMarkS-T, for ab initio identification of protein-coding regions in RNA transcripts.

159 ws an unbiased investigation of the complete protein-coding regions in the genome.

160 analysis predicts that there are at least 34 protein-coding regions in these genomes that were not ap

161 rovided from this output; these lead to the 'Protein Coding Regions' in the NCBI database.

162 tide sequence, length and GC content), (iii) protein coding regions (including amino acid sequence an

163 es involving insertions and deletions within protein-coding regions, including a look at some human-s

164 by inserting the enhanced green fluorescent protein coding region into the 5' untranslated leader se

165 The protein coding region is divided into three exons and ex

166 A new method to predict protein coding regions is developed in this paper based

167 Accurate annotation of protein coding regions is essential for understanding ho

168 tebrate cannabinoid receptor genes where the protein-coding region is typically intronless.

169 f positive selection (adaptive evolution) in protein-coding regions is a d(N)/d(S) ratio >1, where d(

170 wide association studies are located outside protein-coding regions, making it difficult to define me

171 Novel exon 1 protein-coding regions N-terminally extend human KCNE3 a

172 cific in-frame deletion in the nonstructural protein coding region (NotI, approximately nucleotides 1

173 approximately 500 bp) >40 kb upstream of the protein coding region of a human gene is able to direct

174 ariety of ways, duplicating and amending the protein coding region of existing genes as well as gener

175 on reads, we capture 96 to 100% of the viral protein coding region of HIV, respiratory syncytial and

176 The full protein coding region of human immunodeficiency virus (H

177 ty-one mutations were introduced into the CI protein coding region of modified tobacco etch virus (TE

178 of splice forms that lead to changes in the protein coding region of RAGE, which we have classified

179 repeat (IR) RNA derived from the premembrane protein coding region of the DENV-2 RNA genome.

180 eats (VNTR), were discovered in the putative protein coding region of the duplicated chicken THRSPalp

181 Mutations in the protein coding region of the human PrP gene (PRNP), whic

182 The annotated protein coding region of the transporter gene consists o

183 ber of amino acid replacements in the mature protein coding region of these genes.

184 dentifies a 70 nt TS response element in the protein coding region of TS mRNA with in vitro and in vi

185 We resequenced protein coding regions of 3 genes with established roles

186 the 5'-upstream regulatory regions and also protein coding regions of cytochrome P450 2E1 (CYP2E1) a

187 Differences in the protein coding regions of KoRV that distinguish it from

188 nt long, that are precisely complementary to protein coding regions of more than 500 different genes

189 osons constitute the majority of pseudogenic protein coding regions of most eukaryotic genomes.

190 virus-infected chimpanzees, we amplified the protein coding regions of multiple non-human primate ICA

191 bined with existing data to characterize the protein coding regions of myriapods and to attempt to re

192 used to search for specific mutations in the protein coding regions of persyn mRNA and the persyn gen

193 Protein coding regions of plants are often methylated al

194 croarray containing almost all the predicted protein coding regions of serovar Typhimurium strain LT2

195 one unmet goal is to minimize the essential protein coding regions of the exported DNA while maintai

196 ther methods, only non-synonymous changes in protein coding regions of the genome are considered.

197 Even within protein coding regions of the genome, establishing the c

198 luate the contribution of regulatory and non-protein coding regions of the genome, we conducted aggre

199 how this mutation, which does not alter the protein-coding region of a gene, causes an affect at the

200 d identify a single 5-bp deletion within the protein-coding region of a new retinal photoreceptor-spe

201 elopmental pathways, including an SNP in the protein-coding region of BMP4 (rs17563, P = 9.080 x 10(-

202 The protein-coding region of both genes is divided into thre

203 In this mutant mouse, the protein-coding region of CaMKIIalpha is intact, but mRNA

204 The protein-coding region of DINB1, the human ortholog of DN

205 In the core protein-coding region of hepatitis C virus (HCV), eviden

206 nes that have intronless coding regions, the protein-coding region of Kv1.7 is interrupted by a 1.9-k

207 we were unable to identify a mutation in the protein-coding region of Mlh3 in the susceptible mouse s

208 cific interaction between TS protein and the protein-coding region of p53 mRNA, and in vitro translat

209 e fibrillarin lead to Nm modification in the protein-coding region of peroxidasin (Pxdn).

210 element (cre) has been identified within the protein-coding region of several picornaviruses.

211 Interestingly, the protein-coding region of the CiCBR gene is interrupted b

212 The protein-coding region of the gene for this primitive MiC

213 Sequence analysis of the entire protein-coding region of the GJA8 gene from the pedigree

214 gene system that has a UGA codon within the protein-coding region of the luciferase mRNA.

215 tification of two additional elements in the protein-coding region of the message: the 63-nucleotide-

216 functional consequences of mutations in the protein-coding region of the pheromone biosynthetic fatt

217 The 3822 bp protein-coding region of the T. brucei mitochondrial RNA

218 We have sequenced the entire protein-coding region of this locus in 30 microdissected

219 Here we report such data from the protein-coding region of xanthine dehydrogenase (Xdh) in

220 Here we sequence the protein-coding regions of 10,503 adult participants in t

221 We sequenced the protein-coding regions of 18,666 genes in each of 3734 p

222 atalog more than 10 million mutations in the protein-coding regions of 2,735 mutant lines of tetraplo

223 verlapping instances in the untranslated and protein-coding regions of 30,675 transcripts from 20,059

224 tterns of polymorphism and divergence in the protein-coding regions of 33 genes across 31 lines of Dr

225 e variation in 2538 patients with DCM across protein-coding regions of 56 commonly tested genes and c

226 We sequenced the protein-coding regions of 9,793 genomes from patients wi

227 e and sort through every guide targeting the protein-coding regions of any mouse or human gene.

228 er the structure, expression, or function of protein-coding regions of cancer-biology related genes (

229 Cis-regulatory modules are non-protein-coding regions of DNA essential for the control

230 ments combining CPC regulatory elements with protein-coding regions of each single-repeat MYB gene su

231 d no correlation to genetic variation in the protein-coding regions of five genes thought to be impor

232 s identified many recurrent mutations in the protein-coding regions of genes but rarely in gene regul

233 o copy-number variants or point mutations in protein-coding regions of genes contribute to risk, and

234 sites are nearly always in highly conserved, protein-coding regions of host mRNAs.

235 Owing to the degeneracy of the genetic code, protein-coding regions of mRNA sequences can harbour mor

236 a type A(12) infectious cDNA and the capsid protein-coding regions of O/CHA/90 and its cell culture-

237 utation(s) occurred in the cis-regulatory or protein-coding regions of tga1, and whether similar muta

238 We sequenced all protein-coding regions of the genome (the "exome") in tw

239 es highlight the value of regulatory and non-protein-coding regions of the genome in addition to prot

240 tigation of disease pathogenesis confined to protein-coding regions of the genome may be incomplete b

241 c variations that occur in the extensive non-protein-coding regions of the genome remain poorly under

242 disease susceptibility regions reside in non-protein-coding regions of the genome.

243 Furthermore, for the majority of the protein-coding regions of the HIV-1 variants in LSC63 (e

244 Sequencing of the protein-coding regions of the human genome (the exome) h

245 evident that confinement to the analysis of protein-coding regions of the human genome is insufficie

246 The protein-coding regions of the HvGPx41 and HvGPx42 cDNA e

247 ively predicting the effects of mutations in protein coding regions on nucleic acid binding affinitie

248 clones were polyadenylated near the end of a protein-coding region, one of them at the site of post-t

249 from a protein-centric standpoint; however, protein-coding regions only make up approximately 1% to

250 Of the 113 protein coding regions, only 21 code for proteins with h

251 ent of their gene-intrinsic 5'UTR, promoter, protein coding region, or poly(A) sequence.

252 e methods designed for human to sequence the protein-coding regions, or exomes, of four non-human pri

253 For variants in protein-coding regions, our understanding of the genetic

254 hat the point mutations in the nonstructural protein-coding region (P2, P3) that accumulated in the s

255 accurate enough to predict all or even most protein-coding regions perfectly.

256 denylation signals leading to the use of CDS protein-coding region poly(A) sites are distinct from th

257 cript consisting of an sgRNA adjoining a GFP protein coding region produced indels and viral-based GF

258 Cancer-associated somatic mutations outside protein-coding regions remain largely unexplored.

259 RUB replicons have the structural protein coding region replaced with a reporter gene such

260 our current understanding that expansions in protein-coding regions result in extended homopolymeric

261 rmed by PCR-based DNA sequencing, to examine protein-coding regions, RNA splice junctions, and 5' unt

262 ding sites are found to occur within E. coli protein-coding regions significantly less often than exp

263 against custom protein databases to identify protein coding regions, start and stop codons and other

264 y of disease-associated variants lie outside protein-coding regions, suggesting a link between variat

265 tibility loci are found to be located in non-protein-coding regions, suggesting their involvement in

266 ecies, but lack exons 1 and 2, including the protein-coding region, suggestive of species specificity

267 lymorphism in the lipopolysaccharide binding protein coding region that was reported to exist at the

268 cript revealed that the sequences within the protein-coding region that encode transmembrane sequence

269 RV-W) family includes proviruses with intact protein-coding regions that appear to be under selection

270 al introns and ORFs of unknown function, and protein-coding regions that are generally larger than th

271 ollaborative effort to maintain a dataset of protein-coding regions that are identically annotated on

272 times more alternative nucleotides than core protein-coding regions that diversify exclusively via AS

273 nd Southern blot analyses, we determined the protein coding region to be contained in three exons int

274 uses a peculiar feature of some fluorescent protein coding regions to express two different fluoresc

275 nomes, and have reporters that extend beyond protein coding regions to other areas of the transcribed

276 and Oxford Nanopore Technologies reduce dark protein-coding regions to approximately 50.5%, 35.6%, an

277 code may have been optimized for permitting protein-coding regions to carry this extra information a

278 and includes such variables as the length of protein-coding regions, transcript isoforms, variation i

279 rice PHYC gene contains three introns in the protein-coding region typical of most angiosperm PHY gen

280 stream ORFs on the translation of downstream protein-coding regions under normoxia, which was further

281 Contigs containing putative protein-coding regions unrelated to transposable element

282 genes are translated upstream of the primary protein-coding region (uORFs) and 4% are translated down

283 tool to identify evolutionary signatures of protein-coding regions using multispecies genome alignme

284 imulation of randomly selected low-frequency protein-coding regions using twelve different balanced s

285 ith the luciferase gene replacing the capsid protein-coding region was coexpressed in transfected HeL

286 essure directed against HVR-1, but not other protein-coding regions, was also detected.

287 straints imposed on conserved non-coding and protein-coding regions, we compared substitution rates i

288 nsposable elements (TEs) on the evolution of protein-coding regions, we examined 13 799 human genes a

289 le nucleotide variations (SNVs) are found in protein-coding regions, we propose to identify SNVs in e

290 disruption, we concluded that 321 of the 782 protein coding regions were inactivated.

291 Further analysis showed that CNVs deleting protein coding regions were largely responsible for the

292 Variants affecting protein-coding regions were classified in silico using p

293 nome revealed that all site mutations within protein-coding regions were nonsynonymous mutations.

294 sis enabled us to discover a number of novel protein-coding regions, which includes translated pseudo

295 tude and the phase of the period-3 signal in protein-coding regions, which is not found in non-coding

296 found 453 single nucleotide polymorphisms in protein-coding regions, which were used to assess the ev

297 A protein-coding region with an NC-like sequence is presen

298 Scd3 shares 91 and 88% identity in the protein-coding region with Scd1 and Scd2, respectively,

299 t genes identified in the EST screen contain protein-coding regions with an excess of nonsynonymous o

300 e at least 10 nonsynonymous substitutions in protein-coding regions, with enrichment for disease-resi