ライフサイエンスコーパス: protein complex

1 vrPtoB, and activate ETI through the Pto/Prf protein complex.

2 ture together with cross-links formed by the protein complex.

3 tion for each amino acid within a protein or protein complex.

4 nucleating the formation of the multisubunit protein complex.

5 ethanolamine (NAE 18:3) requires an intact G-protein complex.

6 a detailed working model for assembling the protein complex.

7 SNAP23 to form a ternary BAX-SNAP23-ATG16L1 protein complex.

8 nd processed in part by the Mre11-Rad50-Nbs1 protein complex.

9 hat forms favorable interactions in the drug-protein complex.

10 leads to the spatial assembly of multimeric protein complexes.

11 dehydrate proteins and place them in protein-protein complexes.

12 ry, especially for the study of proteins and protein complexes.

13 tential to suggest structural information of protein complexes.

14 ng 22 protein-metal complexes and 10 protein-protein complexes.

15 ovide information on the organization of RNA-protein complexes.

16 tion for future structural studies of lncRNA-protein complexes.

17 ng from small ions to nanocrystals and large protein complexes.

18 rt a charge-directed unfolding mechanism for protein complexes.

19 advances in determining the 3D structures of protein complexes.

20 ause fluctuations in the oligomeric state of protein complexes.

21 red microdomains enriched in cholesterol and protein complexes.

22 pray due to clogging was observed for larger protein complexes.

23 f protein surfaces for prediction of protein-protein complexes.

24 F1 is recruited by the GAA motif to form RNA-protein complexes.

25 ntification of putative new members of known protein complexes.

26 perones and proteases or formation of stable protein complexes.

27 near-native and non-native conformations of protein complexes.

28 ays have recently allowed direct analysis of protein complexes.

29 ins, ribonucleoprotein assemblies, and large protein complexes.

30 in (mETC) composed of several large membrane-protein complexes.

31 and interactions of cellular organelles and protein complexes.

32 uantitative studies of high-molecular-weight protein complexes.

33 used in predicting the structures of protein-protein complexes.

34 our modified DTIM instrument, we studied two protein complexes.

35 tant (K252R) were restructured into discrete protein complexes.

36 fer interaction patterns in a set of protein-protein complexes.

37 its were explored for a range of protein and protein complexes.

38 ctually drive the formation of different DNA-protein complexes.

39 ry to build integrative structural models of protein complexes.

40 nd specific cellular RNA interactions in RNA-protein complexes.

41 a multistep affinity enrichment of specific protein complexes.

42 d interaction of many different proteins and protein complexes.

43 of biopharmaceuticals to cryo-EM analysis of protein complexes.

44 o-hybrid techniques and of affinity-purified protein complexes.

45 he fraction of a protein associated with RNA-protein complexes.

46 energy dissipation functions within pigment-protein complexes.

47 l surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis.

48 ants of numb or the alpha-subunit of Adaptor Protein complex-2 enhance dominantly this phenotype whil

49 milar to that in the M2R-heterotrimeric G(o) protein complex(3).

50 The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a protein coa

51 in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly

52 Deficiency of the adaptor protein complex 4 (AP-4) leads to childhood-onset heredi

53 rticles, an exemplary protein, a noncovalent protein complex, a virus-like particle, a polymer, and a

54 this system involves two distinct receptor-G protein complexes, a conventional ternary complex that a

55 matically studying the phase behavior of RNA-protein complexes across varied mixture compositions, we

56 its negative regulator ARRB2 to form a multi-protein complex also containing downstream signaling pro

57 binders against labile membrane proteins or protein complexes and allows selections in the presence

58 reducing molecules do not adduct to membrane protein complexes and are also compatible with ion-mobil

59 teins, and individual proteins participating protein complexes and functional interactions.

60 ed from specific functional linkages such as protein complexes and ligand-receptor pairs are suitable

61 In recent years it has become obvious that protein complexes and lipids are not uniformly distribut

62 S) provides the capacity to monitor membrane protein complexes and noncovalent binding of ligands and

63 dentifies groups of genes that correspond to protein complexes and pathways, and finds novel protein

64 nt platform for studies of large protein and protein complexes and provides a roadmap for extending t

65 nce and exciton dynamics in light-harvesting protein complexes and semiconducting materials.

66 so been progress in the understanding of the protein complexes and signal transduction pathways regul

67 n and dissociation of hundreds of functional protein complexes and the dynamics of host-host, virus-h

68 s mechanoregulation by the radial spoke (RS) protein complexes and the microtubule central pair (CP).

69 rger, more complex systems, namely, membrane protein complexes and their interactions with ligands.

70 We establish pro-viral roles for cellular protein complexes and translocating proteins.

71 ve structure-function model for the XIST RNA-protein complex, and suggests a general strategy for mec

72 deling, ligand-receptor binding, assembly of protein complexes, and changes in membrane organization.

73 shown SphK2 is associated with HIF-1alpha in protein complexes, and is enriched at the promoters of H

74 t to gene structure, function, membership in protein complexes, and promoter architecture.

75 ch for the reconstitution of labile membrane-protein complexes, and used it to reconstitute Rhodobact

76 chiometry and interactions of supramolecular protein complexes are a critical determinant of biologic

77 ere we present an alternative approach where protein complexes are assembled at physiological concent

78 Eluted proteins and protein complexes are detected by the mass spectrometer

79 Interactions between exocyst and SNARE protein complexes are known, but their functional conseq

80 pand, alternative strategies to characterize protein complexes are needed.

81 own how unincorporated, orphan components of protein complexes are recognised and eliminated from mem

82 Proteins and protein complexes are separated from small molecule non-

83 of mass spectrometry (MS) to study membrane protein complexes are yielding valuable insights into th

84 c photosynthesis: they stabilize the pigment-protein complexes, are active in harvesting sunlight and

85 load MCM2-7, the minichromosome maintenance protein complex, around DNA and initiate DNA replication

86 rade spread, we identified the PRV US9/gE/gI protein complex as a viral factor facilitating the prote

87 MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenanc

88 ence of the alpha1 subunit and c-Src in same protein complex, as well as a direct interaction between

89 osed of several smaller monomers, as well as protein complexes assembled from a few proteins.

90 eling is a useful tool for studying rates of protein complex assembly and degradation.

91 del in which spatial segregation of membrane protein complex assembly and quality control improves as

92 nt scaffolding factor in the nucleus, aiding protein complex assembly in the dense intracellular mili

93 k between INM proteome identity and membrane protein complex assembly in the remaining ER.

94 lay the foundation for a theory of reliable protein complex assembly, we study here an equilibrium t

95 lines reveals the dysregulation of specific protein complexes associated with surveillance of mutati

96 he disruption of the mitochondrial mitofilin protein complex at cristae junctions in patient fibrobla

97 autophagy and trafficking, Ambra1 scaffolds protein complexes at chromatin, regulating transcription

98 Protein complexes at the cell surface facilitate the det

99 A conserved MT-associated protein complex, Augmin, recruits gamma-TuRC to pre-exis

100 Furthermore, we show that a three-protein complex between A33, A34, and B5 forms in the en

101 In conclusion, we describe a novel protein complex between ficolin-2 and ficolin-3 present

102 l tool to assist the structure prediction of protein complexes but has been limited to the study of p

103 r hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neu

104 l model for the disassembly of ubiquitylated protein complexes by Cdc48.

105 We purified SMALP-lipid-protein complexes by chromatography and quantitatively a

106 ave been developed to minimize activation of protein complexes by manipulating charge on protein comp

107 for autophagic degradation of macromolecular protein complexes by the action of intrinsic autophagy r

108 e can distinguish oblate- and prolate-shaped protein complexes by using the CCS, molecular weight, an

109 aithful inheritance of DNA, a macromolecular protein complex called the kinetochore sustains the conn

110 -binding factor subunit beta, forming a four-protein complex called VCBC.

111 a indicate that the Pneumocystis Msg surface protein complex can act to suppress host macrophage infl

112 s assembly." In the latter regime, different protein complexes can coexist without forming erroneous

113 PZA2 encodes a subunit of an F-actin-capping protein complex (CapZ).

114 ed to co-sediment with other RNAs in similar protein complexes, cellular compartments, or with simila

115 r of HSF2BP and showed that the BRME1/HSF2BP protein complex co-immunoprecipitates with BRCA2, RAD51,

116 DNA motifs recognized by the CBC:HapX protein complex comprise a bipartite DNA binding site 5'

117 Mechanistically, STXBP4 assembles a protein complex comprising alpha-catenin and a group of

118 er than actin to the plasma membrane through protein complexes comprising relatives of beta-catenin (

119 The heterotrimeric G protein complex, consisting of canonical Galpha, Gbeta a

120 sses Akt activity and tumor growth through a protein complex containing Aldob, Akt, and protein phosp

121 cell antigen receptor (TCR) and expressed a protein complex containing the agonistic natural killer

122 ta also indicated the existence of different protein complexes containing the alpha1 subunit and c-Sr

123 growth in the nucleus and macromolecular RNA-protein complexes contributes to the preferential transl

124 ighlight the diverse mechanisms by which RGS protein complexes control plasticity in response to opio

125 mainly involved in the formation of coatomer protein complex (COPI) vesicles, maintenance and functio

126 were attached onto the resulting microsphere-protein complex, creating a significant difference in th

127 his approach using the Spindlin1 and SPINDOC protein complex, culminating in a structural model with

128 ased tools includes modeling and analysis of protein complexes, delineation of interfaces and the mod

129 ependent beta-1,4-glucan synthase that forms protein complexes displaying similar ultrastructural fea

130 e simple general framework for understanding protein complex dissociation in a vacuum and highlights

131 sess the identity and purity of proteins and protein complexes during and after protein purification

132 ta, developing a novel algorithm to simulate protein complex dynamics.

133 ectrospray ionization of native proteins and protein complexes effectively reduces the number of nons

134 ntal model of a G-protein-coupled receptor-G-protein complex embedded in a phospholipid bilayer, whic

135 tural homology with YidC and the ER membrane protein complex (EMC) implicates an evolutionarily conse

136 The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago i

137 The ER membrane protein complex (EMC), comprising eight conserved subuni

138 s on the endoplasmic reticulum (ER) membrane protein complex (EMC).

139 e for determining structures of undiscovered protein complexes enriched directly from endogenous sour

140 re reconstructed ab initio from unidentified protein complexes enriched directly from the endogenous

141 olutionarily conserved chromosome-associated protein complex essential for chromosome segregation, ge

142 we propose that a dedicated iron-acquisition protein complex exists at the cell surface of Arabidopsi

143 component of the telomere-specific shelterin protein complex, facilitates end protection through sequ

144 raction methods to demonstrate that XIST RNA-protein complex folds into an evolutionarily conserved m

145 bling the effective size of conventional Fab-protein complexes for cryoEM.

146 ntral to the binding of trypsin and BPTI and protein complex formation in general.

147 ly tend to covary, suggesting importance for protein complex formation.

148 Protein complexes from both capillary sizes displayed si

149 led protocol that enables direct ejection of protein complexes from membranes for analysis by native

150 ilitates the computational reconstruction of protein complexes from proteins migrating in the same fr

151 Detailed mechanistic understanding of protein complex function is greatly enhanced by insights

152 s, histone readers, and chromatin regulatory protein complexes, has inspired the field to identify an

153 The different molecular forms of a protein complex have come to be called "complex isoform"

154 er and outer membranes to form the ~45-50-nm protein complex, have made investigation of the structur

155 Given the known role of the coatomer protein complex I, we speculate that loss of COPA functi

156 are synthesized by intraflagellar transport protein complexes, IFT-B and IFT-A, which mediate bidire

157 Vesicles that are coated by coat protein complex II (COPII) are the primary mediators of

158 dy Schekman led to the discovery of the coat protein complex II (COPII).

159 roaches, to obtain atomic models of multiple protein complexes implicated in intraerythrocytic surviv

160 rovides valuable insight into this essential protein complex in neural development.

161 ATE complex (TPC) is a key endocytic adaptor protein complex in plants.

162 n the intrinsic flexibility of LHCII pigment-protein complexes in a membrane environment, revealing p

163 of CHCHD10 variants in mitofilin-associated protein complexes in brain has not been examined.

164 t cohesin is among the most commonly mutated protein complexes in cancer.

165 racterize the in situ mobility of individual protein complexes in grana thylakoid membranes isolated

166 12 different mitotic proteins and associated protein complexes in multiple states using 15 interactin

167 protein complexes by manipulating charge on protein complexes in solution and the gas-phase.

168 ed to get structural insights on large multi-protein complexes in solution, it also demonstrates that

169 ssential functions, an array of proteins and protein complexes interact with Pol II to regulate its a

170 Y, where the l- enantiomer-substrate-binding protein complex interacted more efficiently with the Yec

171 The RNA exosome is a multisubunit protein complex involved in RNA surveillance of all clas

172 of change, which reflected the remodeling of protein complexes involved in adaptation to perturbation

173 There are many large protein complexes involved in transcription in a chromat

174 Finally, the dissociation behaviors of protein complexes ionized using micrometer and submicrom

175 n cross section (CCS) values for protein and protein complex ions ranging from 6-1600 kDa, exhibiting

176 emplify how a structure-encoded synaptogenic protein complex is also used for repulsive cell guidance

177 Analysis of RNA-protein complexes is central to understanding the molecu

178 Determining structures of protein complexes is crucial for understanding cellular

179 The mass of the observed protein complexes is determined and this information, in

180 functionality of energy-converting membrane protein complexes is unknown.

181 The exocyst, an octameric protein complex, is an essential component of the membra

182 The DNA and protein complex known as chromatin is subject to posttra

183 papillomavirus (HPV) infection, the cellular protein complex known as retromer binds to the L2 capsid

184 tion impairs the regulatory functions of the protein complex leading to a loss of exonuclease activit

185 p-down backbone fragmentation of noncovalent protein complexes, leading to comparable sequence covera

186 Illumination of CdS QD:MoFe protein complexes led to redox changes in the MoFe prote

187 omic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a prot

188 cently reported for a photosynthetic pigment-protein complex (Nature Commmun, 9, 2018, 99).

189 s in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ER

190 parately study the binding interfaces of RNA/protein complexes of different stoichiometry, and provid

191 ner membrane called cristae that contain the protein complexes of the oxidative phosphorylation syste

192 on mobility is demonstrated for a variety of protein complexes of varying topologies.

193 nwinding, suggests that RepC and PcrA form a protein complex on the DNA binding site before nicking.

194 The replisome is a protein complex on the DNA replication fork and function

195 rface glycoprotein (Msg) is a 120-kD surface protein complex on the organism with importance in adhes

196 However, detection and quantification of protein complexes on a proteome-wide scale is technicall

197 surface-induced dissociation of proteins and protein complexes on three instrument platforms.

198 tructural features of pre-purified proteins, protein complexes or clarified cell lysates.

199 The cohesin protein complex organizes the genome by topologically li

200 electronic spectra of photosynthetic pigment-protein complexes over a decade ago, the origin and mech

201 r associated uncertainties, for proteins and protein complexes over a large m/z range.

202 It is therefore likely that many protein complexes persist because a simple ratchet-like

203 Protein complexes play critical roles in many aspects of

204 These membrane protein complexes possess numerous subunit isoforms, whi

205 rrent databases for native-like proteins and protein complexes provide CCS values obtained using norm

206 n with information from databases of protein-protein complexes, R-DeeP facilitates the computational

207 When applied to protein complexes ranging from a 365 kDa CRISPR-Cas Csy

208 on (CCS) values for a series of proteins and protein complexes ranging in size from 8.6 to 810 kDa ar

209 t is kinetically embedded between receptor-G protein complex rearrangements and G protein activation.

210 t Cryo-EM structures of the full-length GlyR protein complex reconstituted into lipid nanodiscs that

211 We further consider how different sorting-protein complexes relate to these routes and discuss oth

212 (b) Some non-covalent drug-protein complexes rely on rather affine bindings and hav

213 Such drug-protein complexes represent so-called "fake antigens," a

214 H+-ATP complex (V-ATPase) is a multisubunit protein complex required for acidification of intracellu

215 CPLANE is a protein complex required for assembly and maintenance of

216 The necrosome is a protein complex required for signaling in cells that res

217 mer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins withi

218 he molecular mechanism behind an ultrastable protein complex responsible for resisting shear forces a

219 The extent to which noncovalent protein complexes retain native structure in the gas pha

220 Recent structures of family B GPCR-G(s) protein complexes reveal a disruption in the alpha-helix

221 Thus, our results support that SHR-SCR protein complex stoichiometry and regulation of SHR tran

222 ing potential artifacts and perturbations of protein complex stoichiometry.

223 capillaries on the native structures of the protein complexes streptavidin, concanavalin A, and C-re

224 One of the challenges in computational protein complex structure prediction is to identify near

225 two methods to improve computational protein-protein complex structure prediction.

226 ries do not result in significant changes to protein complex structure under charge reducing conditio

227 iated with experimental determinations of 3D protein complex structures, computational docking has ev

228 ra can help to further obtain information on protein complex subunits.

229 ities to understand the intricate details of protein complexes such as the impact of post-translation

230 ular dynamics simulations of the SMC-kleisin protein complexes suggest that these complexes exist as

231 Pulmonary surfactant (PS) is a lipid-protein complex that adsorbs to the air-water surface of

232 demonstrated that beta-catenin is part of a protein complex that binds the NF-kappaB DNA consensus s

233 It is the key enzymatic protein complex that catalyzes histone H3 lysine 27 (H3K

234 The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precurso

235 on requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an

236 PI3,5P2, in part, through stabilization of a protein complex that includes its opposing lipid kinase,

237 iscover a specialized role of the Stx17-CFTR protein complex that is critical to prevent defective au

238 organizing system (MICOS) is a multisubunit protein complex that is essential for the proper archite

239 d a transposon screen to identify a membrane protein complex that spatially regulates S. aureus pepti

240 C is an essential component of a cytoplasmic protein complex that targets beta-catenin for destructio

241 tosystem II (PSII) is a multisubunit pigment-protein complex that uses light-induced charge separatio

242 Cytoplasmic dynein is a eukaryotic motor protein complex that, along with its regulatory protein

243 ted seed polysome profiles and the mRNAs and protein complexes that are associated with these ribosom

244 ure-informative mass spectral signatures for protein complexes that complement other structure charac

245 Biomolecular machines are protein complexes that convert between different forms o

246 ranes in chloroplasts contain photosynthetic protein complexes that convert light energy into chemica

247 The components of the protein complexes that generate cadherin-based junctions

248 While the protein complexes that gut bacteria use to degrade starc

249 Telomeres comprise specialized nucleic acid-protein complexes that help protect chromosome ends from

250 mes are multimeric heterogeneous mega-Dalton protein complexes that play key roles in the host innate

251 MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetyla

252 rine (PS) dependent manner to assemble multi-protein complexes that regulate clot formation; however,

253 Inflammasomes are multi-protein complexes that regulate the cleavage of cysteine

254 Many chromatin-binding proteins and protein complexes that regulate transcription also bind

255 define in-solution architectures of dynamic protein complexes that remain inaccessible to other appr

256 Telomeres consist of TTAGGG repeats bound by protein complexes that serve to protect the natural end

257 id membranes scaffold an assortment of large protein complexes that work together to harness the ener

258 d MED13 are components of the Mediator multi-protein complex, that facilitates the initial steps of g

259 ne of eight genes encoding for subunits of a protein complex, the BBSome, which mediates trafficking

260 ned during ER escape of large macromolecular protein complexes, the action of RTN counters this, pres

261 Protein complexes themselves do not escape physical cons

262 se to investigate the presence or absence of protein complexes through some easily measurable kinetic

263 ht to regulate gene expression by organizing protein complexes through unclear mechanisms.

264 , we investigate the system-wide dynamics of protein complexes throughout infection with the herpesvi

265 in genes encoding the eight-protein exocyst protein complex to kidney disease, but the underlying me

266 uced selective disassembly of a multisubunit protein complex to modulate activity.

267 eighboring proteins without the need for the protein complex to remain intact.

268 HDACs are commonly found in various protein complexes to confer distinct cellular functions,

269 ome biogenesis, where they remodel large RNA-protein complexes to facilitate transitions to the next

270 intricate thylakoid network organizes these protein complexes to finely tune the photosynthetic reac

271 The Tuberous Sclerosis Complex (TSC) protein complex (TSCC), comprising TSC1, TSC2, and TBC1D

272 ate assembly patterns of multiple classes of protein complexes under different stress conditions.

273 ochondrial respiratory chain, formed by five protein complexes, utilizes energy from catabolic proces

274 ne fluidity rather than for the formation of protein complexes via direct protein-protein interaction

275 o-EM) structure of this large membrane-bound protein complex, we report an atomistic model of the PLC

276 Using a benchmark of other LRR protein complexes, we further demonstrated that the pres

277 and loaded into newly generated Argonaute 2 protein complexes weeks after dosing, enabling continuou

278 These and other protein complexes were associated with sensitivity to kn

279 The formation of heteromeric protein complexes were validated by coimmunoprecipitatio

280 ial genes encoding oxidative phosphorylation protein complexes, whereas nuclear genes encoding other

281 The reaction is initiated by the RAG1-RAG2 protein complex which binds and cleaves at discrete gene

282 Integral to these processes is the tip-link protein complex, which conveys force to open the inner-e

283 nformatics analysis of the Protein Data Bank protein complexes, which revealed over 400 cases where t

284 tochondrial calcium uniporter (MCU), a multi-protein complex whose assembly in the inner mitochondria

285 Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, a

286 Ejecting the membrane protein complex with bound lipids in the mass spectromet

287 s demonstrate that ATRX forms a constitutive protein complex with FANCD2 and protects FANCD2 from pro

288 cid/base regulators in cancer cells, forms a protein complex with MCT1 and MCT4 in tissue samples fro

289 ed upon binding to PPM1G and forms a ternary protein complex with PPM1G and NF-kappaB at target gene

290 Mechanistically, S18-2 formed a multimeric protein complex with prohibitin and the ring finger prot

291 Bin1 participates in protein complexes with Arf6 and GluA1, and manipulations

292 has enabled the elucidation of heterogeneous protein complexes with different cofactors, post-transla

293 the proteins in the CCS database shows that protein complexes with low apparent densities are struct

294 a comparison of known structures of PC4-like proteins complexed with ssDNA reveals a divergence in th

295 as sybodies, against any purified protein or protein complex within a 3-week period.

296 osynthetic regulation at the level of single protein complexes within the cell.

297 technical advances to resolve the individual protein complexes within these membranes.

298 of cellular processes, which are mediated by protein complexes within this subcellular compartment.

299 ion of the stability of this and other large protein complexes, working in their natural environment

300 translation along the DNA of the SMC-kleisin protein complexes would allow these motors to couple to