ライフサイエンスコーパス: protein glycosylation

1 ion or tunicamycin-mediated inhibition of ER protein glycosylation.

2 e development and maintenance, or defects in protein glycosylation.

3 cells with knock-in/out enzymes involved in protein glycosylation.

4 as a method to compensate for deficiency in protein glycosylation.

5 niae encodes an unusual pathway for N-linked protein glycosylation.

6 to UDP-sugar biosynthesis to support virion protein glycosylation.

7 needed to reveal the biological function of protein glycosylation.

8 rst two committed steps of asparagine-linked protein glycosylation.

9 he impact of nucleotide and NS metabolism on protein glycosylation.

10 and enables proteome-wide discovery of O-Man protein glycosylation.

11 alyzing the first committed step of N-linked protein glycosylation.

12 silsesquioxane, dendrimer), (d) peptide and protein glycosylation.

13 not by tunicamycin treatment, which inhibits protein glycosylation.

14 e biology of a major type of cancer-relevant protein glycosylation.

15 des a semiquantitative assessment of overall protein glycosylation.

16 ct cellular localization, and regulation for protein glycosylation.

17 abolishes the ability of ACER2 to regulation protein glycosylation.

18 binding affinity for PrP was not altered by protein glycosylation.

19 LNT enzyme in initiating mucin type O-linked protein glycosylation.

20 icamycin (TM), an agent that blocks N-linked protein glycosylation.

21 acter jejuni has systems for N- and O-linked protein glycosylation.

22 vertebrate nucleotidases may play a role in protein glycosylation.

23 affect either DNA synthesis or UDP-dependent protein glycosylation.

24 are required for DNA, RNA, and UDP-dependent protein glycosylation.

25 ains is at least partly mediated by envelope protein glycosylation.

26 jejuni virulence by affecting the degree of protein glycosylation.

27 can be employed to modulate the patterns of protein glycosylation.

28 (ER) stress, which results from a decline in protein glycosylation.

29 ts suggest that the genes may be involved in protein glycosylation.

30 hexose metabolism in a manner beneficial for protein glycosylation.

31 prevention of intravascular thrombosis, and protein glycosylation.

32 used glucose deprivation as a tool to alter protein glycosylation.

33 her dendrites also possess the machinery for protein glycosylation.

34 N-acetylglucosamine and thus is a measure of protein glycosylation.

35 lglucosamine (O-GlcNAc), a prevalent form of protein glycosylation.

36 ectivity and unexpectedly increases rates of protein glycosylation.

37 y has become a popular approach for studying protein glycosylation.

38 screen hits were genes involved in N-linked protein glycosylation.

39 ino acid residues, forming multiple types of protein glycosylation.

40 tive in its reliance on mechanical force and protein glycosylation.

41 covery further advances our understanding of protein glycosylation.

42 n be made to promote further explorations of protein glycosylation.

43 ial to determining the microheterogeneity of protein glycosylation.

44 burst (in 3 of 3 patients tested), corrected protein glycosylation (2 of 2), and normal neutrophil ch

45 ree genes are involved in dolichol-dependent protein glycosylation, a pathway not previously implicat

46 The abundance and ubiquity of protein glycosylation across three domains of life invol

47 , genes required for mannose utilization and protein glycosylation, activated a pheromone-response-pa

48 N-acetylglucosamine (O-GlcNAc) is one of the protein glycosylations affecting various intracellular e

49 oligosaccharide precursor and total cellular protein glycosylation, along with hypoglycosylation of a

50 s the use of DEN-gas sheathless CE-ESI-MS in protein glycosylation analysis, where precision is essen

51 Altered protein glycosylation and antibodies that recognize endo

52 Protein glycosylation and capsular polysaccharide format

53 hose members include essential components of protein glycosylation and cell-wall synthesis pathways.

54 proteins involved in vesicular transport and protein glycosylation and degradation, pointing to key n

55 a has different vesicles that play a role in protein glycosylation and folding quality control, analo

56 notype of B. fragilis mutants with defective protein glycosylation and found that the glycan added to

57 Our findings reveal that defects in protein glycosylation and gene expression underlie immun

58 ecific genetic interactors that restore both protein glycosylation and growth of yeast harboring the

59 Thus, protein glycosylation and HCF-1 cleavage occur in the sa

60 Decreased KCC2 surface expression, reduced protein glycosylation and impaired chloride extrusion co

61 ferred by enforced beta cell-specific GnT-4a protein glycosylation and involved the maintenance of gl

62 This review focuses on bacterial protein glycosylation and its impact in pathogenesis.

63 ize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection

64 emented with galactose showed restoration of protein glycosylation and no evidence of glycogen accumu

65 Protein glycosylation and phosphorylation are two import

66 chnique in comprehensive characterization of protein glycosylation and phosphorylation; however, the

67 ol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as t

68 IL-1beta stimulates GLUT1 protein glycosylation and plasma membrane incorporation.

69 o provide the glycosyl subunits required for protein glycosylation and production of high titers of i

70 mutations (p.Ser577Arg, p.Ser650Pro) impair protein glycosylation and reduce JAG1 cell surface expre

71 ited defects in manganese-dependent steps in protein glycosylation and showed an overall decrease in

72 es but also has striking negative effects on protein glycosylation and sorting.

73 cal functions of the Golgi, such as accurate protein glycosylation and sorting.

74 n allowed improved site-specific analysis of protein glycosylation and superior to positive ion mode

75 was primarily mediated via loss of envelope protein glycosylation and that this was associated with

76 It is considerably important to study protein glycosylation and the associated glycans for dia

77 numbers of proteins providing information on protein glycosylation and their microheterogeneity.

78 teases in Archaea, suggesting a link between protein glycosylation and this protease family.

79 ed protein, Golgb1 has specific functions in protein glycosylation and tissue morphogenesis.

80 respiratory chain), dolichols (important for protein glycosylation), and isoprenoids (lipid moieties

81 um (ER) is required for membrane biogenesis, protein glycosylation, and GPI anchoring.

82 ination through control of lipid metabolism, protein glycosylation, and organization of microvilli in

83 uption of calcium homeostasis, inhibition of protein glycosylation, and reduction of disulfide bonds

84 uption of calcium homeostasis, inhibition of protein glycosylation, and reduction of disulfide bonds,

85 nthesis of cell wall matrix polysaccharides, protein glycosylation, and vesicle trafficking.

86 is, lipid metabolism, carotenoid metabolism, protein glycosylation, antibiotics and cytotoxins biosyn

87 Alterations in protein glycosylation are a key feature of oncogenesis a

88 Alterations of protein glycosylation are closely related with pathophys

89 Both de novo DNA synthesis and UDP-dependent protein glycosylation are important for the perplexed ph

90 Changes in O-linked protein glycosylation are known to correlate with diseas

91 Alterations in protein glycosylation are observed in many solid tumor t

92 Regulatory pathways for protein glycosylation are poorly understood, but express

93 However, the molecular mechanisms underlying protein glycosylation are still poorly understood.

94 eterogeneous group of diseases with aberrant protein glycosylation as a hallmark.

95 h3 and ZRSR2 mutants identify cell cycle and protein glycosylation as common pathways disrupted.

96 for cell wall carbohydrate biosynthesis and protein glycosylation as well as for AsA biosynthesis.

97 genes encoding enzymes directly involved in protein glycosylation as well as loci likely to be invol

98 dge of the biosynthetic pathways involved in protein glycosylation, as well as how changes in glycosy

99 Investigating aberrant protein glycosylation associated with diseases is useful

100 to enable and expedite the identification of protein glycosylation based on protein size and affinity

101 we analyze Asn-linked and Ser/Thr/Tyr-linked protein glycosylation between brain regions and sexes in

102 of the endoplasmic reticulum calcium stores, protein glycosylation block, and formation of aberrant p

103 are subjected to calcium depletion stress or protein glycosylation block, the transcription of a fami

104 Here, we highlight how regulated changes in protein glycosylation both at the cell surface and on se

105 However, direct analysis of protein glycosylation by glycopeptide-based mass mapping

106 the reliable structural characterization of protein glycosylation by mass spectrometry at the picomo

107 Protein glycosylation by ST6Gal-I restricts access of an

108 Characterization of protein glycosylation by tandem mass spectrometry remain

109 ary fragmentation techniques for analysis of protein glycosylation by tandem mass spectrometry.

110 th various biochemical probes at the site of protein glycosylation by using the Staudinger ligation.

111 Decreasing protein glycosylation can disrupt protein folding, preve

112 n of stress pathways following inhibition of protein glycosylation can promote EC proliferation and a

113 Alterations of protein glycosylation can serve as sensitive and specifi

114 ansform insect cells, which has enhanced its protein glycosylation capabilities.

115 Protein glycosylation catalyzed by the O-GlcNAc transfer

116 Increased protein glycosylation causes the inhibition of a nuclear

117 Mechanistically, PGM3 inhibition, reducing protein glycosylation, causes a sustained Unfolded Prote

118 MPI mutations in humans impair protein glycosylation causing congenital disorder of gly

119 nditional (temperature-sensitive) defects in protein glycosylation (CHO K12 and BHK tsBN7) induce CHO

120 Protein glycosylation contributes to essential biologica

121 Our studies suggest that envelope protein glycosylation contributes to ZIKV pathogenesis,

122 ental and essential property as mutants with protein glycosylation defects have impaired growth and a

123 e animals and cells derived from them showed protein glycosylation deficiencies similar to those foun

124 by a severe reduction in the HEV-associated proteins, glycosylation-dependent cell adhesion molecule

125 nd activity in invasive cancers, and altered protein glycosylation detected in malignant tumors at al

126 Candida albicans mutant strains defective in protein glycosylation did not show altered plasminogen b

127 rbohydrate interactions allowing us to study protein glycosylation directly on unmodified glycoprotei

128 r understanding of the mechanisms regulating protein glycosylation during neutrophil granulopoiesis a

129 ine pathway, as well as direct inhibitors of protein glycosylation efficiently inhibited TSP-1 transc

130 Protein glycosylation events that happen early in the se

131 homeostasis, resulting in global changes in protein glycosylation, expression and functional effects

132 pacity, biochemicals related to methylation, protein glycosylation, extracellular matrix structure, s

133 was used to characterize the requirement of protein glycosylation for cell membrane stability during

134 erscores the importance of asparagine-linked protein glycosylation for proper functioning of the neur

135 ndings underscore the importance of N-linked protein glycosylation for proper functioning of the neur

136 hreonine side chains represent the two major protein glycosylation forms.

137 roles for a number of novel gene products in protein glycosylation, GPI-anchor attachment, ER quality

138 Protein glycosylation has an important influence on a br

139 Envelope protein glycosylation has been identified as a virulence

140 Protein glycosylation has been implicated in key biologi

141 Protein glycosylation has been long recognized as an imp

142 anslational modifications (PTMs) in mammals, protein glycosylation has been observed to alter in mult

143 While protein glycosylation has been reported in several spiro

144 Burkholderia cenocepacia O-linked protein glycosylation has been reported, but the chemica

145 Aberrant protein glycosylation has been shown to have a significa

146 Protein glycosylation has essential roles in a plethora

147 ed role for TRAPPC11 in LLO biosynthesis and protein glycosylation in addition to its established fun

148 irst study to conclusively identify sites of protein glycosylation in any of the mollicutes.

149 rk for understanding the process of N-linked protein glycosylation in Bacteria and for devising strat

150 The study of protein glycosylation in biological fluids and tissues h

151 identification of a unique system of general protein glycosylation in C. jejuni, a C. jejuni protein

152 d Mn(2+), which are both required for proper protein glycosylation in cells.

153 AP) method provides a platform for analyzing protein glycosylation in clinical specimens and could co

154 to be used for characterizing site-specific protein glycosylation in complex samples.

155 sly unrecognized cell-type-specific role for protein glycosylation in epithelial phenotype developmen

156 The precise roles of protein glycosylation in multicellular development are p

157 samine, along with decreased O- and N-linked protein glycosylation in patients' cells.

158 n (HLA) complexes, and discuss the role of S protein glycosylation in potentially modulating the inna

159 The importance of protein glycosylation in regulating lipid metabolism is

160 We review the effects of protein glycosylation in regulation of gastrointestinal

161 amine pathway suggests a regulatory role for protein glycosylation in Synechocystis under HL.

162 dit an endogenous insect cell gene and alter protein glycosylation in the BICS.

163 unfolded protein response (UPR) by altering protein glycosylation in the endoplasmic reticulum (ER).

164 dolichol biosynthesis and dolichol-dependent protein glycosylation in the endoplasmic reticulum.

165 edict a link between SUN-domain proteins and protein glycosylation in the endoplasmic reticulum.

166 Protein glycosylation in the Golgi apparatus produces st

167 this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sort

168 To investigate the roles of protein glycosylation in the heterogeneity of high-grade

169 d recently that there is a system of general protein glycosylation in the human enteropathogen Campyl

170 esis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticu

171 reduced hyaluronan accumulation and impaired protein glycosylation in the palatal mesenchyme.

172 Understanding the biosynthetic pathway of protein glycosylation in various expression cell lines i

173 rovide greater understanding of the roles of protein glycosylation in vertebrate development.

174 s provide new information about the roles of protein glycosylation in yeast and, in particular, the s

175 Here, we investigated the role of E protein glycosylation in ZIKV pathogenesis using two con

176 essing the biological importance of specific protein glycosylations in the production of safe and eff

177 s regulating goblet cell differentiation and protein glycosylation, including forkhead box A3 (Foxa3)

178 Because the level of protein glycosylation increased with iron limitation, ir

179 Tunicamycin, which is an inhibitor of protein glycosylation, induces ER stress and apoptosis.

180 Since protein glycosylation influences the CSH status of C. al

181 In order to obtain site-specific protein glycosylation information, intact glycopeptides,

182 Pharmacological inhibition of GFAT or protein glycosylation inhibited increased proliferation

183 y more resistant to growth inhibition by the protein glycosylation inhibitor tunicamycin (Tm) than ei

184 zation, misfolded DAT, induced either by the protein glycosylation inhibitor tunicamycin or by its C-

185 In addition, we uncover a defect in protein glycosylation intrappc11mutants that is associat

186 RK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated c

187 Protein glycosylation is a common post-translational mod

188 Protein glycosylation is a common post-translational mod

189 Protein glycosylation is a complex post-translational mo

190 N-Linked protein glycosylation is a frequent post-translational m

191 In B. fragilis, protein glycosylation is a fundamental and essential pro

192 Aberrant protein glycosylation is a hallmark of cancer, but few d

193 Aberrant protein glycosylation is a hallmark of cancer.

194 Consequently, aberrant protein glycosylation is a hallmark of most pathological

195 Protein glycosylation is a heterogeneous post-translatio

196 Protein glycosylation is a highly important, yet poorly

197 factor, and support the view that defective protein glycosylation is a major disease mechanism in ge

198 Protein glycosylation is a post-translational modificati

199 Detailed structural elucidation of protein glycosylation is a tedious process often involvi

200 N-Linked protein glycosylation is a very common post-translationa

201 Nuclear and cytoplasmic protein glycosylation is a widespread and reversible pos

202 Protein glycosylation is among the most common and well-

203 N-Linked protein glycosylation is an essential and highly conserv

204 Protein glycosylation is an essential posttranslational

205 Since protein glycosylation is an important determinant of cel

206 Protein glycosylation is an important post-translational

207 Protein glycosylation is central to the physiology of B.

208 The analysis of protein glycosylation is conducted routinely in high per

209 Comprehensive characterization of protein glycosylation is critical for understanding the

210 Protein glycosylation is essential for cell survival and

211 Asparagine-linked protein glycosylation is essential for the virulence of

212 Protein glycosylation is essential to trafficking and im

213 Taken together our results indicate that protein glycosylation is governed by more diversified re

214 Protein glycosylation is highly diverse and essential fo

215 Protein glycosylation is involved in many biological pro

216 A major type of protein glycosylation is O-GalNAcylation, in which GalNA

217 The examination of protein glycosylation is of high importance, especially

218 Protein glycosylation is one of the most abundant post-t

219 Protein glycosylation is one of the most common protein

220 Protein glycosylation is one of the most common protein

221 Protein glycosylation is one of the most important prote

222 N-Linked protein glycosylation is one of the most prevalent post-

223 Emerging evidence strongly suggests that protein glycosylation is strongly related to this diseas

224 Protein glycosylation is the most complex post-translati

225 Protein glycosylation is the most frequent post-translat

226 Altered protein glycosylation is typically associated with cogni

227 Protein glycosylation is widely recognized as a modulato

228 Protein glycosylation is widespread throughout all three

229 in Golgi complex fragmentation, and reduced protein glycosylation, leading to reduced secretion of c

230 the boundaries, of the previously identified protein glycosylation locus of C. jejuni.

231 is of genes within the previously identified protein glycosylation locus.

232 ation of these SLPs as new adjuvants and the protein glycosylation mechanisms in these bacteria.

233 is brefeldin A-sensitive and insensitive to protein glycosylation, monensin treatment, and low tempe

234 is brefeldin A-sensitive and insensitive to protein glycosylation, monensin treatment, and low tempe

235 ing RNAs, protein synthesis and degradation, protein glycosylation, motility, and biofilm formation.

236 US1 transcription in the mannose utilization/protein glycosylation mutants required some but not all

237 nthetic growth defect in mannose utilization/protein glycosylation mutants, we suggest that the Sho1

238 have developed a method using MRM to monitor protein glycosylation normalized to absolute protein con

239 discovered a novel form of serine/threonine protein glycosylation (O-linked beta-GlcNAc; O-GlcNAc) t

240 N-linked protein glycosylation occurs in all three branches of li

241 As a consequence, aberrant protein glycosylation occurs, including increased sialyl

242 To examine protein glycosylation of alpha-DG, a facile synthetic ap

243 d molecular chaperone activity that mediates protein glycosylation of bacterial adhesins.

244 obic proteins in pathogenesis and of surface protein glycosylation on exposure of the proteins, the l

245 Aberrant protein glycosylation on the cell surface is often a hal

246 l gaps in our knowledge about the effects of protein glycosylation on the heart and vascular system,

247 files in serum/plasma are due to a change in protein glycosylation or a change in protein concentrati

248 Consistent with its role in protein glycosylation, OST3/6 resides in the endoplasmic

249 Since defects in the O-mannosylation protein glycosylation pathway are primarily responsible

250 The O-linked protein glycosylation pathway in Neisseria gonorrhoeae i

251 Campylobacter jejuni has an N-linked protein glycosylation pathway that is required for effic

252 tly discovered to contain a general N-linked protein glycosylation pathway.

253 he discovery of asparagine-linked (N-linked) protein glycosylation pathways in bacteria, major effort

254 trate GlycoPRIME by constructing 37 putative protein glycosylation pathways, creating 23 unique glyca

255 nt acetyltransferase in both N- and O-linked protein glycosylation pathways.

256 relatively primordial nature of insect cell protein glycosylation pathways.

257 Protein glycosylation (pgl) genes have been annotated on

258 a starting point, two enzymes of the general protein glycosylation (Pgl) pathway in C. jejuni (PglF a

259 Herein, enzymes in the N-linked protein glycosylation (Pgl) pathway of Campylobacter jej

260 Mutants in the N-linked general protein glycosylation (pgl) system of C. jejuni are sign

261 d by post-translational processing involving protein glycosylation, phosphorylation, and proteolysis.

262 pe of post-translational modification (PTM), protein glycosylation plays a crucial role in protein st

263 -inflammatory therapy response marker, since protein glycosylation plays an essential role in the inf

264 As a common post-translational modification, protein glycosylation plays an important role in many bi

265 Protein glycosylation plays an important role in the inf

266 Protein glycosylation plays an important role in various

267 Protein glycosylation plays essential roles in protein s

268 the elucidation of the functional role that protein glycosylation plays in pathogenesis.

269 scutoid (Scu) cells-with distinct actin and protein glycosylation polarity patterns.

270 s in genes with diverse functions, including protein-glycosylation, polyunsaturated fatty acid metabo

271 Heterogeneity of protein glycosylation poses great challenges for analysi

272 Domain mapping studies in combination with a protein glycosylation prediction program identified mult

273 UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pa

274 ons as an obligate glycosyl carrier lipid in protein glycosylation reactions.

275 chyl phosphate, an obligate lipid carrier in protein glycosylation reactions.

276 Complete characterization of protein glycosylation requires the identification of int

277 ristic of defects in cell wall integrity and protein glycosylation, respectively.

278 Impaired protein glycosylation seems to be the major factor under

279 ejuni 81-176 pgl mutants impaired in general protein glycosylation showed reduced ability to adhere t

280 Addition of the E protein glycosylation site in a lineage II strain that l

281 (V2.0), based on the AlphaMax algorithm for protein glycosylation site prediction.

282 Western blots, enzyme assays, protein glycosylation studies, and immunohistochemical s

283 The wide-spread conservation of this protein glycosylation system within the phylum suggests

284 nzymatic tagging; identification of sites of protein glycosylation; targeted glycoproteomics; and fun

285 ycosylation (CDGs) are disorders of abnormal protein glycosylation that affect multiple organ systems

286 uman diseases have been linked to defects in protein glycosylation that affects a wide range of organ

287 ntal processes, but the pivotal and specific protein glycosylation that is a necessary for recovery f

288 them, O-mannosylation is an unusual type of protein glycosylation that is largely restricted to the

289 ants in VMA21 in male patients with abnormal protein glycosylation that result in mild cholestasis, c

290 Dolichol is a required cofactor for protein glycosylation, the most common posttranslational

291 , reducing experimental barriers to studying protein glycosylation, the most widespread and complex f

292 Despite the importance of protein glycosylation to brain health, current knowledge

293 Nature uses protein glycosylation to increase the serum stability of

294 present a method to obtain information about protein glycosylation using a minimal amount of protein.

295 Prior to this discovery, it was dogma that protein glycosylation was restricted to the luminal comp

296 Protein glycosylation was variably affected.

297 act as a competitive inhibitor of mannose in protein glycosylation, we added mannose together with 2-

298 o overcome the challenges in the analysis of protein glycosylation, we have developed a comprehensive

299 As an independent means to modify protein glycosylation, we used Chinese hamster ovary ldl

300 ed the effect of UDP-GlcNAc availability and protein glycosylation with O-linked N-acetylglucosamine