ライフサイエンスコーパス: protein interaction domain

1 xtended by a 70-residue linker to the RPA70N protein interaction domain).

2 evelopmental control and requires the FCA WW protein interaction domain.

3 nal repeat structure suggestive of a protein-protein interaction domain.

4 inases (MAGUKs) that contain the PDZ protein-protein interaction domain.

5 o profile the binding sites for any class of protein interaction domain.

6 as well as the FIP3-Fas receptor-interacting protein interaction domain.

7 large to be a membrane spanning or a protein/protein interaction domain.

8 , in this case, serves as autonomous protein-protein interaction domain.

9 hat the C-terminal half of VirB11 contains a protein interaction domain.

10 t Cry3 lacks both an NLS motif and a protein-protein interaction domain.

11 c ring finger functioning as a major protein-protein interaction domain.

12 des a homeodomain protein with a SIX protein-protein interaction domain.

13 tylated histones, and the C-terminal protein-protein interaction domain.

14 rminal ssDNA-binding domain and a C-terminal protein interaction domain.

15 potent, protease-resistant ligands to a PDZ protein-interaction domain.

16 ecreted protein containing a large number of protein interaction domains.

17 a-grasp motif most commonly found in protein-protein interaction domains.

18 th Pkn4 and each contains well-known protein-protein interaction domains.

19 complexes created via a multitude of protein-protein interaction domains.

20 that contains a calmodulin binding site and protein interaction domains.

21 e-activated deoxyribonuclease superfamily of protein interaction domains.

22 ding pathway through a unique combination of protein interaction domains.

23 otif, sequences that act as specific protein-protein interaction domains.

24 with similarity to the PDZ family of protein-protein interaction domains.

25 and substrates by means of carboxy-terminal protein interaction domains.

26 pecialized proteins that often carry protein/protein interaction domains.

27 ty of targeting proteins via its TPR protein-protein interaction domains.

28 ter association of the CREB and CREB binding protein interaction domains.

29 ts of MAGUK proteins have additional protein-protein interaction domains.

30 iation (RA) and Src homology 3 (SH3) protein-protein interaction domains.

31 TPR motifs function as protein-protein interaction domains.

32 urs via both extracellular and intracellular protein interaction domains.

33 not require amino- or carboxy-terminal E2F1 protein interaction domains.

34 ed perhaps as modular "polar zipper" protein-protein interaction domains.

35 nd substrates through their variable protein-protein interaction domains.

36 Leupaxin possesses two types of protein interaction domains.

37 mino acid sequence contains multiple DNA and protein interaction domains.

38 strates via their conserved C-terminal (CCT) protein interaction domains.

39 rstand the functional intricacies of protein-protein interaction domains.

40 ors based on targeting by eukaryotic protein-protein interaction domains.

41 ther bHLH factors, R harbors several protein-protein interaction domains.

42 40 propellers on TOPLESS function as protein-protein interaction domains.

43 e residues, they provide regulatable protein-protein interaction domains.

44 ssed scaffold protein that contains multiple protein interaction domains.

45 GTPase, protein kinase, and multiple protein-protein interaction domains.

46 ese problems, we have focused on families of protein interaction domains.

47 e in the category of multifunctional modular protein interaction domains.

48 ospholipid-binding domains and/or as protein-protein interaction domains.

49 d in deletion mutants lacking several of the protein interaction domains.

50 ibose) polymerases that have SAM and ankyrin protein-interaction domains.

51 cellular signalling networks contain modular protein-interaction domains.

52 release the N-terminus of RPA32 and the two protein-interaction domains.

53 iously discovered role in regulating protein-protein interactions, domain 4 is an autoinhibitory doma

54 X11alpha/Mint-1 has multiple protein-protein interaction domains, a Munc-18 interaction domai

55 The adapter protein FADD consists of two protein interaction domains: a death domain and a death

56 C-terminal, winged helix-loop-helix, protein-protein interaction domain adopts several conformations

57 essive because it lacks an effective protein-protein interaction domain although it does possess a nu

58 olymerase catalytic domain and a WWE protein-protein interaction domain, although similar proteins ha

59 t contains the U2AF homology motif, a common protein interaction domain among splicing factors.

60 erminus is composed of two potential protein-protein interaction domains: an "MAM" domain (named afte

61 analysis indicates an N-terminal POZ protein-protein interaction domain and a C-terminal kelch repeat

62 s that this structure functions as a protein-protein interaction domain and a signaling element.

63 a novel protein that contains a GYF protein-protein interaction domain and interacts specifically wi

64 This study defines the plant B-box as a protein interaction domain and offers novel insight into

65 re examined: rfa1-M2 which is mutated in the protein interaction domain and rfa1-M4 which is mutated

66 human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine re

67 ontaining a conserved amino terminal BTB/POZ protein interaction domain and three C-terminal Kruppel-

68 e revealed an amino-terminal BTB/POZ protein-protein interaction domain and three carboxy-terminal zi

69 racterized by the presence of two tandem PDZ protein interaction domains and a C-terminal domain that

70 ree consecutive Src homology 3 (SH3) protein-protein interaction domains and a C-terminal SH2 domain.

71 contain three carboxyl-terminal LIM protein-protein interaction domains and a proline-rich, pre-LIM

72 each scaffold protein has a different set of protein interaction domains and a unique set of interact

73 DZ proteins usually contain multiple protein-protein interaction domains and act as molecular scaffol

74 pears to have distinct enzymatic and protein-protein interaction domains and functions as a homodimer

75 The adapter protein FADD consists of two protein interaction domains and is an essential componen

76 MAGI-2 contains eight potential protein-protein interaction domains and is localized to tight ju

77 tial extracellular and intracellular protein-protein interaction domains and its wide mRNA expression

78 allosteric changes transpire in the protein-protein interaction domains and linker regions, and thus

79 f (beta)APP identifies PI domains as general protein interaction domains and may have important impli

80 Mapping of protein interaction domains and motifs onto the 3D struc

81 ly, by overlapping the sequences of pairs of protein interaction domains and peptides, we have been a

82 evance for understanding the large family of protein interaction domains and the modular organization

83 copeptide repeat region, likely serving as a protein interaction domain, and a novel C-terminal regio

84 Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and func

85 that this activity is due to a novel protein-protein interaction domain, and that homotypic interacti

86 of MG200, previously described as a protein-protein interaction domain, and to a 25-residue-long pep

87 target a conserved cysteine within the NR0B1 protein interaction domain, and we demonstrate that thes

88 n amino-terminal C2 domain, three WW protein-protein interaction domains, and a carboxy-terminal hect

89 series of spectrin repeats, two GEF domains, protein interaction domains, and a putative kinase domai

90 hCNK1 contains several protein-protein interaction domains, and Rho interacts with one

91 Many signaling proteins contain multiple protein interaction domains, and the decoy mechanism may

92 se, coined dAnk1-3, contain a common protein-protein interaction domain (ankyrin repeats), indicating

93 motifs indicative of protein-protein or RNA-protein interaction domains are discernible in the predi

94 Catalytic centers or protein-protein interaction domains are in close relationship wi

95 nitrogen (N) deprivation, and its predicted protein interaction domains are necessary for function.

96 lin-10 gene activity, suggesting that these protein interaction domains are not essential for LIN-10

97 The GRSP1 protein contains a FERM protein interaction domain as well as two coiled coil do

98 rmining potential ligand binding and protein-protein interaction domains, as well as providing new in

99 They share a BTB/POZ protein interaction domain at the amino end and a zinc-f

100 Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich s

101 nation machinery, while a C-terminal protein-protein interaction domain binds a specific substrate fo

102 basic helix-loop-helix/Per-ARNT-Sim protein-protein interaction domain, binds the C-terminal activat

103 Mutant forms of CAP that lack protein interaction domains block TrkA localization to l

104 region does not show any homology with known protein interaction domains but has been suggested to be

105 bear any obvious resemblance to other known protein interaction domains but is highly conserved amon

106 ding E2f, interact through carboxyl-terminal protein interaction domains, but genetic evidence sugges

107 NHERF-1 contains multiple protein interaction domains, but the mechanism by which

108 e characterized by the presence of a protein-protein interaction domain called the POZ or BTB domain

109 We recently identified a new protein-protein interaction domain, called the L27 domain, which

110 Our results suggest that these novel protein interaction domains can perform functions simila

111 Protein-interaction domains can create unique macromolec

112 es show that PDZ domains (like other protein-protein interaction domains) can engage in a variety of

113 The N terminus of SPY contains a protein-protein interaction domain consisting of 10 tetratricope

114 ne (GlcNAc) transferase (OGT) with a protein-protein interaction domain consisting of 10 tetratricope

115 ng of X-RAR alpha could be attributed to the protein interaction domain contained within X.

116 kstrin homology (PHn) domain and an adjacent protein interaction domain designated as PHn-CC-Ex, amin

117 us, this study characterizes a novel protein/protein interaction domain disrupted in a KLF gene varia

118 ns that converted the GK from an enzyme to a protein interaction domain dramatically reduce flexibili

119 rge and complex, with multiple enzymatic and protein-interaction domains, each of which is targeted b

120 S arises from its more general function as a protein interaction domain, enabling TFIIS to bind a car

121 mot80, but not a mutant lacking its polarity protein interaction domain, enhances ERK1/2-dependent pr

122 amphipathic helix that may encode a protein-protein interaction domain essential for targeting the p

123 n of these complexes and, along with protein-protein interaction domains, form the core of AKAP funct

124 apply the approach to two of the most common protein interaction domains found in humans, an SH3 doma

125 Here we review the function of modular protein interaction domains found in OSR1 and SPAK as we

126 broad complex) is a diverse group of protein-protein interaction domains found within metazoan protei

127 lar to the SAM (sterile alpha motif) protein-protein interaction domain, found in several ETS transcr

128 Here, we show that the PDZ protein interaction domain from the cell polarity protei

129 sequence (DSLL) comprising the core of this protein interaction domain functions as a transplantable

130 e guanylate kinase as it evolved into the GK protein interaction domain (GKPID) to investigate the ro

131 A molecular complex scaffolded by the GK protein-interaction domain (GKPID) mediates spindle orie

132 alpha-SynDelta6, missing part of the protein-protein interaction domain, had reduced toxicity but no

133 is data showed that CMF1 has crucial protein-protein interaction domains, has a retinoblastoma protei

134 Moreover, the effects of mutations in the protein interaction domain have not been analysed.

135 rmore, mutations within two highly conserved protein interaction domains have a dominant-negative eff

136 iological functions of many distinct protein-protein interaction domains have been dissected through

137 oplasm, a process which requires the protein-protein interaction domain (I) in NCp7; subsequently, th

138 eucine residue within the first helix of the protein interaction domain impairs its function in BR si

139 more, DOZ reduces the flexibility of protein-protein interaction domains important for receptor signa

140 The conserved BTB protein interaction domain in NAC1 is the minimal region

141 of the enhanceosome, requires a new protein-protein interaction domain in the p65 subunit of NF-kapp

142 de protocols for constructing microarrays of protein interaction domains in individual wells of 96-we

143 g mutational analyses, we mapped the protein-protein interaction domains in JMJ, Nkx2.5, and GATA4.

144 ent binding of ubiquitin ligases to multiple protein interaction domains in LIM-HD recruited protein

145 ar to those of B-boxes, which act as protein-protein interaction domains in several transcription fac

146 Such tethering can occur via protein interaction domains in the kinase or via anchori

147 binding specificity and organization of the protein interaction domains in wheat PABP was investigat

148 our proteins, each with well defined protein-protein interaction domains, include three 'scaffolds' (

149 This GEF contains several protein-protein interaction domains, including a PDZ domain.

150 c domains, a kinase and a GTPase, as well as protein interactions domains, including a WD40 domain.

151 s implicated both the BRCT and Myb domain as protein interaction domains involved in telomere length

152 tic evidence suggests that an amino-terminal protein interaction domain is also important.

153 nalysis and GST pull-down assay, the protein-protein interaction domain is defined as a coiled-coil d

154 This protein-protein interaction domain is important for the regulati

155 Regulation of protein interaction domains is required for cellular sig

156 suggesting that intact function of this BRCT protein-interaction domain is required both for coordina

157 Ralpha(DeltaRIIa) demonstrated that the RIIa protein interaction domain located within R1A was respon

158 taCC) demonstrated that the coiled-coil (CC) protein interaction domain located within the PML moiety

159 myosins form heavy chain dimers and contain protein interaction domains located at their unique N-te

160 This protein interaction domain may be important in other STA

161 The presence or absence of the protein interaction domain may govern the types of ribon

162 ta suggest that the presence of two distinct protein interaction domains may help to determine the sp

163 These X11alpha protein interaction domains may modulate its effect on A

164 n as the leucine rich region, functions as a protein interaction domain, mediating self-association o

165 expression of its N-terminal, TPR-containing protein interaction domains mimics the effects of LGN in

166 tein interactions and an increasing focus on protein-interaction domains: most frequently, pull-down

167 The N-terminal protein interaction domain (N-domain) of the signal tran

168 he organ of Corti, and carry several protein-protein interaction domains, no functional connection be

169 not map to any of the previously identified protein interaction domains, nor, with one exception, to

170 , constructed without the C-terminal protein-protein interaction domain of alpha, bound DNA with 200-

171 The enhancement requires the presence of the protein interaction domain of gp32 (the acidic carboxy-t

172 iptional activator and that mutations in the protein interaction domain of IRF6 disrupt this activity

173 l analysis of JMJ indicates that the protein-protein interaction domain of JMJ mediates the repressio

174 The PDZ protein interaction domain of neuronal nitric oxide synt

175 with a selective mutation in the N-terminal protein interaction domain of PKGIalpha display inherite

176 eins that interact with PKGI, the N-terminal protein interaction domain of PKGIalpha was used to scre

177 Incubation with the protein interaction domain of RBM inhibited splicing in

178 residues of SKIP thus defining a new protein-protein interaction domain of SKIP.

179 One of these regions is similar to a protein interaction domain of SWI2/SNF2, which is a subu

180 les and the DNA methyltransferase-associated protein interaction domain of the alpha subunit are key

181 The protein interaction domain of the neuronal protein X11 b

182 ion of a critical residue in the NHL protein-protein interaction domain of the protein.

183 that the CRD may function as a major protein-protein interaction domain of these kinases.

184 Thus, betaAPP interaction with the protein interaction domain of X11 stabilizes cellular be

185 ology 3 (SH3) and guanylate kinase-like (GK) protein interaction domains of Dlg, whereas an intramole

186 nteractions between the second and third PDZ protein interaction domains of Par-3 and the aPKC Kinase

187 tion is provided by the second and third PDZ protein interaction domains of Par-3.

188 The in vivo significance of these protein-protein interaction domains of PCDH15 in hair cells has

189 Phosphorylation at Ser-384 remodels the protein interaction domains of RPA.

190 ) and caspase recruitment domains, which are protein interaction domains of the death fold superfamil

191 rminal caspase recruitment domain, which are protein interaction domains of the death fold superfamil

192 ne/histidine-rich region (CH1 domain) of the protein interaction domains of the transcriptional coreg

193 These results suggest that additional protein interaction domains of X11alpha modulate various

194 hat Rtt105 binds to multiple DNA binding and protein-interaction domains of RPA and configurationally

195 Novel protein-protein interaction domains on acetylated Tat are then e

196 teraction between SAP97 and CASK through L27 protein-interaction domains on each protein.

197 ain of Elk-3, but not the C-terminal-binding protein interaction domain, partially alleviated this re

198 Like other protein-protein interaction domains, PDZ domains are involved in

199 NHERF1 begins with two modular protein-protein interaction domains-PDZ1 and PDZ2-and ends with

200 tein networking by directly interacting with protein-interaction domains (PIDs).

201 -shaped structure, with two pairs of protein-protein interaction domains positioned approximately 10

202 In particular, SH3, WW, and several new protein-interaction domains prefer ligand sequences that

203 et of four zinc fingers and a likely protein-protein interaction domain provided by the C-terminal pa

204 s function simply as general purpose protein-protein interaction domains put to diverse uses.

205 sal membrane protein motifs, including lipid-protein interactions, domain rearrangement, and water-me

206 and ARF7 C-terminal domains (i.e., a protein-protein interaction domain referred to as domain III/IV

207 inclusion or exclusion of exons that encode protein interaction domains, regulatory signals, or tran

208 sized that this region constitutes a protein-protein interaction domain required for cooperative asse

209 e that the Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holoco

210 pose that amino acids 91-97 of ATM contain a protein interaction domain required for the DNA damage-i

211 n to associate with two proteins through the protein interaction domain retained in POT1(DeltaOB)-the

212 a nucleic acid-binding domain and a protein-protein interaction domain separated by a flexible serin

213 f the E2F1 transcription factor is a protein-protein interaction domain since it associates with cycl

214 , Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substra

215 reted proteins that contain specific protein-protein interaction domains, such as von Willebrand A, Y

216 encodes a protein containing several protein-protein interaction domains, suggesting that it brings d

217 which, the TAZ2 domain is known as a protein-protein interaction domain that binds to E1A and various

218 the C terminus of Bre2 as a critical protein-protein interaction domain that binds to the Dpy-30 doma

219 The Src-homology 2 (SH2) domain is a protein interaction domain that directs myriad phosphoty

220 YRIN domain is a recently identified protein-protein interaction domain that is found at the N termin

221 ant was isolated that abolishes a WW protein-protein interaction domain that may be important for REF

222 data provide evidence that the SCAN box is a protein interaction domain that mediates both hetero- an

223 he death-effector domain (DED) is a critical protein interaction domain that recruits caspases into c

224 valis to streptococci is driven by a protein-protein interaction domain that resembles the eukaryotic

225 ion to its catalytic domain, several protein-protein interaction domains that allow it to interface w

226 ve a large number and typically a variety of protein interaction domains that allow many different pr

227 he coactivators CBP and p300 through protein-protein interaction domains that are evolutionarily cons

228 PDZ domains are modular protein interaction domains that bind in a sequence-spec

229 endent DNA-based motor is coupled to protein-protein interaction domains that can attach the motor to

230 A family of adaptor proteins containing protein interaction domains that can interact with NPxY

231 protein containing unique N- and C-terminal protein interaction domains that co-assembles with myosi

232 latory proteins, consists of two LIM protein-protein interaction domains that enable it to function a

233 series of putative nucleic acid and protein-protein interaction domains that fold into an elongated

234 tivation domain had homology to "PQ" protein-protein interaction domains that have been described pre

235 Bromodomains are acetyl-lysine specific protein interaction domains that have recently emerged a

236 FE65 contains two distinct protein interaction domains that interact with LRP and A

237 ta identify evolutionarily conserved protein-protein interaction domains that link mLin-2/CASK to SAP

238 e protein kinase interaction domain as novel protein interaction domains that mediate the binding bet

239 PDZ motifs are protein-protein interaction domains that often bind to COOH-term

240 in a PDZ domain and one or more LIM domains, protein interaction domains that participate in a wide v

241 e-associated recruitment domains (CARDs) are protein interaction domains that participate in activati

242 SH3 domains are common protein interaction domains that typically bind proline-

243 ic acid-binding domains and adaptor (protein-protein interaction) domains that comprise the repair ma

244 (e.g., localization and/or specific protein-protein interaction domains) that allow it to efficientl

245 amily of proteins containing a novel protein/protein interaction domain, the EH domain, of as yet unk

246 Repression by ZnF-SCM required a protein interaction domain, the SPM domain, which sugges

247 t the homeodomain of PDX-1 acts as a protein-protein interaction domain to recruit multiple proteins,

248 PDZ is a modular protein interaction domain used in organizing signaling

249 the liver or intestine and may be a general protein interaction domain utilized by fatty acid-bindin

250 Both protein interaction domains (VHS and the coiled-coil dom

251 A second protein-protein interaction domain was identified at amino acids

252 Using yeast two-hybrid analysis to map protein interaction domains, we identified the GGL domai

253 pt, two peptides targeted against receptor-G protein interaction domains were examined.

254 Three protein-protein interaction domains were identified in enkurin:

255 Several characterized protein-protein interaction domains were identified, as well as

256 The protein interaction domains were localized to the C term

257 mal subunit interaction domain and a protein-protein interaction domain which mediates homomer and he

258 ition by Cyp-40 required both its C-terminal protein-interaction domain, which bound specifically to

259 interaction domain, and a number of protein-protein interaction domains (with receptors, other trans

260 We identified a protein-protein interaction domain within the amino-terminus of

261 interaction assay identified a DEAF-1/DEAF-1 protein interaction domain within the NES region.

262 several ways including the presence of a WW protein interaction domain within the SAC domain.

263 nd are recruited by the 4-amino acid protein-protein interaction domain, WRPW.