ライフサイエンスコーパス: protein kinase A

1 aling, and activation of cAMP-dependent PKA (protein kinase A).

2 different 26S component than is modified by protein kinase A.

3 g activation of the small GTPase RhoA and of protein kinase A.

4 dependent on local CRF receptors coupled to protein kinase A.

5 ed nitrogen starvation-induced activation of protein kinase A.

6 inding domain fused to the Calpha subunit of protein kinase A.

7 a regulator of cAMP-dependent signalling by protein kinase A.

8 o study the cAMP binding domain A (CBD-A) of Protein kinase A.

9 neurons is induced by neuronal activity and protein kinase A.

10 ssociation with 14-3-3 proteins and involves protein kinase A.

11 equent stimulation of CFTR by cAMP-dependent protein kinase A.

12 s dependent on Pg phosphorylation at S665 by protein kinase A.

13 transcription factor that acts downstream of protein kinase A.

14 erlotinib was independent of cAMP, cGMP, and protein kinase A.

15 hosphorylation of NMDA and AMPA receptors by protein kinase A.

16 cycle regulator, and the metabolic regulator protein kinase A.

17 enhancing phospholamban phosphorylation via protein kinase A.

18 NHE3 is inhibited by protein kinase A.

19 is an inhibitor of protein phosphatase-1 and protein kinase A.

20 ith forskolin and H89 to activate or inhibit protein kinase A (a family of enzymes whose activity dep

21 ctive transport can be promptly increased by protein kinase A, a key player in neuromodulation.

22 e of the catalytic subunit of cAMP-dependent protein kinase A, a ubiquitous phosphoryl transferase in

23 t the molecular level, capacitation requires protein kinase A activation, changes in membrane potenti

24 n phosphatase PP1-alpha catalytic subunit or protein kinase A activation.

25 Protein kinase-A activation downstream of T-cell recepto

26 involving both an increase in cAMP-dependent protein kinase A activity and the GLI3R to GLI3A ratio.

27 taneous measurement of cytosolic calcium and protein kinase A activity are shown, but the PIE-FLIM ap

28 a-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca(2+) influx throu

29 protein level, female ARVMs exhibited higher protein kinase A activity, consistent with pathway enric

30 mediated inhibition of adenylate cyclase and protein kinase A activity.

31 maps of the kinase domain of cAMP-dependent protein kinase A allow for a molecular explanation for t

32 -induced phosphorylation of USP20 Ser-333 by protein kinase A-alpha (PKAalpha) was required for optim

33 nits that can no longer be phosphorylated by protein kinase A-an essential downstream mediator of bet

34 Dual-specificity protein kinase A anchoring protein 1 (dAKAP1) is a multi

35 r C-terminal tail, often in conjunction with protein kinase A anchoring protein 79 (AKAP79; AKAP150 i

36 ed a novel mTORC1-interacting protein called protein kinase A anchoring protein 8L (AKAP8L).

37 been described to enhance PKA's affinity for protein kinase A anchoring proteins, which alters its su

38 Protein kinase A-anchoring protein 79/150 (AKAP), residi

39 The protein kinase A-anchoring protein dAKAP1 compartmentali

40 fically Ca2+/calmodulin activated kinase II, protein kinase A and exchange protein activated by cAMP

41 hibit excellent selectivity toward EPAC over protein kinase A and G protein-coupled receptors.

42 eta2 -adrenergic receptor phosphorylation at protein kinase A and G-protein receptor kinase sites in

43 3 antagonizes TGFbeta-mediated activation of protein kinase A and inhibition of Protein kinase B (AKT

44 Our results point to a model wherein protein kinase A and its vesicle-associated target, syna

45 -kinase anchoring proteins (AKAPs) that bind protein kinase A and other important signalling enzymes

46 ase anchoring proteins (AKAPs) that localize protein kinase A and other signaling enzymes to discrete

47 Protein kinase A and protein kinase G are regulated by o

48 i-protein reduces cAMP levels and attenuates protein kinase A and protein phosphatase 2A activities.

49 ncreased phosphorylation of phospholamban by protein kinase A and relief of sarco/endoplasmic reticul

50 ive Escherichia coli, an action dependent on protein kinase A and STAT3 in macrophages.

51 As a scaffolding protein for Protein Kinases A and C (PKA and PKC, respectively), AKA

52 m/calmodulin-dependent protein kinase II and protein kinases A and C regulate the activity of T-type

53 on (e.g. by Pho85-Pho80, Cdc28-cyclin B, and protein kinases A and C) and dephosphorylation (e.g. by

54 proteins form signaling complexes containing protein kinases A and C, which phosphorylate and activat

55 Although both PGE(2) (via protein kinase A) and FGF-2 (via protein kinase B, also

56 olism was found to be regulated by cAMP/PKA (protein kinase A)- and proteasome-dependent signaling ev

57 -dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative inju

58 t S373, S365, and S368, well-known Cx43 Akt, protein kinase A, and protein kinase C phosphorylation s

59 s subsequent phosphorylation by Pho85-Pho80, protein kinase A, and protein kinase C.

60 enylyl cyclase inhibitor MDL 12330A, and the protein kinase A antagonist cAMPS-Rp.

61 We observed that the adenylyl cyclase-cAMP-protein kinase A axis is involved in HCAR1 downmodulatio

62 xpression levels of AKAP7, a gene encoding a protein kinase A-binding scaffolding molecule, were sign

63 II reduced its subsequent phosphorylation by protein kinase A but not by protein kinase C.

64 d through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosi

65 ia a pathway that requires the activation of protein kinase A by a bicarbonate-dependent soluble aden

66 rient-sensing (mTOR) and signaling pathways (protein kinases A, C, and D).

67 ccurs via the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA)-dependent signaling pathway.

68 In the myocardium, PKARIalpha (type-1 protein kinase A) can be reversibly oxidized, forming in

69 Toxoplasma gondii encodes three protein kinase A catalytic (PKAc1-3) and one regulatory

70 ipal component analysis of available GRK and protein kinase A crystal structures to identify their do

71 67 kDa laminin-receptor (67LR) resulting in protein kinase A dependent activation of protein phospha

72 Persistent modulation was protein kinase A dependent and associated with a reducti

73 myocytes with isoproterenol, evokes dynamic, protein kinase A-dependent augmentation of Ca(V) 1.2 cha

74 Although beta2AR stimulation in DC induces protein kinase A-dependent cAMP-responsive element-bindi

75 21680) suppresses aPL Ab-mediated NETosis in protein kinase A-dependent fashion.

76 Protein kinase A-dependent increase in the potency of in

77 roperties of T-type Ca(2+) channels in a D2R-protein kinase A-dependent manner without affecting thei

78 Ca(2+) channels in a positive direction in a protein kinase A-dependent manner.

79 n an exchange protein activated by cAMP- and protein kinase A-dependent manner.

80 ntraction in the Langendorff model through a protein kinase A-dependent mechanism.

81 cular level, metoprolol expectedly decreased protein kinase A-dependent phospholamban and ryanodine r

82 Inhibition of protein kinase A did not affect the 2-PAA-related enhanc

83 nge is caused by cocaine-exacerbated D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons

84 TP induction is caused by sensitized D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons

85 optimal linker allows its phosphorylation by protein kinase A during bacterial co-expression and subs

86 r-518 of Merlin is a substrate of the Aurora protein kinase A during mitosis and that its phosphoryla

87 probability >0.3) in the absence of ATP and protein kinase A, each normally required for CFTR activi

88 ominently upregulated via activation of PKA (protein kinase A), essential molecular details remained

89 nels are not characteristically activated by protein kinase A even though the phosphorylation levels

90 s of renal tubule epithelial cells; elevates protein kinase A, extracellular signal-regulated kinases

91 in the activation loops of AGC kinase group (protein kinase A, G, and C families) is required for act

92 Ryanodine receptor was protein kinase A-hyperphosphorylated, S-nitrosylated, ox

93 vidences of an important protective role for protein kinase A in cancer cells under several cellular

94 r282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replace

95 ines produced upon LPS challenge occurs in a protein kinase A-independent manner and, rather, is asso

96 Since protein kinase A inhibition by H-89 and knockdown of bet

97 Spinal protein kinase Cdelta (PKCdelta) or protein kinase A inhibition restores phrenic motor facil

98 Treatment with the protein kinase A inhibitor H89 or the anion exchange inh

99 these effects were blocked by co-addition of protein kinase A inhibitor.

100 hich via CCR1/CCR2 on cancer cells, activate protein kinase A, leading to enhanced malignant cell gly

101 o and found that a positive feedback loop on protein kinase A mediated by the AMP-activated protein k

102 One involves cAMP/protein kinase A-mediated activation of the Src homology

103 f betaAR enlargement of the zone arises from protein kinase A-mediated enhancement of L-type Ca(2+) c

104 and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S

105 with changes in the levels of cAMP-dependent protein kinase A-mediated phosphorylation of synapsin-1.

106 oupled receptor (GPCR) pathways, attenuating protein kinase A-mediated phosphorylation of the E3 ubiq

107 sed imaging reveals that activity-driven and Protein Kinase A-mediated PS1 phosphorylation at three d

108 2 activation inhibited protein kinase C- and protein kinase A-mediated sensitization processes throug

109 t-evoked temporal Ca(2+) release profile and protein kinase A modulation of Ca(2+) release are marked

110 tion coupling is cAMP-dependent, neither the protein kinase A nor the exchange protein directly activ

111 tformin-induced stimulation of AMP-activated protein kinase (a nutrient deprivation sensor that does

112 Phosphorylation by protein kinase A of specific serine residues on Rad decr

113 Protein kinase A or C blockade prevented PTH but not FGF

114 calization mutant, or a mutant lacking the 5 protein kinase A or C phosphorylation sites interfered w

115 The prephosphorylation of Pah1 by protein kinase A or protein kinase C reduced its subsequ

116 This effect is not mediated by the canonical protein kinase A pathway but rather, through direct acti

117 In addition, activating the protein kinase A pathway diminished the contractile sexu

118 is provided for the involvement of the cAMP-protein kinase A pathway in gating the recovery.

119 arrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta t

120 lic adenosine monophosphate (cAMP)-dependent protein kinase A pathway to inhibit HIV-1 activation and

121 e cardiac function, particularly through the protein kinase A pathway, and could potentially be respo

122 esponsive transcription factor Sef1, and the protein kinase A pathway.

123 stream regulator of the cyclic AMP-dependent Protein Kinase A pathway.

124 hways, such as the A-kinase anchor protein 2/protein kinase A pathway.

125 e to EPO regulation through a cAMP-dependent protein kinase A pathway.

126 s-talk in the sarcomere and dysregulation of protein kinase A pathways in HCM.

127 with GO enrichment for neuronal function and protein kinase A pathways.

128 n (Pg) and direct phosphorylation at S665 by protein kinase A: Pg deficiency as well as overexpressio

129 HERF1 knockdown attenuated the induction of (protein kinase A) phospho-vasodilator-stimulated phospho

130 Using a novel mouse model lacking protein kinase A-phosphorylatable troponin I (TnI) and M

131 PKD and was associated with higher levels of protein kinase A-phosphorylated (Ser133) cAMP-responsive

132 yR1 from Tric-a KO mice are not activated by protein kinase A phosphorylation, demonstrating a defect

133 In model organisms, it impairs PKA (protein kinase A) phosphorylation, increases calcium sen

134 at cAMP inhibits myometrial contractions via protein kinase A (PKA) activation, but this has yet to b

135 Lm211 can inhibit Nrg1III by limiting protein kinase A (PKA) activation, which is required to

136 Protein kinase A (PKA) activation, which mediates CD dis

137 re, adropin(34-76) suppressed cAMP activated protein kinase A (PKA) activities, resulting in reduced

138 This effect correlated with increased protein kinase A (PKA) activity and hyperphosphorylation

139 Dynamic subcellular regulation of protein kinase A (PKA) activity is important for the mot

140 The inhibitor of protein kinase A (pkA) activity KT5720 blocked growth of

141 -activated current was not affected when the protein kinase A (PKA) activity was blocked with H89, or

142 cyclic nucleotide-gated (CNG) channels or by protein kinase A (PKA) activity.

143 Luteinizing hormone (LH) via activation of protein kinase A (PKA) acutely stimulates luteal progest

144 ) and 5-HT(7) activation undermines pMF; (2) protein kinase A (PKA) and (3) NADPH oxidase mediate inh

145 f PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase

146 (NGF) as well as multiple kinases, including protein kinase A (PKA) and C (PKC).

147 Here, we used protein kinase A (PKA) and Cepsilon (PKCepsilon), as wel

148 depend on phosphorylation by cAMP-dependent protein kinase A (PKA) and CFTR-ATPase activity.

149 (Epac 1-2)] are alternative cAMP targets to protein kinase A (PKA) and Epac2 is abundant in the cere

150 Protein kinase A (PKA) and exchange protein directly act

151 on at the tandem site, through its effectors protein kinase A (PKA) and exchange proteins directly ac

152 a physical and functional connection between protein kinase A (PKA) and Gpr161 (an orphan GPCR) signa

153 a2 integrin activation on PMNs by activating protein kinase A (PKA) and inhibiting activation of the

154 A-anchoring protein dAKAP1 compartmentalizes protein kinase A (PKA) and other signaling enzymes at th

155 h depended on the activity of cAMP-dependent protein kinase A (PKA) and protein kinase C (PKC).

156 ifferent sensitivities to signaling via cAMP/protein kinase A (PKA) and protein kinase C (PKC).

157 potentiation requires the activation of both protein kinase A (PKA) and the GTPase Ras, and is induce

158 Cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) are important mediators and regul

159 We have used protein kinase A (PKA) as a model system as a generic pr

160 ing unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell

161 hat cAMP promotes phosphorylation of S897 by protein kinase A (PKA) as well as increases the phosphor

162 e protein phospholamban (PLN) is targeted by protein kinase A (PKA) at Ser(16) and by Ca(2+)/calmodul

163 A protein kinase A (PKA) biosensor allowed us to resolve m

164 We generate a novel genetically encoded protein kinase A (PKA) biosensor anchored onto the myofi

165 ion of the A kinase activity reporter (AKAR) protein kinase A (PKA) biosensor as an example-first in

166 lin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) both in vitro and in heterologous

167 ased; this was associated with a decrease of protein kinase A (PKA) catalytic subunit alpha (Calpha)

168 ignaling promotes the formation of a SMAD3/4-protein kinase A (PKA) complex that activates C-terminal

169 ing Ras-cAMP-PKA pathway at the level of the protein kinase A (PKA) enzyme.

170 , cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circuit c

171 Protein Kinase A (PKA) exists as a tetrameric holoenzyme

172 Using voltage-clamp and cAMP-protein kinase A (PKA) FRET sensors, we hypothesized tha

173 Protein kinase A (PKA) holoenzyme, comprised of a cAMP-b

174 ponses relies on the activation of localized protein kinase A (PKA) holoenzymes.

175 g via dynamic and differential modulation of protein kinase A (PKA) in each class of spiny projection

176 gulates signal transduction through cAMP and protein kinase A (PKA) in melanocytes, is a major inheri

177 ophosphate, and the subsequent activation of protein kinase A (PKA) induce a mesenchymal-to-epithelia

178 Regulatory subunits of protein kinase A (PKA) inhibit its kinase subunits.

179 cued by Rho-associated protein kinase (ROCK)/protein kinase A (PKA) inhibitor fasudil, a drug already

180 Protein kinase A (PKA) integrates inputs from G-protein-

181 In eukaryotes, protein kinase A (PKA) is a master regulator of cell pro

182 Ser133 phosphorylation by protein kinase A (PKA) is a well-characterized CREB acti

183 rylation of the regulatory domain of CFTR by protein kinase A (PKA) is required for its channel activ

184 The activity of the archetypal protein kinase A (PKA) is typically thought of in regard

185 ngoing cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) levels, strongly limiting SK chan

186 Protein Kinase A (PKA) mediates synaptic plasticity and

187 Protein Kinase A (PKA) modulates Hh signaling activity t

188 ed expression of genes in the cAMP-dependent protein kinase A (PKA) pathway and PKA catalytic activit

189 ormone (ACTH)-induced activation of the cAMP/protein kinase A (PKA) pathway by melanocortin 2 recepto

190 In many of these tumors, the cAMP-dependent protein kinase A (PKA) pathway is activated.

191 m, the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway plays a critical role in

192 n was emulated by positive modulators of the protein kinase A (PKA) pathway, inhibited by the CB1R an

193 Protein kinase A (PKA) phosphorylation of GRK2 at Ser-68

194 Mice that lack a well-conserved protein kinase A (PKA) phosphorylation site, S551, showe

195 (K(2P)-channel) THIK-1 has several predicted protein kinase A (PKA) phosphorylation sites.

196 nt structure and contractile properties in a protein kinase A (PKA) phosphorylation-dependent manner.

197 rat ventricular cardiomyocytes is driven by protein kinase A (PKA) phosphorylation.

198 racellular signal-regulated kinase (ERK) and protein kinase A (PKA) play important roles in LTP and s

199 Protein kinase A (PKA) plays critical roles in neuronal

200 gh PAR(2) Inhibitors of adenylyl cyclase and protein kinase A (PKA) prevented the effects of Lgmn.

201 LI-1, and inhibitors of adenylyl cyclase or protein kinase A (PKA) prevented the effects of Lgmn.

202 is initiated by PDEs actively targeting the protein kinase A (PKA) R-subunit through formation of a

203 Treatment of WT preparations with protein kinase A (PKA) reduced the SRX, whereas, in nonp

204 The cAMP-dependent protein kinase A (PKA) regulates various cellular functi

205 The regulation of L-type Ca(2+) channels by protein kinase A (PKA) represents a crucial element with

206 TG) mice expressing non-phosphorylatable TnI protein kinase A (PKA) residues (i.e. serine to alanine

207 ternalization is associated with a late cAMP/protein kinase A (PKA) response at the Golgi/TGN.

208 We demonstrate that Ras/MAPK and Protein Kinase A (PKA) signaling act downstream of AdoR

209 t disease-related mutations that impair cAMP protein kinase A (PKA) signaling are present within the

210 e we show that stimulation of cAMP-dependent protein kinase A (PKA) signaling in cells inactivates Ca

211 Luteinizing hormone (LH) activates protein kinase A (PKA) signaling in luteal cells, increa

212 lincRNA signatures support a major role for protein kinase A (PKA) signaling in shaping the FLC gene

213 hrough activation of the beta-adrenergic and protein kinase A (PKA) signaling pathway.

214 regulation is mediated by the cAMP-dependent protein kinase A (PKA) signaling pathway.

215 ression of fasting-responsive cAMP-dependent protein kinase A (PKA) signaling pathways also suggests

216 ory synapses is dependent on downstream cAMP/protein kinase A (PKA) signaling, which differs between

217 ls respond to multiple signals that activate protein kinase A (PKA) signaling, which positively regul

218 al activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

219 response to dopamine acting via D1 receptor/protein kinase A (PKA) signaling.

220 tide and inhibitors of adenylate cyclase and protein kinase A (PKA) signaling.

221 f the beta-adrenergic receptor (betaAR)/cAMP/protein kinase A (PKA) signalling pathway leads to enhan

222 role of S1928 phosphorylation of Ca(v)1.2, a protein kinase A (PKA) site using S1928A Ca(v)1.2 phosph

223 ely, GLI3 phosphorylation pattern at primary protein kinase A (PKA) sites and secondary casein kinase

224 ological agents that raise cAMP and activate protein kinase A (PKA) stimulate 26S proteasome activity

225 activation (LDA) under conditions of maximal protein kinase A (PKA) stimulation.

226 AKAPs anchor protein kinase A (PKA) through PKA regulatory subunits,

227 In yeast, glucose activates protein kinase A (PKA) to accelerate aging by inhibiting

228 unchanged K (m)), phenocopies the ability of protein kinase A (PKA) to activate PDE4 long isoforms en

229 Here, we review mechanisms that bestow protein kinase A (PKA) versatility inside the cell, appr

230 ed PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha but not phospholipase

231 Protein kinase A (PKA) was identified as a downstream ta

232 ion to mitochondria and its interaction with protein kinase A (PKA), a known node in the beta-adrener

233 ry subunit 1beta (PRKAR1beta), activation of protein kinase A (PKA), and phosphorylation of alpha4-in

234 SOCE also activated the cAMP effector, protein kinase A (PKA), as determined by the PKA reporte

235 s with inhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphodiesterase 3B (PDE3B), an

236 odulin-dependent protein kinase II (CaMKII), protein kinase A (PKA), protein kinase C (PKC), and AMPA

237 s a multivalent binding protein that targets protein kinase A (PKA), RNAs, and other signaling enzyme

238 of Rho-associated protein kinase (ROCK) and protein kinase A (PKA), we attempted to rescue Ophn1-dep

239 We also noted that protein kinase A (PKA), which mediates phosphorylation o

240 Synaptic SK2 levels are also regulated by protein kinase A (PKA), which phosphorylates SK2 in its

241 Exendin-4 regulated Cx36 coupling via both protein kinase A (PKA)- and Epac2-mediated mechanisms in

242 e C-terminal type I PDZ motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which

243 eurons, and these effects were mediated by a protein kinase A (PKA)-dependent enhancement of presynap

244 and IBMX increased NCC phosphorylation via a protein kinase A (PKA)-dependent pathway.

245 licle-stimulating hormone (FSH) promotes the protein kinase A (PKA)-dependent phosphorylation of insu

246 esicles to the plasma membrane and increased protein kinase A (PKA)-dependent protein phosphorylation

247 neurons, with GLP-1R activation promoting a protein kinase A (PKA)-dependent signaling cascade leadi

248 ity profiling revealed that GD1a activated a protein kinase A (PKA)-dependent signaling pathway and i

249 major calcium signaling molecule, and report protein kinase A (PKA)-independent CFTR activation by ca

250 nses to subsequent stresses, as seen for the protein kinase A (PKA)-mediated general stress response

251 g brown adipocytes through cyclic AMP (cAMP)/protein kinase A (PKA)-mediated lipolysis and fatty acid

252 tractile impairments were caused by impaired protein kinase A (PKA)-mediated phosphorylation because

253 to this site triggers the relief of Ig20 and protein kinase A (PKA)-mediated phosphorylation of Ser-2

254 show that GIE deformability is regulated by protein kinase A (PKA)-mediated phosphorylation of the S

255 by suppressing inhibitory modulation by cAMP-protein kinase A (PKA)-mediated phosphorylation.

256 Hyperglycemia is associated with protein kinase A (PKA)-mediated stimulation of L-type Ca

257 inked to GluA1 phosphorylation at Ser-845, a protein kinase A (PKA)-targeted site within its intracel

258 transcription principally by activating the protein kinase A (PKA)-targeted transcription factors.

259 One of the most important protein kinases is protein kinase A (PKA).

260 phosphatase is subject to phosphorylation by protein kinase A (PKA).

261 ete partner HSPB6 which is phosphorylated by protein kinase A (PKA).

262 ttle agonist action of I942 towards EPAC2 or protein kinase A (PKA).

263 iosynthetic enzyme, ferrochelatase (FECH) by protein kinase A (PKA).

264 tor forskolin and prevented by inhibitors of protein kinase A (PKA).

265 perilipin 1 (Plin1) in the lipid droplet by protein kinase A (PKA).

266 cell processes largely through activation of protein kinase A (PKA).

267 ex via phosphorylation of MeCP2 at Ser421 by Protein Kinase A (PKA).

268 mitters via activation of its main effector, protein kinase A (PKA).

269 erotrimeric Gbetagamma subunits, PIP(3), and protein kinase A (PKA).

270 associated with cAMP-mediated activation of protein kinase A (PKA).

271 nhibits breakdown of cAMP and thus activates protein kinase A (PKA).

272 14-3-3 proteins after its phosphorylation by protein kinase A (PKA).

273 ls transduced between the two CNB domains of protein kinase A (PKA).

274 KCa3.1 channels, mediated by cAMP-dependent protein kinase A (PKA).

275 levation of cardiac output via activation of protein kinase A (PKA).

276 nk between heat shock protein 90 (HSP90) and protein kinase A (PKA).

277 g L-type Ca(V)1.2 channel (LTCC) activity by protein kinase A (PKA).

278 ays in insulin-secreting beta-cells to cause protein kinase A (PKA)/exchange protein activated by cAM

279 beta-cell function is mediated through cAMP/protein kinase A (PKA)/nephrin-dependent pathways, we fo

280 mutations in either the catalytic subunit of protein kinase A (PRKACA) or the guanine nucleotide-bind

281 rotein 1 (Drp1) activation via inhibition of protein kinase A-regulated S637 phosphorylation, resulti

282 Our data indicate that protein kinase A regulates beta-cell coupling through a

283 was associated with decreased expression of protein kinase A regulatory subunit 1beta (PRKAR1beta),

284 odomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid dro

285 arts stimulation of Ca(V)1.3 and Ca(V)2.2 by protein kinase A, revealing an evolutionarily conserved

286 nd systems: cAMP-bound regulatory subunit of Protein Kinase A (RIalpha) and IBMX-bound phosphodiester

287 its a remarkable degree of conservation with protein kinase A (root mean square deviation = 1.8 A), i

288 Pho85-Pho80 (Ser-114, Ser-602, and Ser-748), protein kinase A (Ser-667 and Ser-774), and protein kina

289 ermine that ethanol activates a Galphas-cAMP-protein kinase A signaling pathway in IL2 neurons to sti

290 ated the expression of lipolytic enzymes and protein kinase A signaling, resulting in enhanced adipos

291 ivation of the beta-adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L-

292 -adrenergic receptor (beta2 AR) at both the protein kinase A site serine 261/262 and the G-protein-c

293 llular signal-regulated kinase signaling and protein kinase A substrate dephosphorylation.

294 We focus on protein kinases, a superfamily of phosphotransferases th

295 signal transduction pathways including Ras, protein kinase A, target of rapamycin (TOR), phospholipa

296 s of PGA2 by activating Rap1/Rac1 GTPase and protein kinase A targets at cell adhesions and cytoskele

297 erent isoforms, facilitate this by targeting protein kinase A to specific substrates.

298 We identify protein kinase C, but not protein kinase A, to be responsible for the phosphorylat

299 KDM4B is phosphorylated by protein kinase A under conditions that promote castratio

300 ially PAK-dependent and likely also involves protein kinase A, which is known to reduce PREX1 functio

301 affected either by blocking the activity of protein kinase A with H89, or by blocking the activity o