ライフサイエンスコーパス: protein kinase C-alpha

1 , and phosphorylated stoichiometrically with protein kinase C alpha.

2 Ser9 and with the upregulated expression of protein kinase C alpha.

3 at the N terminus, was not phosphorylated by protein kinase C alpha.

4 eled lipids and oligonucleotides targeted to protein kinase C-alpha.

5 ranule release and GPIIb/IIIa activation via protein kinase C-alpha.

6 ession was associated with redistribution of protein kinase C-alpha.

7 eta1 expression by a mechanism that involves protein kinase C-alpha.

8 in vitro as well as in vivo of both DMPK and protein kinase C-alpha.

9 ly that has the ability to bind and activate protein kinase C-alpha.

10 thase, syntrophins, protein interacting with protein kinase C alpha 1, syntenin-1, and sorting nexin

11 The protein kinase C-alpha-activated phosphoswitch opened th

12 Purified protein kinase C-alpha activates PLD1a and 1b in a manne

13 sitol 3-kinase/AKT and phospholipase C gamma/protein kinase C alpha activation were required for kera

14 tly applying reactive oxygen species induced protein kinase C-alpha activation and phosphorylation of

15 ism involves reactive oxygen species-induced protein kinase C-alpha activation resulting in phosphory

16 ctivated in a synergistic manner in vitro by protein kinase C-alpha, ADP-ribosylation factor 1 (ARF1)

17 OA), and CD38, with downregulation of PRKCA (Protein kinase C-alpha), among smooth muscle genes.

18 n increase in CaR protein and phosphorylated protein kinase C alpha and beta in caveolin-rich fractio

19 acylglycerol (DAG) mass and translocation of protein kinase C alpha and beta to a membrane fraction i

20 ndirectly, via recruitment of Ca2+-dependent protein kinase C alpha and betaI.

21 nd in vitro kinase assays, we identified the protein kinase C alpha and epsilon isozymes as the kinas

22 possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-HO-1 activation

23 served notably high levels of phosphorylated protein kinase C alpha and its suppression by EGCG and d

24 Inhibition of the protein kinase C alpha and NFkappaB pathways had no effe

25 ation is a dynamic process that involves the protein kinase C alpha and protein phosphatase 2A (PP2A)

26 dependent upon PLD and the PLD1 regulators, protein kinase C alpha and RalA.

27 ction 1-40 of betaAP differentially degrades protein kinase C-alpha and -gamma (PKCalpha and PKCgamma

28 e kinase activity and autophosphorylation of protein kinase C-alpha and -zeta, but not of protein kin

29 s by a mechanism that involves activation of protein kinase C-alpha and that it is associated with th

30 cal administration of Go6976 an inhibitor of protein kinases C alpha and beta inhibited growth of tum

31 ogene products, most notably bcl-2, c-raf-1, protein kinase C-alpha, and H-ras, have been evaluated a

32 sitol 3-kinase/AKT and phospholipase C gamma/protein kinase C alpha) are obligatory to keratinocyte s

33 Both the protein kinase C (alpha/beta) inhibitor Go6976 and expre

34 ses electrical and mechanical disruption via protein kinase C alpha/beta (PKCalpha/beta) activation.

35 mechanism that requires direct activation of protein kinase C alpha by syndecan-4.

36 partially confirmed by docking trials in the protein kinase C-alpha C1A zinc finger.

37 showed tightly compact bipolar cell nuclei (protein kinase C alpha/calbindin positive) with blur/los

38 deoxynucleotides against bcl-2, c-raf-1, and protein kinase C-alpha continue to be the focus of ongoi

39 racellular calcium, stimulation of classical protein kinase C-alpha (cPKC-alpha), and the activity of

40 When protein kinase C-alpha, -epsilon, and -zeta were overexp

41 Overexpressing protein kinase C-alpha, ERK1, and c-Jun led to 4.7-, 5.1

42 ffect of the test agents on Bcl(2), BAX, and protein kinase C alpha expression levels were examined i

43 d cell-to-cell contact and fusion, decreased protein kinase C alpha expression, and ultimately reduce

44 gonucleotides are 1) effective inhibitors of protein kinase C-alpha expression, and 2) represent a cl

45 oate oligodeoxynucleotide inhibitor of human protein kinase C-alpha expression.

46 ified was used to examine the role played by protein kinase C-alpha in mediating the phorbol ester-in

47 ces in the levels of phospholipase C-beta or protein kinase C-alpha in the two groups of subjects in

48 Activation of PLD1a and 1b by protein kinase C-alpha is synergistic with ARF and with

49 the Hippo pathway and that is inactivated by protein kinase C-alpha isoform, was activated.

50 Level of active protein kinase C-alpha isoform, which requires PKP2 for

51 Expression of protein kinase C-alpha mRNA did not begin to decline unt

52 believed to result from RNase H cleavage of protein kinase C-alpha mRNA.

53 xpression, respectively, blocks and augments protein kinase C-alpha/nuclear factor of kappa light pol

54 actor-1, Rho family GTP-binding proteins, or protein kinases C-alpha, or -beta1.

55 protein expression, by means of blunting the protein kinase C-alpha pathway.

56 . coli invasion because of downregulation of protein kinase C-alpha phosphorylation.

57 1) were shown previously to bind tightly to protein kinase C alpha (PK-C alpha) in a stereospecific

58 Protein kinase C alpha (PKC alpha) activity was shown to

59 4,5-bisphosphate, and together they regulate protein kinase C alpha (PKC alpha) activity.

60 odels can be proposed for the docking of the protein kinase C alpha (PKC alpha) C2 domain to membrane

61 P assembly dynamics by scaffolding a DP-PKP2-protein kinase C alpha (PKC alpha) complex, which is dis

62 Protein kinase C alpha (PKC alpha) has been implicated i

63 ocrine form of proliferation, high levels of protein kinase C alpha (PKC alpha), and infiltration via

64 ar Ca 2+ levels and subsequent activation of protein kinase C alpha (PKC alpha).

65 t retinoic acid stimulates the expression of protein kinase C alpha (PKC) in B16 mouse melanoma cells

66 keratin 5 promoter directs the expression of protein kinase C-alpha (PKC alpha) to epidermal keratino

67 th the endogenously expressed Ca2+-dependent protein kinase C-alpha (PKC-alpha) and -betaI and the Ca

68 that 1,25(OH)(2)D(3) specifically activated protein kinase C-alpha (PKC-alpha) and also caused a red

69 IG-I activity but also identify conventional protein kinase C-alpha (PKC-alpha) and PKC-beta as impor

70 nucleotide (ISIS 4189) which inhibits murine protein kinase C-alpha (PKC-alpha) gene expression, both

71 in basic protein upon phosphorylation by the protein kinase C-alpha (PKC-alpha) in the presence of ad

72 Protein kinase C-alpha (PKC-alpha) is the kinase respons

73 ences in the 3'-untranslated region of human protein kinase C-alpha (PKC-alpha) mRNA has been shown t

74 We show that activation of protein kinase C-alpha (PKC-alpha) phosphorylated and do

75 a cytosolic phospholipase A(2) (cPLA(2)) and protein kinase C-alpha (PKC-alpha) to vesicles that mode

76 PLD1 is activated in a synergistic manner by protein kinase c-alpha (PKC-alpha), ADP-ribosylation fac

77 ive factors early growth response 1 (EGR-1), protein kinase C-alpha (PKC-alpha), and a key metabolic

78 amined the role of specific ET receptors and protein kinase C-alpha (PKC-alpha), and analyzed ET-1-re

79 C-terminal domain of polycystin-1 stimulated protein kinase C-alpha (PKC-alpha), but not the extracel

80 expresses a transgene coding for the enzyme protein kinase C-alpha (PKC-alpha), is both malignant an

81 s of extensive structure-function studies of protein kinase C-alpha (PKC-alpha), we have proposed an

82 ssion electron microscopy, and bipolar cell (protein kinase C-alpha [PKC-alpha] and recoverin) immuno

83 yl diiodide)), were tested for inhibition of protein kinase C(alpha) (PKC(alpha)).

84 ll viability and increased apoptosis through protein kinase C-alpha (PKCA) downregulation.

85 eased intracellular Ca(2+) concentration and protein kinase C alpha (PKCalpha) activity, ultimately r

86 Addition of phorbol ester and protein kinase C alpha (PKCalpha) also stimulated PLD ac

87 TOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskel

88 Protein kinase C alpha (PKCalpha) and transforming growt

89 Protein kinase C alpha (PKCalpha) can activate both pro-

90 We show that protein kinase C alpha (PKCalpha) catalyzes S42 phosphor

91 Here we show that protein kinase C alpha (PKCalpha) interacts with TRM61,

92 Protein kinase C alpha (PKCalpha) is overexpressed in nu

93 erapy identified a crucial role for enhanced protein kinase c alpha (PKCalpha) signaling and downstre

94 We report that inhibition of protein kinase C alpha (PKCalpha) specifically targets C

95 Here we present data linking protein kinase C alpha (PKCalpha) to the regulated expre

96 We found out that in bystander AL cells, protein kinase C alpha (PKCalpha) translocated from cyto

97 ERCA2 impaired the membrane translocation of protein kinase C alpha (PKCalpha), a known regulator of

98 We have reported previously that protein kinase C alpha (PKCalpha), a negative regulator

99 n of focal adhesion kinase (FAK), ezrin, and protein kinase C alpha (PKCalpha), all of which are invo

100 ine synthetase (GS), the bipolar cell marker protein kinase C alpha (PKCalpha), and the horizontal ce

101 cribe a new signalling pathway that involves protein kinase C alpha (PKCalpha), histone deacetylase 6

102 the cytoplasmic domain of beta5 integrin and protein kinase C alpha (PKCalpha), stimulates apoptotic

103 traspanin membrane scaffold, CD82, regulates protein kinase c alpha (PKCalpha)-mediated signaling cri

104 n a manner that is codependent upon EGFR and protein kinase C alpha (PKCalpha).

105 perturbing a consensus site for the Ser/Thr protein kinase C alpha (PKCalpha).

106 o the brain, and their contributions involve protein kinase C alpha (PKCalpha).

107 Significant stimulation of protein kinase C-alpha (PKCalpha) by n-alcohols was obse

108 The phosphatase calcineurin (Cn) and/or protein kinase C-alpha (PKCalpha) can both lower phospho

109 The C terminus (ct) of protein kinase C-alpha (PKCalpha) has a type I PDZ bindi

110 Protein kinase C-alpha (PKCalpha) has been studied widel

111 Subsequently, ALMS1 was found to bind to protein kinase C-alpha (PKCalpha) in the adipocyte, and

112 r localization and proteolytic processing of protein kinase C-alpha (PKCalpha) in tiger salamander br

113 eceptor for activated C kinase-1 (RACK1) and protein kinase C-alpha (PKCalpha) were recruited in a ci

114 The protein kinase C alpha (PRKCA) gene, encoding a Th17-cel

115 date multiple sclerosis susceptibility gene, protein kinase C alpha (PRKCA), maps within this interva

116 Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcript.

117 Depletion of protein kinase C-alpha protein expression by this oligon

118 eta1 gamma12 dimer on the gamma subunit with protein kinase C alpha regulates its activity in an effe

119 odifications have been incorporated into the protein kinase C-alpha targeting oligonucleotide, and th

120 ed in signal transduction [e.g., annexin II, protein kinase C alpha, the G alpha subunits of heterotr

121 with our previous study on the C2 domain of protein kinase C-alpha, these results demonstrate that C

122 ting with C-kinase) and by dephosphorylating protein kinase C alpha to activate the conversion of l-s

123 show that GA does not affect the ability of protein kinase C alpha to be activated by phorbol esters

124 PMA also induced the recruitment of protein kinase C alpha to the caveolae/DIGs fraction.

125 and NSC 631941, revealed that they bound to protein kinase C alpha with K(i) values of 75.6 +/- 1.3

126 g phosphorylation of serine-162, a target of protein kinase C-alpha, with an aspartic acid substituti