ライフサイエンスコーパス: protein precursor

1 sgenic (Tg) mouse model overexpressing Abeta-protein precursor.

2 insects, vitellogenin (Vg) is the major yolk protein precursor.

3 RNA replicase, and RNA2, encoding the capsid protein precursor.

4 e a mature/active enzyme from a single chain protein precursor.

5 retase cleavage site within the amyloid beta-protein precursor.

6 pe protease inhibitor domain of amyloid beta-protein precursor.

7 ue to the accumulation of the truncated core protein precursor.

8 produced from the metabolism of the amyloid protein precursor.

9 boxy terminus (M-site) of the viral assembly protein precursor.

10 ynthesis we engineered a single-site minimal protein precursor.

11 s carrying a "memory" of the original folded protein precursor.

12 the amyloidogenic processing of amyloid beta protein precursor.

13 tellogenin (Vg) gene encoding the major yolk protein precursor.

14 ase) via alternative trafficking of a shared protein precursor.

15 e), via differential trafficking of a common protein precursor.

16 ise from alternative trafficking of a single protein precursor.

17 t RNA polymerase and RNA2 encodes the capsid protein precursor.

18 isease, is derived from an integral membrane protein precursor.

19 actions and in autoproteolytic activation of protein precursors.

20 protein lost the ability to cleave the core protein precursors.

21 ation of non-inserted mitochondrial membrane protein precursors.

22 gene codes for several alternatively spliced protein precursors.

23 responsible for the processing of secretory protein precursors.

24 g signals, interacting with only a subset of protein precursors.

25 ed for receptor-mediated endocytosis of yolk protein precursors.

26 on of transport vesicles containing vacuolar protein precursors.

27 betaE(C) of LC in IgG helps generate amyloid protein precursors.

28 rporation into sugars, starch, proteins, and protein precursors.

29 processing of APP and other plasma membrane protein precursors.

30 on of nontranslocated secretory and membrane protein precursors.

31 erate their mature enzymes from single-chain protein precursors.

32 a machine that handles numerous beta-barrel protein precursors.

33 ir mature enzymes from inactive single chain protein precursors.

34 Processing of the amyloid beta protein precursor (A beta PP) by the beta and gamma secr

35 lzheimer's disease gene product amyloid beta protein precursor (A beta PP) is sequentially processed

36 ctor XIa (ie, protease nexin-2/ amyloid beta-protein precursor, A beta PP) in the organized vascular

37 B. beta-Amyloid also bound to the C-reactive protein precursor, a protein involved in inflammation, a

38 The amyloid-beta protein precursor, a type 1 transmembrane protein, gives

39 n the levels of cell-associated amyloid beta-protein precursor (AbetaPP) and cell death.

40 ntified within the Abeta region of the Abeta protein precursor (AbetaPP) gene that appear to enhance

41 Proteolytic processing of amyloid beta protein precursor (AbetaPP) generates peptides that regu

42 The amyloid-beta protein precursor (AbetaPP) is a type I transmembrane mo

43 Similarly, accumulation of the Abeta protein precursor (AbetaPP) is also observed at sites of

44 The amyloid beta-protein precursor (AbetaPP) is best known as the parent

45 The amyloid beta-protein precursor (AbetaPP) is best recognized as the pr

46 lly linked to the processing of amyloid beta protein precursor (AbetaPP).

47 Secretory protein precursors accumulated in sec31-sec35 mutants at

48 convertases (PCs) play an important role in protein precursor activation through processing at paire

49 (1,311 nt), which encodes the 43-kDa capsid protein precursor alpha.

50 nd encodes the 401 amino acids of the capsid protein precursor alpha.

51 , coupled with the accumulation of the YARS2 protein precursor and a lower amount of mature enzyme.

52 Both caspase-cleaved amyloid beta-protein precursor and activated caspase-9 were present i

53 Protein precursor and CID product masses can be determin

54 The enzyme is synthesized as a protein precursor and is activated by an autocatalytic s

55 ns and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loose amino acid

56 a multiprotein protease that cleaves amyloid protein precursor and other type I transmembrane protein

57 Various mutations in the amyloid protein precursor and presenilin genes can lead to early

58 mutations in the genes encoding amyloid beta protein precursor and presenilins, raising the possibili

59 embrane proteins, including the amyloid beta-protein precursor and the Notch receptor, and is compose

60 ty of substrates, including the amyloid beta-protein precursor and the Notch receptor.

61 embrane proteins, including the amyloid beta-protein precursor and the Notch receptor.

62 e processing and entry of viral or bacterial protein precursors and confer increased infectivity of p

63 Replicase protein precursors and mature products are thought to me

64 sence of vesicle clusters containing storage protein precursors and vacuolar sorting receptors (VSRs)

65 and thrombospondin type 1 domain-containing protein precursor) and TNS3 (tensin 3), that were unique

66 equence, termed an intein, is excised from a protein precursor, and the flanking polypeptides are rel

67 dentify individual antigenic peptides, their protein precursors, and their relative importance in the

68 h the aberrant localization of the above Atg proteins, precursor Ape1, a cargo of the Cvt pathway and

69 ease is derived from a large heparin-binding protein precursor APP.

70 sts that dysregulated levels of amyloid beta-protein precursor (APP) and its catabolites contribute t

71 embrane proteins, including the amyloid beta-protein precursor (APP) and the Notch receptor.

72 ons in the transmembrane domain of amyloid B-protein precursor (APP) associated with early-onset fami

73 produced from the processing of amyloid beta-protein precursor (APP) by beta- and gamma-secretases, t

74 Sequential cleavages of the amyloid beta-protein precursor (APP) by the beta- and gamma-secretase

75 ta) is released from the larger amyloid beta-protein precursor (APP) by unidentified enzymes referred

76 Mutations in the gene encoding the amyloid protein precursor (APP) cause autosomal dominant Alzheim

77 xin-2 (PN-2), a soluble form of amyloid beta-protein precursor (APP) containing a Kunin protease inhi

78 The promoter of the amyloid beta-protein precursor (APP) gene directs high levels of cell

79 els that coexpress human PS and amyloid beta-protein precursor (APP) genes and analyzed quantitativel

80 a272-299) with mice expressing human amyloid protein precursor (APP) harboring familial AD mutations

81 Although the Alzheimer amyloid protein precursor (APP) has been studied intensely for m

82 e proteolytic processing of the amyloid beta-protein precursor (APP) has revealed that one of the two

83 ate amyloidogenic processing of amyloid-beta protein precursor (APP) in cell culture studies in vitro

84 In order to localize amyloid protein precursor (APP) in nerve terminals, we have immu

85 The A beta protein precursor (APP) is cleaved by beta-secretase to

86 nd regulates the translation of amyloid-beta protein precursor (App) mRNA, but the detailed mechanism

87 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alz

88 eta1-42 in the absence of human amyloid beta protein precursor (APP) overexpression.

89 heimer disease, is derived from amyloid beta-protein precursor (APP) through sequential proteolytic c

90 cleave the tau protein (Tau) and the amyloid protein precursor (APP) to hinder the formation of toxic

91 sted in acute dosing studies in amyloid beta protein precursor (APP) transgenic mice, and plasma and

92 nfluence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, and have been

93 d beta-peptide (Abeta) from the amyloid beta-protein precursor (APP).

94 ecreted proteolytic product of the amyloid b-protein precursor (APP).

95 olytic processing of the Alzheimer's amyloid protein precursor (APP).

96 rboxyl-terminal fragment of the amyloid beta protein precursor (APP).

97 , Abeta42, which is derived from the amyloid protein precursor (APP).

98 ts, is derived by proteolysis of the amyloid protein precursor (APP).

99 that lies at the N-terminus of the viral Gag protein precursor appears to be one of the crucial steps

100 beta-Amyloid protein precursors (APPs, 695-770 amino acids) are the s

101 ro that in the absence of CALR, immature MPO protein precursors are degraded in the proteasome.

102 aled unexpectedly that the Dreissenid thread protein precursors are mechanoresponsive alpha-helical p

103 Euglena chloroplast protein precursors are transported as integral membrane

104 and the secreted peptide VGF (non-acronymic) protein precursor at 3 hr.

105 phylococcus aureus sortase A cleaves surface protein precursors bearing C-terminal LPXTG motif sortin

106 at system mediates Sec-independent export of protein precursors bearing twin arginine signal peptides

107 t) system mediates Sec-independent export of protein precursors bearing twin arginine signal peptides

108 collectively referred to as the amyloid beta protein precursor (betaAPP).

109 's disease (AD) etiology, including the beta protein precursor (betaPP), amyloid beta (Abeta) peptide

110 pterans (moths) produce Vg as the major yolk protein precursor, but also manufacture a class of minor

111 a lipoprotein lipase to replace Vg as a yolk protein precursor, but instead utilize a class of protei

112 irus type 1 (HIV-1), are mediated by the Gag protein precursor, but the molecular details of these pr

113 e proprotein convertase (PC) family activate protein precursors by cleavage after basic residues.

114 dy and subsequent accumulation of these yolk protein precursors by developing oocytes.

115 Proteolytic processing of capsid assembly protein precursors by herpesvirus proteases is essential

116 Since processing of PV1 capsid protein precursors by the CVB3 3CD was again incomplete,

117 ernalization of vitellogenin, the major yolk-protein precursor, by oocytes during egg development.

118 Thus, a tripartite ELP-intein-target protein precursor can be purified by cycles of salt addi

119 l excitatory amino acid transport by amyloid protein precursors could protect the brain against excit

120 Cytoplasmic accumulation of protein precursors demonstrates that the initial contact

121 Amyloid protein precursor-dependent stimulation of aspartate upt

122 Cleavage of surface protein precursors did not require a mature assembled ce

123 e single turnover enzymes that splice out of protein precursors during maturation of the host protein

124 activated gene of the sphingolipid activator protein precursor exhibit two distinct clinical phenotyp

125 assembled in vitro commonly involve a single protein precursor, fibrils formed in vivo can contain mo

126 that Saf1 is part of a pathway that targets protein precursors for proteasomal degradation.

127 ue Arg B263 results in the accumulation of a protein precursor form.

128 In a study of secretory protein precursors, formation of a protease-resistant ri

129 es cerevisiae mediates transport of vacuolar protein precursors from the late Golgi to the lysosome-l

130 Cytochrome c1 is synthesized as a protein precursor fused with cytochrome b.

131 ength open reading frames for the retroviral protein precursors Gag-Pro-Pol or Env were each present

132 t a variety of mutations in the beta-amyloid protein precursor gene and the Presenilin-1 and -2 genes

133 Insect yolk protein precursor gene expression is regulated by nutrit

134 amino acid signal activating the major yolk protein precursor gene, vitellogenin (Vg).

135 of reproductive arrest during which the yolk protein precursor genes (YPPs) are repressed.

136 bodies, which subsequently derepresses yolk protein precursor genes and makes them responsive to act

137 Transcription of yolk protein precursor genes is repressed until mosquitoes ta

138 The amyloid beta-protein precursor gives rise to the amyloid beta-protein

139 h transgenic mice that produce human amyloid protein precursors (hAPP) and Ass in neurons.(4,5) No am

140 mpare the effects of different human amyloid protein precursors (hAPP) and their products on plaque f

141 wth factor promoter to express human amyloid protein precursors (hAPPs) in neurons of transgenic mice

142 The amyloid protein precursor has been well conserved through evolut

143 The 544-amino-acid Gag protein precursor has little sequence similarity with it

144 Tau and the amyloid protein precursor have important roles in normal neurona

145 ound in tobacco, suggesting that the two pre-protein precursors have evolved from a common ancestral

146 All Euglena chloroplast protein precursors have functionally similar bipartite p

147 nds, APOE and APP (encoding the amyloid beta-protein precursor), have now all been genetically linked

148 -sulfide isomerase, 78 kDa glucose-regulated protein precursor, heat shock protein 60 (HSP60), HSP70,

149 carboxyterminal domain of the hedgehog (hh) protein precursor (Hh) generates an amino-terminal produ

150 vasculotropic Dutch/Iowa mutant amyloid beta-protein precursor in brain.

151 d concomitant accumulation of the respective protein precursor in the cytoplasm.

152 rritin (Bg yolk ferritin), is the major yolk protein precursor in the schistosomiasis vector snail B.

153 Overexpression of mutant forms of beta protein precursor in transgenic mice by neuron-specific

154 Thus, overexpression of part of beta protein precursor in transgenic mice led to development

155 nduced by the accumulation of outer membrane protein precursors in the periplasmic space, and leads t

156 Many membrane-bound protein precursors, including cytokines and growth facto

157 moderate levels of expression, human amyloid protein precursors increased glutamate/aspartate uptake

158 of I7L or of the cleavage sites in the core protein precursors inhibits processing.

159 the misfolding and aggregation of functional protein precursors into fibrillar states.

160 Amyloid-beta protein precursor intracellular domain-associated protei

161 oduce amyloid beta-peptides and amyloid beta-protein precursor intracellular domain.

162 n peaks leading to the isolation of multiple protein precursor ions in a single window and consequent

163 priate dc voltages while multiply protonated protein precursor ions were injected into the collision

164 For low-charged protein precursor ions with no or limited mobile protons

165 try of denatured, multiply charged high mass protein precursor ions yield extremely dense spectra wit

166 backbone bonds of highly charged peptide and protein precursor ions.

167 we show that a full unfolding of the native protein precursor is a requirement for establishing irre

168 When Rieske iron-sulfur protein precursor is used as substrate for reconstituted

169 Vitellogenesis (the synthesis of yolk protein precursors) is a key event in the mosquito repro

170 Thus, tau- and amyloid protein precursor-knockout mice were protected against l

171 y interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein, the homolog of ma

172 this model a maturation cleavage of a capsid protein precursor locks the virus in a metastable state,

173 Here, we demonstrate that the amyloid protein precursor may participate in the regulation of t

174 ty of substrates, including the amyloid beta-protein precursor of Alzheimer's disease and the Notch r

175 These self-cleaving proteins include the Tsh protein precursor of Escherichia coli, in which the larg

176 an inactive 119 kDa tetrameric alpha 2beta 2 protein precursor of MADH with incompletely synthesized

177 SAA is a protein precursor of reactive AA amyloidosis, the major

178 ivity suggesting it may represent the common protein precursor of S-SMase and L-SMase.

179 Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essenti

180 ng such inhibitors is difficult because many protein precursors of aggregation are partially folded o

181 Envelope protein precursors of many viruses are processed by a ba

182 lysing transcriptome sequence data, here the protein precursors of six of these myoactive peptides (t

183 keratinocytes (the majority being structural protein precursors of the cornified envelope) and the ot

184 at major cytoplasmic and membrane-associated protein precursors of the presynaptic active zone are tr

185 time, WO1 and WO2 do not bind to the native protein precursors of these amyloids, nor do they bind t

186 ns of glycine-glycine pairs in proteins (and protein precursors) of intact leaves of plants exposed t

187 is incorporated exclusively into protein (or protein precursors) of intact, water-stressed soybean le

188 it of the RNA replicase and the viral capsid protein precursor on separate genomic segments (RNA1 and

189 ctra of multiple charge states from a single protein precursor or multiple ETD/proton-transfer reacti

190 ctably affect antibody recognition of the CA protein precursor or release of VLPs assembled by the pr

191 in, an aprotinin mutant (6L15), amyloid beta-protein precursor, or tissue factor pathway inhibitor.

192 des generated from proteolytic processing of protein precursors, or proteolytic proteoforms, play an

193 e replication complex in the form of a large protein precursor (P3) to be fully functional in replica

194 for cleavage of each of the three major core protein precursors (P4a, P4b, and P25K) in vivo.

195 The cytomegalovirus (CMV) assembly protein precursor (pAP) interacts with the major capsid

196 The assembly protein precursor (pAP) of cytomegalovirus (CMV), and it

197 affolding constituent is called the assembly protein precursor (pAP).

198 ents of cytomegalovirus, called the assembly protein precursor (pAP, pUL80.5) and the maturational pr

199 132A-pPR), and the sequence-related assembly protein precursor (pAP, pUL80.5).

200 arent molecule protease nexin-2/amyloid beta-protein precursor (PN-2/AbetaPP), which is elevated in H

201 an immunodeficiency virus type 1 (HIV-1) Gag protein precursor, Pr55(Gag), to membrane is an indispen

202 tained the translocation competence of small-protein precursors, precluded their aggregation and degr

203 (354 to 467 kDa) asparagine-rich (19 to 20%) protein precursors predicted to form alpha-helical coile

204 mplex in the form of a larger 3AB-containing protein precursor prior to complex assembly rather than

205 The rich present-day field of protein precursor processing via post-translational prot

206 The TATA-less human amyloid beta-protein precursor promoter contains an initiator element

207 optimal transcription from the amyloid beta-protein precursor promoter.

208 pes A, B, and C), and sphingolipid-activator-protein-precursor (prosaposin) deficiency.

209 orically, the ability to monitor the amyloid protein precursor protein has been crude.

210 rsor (pUL80a), and the other is the assembly protein precursor (pUL80.5) encoded by a shorter genetic

211 ng by its own VP4 protease yields the capsid protein precursor pVP2, the ribonucleoprotein-forming VP

212 Processing of the capsid protein precursor region generates a unique intermediate

213 logenesis, which includes production of yolk protein precursors, requires blood feeding.

214 A survey of human mitochondrial protein precursors revealed that, similar to YMIP, HMIP

215 itors and designed to mimic the amyloid beta-protein precursor substrate bind specifically to the PS

216 ing E2-dependent vitellogenin (VTG; egg yolk protein precursor) synthesis, (b) VTG-dependent egg deve

217 transmembrane domain mutants of the amyloid protein precursor that are cleaved by pharmacologically

218 tiserum that indeed detected a short-lived F protein precursor that we named PreF(0).

219 s type 1 (HIV-1), gp160, is synthesized as a protein precursor that when proteolytically cleaved yiel

220 in familial AD mutations on the amyloid beta-protein precursor, the presenilins themselves, and apopt

221 HID was found to trigger processing of DREDD protein precursor through a mechanism that is insensitiv

222 id, is produced at multiple sites within its protein precursor thyroglobulin.

223 tein rearrangement that converts an inactive protein precursor to biologically active proteins.

224 where thyroglobulin is iodinated to form the protein precursor to T(4) and T(3).

225 (RAP-/-) mice was crossed with human amyloid protein precursor transgenic (hAPP tg) mice, and plaque

226 ino acid carboxyl-terminal sequences of beta protein precursor, under the control of a cytomegaloviru

227 ucts were detected in parallel with the coat protein precursor using MALDI-TOF MS.

228 rotein synthesis with production of the yolk protein precursor vitellogenin.

229 btained the entire mRNA sequence of the yolk protein precursor, vitellogenin, and monitored its trans

230 Among multiple yolk protein precursors, vitellogenin (Vtg) is a well-known m

231 nsiently coexpressing the RNA-2-encoded coat protein precursor (VP60) with the RNA-1-encoded 24,000-m

232 The primary structure of the protein precursor was identified for this gene.

233 Processing of the PV1 capsid protein precursor was incomplete, presumably due to inef

234 Here we show that amyloid beta-protein precursor was proteolytically cleaved by caspase

235 IM23 translocon to deliver the mitochondrial protein precursors, we have determined the crystal struc

236 oteins to the C terminus of the CMV assembly protein precursor were produced and purified from bacter

237 proOmpA, as lipoprotein and lambda receptor protein precursors were also transported efficiently.

238 es not previously observed) from 6 different protein precursors were identified using database search

239 bility that caspase cleavage of amyloid beta-protein precursor with the generation of C31 may be invo

240 ouse model overexpressing human amyloid beta-protein precursor with the Swedish double mutation, to C

241 ane space likely involves the release of the protein precursor within the lipid bilayer of the inner

242 a corresponding purified cysteine-containing protein precursor, without the need for bespoke biologic

243 (20E) hormonal cascade, which activates yolk protein precursor (YPP) genes in the female fat body, an

244 of blood, 20-hydroxyecdysone activates yolk protein precursor (YPP) genes in the metabolic tissue, t

245 rrest) preventing the activation of the yolk protein precursor (YPP) genes Vg and VCP prior to blood

246 quired for activation of genes encoding yolk protein precursors (YPP).

247 The production of yolk protein precursors (YPPs), a central event in egg matura