ライフサイエンスコーパス: protein processing

1 negative regulator of the amyloid precursor protein processing.

2 to affect virus particle production and Gag protein processing.

3 es a new paradigm for cellular regulation of protein processing.

4 heterologous cells, reflects loss of normal protein processing.

5 f the wild-type I7 protein in trans restored protein processing.

6 a major defect in viral translation or viral protein processing.

7 , Env, and genomic RNA incorporation and Gag protein processing.

8 n motifs implicated in vesicle transport and protein processing.

9 sly unrecognized importance in polyglutamine protein processing.

10 ltransferase involved in post-isoprenylation protein processing.

11 l of the replication, protein synthesis, and protein processing.

12 essary for initiation of translation and for protein processing.

13 udding, Gag-Pol and genome incorporation, or protein processing.

14 d by catalytic activity, mRNA induction, and protein processing.

15 recursor protein are important in regulating protein processing.

16 in E function, and altered amyloid precursor protein processing.

17 t gamma-secretase, on beta-amyloid precursor protein processing.

18 binding while mutation at N17 influenced Env protein processing.

19 o the endoplasmic reticulum and in secretory protein processing.

20 nt with a role for the pwi/WRB protein in TA-protein processing.

21 ses an impairment of protein degradation and protein processing.

22 class II interaction with no requirement for protein processing.

23 spectively, with viral replication and viral protein processing.

24 s and genes involved in lipid metabolism and protein processing.

25 potential of IZPs for studying ER-dependent protein processing.

26 mic reticulum (ER) is intimately involved in protein processing.

27 that regulates vital cellular functions and protein-processing.

28 or a Smo-agonist-induced inhibition of Gli3 protein processing, a known in vivo indicator of Hh sign

29 riminate the impacts of mutations on amyloid protein processing, Abeta aggregation propensity, and ot

30 nses to cellular stressors and contribute to protein processing abnormalities previously observed in

31 egion and heterogeneity of amyloid precursor protein processing across Alzheimer brain regions.

32 tion, fatty-acid beta-oxidation, and RNA and protein processing) across multiple tissues post MI and

33 for a major role for amyloid-beta precursor protein processing, amyloid-beta aggregation, lipid meta

34 evels and the related amyloid-beta precursor protein processing, amyloid-beta load and eIF4B phosphor

35 t GSK-3 alpha may regulate amyloid precursor protein processing and Abeta formation.

36 led with reduced levels of amyloid precursor protein processing and Abeta production, compared with t

37 zed since day 1 for its role in SARS-CoV-2 S protein processing and activation.

38 with IVA, which lead to abnormalities in IVD protein processing and activity.

39 rther understanding of mechanisms regulating protein processing and aggregation, as well as of the to

40 proteins during the whole lifetime; abnormal protein processing and aggregation; and cellular toxic e

41 We hypothesized that functional protein processing and antigen presentation machinery ar

42 ritical relevance in disparate areas such as protein processing and beta-amyloid and prion behavior.

43 ependent gamma-glutamyl carboxylation during protein processing and block the secretion of under-gamm

44 (32) mutants exhibited stable IN and RT, and protein processing and cDNA production were unaffected.

45 fusion, although still allowing efficient F-protein processing and cell surface transport.

46 tive extracellular matrix assembly to faulty protein processing and cellular trafficking caused by ge

47 n contributions of N-linked glycosylation to protein processing and correct disulfide bond formation,

48 nts, suggesting a unique role of VPEgamma in protein processing and degradation in Arabidopsis.

49 it suggests a role for hBH in intracellular protein processing and degradation.

50 se results suggest that slower nonstructural protein processing and delayed 26S RNA synthesis in wild

51 Furthermore, scaffolding protein processing and DNA encapsidation were inhibited

52 d number of animals, evidence of abnormal ER protein processing and dysregulation of translational co

53 the importance of the maintenance of proper protein processing and folding as a partial antidote to

54 We examined cellular protein processing and functional expression of photorec

55 pression mimicked the I3C inhibition of CD40 protein processing and G(1) cell cycle arrest, whereas s

56 nd 11, two enzymes involved in both cytokine protein processing and induction of apoptosis, were redu

57 ies also showed that N17 was involved in Env protein processing and later virion incorporation based

58 hat the protein does not have a role in seed protein processing and maturation.

59 Abnormal protein processing and modification is associated with A

60 -Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this org

61 results offer unexpected insights into viral protein processing and pathogenesis that may be applicab

62 nses ranging from intracellular signaling to protein processing and presentation.

63 Pase domain, as well as proteins involved in protein processing and protease inhibition.

64 nserved and essential modification mediating protein processing and quality control in the endoplasmi

65 transcriptional mechanisms involving altered protein processing and rapid turnover exist to limit E-c

66 CF-causing mutation and results in defective protein processing and reduced CFTR function, leading to

67 e folding defect, which disrupted ovine CFTR protein processing and reduced membrane stability.

68 lon2 defects in auxin metabolism and matrix protein processing and rescued the abnormally large size

69 case, proteins related to amyloid precursor protein processing and secretion are S-nitrosated, corre

70 ed regarding the mechanisms that control Wnt protein processing and secretion from cells, transport t

71 owever, genes whose products are involved in protein processing and secretion were not highly regulat

72 re expressed in vitro and the impact on BMP9 protein processing and secretion, endothelial signaling,

73 Among these are proteins with key roles in protein processing and secretion, such as calreticulin,

74 -terminal sequences of LFNG, which allow for protein processing and secretion, with the N-terminus of

75 ticulum (ER) stress that inhibits normal Wnt protein processing and secretion.

76 at rapid LFNG turnover could be regulated by protein processing and secretion.

77 cessing, mRNA half-life and translation, and protein processing and secretion.

78 ns influence G551D-CFTR function, we studied protein processing and single-channel behaviour.

79 Despite the Golgi apparatus being the major protein processing and sorting site within the secretory

80 The W173G mutation affects protein processing and stability and results in severe m

81 Analysis of the protein processing and stability by metabolic pulse-chas

82 ns of PLP1 with CS1 and CS2 are critical for protein processing and suggest that the interactions pla

83 n regulating amyloidogenic amyloid precursor protein processing and support a model wherein Abeta pro

84 in Ca(2+)(ER) dynamics, agonist mediated ER-protein processing and surface expression.

85 l enrichment in CSPs with post-translational protein processing and synaptic functions in the develop

86 n this review is on the enzymology of prenyl protein processing and the functional significance of pr

87 beta-Amyloid precursor protein processing and the generation of Abeta have been

88 work unveils a link between postprenylation protein processing and the p53 pathway, indicating that

89 erase Pin1, which is able to regulate Notch3 protein processing and to stabilize the cleaved product,

90 This finding may have important roles in protein processing and trafficking in the Golgi as well

91 nk between the mitotic regulator, Lte1p, and protein processing and trafficking in the secretory/endo

92 ould be useful for numerous other studies on protein processing and transport.

93 hat blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of

94 s), where acidic conditions facilitate spike protein processing and viral genome release.

95 g phenotype, we show that the effects on Gag protein processing and virus particle production of both

96 CS2, but not at CS1, and results in altered protein processing and virus replication.

97 irs severely channel gating without altering protein processing and which affects a residue in the sa

98 ally restoring the CFTR function in terms of protein processing and/or channel gating.

99 mutations in GALC can cause GLD by impairing protein processing and/or folding and that pharmacologic

100 s suggested that mutations negatively affect protein processing and/or function, and a bmp9-deficient

101 Proteases, which are involved in an array of protein-processing and intracellular signaling events in

102 ence with farnesyltransferase function ( ie, protein processing), and blockade of signal transduction

103 -Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Ab

104 ding inflammation, oxidative stress, altered protein processing, and decreased mitochondrial function

105 machinery, protein trafficking, constitutive protein processing, and immune function.

106 te the activity of mitochondrial proteins by protein processing, and mediate the degradation of damag

107 n expression pattern, apparent regulation of protein processing, and mesoderm-inducing activity suppo

108 rch has been focused on the gene expression, protein processing, and mutations of MYOC/TIGR, which is

109 g neuropeptide metabolism, amyloid precursor protein processing, and neuronal apoptosis are up-regula

110 n implicated in learning and memory, amyloid protein processing, and neuronal plasticity.

111 expression of genes for beta cell identity, protein processing, and organelle homeostasis.

112 FTR function, Pro205 is critical for correct protein processing, and Pro99 may contribute either dire

113 ripts involved in phospholipid biosynthesis, protein processing, and protein maturation.

114 e at nsP1 538 on viral growth, nonstructural protein processing, and RNA synthesis.

115 onal relationship between membrane topology, protein processing, and subcellular distribution, and su

116 unction in transcription, energy production, protein processing, and the upregulation of cyclophilin

117 tide metabolism, DNA replication and repair, protein processing, and virion structure.

118 Although amyloid precursor protein processing appeared unaffected, we find that LPS

119 if issues related to Nodal transcription and protein processing are not considered.

120 The mechanisms that couple translation and protein processing are poorly understood in higher eukar

121 ation-induced defects in anchor assembly and protein processing are rapid, and occur without altered

122 d fitness in Vero E6 cells and reduced spike protein processing, as compared to parental SARS-CoV-2.

123 inhibitors) effectively blocked endogenous S protein processing at both sites in HeLa cells, and SARS

124 exothermic, heat is available for downstream protein processing; because the feedstock gases are chea

125 otic debris and is associated with increased protein processing but reduced T cell activation.

126 hesized to perform a unique function in seed protein processing, but we demonstrated previously that

127 Inhibition of protein processing by ER stress (ionomycin and dithiothr

128 nto the molecular elements that regulate Gli protein processing by the proteasome.

129 n eeyarestatin I, and specifically inhibited protein processing by the ubiquitin-proteasome system.

130 Foamy virus Pol precursor protein processing by the viral protease occurs at only

131 CAAX-box protein processing can be an important part of host-path

132 Rescue of ER protein processing capacity by the combined action of UP

133 Instead, the lesion was in the protein processing capacity of the ER lumen, where p58(I

134 at demand for ER membrane is integrated with protein processing capacity was initially suggested by g

135 n distinct proteolytic systems for precursor protein processing catalyzed by the mitochondrial and st

136 Increased APP (amyloid precursor protein) processing causes beta-amyloid (Abeta) accumula

137 calization were characterized by analysis of protein processing, cDNA production, genomic RNA protect

138 calizations and interactions of CaSR with ER-protein processing chaperone, 78-kDa glucose regulated p

139 olved in, for example, energy metabolism and protein processing compared to minor changes during the

140 bute to amyloidogenic amyloid-beta precursor protein processing, compromise trophic signalling and sy

141 s involved in proliferation, metabolism, and protein processing, consistent with stress responses doc

142 tivity support the hypothesis that localized protein processing controls production of a dorsal mesod

143 i) sORF peptides trigger proteasome-mediated protein processing, converting the Shavenbaby (Svb) tran

144 ded with the increased auxin sensitivity and protein processing correlated with the manifestation of

145 However, inhibition of K-RasB protein-processing could not be detected.

146 Suppression of translation relative to ER protein processing (cycloheximide) produced approximatel

147 To identify compounds that could inhibit protein processing dependent on the HERV-K10 protease, a

148 nated archaeosortase A (ArtA), as the likely protein-processing enzyme for PGF-CTERM.

149 ngs contain high levels of amyloid precursor protein processing enzymes (BACE1 and presenilin 2) and

150 tes with nuclear export of the mRNAs for APP protein processing enzymes, including beta-site amyloid

151 mmodate the difference in specificity of the protein-processing enzymes of procaryotes.

152 ated superfamily of deeply membrane-embedded protein-processing enzymes.

153 These results demonstrate how one protein-processing event can activate latent protease re

154 ptional activation domain, is generated by a protein-processing event.

155 iption isoform is generated through a unique protein-processing event.

156 NRG-2 antibodies were generated to analyze protein processing, expression, and subcellular distribu

157 Although many UPR-regulated genes encode ER protein processing factors, others, such as those encodi

158 zed into four groups: transcription factors, protein processing factors, RNA-binding proteins, and pl

159 Cellular channel protein processing fails in every one of the non-functio

160 emoglobin degradation to secretory organelle protein processing for egress, invasion, and effector ex

161 uld process sulfatide antigens, analogous to protein processing for peptide-reactive T cells.

162 angles as well as aberrant amyloid precursor protein processing found in AD.

163 CA3 region and a switch in amyloid precursor protein processing from non-amyloidogenic to amyloidogen

164 otide polymorphisms at pre-mRNA splicing and protein processing/functional levels.

165 hat unlike GBP2 and GBP5, which impair spike protein processing, GBP1 did not reduce infectivity of s

166 , including one which contains four CAAX-box protein processing genes.

167 ation, intracellular vesicle trafficking and protein processing, granule secretion, aggregate formati

168 rough different mechanisms to interfere with protein processing (i.e., tunicamycin, brefeldin A, and

169 However, the role of post-isoprenylation protein processing in ABA signal transduction has not be

170 hances the understanding of alpha-crystallin protein processing in aging and diseased human lenses.

171 an essential role for peptide deformylase in protein processing in all plant plastids.

172 he conventional secretory pathway, including protein processing in both ER and Golgi, and requires pr

173 we demonstrated previously that Asn-specific protein processing in developing Arabidopsis seeds occur

174 s, tyrosinase (TYR) and Pmel17, to elucidate protein processing in early or late steps of the secreto

175 gnificant downregulation of genes related to protein processing in endoplasmic reticulum, as well as

176 Akt signaling pathway, hemoglobin chaperone, protein processing in endoplasmic reticulum, detoxificat

177 tarch and sucrose metabolism, RNA transport, protein processing in endoplasmic reticulum, etc.

178 ys such as excision repair, mismatch repair, protein processing in endoplasmic reticulum, nucleotide

179 in family of proteins, suggesting a role for protein processing in limb, cardiac and reproductive sys

180 ns revealed pervasive, functionally relevant protein processing in normal and diseased tissue-from 40

181 We investigated POMC expression and protein processing in normal human keratinocytes.

182 regulated DEGs implicated chaperone-mediated protein processing in PD glia and lipid transport in AD

183 portant aspects of postendoplasmic reticulum protein processing in plants.

184 The lack of understanding of the protein processing in silk glands has prevented the reca

185 eterminant domain, functions as a signal for protein processing in the context of not only Gli2 and G

186 , degradation, trafficking, and primarily to protein processing in the endoplasmic reticulum (ER).

187 ysiological importance of GADD34 turnover in protein processing in the endoplasmic reticulum and the

188 ological pathways, including upregulation of protein processing in the endoplasmic reticulum, protein

189 inherited axonopathy pathogenesis, including protein processing in the endoplasmic reticulum, spliceo

190 c acidosis, all of which pose challenges for protein processing in the ER.

191 ed cells suggest that torsinA contributes to protein processing in the secretory pathway, endocytosis

192 systems suggests that mutant torsinA alters protein processing in the secretory pathway.

193 isease mutations underlying PNKD may disrupt protein processing in vivo, a hypothesis supported by ou

194 lesterol synthesis affects amyloid precursor protein processing in vivo, we crossed cholesterol 24-hy

195 ed methodologies permit in vitro and in vivo protein processing in ways previously not possible using

196 ne can be recovered and enriched during whey protein processing into a co-product called whey protein

197 s in GALC activity and a lack of appropriate protein processing into an N-terminal GALC fragment for

198 Since nonstructural protein processing is known to regulate alphavirus RNA s

199 We found that the terminal protein processing is most likely a consequence of the i

200 exocytic vesicles are properly generated and protein processing is normal in the exo70 mutants.

201 t function in glycolysis, transcription, and protein processing is not affected in kcs1Delta.

202 The role(s) of specific proteases in seed protein processing is only vaguely understood; indeed, t

203 hether the requirement for the RCE1-mediated protein processing is related to the absence of the endo

204 indicate that the intracellular site of CAAX protein processing is the ER membrane, presumably on its

205 us, some aspect of translation or subsequent protein processing leads to non-functional or absent ACh

206 f nsp3 as a conserved component of the viral protein processing machinery, which is intimately associ

207 ar mechanism of the defect likely relates to protein processing, metabolic turnover rate, or transloc

208 responses (e.g., antigen presentation), and protein processing / mitochondrial functioning (e.g., ub

209 t regulates cell signaling, immune response, protein processing, molecular trafficking, and DNA repai

210 e functionally involved in amyloid precursor protein processing, notch receptor signaling, and progra

211 Interestingly, only protein processing of DeltaY512-CFTR, like that of Delta

212 ight be regulated, we examined intracellular protein processing of each subunit.

213 related work in this field, focusing on the protein processing of the pro-o(K) activation.

214 e temporal relationship between LOX mRNA and protein, processing of LOXL1 protein, FBLN5 and tropoela

215 lnerability to other insults due to abnormal protein processing or changes in signaling pathways whic

216 ithout detectably altering amyloid precursor protein processing or extracellular Abeta/beta-amyloid b

217 viruses showed no apparent alteration to Gag protein processing or reduction in the yield of virions

218 ic reticulum GTPases that may be involved in protein processing or trafficking.

219 eceptor downmodulation, signal transduction, protein processing or translocation, protein-protein int

220 ion but do not affect reverse transcription, protein processing, or catalytic activity in vitro.

221 n regulating cellular stress associated with protein-processing pathologies.

222 The additional modifications in the prenyl protein processing pathway also affected the interaction

223 ntial role of the endoplasmic reticulum (ER) protein processing pathway in anti-EGFR therapeutic effi

224 ological reasons, including probing the CaaX protein processing pathway.

225 t furin is involved in at least two separate protein processing pathways that each contribute to the

226 array analysis showed that genes involved in protein processing pathways that were germane to the act

227 are suggestive of a role for cotranslational protein-processing pathways in maintaining epithelial lu

228 These results confirm the predicted protein processing pattern for mature SARS-CoV replicase

229 nts were analyzed and shown to have restored protein processing phenotypes in vivo.

230 However, despite the impact on seed protein processing, plants devoid of all known functiona

231 no acids in short linear motifs (SLiMs), and protein processing promote multifunctional behaviour.

232 r of the Kex2/furin family of eukaryotic pro-protein processing proteases, which cleave sites consist

233 he NS proteins include enzymes necessary for protein processing (proteases) and viral replication (RN

234 s a major role in endoplasmic reticulum (ER) protein processing, protein quality control, maintaining

235 In addition to proteins involved in RNA- and protein-processing, proteins associated with neurodegene

236 l important aspects including NT/N precursor protein processing, ratios of different NT/N mRNA isofor

237 The many protein processing reactions of the ATP-hydrolyzing Hsp7

238 ajor role in Env protein function, including protein processing, receptor attachment, and immune evas

239 improved product purification or maximizing protein processing, remain areas for novel vector and ho

240 r homeostatic intracellular nucleic acid and protein processing respectively.

241 uscle, is unique to ALS, dysregulation of ER protein processing, responsible for correct protein fold

242 tative analyses of cell-to-cell fusion and S protein processing revealed that ACE2 shedding by TMPRSS

243 these proteins are known to be necessary for protein processing, reverse transcription, and integrati

244 potential roles for the IN CTD in precursor protein processing, reverse transcription, integration,

245 a variety of drug treatments known to affect protein processing similarly reduced Abeta release from

246 deficiency did not affect amyloid precursor protein processing, soluble Abeta oligomer levels, Abeta

247 Ca(2+) is required for protein processing, sorting, and secretion in eukaryotic

248 some biogenesis, translation initiation, and protein processing/sorting in the Endoplasmic Reticulum

249 ucleotide mutation of this gene that affects protein processing, stability, and function.

250 used to illustrate the complete sequence of protein processing steps available with the platform.

251 show that a complete integrated sequence of protein processing steps can be performed on this platfo

252 dergoes several critical cell-mediated viral protein processing steps, including unfolding and cleava

253 tion in receptor binding but not in envelope protein processing, suggesting that addition of the GFP

254 in phospholipid biosynthesis, transcription, protein processing/synthesis, and protein trafficking.

255 N-Linked glycosylation is a common form of protein processing that can profoundly affect protein ex

256 rotease SplB, an enzyme used for recombinant protein processing, that no longer requires activation b

257 , despite these differences in intracellular protein processing, the T cell and antibody responses ge

258 s suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defecti

259 pt for the absence of A19 and decreased core protein processing, they appeared to have a similar prot

260 ferentiation and has also been implicated in protein processing through its interaction with the ER c

261 Brefeldin A and monensin, inhibitors of protein processing through the Golgi, both blocked the 8

262 e SREBP-1 (sterol regulatory element-binding protein) processing through the conventional cholesterol

263 t on Gli3 by regulating the full-length Gli3 protein processing to generate a Gli3 repressor gradient

264 y dependent on exogenously added trypsin for protein processing to release the HA2 fusion peptide.

265 an engineered-enzyme that may be useful as a protein processing tool.

266 teasome system (UPS) is a major regulator of protein processing, trafficking, and degradation.

267 This last mutation affects S protein processing, transforms the unprocessed furin cle

268 scription and modification, DNA replication, protein processing, virion assembly, and virion structur

269 sis, nucleotide metabolism, DNA replication, protein processing, virion structure and assembly, and v

270 Inhibition of H-Ras, N-Ras, and lamin B protein processing was observed at concentrations of R11

271 correct biochemical step (I7L-mediated core protein processing) was being inhibited.

272 To analyze env protein processing, we used the herpes simplex virus pro

273 the hydrophobic core that prevented envelope protein processing were also found.

274 375, and each was shown to restore envelope protein processing when combined with the C-terminal 81T

275 that of HIV-1 generated a virus with normal protein processing which could package the HIV-1-based v

276 viral particles in spite of normal envelope protein processing, wild-type levels of cell surface exp

277 We identify conditions allowing efficient protein processing with high peptide yields and demonstr

278 P in coordinating endoplasmic reticular (ER) protein processing with mRNA translation was examined in

279 Aberrant protein processing with tissue deposition is associated