ライフサイエンスコーパス: protein synthesis

1 reation, and unnatural-amino-acid-containing protein synthesis.

2 ity while maintaining the ability to inhibit protein synthesis.

3 muscle proteins partly by suppressing muscle protein synthesis.

4 ecause it provides essential amino acids for protein synthesis.

5 A and IF3 maintain the fidelity of bacterial protein synthesis.

6 re and regulation of ribosome biogenesis and protein synthesis.

7 phan is an essential amino acid required for protein synthesis.

8 e tRNAs and therefore play a pivotal role in protein synthesis.

9 or-prone immature ribosomes from engaging in protein synthesis.

10 to a protein environment more favorable for protein synthesis.

11 hrough an aberrant increase in bulk neuronal protein synthesis.

12 -order purposes, as in the case of ribosomal protein synthesis.

13 and so has been thought to depend on ongoing protein synthesis.

14 ired RiBi and the impact of these changes on protein synthesis.

15 d confirmed that inhibition of PGI increases protein synthesis.

16 As when amino acids are available to support protein synthesis.

17 ion, total volatile fatty acids or microbial protein synthesis.

18 ient enzymes that play a fundamental role in protein synthesis.

19 ges on eIF2alpha phosphorylation to regulate protein synthesis.

20 ition that act to buffer IFN-stimulated gene protein synthesis.

21 atments with ABA, a hormone known to inhibit protein synthesis.

22 strikingly, in a manner dependent on axonal protein synthesis.

23 ription in 2-cell embryos, supporting global protein synthesis.

24 r times, presumably because of inhibition of protein synthesis.

25 complex, exhibited global increases in viral protein synthesis.

26 ia binding to their ribosomes and inhibiting protein synthesis.

27 g mRNA surveillance pathways and attenuating protein synthesis.

28 s control of gene expression at the level of protein synthesis.

29 , leading to a significant downregulation of protein synthesis.

30 gated linoleic acids (CLAs) stimulate muscle protein synthesis.

31 of the translation machinery and the rate of protein synthesis.

32 ential connection between 40S maturation and protein synthesis.

33 ent on acute activation of mTORC1 or de novo protein synthesis.

34 g translation initiation and reducing global protein synthesis.

35 l tools to study the molecular mechanisms of protein synthesis.

36 rve as a broad-range repressor of Leishmania protein synthesis.

37 fer RNA analog widely employed in studies of protein synthesis.

38 upon intrathecal inhibition of ERK, RSK, or protein synthesis.

39 antly with polyribosomes and decrease global protein synthesis.

40 start site shift likely has little effect on protein synthesis.

41 or global and quantitative analysis of rapid protein synthesis.

42 ecause of their ability to inhibit bacterial protein synthesis.

43 amycin complex 1) signaling, which decreases protein synthesis.

44 red biochemical markers of cerebral cortical protein synthesis.

45 he 55S monosome and attenuated mitochondrial protein synthesis.

46 CKD-induced loss of muscle mass and improves protein synthesis.

47 adaptive regulation of mRNA translation and protein synthesis.

48 organisms need to reactivate metabolism and protein synthesis.

49 SV-1) by inhibition of both fusion and viral protein synthesis.

50 tion factors) and regulates crucial steps in protein synthesis.

51 eIF4F complex, which regulates cap-dependent protein synthesis.

52 ticity required activation of mTORC1 and new protein synthesis.

53 ical-amino-acid azidonorleucine (ANL) during protein synthesis.

54 luorescence enables visualization of nascent protein synthesis.

55 ncRNAs in the ribosome that are required for protein synthesis.

56 nsition to stationary phase, tone down their protein synthesis.

57 bosome export into the cytoplasm, and global protein synthesis.

58 in the genome owing to their central role in protein synthesis.

59 deletion mutants nor with bulk inhibition of protein synthesis.

60 stress, we isolated multiple genes impacting protein synthesis: a ribosomal RNA helicase gene, tRNA b

61 Isolated IVCs exhibited protein synthesis activities that required initiation an

62 scopy, quantitative measurement of lipid and protein synthesis activity was achieved with high throug

63 e in particular tumor zones and possess high protein synthesis activity.

64 e without NO66, ribosomal RNA, pre-rRNA, and protein synthesis all increased.

65 tribution of each step within the process of protein synthesis along the central dogma.

66 loss of the VDR on muscle fibre composition, protein synthesis, anabolic and catabolic signalling, mi

67 onlight protein with a canonical function in protein synthesis and a noncanonical function in antigen

68 en host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensu

69 Altered protein synthesis and actin dynamics can lead to an abno

70 2 can regulate additional processes, such as protein synthesis and adenylate cyclase activity, throug

71 We propose that dietary influences on protein synthesis and autophagy are critical determinant

72 modulating key cellular processes, including protein synthesis and autophagy.

73 study helps unravel the complex dynamics of protein synthesis and bacterial dynamics in the mouse mi

74 high concentrations, inhibits the process of protein synthesis and bacterial growth to save and redir

75 y amino acid concentration prevents aberrant protein synthesis and blocks LRRK2 G2019S-mediated neuro

76 g the budding yeast Saccharomyces cerevisiae Protein synthesis and central carbon pathways such as gl

77 The resulting imbalance in protein synthesis and degradation is found to disrupt gl

78 Protein turnover, the net result of protein synthesis and degradation, enables cells to remo

79 ed MLIII model to investigate the balance of protein synthesis and degradation, which reflects glomer

80 he liver plays a central role in metabolism, protein synthesis and detoxification.

81 Genes involved in protein synthesis and DNA damage were implicated in etop

82 s causes potent tumor regression by blocking protein synthesis and down-regulating the Wnt signaling

83 in dysregulation of global and gene-specific protein synthesis and enhances cell death upon stress in

84 Expression of ATF4 in TM promotes aberrant protein synthesis and ER client protein load, leading to

85 largely phenocopies ARF loss, with increased protein synthesis and expression of 5'-TOP encoded prote

86 evidence for translational tuning to balance protein synthesis and folding.

87 g to target messenger RNAs (mRNAs) to reduce protein synthesis and have been implicated in many disea

88 hat cannot be phosphorylated by mTOR blocked protein synthesis and inhibited the growth of Ewing sarc

89 e the potent ability of N-MYC in heightening protein synthesis and malignant characteristics in cance

90 of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant cell cyc

91 entify nucleolar Pol II as a major factor in protein synthesis and nuclear organization, with potenti

92 stained AD-like effects of L-655,708 require protein synthesis and plasticity of GluA1 glutamate rece

93 However, the relationship between protein synthesis and presynaptic structural plasticity

94 is a cellular homeostatic circuit regulating protein synthesis and processing in the ER by three ER-t

95 is a dynamic process that entails extensive protein synthesis and recycling, structural remodeling,

96 multiple antioxidant proteins, reduction of protein synthesis and remediation of proteostasis.

97 ligopyrimidine (5'-TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and

98 This effect of mTORC1/2 inhibitors on protein synthesis and RRM2 levels was rescued in cell li

99 EMT) upregulates LARP6 expression to enhance protein synthesis and support invasive growth.

100 olecule broadly inhibits both viral and host protein synthesis and targets a translation step specifi

101 n of the RRM2 protein is dependent on active protein synthesis and that 4E-BP1, a repressor of cap-de

102 tomas are characterized by elevated rates of protein synthesis and that high expression of ABCE1, a t

103 deficiencies lead to compromised chloroplast protein synthesis and the observed whole-plant chlorotic

104 n modulate the pathogenic effect of LRRK2 on protein synthesis and thereby impact neuronal loss is a

105 Thus, CB(1)-iLTD relies on both protein synthesis and ubiquitination to elicit structura

106 plaque and had significant defects in viral protein synthesis and viral replication in Vero CCL-81 c

107 on of the neuronal proteome shows changes in protein synthesis and/or degradation during homeostatic

108 ay/night differences in 1) muscle growth, 2) protein synthesis, and 3) murf expression all persist in

109 ing molecular mechanisms linking metabolism, protein synthesis, and cognition.

110 is methodology enables spatial regulation of protein synthesis, and deciphering, reconstruction and d

111 Max B alone exhibited decreased protein synthesis, and it alone had reduced single-cycle

112 al search for these structures begins during protein synthesis, and it is unclear how much interactio

113 r stem cells in quiescence when RNA content, protein synthesis, and metabolic activities are profound

114 sis, uridine-dependent nucleotide synthesis, protein synthesis, and the inactivation of cellular auto

115 olving the regulation of myofiber branching, protein synthesis, and the organization of nuclei within

116 Therefore, Ebp1 is a central component of protein synthesis, and the ribosome TE is a focal point

117 rming the tasks, we injected an inhibitor of protein synthesis, anisomycin, into M1 to disrupt inform

118 functions such as migration, proliferation, protein synthesis, apoptosis, and differentiation using

119 These RBPs collaborate with the hypoxic protein synthesis apparatus, operating as a translation

120 d thus affecting the status of the cytosolic protein synthesis apparatus.

121 s, ribosomes, and other factors required for protein synthesis are included in full detail, several b

122 the mechanisms driving repression of general protein synthesis are well characterized, how cells repr

123 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global

124 cytic and autophagic pathways, and bacterial protein synthesis, as the respective inhibitors blocked

125 Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

126 ion, suggesting that K63 ubiquitin regulates protein synthesis at a selective stage of elongation.

127 y 60S peptide tunnel exit (TE) factor during protein synthesis at near-atomic resolution by cryoelect

128 the cell-free reaction to pause and re-start protein synthesis at specific points in the protein sequ

129 ve to increase both the rate and fidelity of protein synthesis at the expense of GTP hydrolysis.

130 ibosome profiling is to quantify the rate of protein synthesis at the level of translation.

131 sERr is relieved upon protein synthesis attenuation and is accompanied by the

132 inactivating cell division or outer membrane protein synthesis blocked it the slowest.

133 ificantly decreased 40S fraction and reduced protein synthesis but no major changes in m(2) (6,6)A le

134 of ATI mRNA at inclusions depends on RNA and protein synthesis but requires neither microtubules nor

135 changes were mechanistically independent of protein synthesis but sensitive to pharmacological block

136 A is misincorporated at serine codons during protein synthesis, but direct evidence of its cotranslat

137 lls (HSCs) require highly regulated rates of protein synthesis, but it is unclear if they or lineage-

138 timicrobial peptide apidaecin (Api) inhibits protein synthesis by binding in the nascent peptide exit

139 d a new function of TRIM21 in inhibiting p53 protein synthesis by degrading the RNA-binding protein H

140 t ribosome assembly factor, RbfA, suppresses protein synthesis by immature Escherichia coli 30S subun

141 ommon four-ring naphthacene core and inhibit protein synthesis by interacting with the 70S bacterial

142 that one of these molecules, ppGpp, inhibits protein synthesis by preventing the allosteric activatio

143 s a unique mechanism of action that inhibits protein synthesis by preventing the binding of tRNA for

144 Translation initiation controls protein synthesis by regulating the delivery of the firs

145 e., rocaglamide A) has been shown to inhibit protein synthesis by stabilizing a translation-incompete

146 in regulating cellular amino acid uptake and protein synthesis, by measuring the expression and phosp

147 tudies suggest that aaRS-dependent errors in protein synthesis can be beneficial to some microbial sp

148 ther nutritional and metabolic influences on protein synthesis can modulate the pathogenic effect of

149 binds to the elongation factor 2 and blocks protein synthesis, can spread through the bloodstream an

150 Accurate quantitation of rapid protein synthesis changes can provide insights into prot

151 During protein synthesis, charged tRNAs deliver amino acids to

152 ein translation, although how alterations in protein synthesis contribute to neurodegeneration in hum

153 urons (MBn) in Drosophila melanogaster store protein synthesis-dependent LTM (PSD-LTM) as well as pro

154 e rat hippocampal slices was associated with protein synthesis-dependent presynaptic structural chang

155 of postsynaptic plasticity commonly involve protein synthesis-dependent structural changes of dendri

156 rm of presynaptic plasticity that involves a protein-synthesis-dependent long-lasting reduction in GA

157 ven cancers are reliant on elevated rates of protein synthesis driven by heightened expression of ABC

158 tion of cytosolic proteins and regulation of protein synthesis due to degradation of transcription fa

159 ow" protein infant formula may cause limited protein synthesis during a phase of rapid growth.

160 le anabolic resistance (i.e., reduced muscle protein synthesis during anabolic conditions such as hyp

161 osttranslational modification that regulates protein synthesis during cellular response to oxidative

162 ating changing requirements for splicing and protein synthesis during health and disease.

163 pathological proton leak, restored rates of protein synthesis during synaptogenesis, and normalized

164 y are both required to promote higher muscle protein synthesis during the day compared to night, wher

165 demonstrate that the observed attenuation of protein synthesis during the entry into quiescence is a

166 in translation, suggesting the importance of protein synthesis during the larval immune response.

167 Despite decreased BCL11A protein synthesis earlier in development, BCL11A mRNA co

168 ively, this leads to cellular adaptations of protein synthesis, energy metabolism, mitochondrial resp

169 During protein synthesis, ER luminal chaperones are swept along

170 single non-synonymous polymorphism within a protein synthesis gene (RARS) is associated with heat to

171 Eukaryotic protein synthesis generally initiates at a start codon d

172 We show that a specific cohort of protein synthesis genes (PSGs) are invariantly bound by

173 itors act to repress gene networks linked to protein synthesis homeostasis.

174 of Scleraxis by TGF-beta did not require new protein synthesis; however, protein synthesis was requir

175 hod allows for robust analysis of endogenous protein synthesis in a cell-type-specific manner, in viv

176 we demonstrate the feasibility of perturbing protein synthesis in a mouse liver by targeting translat

177 ow easier than ever to study fine details of protein synthesis in animal models.

178 rograms that promote ribosome biogenesis and protein synthesis in cells stimulated to proliferate by

179 majority of ribosomal DNA transcription and protein synthesis in CRCs occurs in a limited subset of

180 es synaptic plasticity, cognition, and local protein synthesis in dendrites, providing fundamental in

181 lts provide insight into the role of de novo protein synthesis in distinct inhibitory neuron populati

182 fibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis in disuse atrophy.

183 e responsible for fine tuning the control of protein synthesis in dynamic environments.

184 effects of the loss of ribosome recycling on protein synthesis in E. coli.

185 doplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a hig

186 Increased constitutive protein synthesis in FX appears to modify functional and

187 s in 18S rRNA processing, compromised global protein synthesis in haematopoietic cells and caused bon

188 of 103Q-GFP on IVCs adversely affected total protein synthesis in intact cells and on isolated IVCs.

189 contribute to reduced amino acid uptake and protein synthesis in IUGR fetal skeletal muscle.

190 ovide a wide overview of the use of chemical protein synthesis in medicinal chemistry with a special

191 thesis, ribosome biogenesis, and the overall protein synthesis in migratory cells.

192 the METTL21C-AARS1 axis in the regulation of protein synthesis in muscle tissue.

193 d a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and dendrites.

194 Tumor cells require nominal increases in protein synthesis in order to maintain high proliferatio

195 , the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons.

196 lates proteostasis by transiently inhibiting protein synthesis in response to proteostatic stress.

197 nslation initiation factor eIF4E to increase protein synthesis in specific brain cells.

198 vely applied to investigate rapid changes of protein synthesis in the biological and biomedical resea

199 d was applied to quantitate rapid changes of protein synthesis in THP-1 macrophages treated with lipo

200 Gpp, which we show are sufficient to inhibit protein synthesis in vivo.

201 the training-induced upregulation of de novo protein synthesis, including increase of Arc, Egr1, and

202 ondary consequences of dysregulated RiBi and protein synthesis, including proteotoxic stress, metabol

203 protein complexes regulating many aspects of protein synthesis, including ribosome biogenesis and mRN

204 synthesis-dependent LTM (PSD-LTM) as well as protein synthesis-independent, anesthesia-resistant memo

205 gilis upregulated numerous genes involved in protein synthesis, indicating that bacteria inhabiting t

206 n synthesis inhibition to show that targeted protein synthesis inhibition pan-neuronally and in excit

207 proach for cell-type-specific drug-inducible protein synthesis inhibition that enables rapid and reve

208 We use cell-type-specific drug-inducible protein synthesis inhibition to show that targeted prote

209 strate that intrahippocampal infusion of the protein synthesis inhibitor anisomycin disrupts both the

210 ps significantly with that of the well-known protein synthesis inhibitor balsticidin S.

211 Pretreatment with protein synthesis inhibitor cycloheximide antagonized BB

212 express MetRS-L270G in neurons, we measured protein synthesis intensities across the entire nervous

213 2B, an essential enzyme in the initiation of protein synthesis, into large bundles of filaments.

214 Shutoff of global protein synthesis is a conserved response to cellular st

215 substrate for ribosomes actively engaged in protein synthesis is a ternary complex of elongation fac

216 Protein synthesis is an energetically costly cellular ac

217 Eukaryotic protein synthesis is an inherently stochastic process.

218 However, protein synthesis is clearly not always perfectly tuned

219 owth rate hypothesis posits that the rate of protein synthesis is constrained by phosphorus (P) suppl

220 Computational modelling of in vivo protein synthesis is highly complicated, as it requires

221 ery that Hsf1 can be robustly activated when protein synthesis is inhibited, so long as cells undergo

222 Dysregulation of cellular protein synthesis is linked to a variety of diseases.

223 Protein synthesis is quickly and tightly regulated in ce

224 As protein synthesis is the most energy intensive metabolic

225 Under nonpathologic conditions, protein synthesis is tightly controlled by metabolic reg

226 y, normally provided by mTORC1 regulation of protein synthesis, is absent in FX.

227 Despite advances in methods to detect protein synthesis, it has not been possible to measure e

228 bosomes were characterized by assessing bulk protein synthesis kinetics, readthrough, assembly, and s

229 ells led to significant inhibition of global protein synthesis, leading us to ask whether resistance

230 has not been possible to measure endogenous protein synthesis levels in vivo in an entire vertebrate

231 ygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll') and activates a h

232 between second messenger signaling and local protein synthesis machinery.

233 ginate from the cell body because cilia lack protein synthesis machinery.

234 Proteomics can provide information about protein synthesis, modification and degradation, as well

235 to attenuate the response of skeletal muscle protein synthesis (MPS) to anabolic stimuli such as prot

236 Protein synthesis must be finely tuned in the developing

237 These findings reveal that an increase in protein synthesis negatively impacts growth and osmotic

238 translational reprogramming in governing the protein synthesis of ERalpha and FOXM1 contributes to an

239 Mechanistically, mTORC1 activation increases protein synthesis of MKK6 and augments activation of the

240 Increased protein synthesis of profibrotic genes is a common featu

241 ne therapy to treat this disease, as de novo protein synthesis of SP-B in alveolar type 2 epithelial

242 ses was observed, with no effect upon muscle protein synthesis or anabolic signalling.

243 st is amino acids, which can be utilized for protein synthesis or energy generation.

244 ppear to be dependent on sustained bacterial protein synthesis or on intact host actin, vesicular tra

245 omplexoform because of timing differences in protein-synthesis order.

246 ken together, these results demonstrate that protein synthesis pathways like PERK could represent a g

247 atory complexity, and thousands of fold more protein synthesis per gene.

248 inoacidemia-induced increase in myofibrillar protein synthesis (percentage increase from basal before

249 igated the link between cytokinin signaling, protein synthesis, plant growth and osmotic stress toler

250 d especially in chemical biology for peptide/protein synthesis, posttranslational modifications, and

251 Thus, coupling of prenylation to local protein synthesis presents a mechanism for spatially seg

252 D614G did not alter S protein synthesis, processing, or incorporation into SAR

253 Stalled protein synthesis produces defective nascent chains that

254 d in significantly increases of muscle mass, protein synthesis (puromycin incorporation in SUnSET ass

255 plementation affected the basal myofibrillar protein synthesis rates (placebo: 0.040 +/- 0.004%/h; Vi

256 Instead, training increased protein synthesis rates and basal autophagy in the Bcl2(

257 ia-hyperaminoacidemia increased myofibrillar protein synthesis rates by ~35%.

258 fibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis rates during recovery from endurance e

259 Myofibrillar protein synthesis rates were evaluated by using intraven

260 Before the intervention, basal myofibrillar protein synthesis rates were not different among groups

261 n stimulates resting and postexercise muscle protein synthesis rates, and to a greater extent than a

262 t responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-t

263 the fetal hindlimb and lower skeletal muscle protein synthesis rates.

264 sterone levels predicted expression of brain protein synthesis regulators.

265 l memory performance and expression of brain protein synthesis regulators.

266 Protein synthesis represents a major metabolic activity

267 We also demonstrate that cytokinin-induced protein synthesis requires isoforms of the ribosomal pro

268 r, the cells that cause ASD through elevated protein synthesis resulting from these mutations remain

269 tematic and multidimensional deregulation of protein synthesis, showing how this major cellular proce

270 lso to understanding the interaction between protein synthesis shut-off and virus control in chickens

271 s revealed a subset with strong ribosome and protein synthesis signatures; these CTCs expressed proli

272 fferent design of a cell with two orthogonal protein synthesis systems, where Ribo-T produces the pro

273 SK3 contributes to the attenuation of global protein synthesis that is critical for adaptation to sta

274 ading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturat

275 For the network describing protein synthesis, the error rate and the energy expendi

276 n incorporated into liposomes using in vitro protein synthesis, the transmembrane form of the 16-heli

277 Considering the importance of protein synthesis, this method can be extensively applie

278 BMAA may be able to disrupt the integrity of protein synthesis through multiple different mechanisms.

279 eads to the regulation of mRNA stability and protein synthesis through posttranscriptional mechanisms

280 ions restored normal hypoxic sensitivity and protein synthesis to the tRNA biogenesis mutants, but no

281 s minimise energy expenditure by restricting protein synthesis until sufficient resources are stored,

282 and growth rate with OTC), while blocking of protein synthesis using low concentrations of chloramphe

283 CKD suppresses muscle protein synthesis via epigenetic mechanisms that NO66 me

284 on the translational machinery to slow down protein synthesis via phosphorylation of the eukaryotic

285 The results demonstrated that protein synthesis was modulated to facilitate protein se

286 y global or HDAC3/6-selective HDACi, and new protein synthesis was not required for gene suppression

287 not require new protein synthesis; however, protein synthesis was required for expression of Fibromo

288 ents necessary for electron uptake; however, protein synthesis was required for full biofilm formatio

289 r the mechanisms by which these genes impact protein synthesis, we performed a second screen for supp

290 Reductions in protein synthesis were accompanied by mitochondrial enla

291 involved in DNA packaging, replication, and protein synthesis were detected at lower rates and zinc

292 While ribosome biogenesis and global protein synthesis were unaffected by nsun-1 depletion, t

293 act of this potential regulation on rhythmic protein synthesis, were not known.

294 initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-

295 lines is associated with increased rates of protein synthesis, which lead to growth inhibition and h

296 otor deficits and is associated with reduced protein synthesis, while moderately high amino acids sim

297 g tRNA abundance matching the global rate of protein synthesis with available resources.

298 s in cells is precise, rapid, and coupled to protein synthesis with regulation in space and time.

299 Cell proliferation exerts a high demand on protein synthesis, yet the mechanisms coupling the two p

300 ggests that increased constitutive dendritic protein synthesis yields exaggerated mGluR5-dependent lo