ライフサイエンスコーパス: proteolipid protein

1 ithin the lesion, despite the persistence of proteolipid protein.

2 s association with loss of the myelin marker proteolipid protein.

3 rent encephalitogenic determinants of myelin proteolipid protein.

4 chromosome which codes for the major myelin proteolipid protein.

5 a mutant form of the DM20 isoform of myelin proteolipid protein.

6 yelin autoantigens, myelin basic protein and proteolipid protein.

7 anscription factor at the promoter region of proteolipid protein.

8 sion of myelin basic protein and promoter of proteolipid protein.

9 Ig-proteolipid protein 1 (Ig-PLP1) is an Ig chimera express

10 s, and the myelin associated glycoprotein to proteolipid protein 1 (MAG:PLP1) ratio, which declines i

11 ecurrent duplication of the dosage-sensitive proteolipid protein 1 (PLP1) gene but also by nonrecurre

12 disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid p

13 ng leukodystrophy caused by mutations in the proteolipid protein 1 (PLP1) gene, showed increased cell

14 eds of mutations in the X-linked myelin gene proteolipid protein 1 (PLP1) have been identified in hum

15 and found that the majority express the gene Proteolipid protein 1 (PLP1) in both mice and humans.

16 As a major component of CNS myelin, proteolipid protein 1 (Plp1) is indispensable for the ax

17 ent CSF plasmablasts bound to conformational proteolipid protein 1 (PLP1) membrane complexes and, whe

18 linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major myelin pr

19 contrast, virtually all enteric glia express proteolipid protein 1 (PLP1).

20 e ratio of myelin-associated glycoprotein to proteolipid protein 1 and both endothelin 1 and vascular

21 e ratio of myelin-associated glycoprotein to proteolipid protein 1 and several other proteins involve

22 d ratio of myelin-associated glycoprotein to proteolipid protein 1 are likely to be protective physio

23 Alternative splicing of the proteolipid protein 1 gene (PLP1) produces two forms, PL

24 ng leukodystrophy caused by mutations of the proteolipid protein 1 gene (PLP1), which is located on t

25 ry progressive multiple sclerosis to include proteolipid protein 1 gene mutations.

26 Sequencing of the proteolipid protein 1 gene showed a novel mutation, Leu3

27 e we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage wh

28 e ratio of myelin-associated glycoprotein to proteolipid protein 1 in post-mortem human brain tissue

29 e ratio of myelin-associated glycoprotein to proteolipid protein 1, correlated positively with the co

30 ptide ligand (APL) variants derived from the proteolipid protein-1 (PLP1) epitope were expressed on i

31 Ig-PLP1 is an Ig chimera expressing proteolipid protein-1 (PLP1) peptide corresponding to aa

32 o measure the myelin-associated glycoprotein:proteolipid protein-1 ratio (MAG:PLP1), an index of ante

33 with a retroviral vector designed to encode proteolipid protein (101-157) targeted for secretion.

34 of copolymers to I-A(s) in competition with proteolipid protein 139-151 (blocking), cytokine product

35 of Ag-specific tolerance using two regimens, proteolipid protein 139-151 (PLP139-151) peptide-coupled

36 and a DNA vaccine encoding the self-peptide proteolipid protein 139-151 (PLP139-151) provides protec

37 olecule VLA-4 antagonist, to regulate active proteolipid protein 139-151 (PLP139-151)-induced R-EAE.

38 ybridoma stimulated by a set of three myelin proteolipid protein 139-151 altered peptide ligands.

39 144) from an autoantigenic peptide of myelin proteolipid protein 139-151 by a single amino acid subst

40 Likewise, when combined with proteolipid protein 139-151 in CFA, GM-CSF fused to prot

41 ipid protein 139-151 in CFA, GM-CSF fused to proteolipid protein 139-151 peptide inhibited EAE in SJL

42 ke E2, drastically suppressed EAE induced by proteolipid protein 139-151 peptide when given at initia

43 alomyelitis (EAE) induced in SJL/J mice with proteolipid protein 139-151 was demonstrated by using th

44 T cell lines were selected from proteolipid protein 139-151-immunized female SJL mice in

45 ncephalomyelitis (EAE) in humanized mice and proteolipid protein 139-151-induced EAE in SJL/J mice.

46 hat anti-GITR mAb treatment of SJL mice with proteolipid protein 139-151-induced experimental autoimm

47 ively induced EAE were able to present Ag to proteolipid protein 139-151-specific T cell lines in vit

48 Adoptive transfer of proteolipid protein 139-151-specific T cell lines was us

49 e inhibitors crossreacted with MBP 85-99- or proteolipid protein 139-151-specific T cells.

50 nduced unresponsiveness to the self peptide, proteolipid protein 139-151.

51 he frequency and effector function of myelin proteolipid proteins 139-151/I-A(s)-tetramer(+) cells in

52 tified a promoter variant (-113C>A) in PLP2 (proteolipid protein 2) that results in an approximately

53 n immunoglobulin gene superfamily member, or proteolipid proteins, 4-hydrophobic domain-motif protein

54 and TNF-alpha in response to the immunogen, proteolipid protein 56-70.

55 ice injected i.p. with a peptide fragment of proteolipid protein (a candidate autoantigen in multiple

56 ression is associated with downregulation of proteolipid protein, a highly abundant myelin sheath com

57 ignals may control the surface expression of proteolipid protein, a process that involves reduced end

58 indicate that the adhesive properties of the proteolipid protein, along with the reduction of sialic

59 pathology and to mediate neuroprotection in proteolipid protein alpha-syn (PLP-SYN) mice, a transgen

60 reflected in decreased expression of MBP and proteolipid protein and a reduction in the total number

61 We revisit the role of the proteolipid protein and analyze the contribution of olig

62 Proteolipid protein and carbonic anhydrase-II transcript

63 myelin proteins that are not MMP substrates (proteolipid protein and DM20).

64 The two proteins, proteolipid protein and DM20, which are encoded by alter

65 a point mutation in the mouse gene encoding proteolipid protein and is characterized by severe dysmy

66 ociated with oligodendroglial lineage (e.g., proteolipid protein and PMP-22).

67 elitis, stimulation of lymph node cells with proteolipid protein and recombinant murine interleukin (

68 the amounts of myelin basic protein, myelin proteolipid protein, and 2',3'-cyclic nucleotide 3'-phos

69 teins including myelin basic protein, myelin proteolipid protein, and 2'3'-cyclic nucleotide 3'-phosp

70 sociates with myelin proteins such as myelin proteolipid protein, and assembles lipid-rich microdomai

71 teins, including myelin basic protein (MBP), proteolipid protein, and myelin oligodendrocyte glycopro

72 for reactivity against myelin basic protein, proteolipid protein, and myelin oligodendrocyte glycopro

73 ein and a decrease in neurofilament protein, proteolipid protein, and several pro-inflammatory marker

74 n oligodendrocyte glycoprotein (MOG)35-55 in proteolipid protein- and MOG-induced models of EAE, resp

75 However, we now find that proteolipid proteins are actually major myelin constitue

76 In conclusion, P0 and the proteolipid proteins are evolving in parallel in myelina

77 The loss of Cx47 was associated with loss of proteolipid protein at the chronic stage of MHV-A59 infe

78 nic Ags (guinea pig myelin basic protein and proteolipid protein) by lymph node cells from animals im

79 duced Nf1 loss of function with an inducible proteolipid protein Cre allele.

80 ts and are specific for two different myelin proteolipid protein-derived peptides presented by HLA-A2

81 t immunization with myelin basic protein and proteolipid protein determinants results in clinical dis

82 we show here that the immunodominant myelin proteolipid protein epitope (PLP(178-191)) elicited iden

83 -cell responses to the immunodominant myelin proteolipid protein epitope (PLP139-151) did not arise b

84 (HI574-586) of an immunodominant self-myelin proteolipid protein epitope (PLP139-151) induced a rapid

85 nization of SJL mice with the immunodominant proteolipid protein epitope, PLP139-151, surface express

86 re able to endogenously present a variety of proteolipid protein epitopes to specific Th1 lines.

87 taining human myelin basic protein and human proteolipid protein epitopes, prevented clinical symptom

88 ll response against myelin basic protein and proteolipid protein epitopes.

89 Th1 cells reactive to myelin proteolipid protein expressed more H1R and less H2R than

90 Xenopus, DM gamma, a membrane protein of the proteolipid protein family, is expressed in a subset of

91 nding of the disease, dosage sensitivity and proteolipid protein function during myelinogenesis.

92 The proteolipid protein gene (PLP) is normally present at ch

93 Alternative products of the proteolipid protein gene (PLP), proteolipid protein (PLP

94 h conditions resulting from mutations in the proteolipid protein gene (PLP).

95 stem (CNS) caused by mutations involving the proteolipid protein gene (PLP).

96 ease (PMD) is a leukodystrophy linked to the proteolipid protein gene (PLP).

97 Although the myelin proteolipid protein gene (Plp1) is highly expressed in t

98 er disease (PMD) is caused by myelin protein proteolipid protein gene (PLP1) mutations.

99 mpy mutant mouse has a point mutation in the proteolipid protein gene (plp1).

100 genomic duplications of the dosage-sensitive proteolipid protein gene (PLP1).

101 activation in the peripheral lymphocytes nor proteolipid protein gene coding alterations were identif

102 indicate that, occasionally, females with a proteolipid protein gene duplication can manifest an ear

103 uorescent in situ hybridization identified a proteolipid protein gene duplication in both patients.

104 oscopic duplication that contains the entire proteolipid protein gene is the major cause of Pelizaeus

105 Duplication of the proteolipid protein gene is the most common molecular ab

106 zaeus-Merzbacher disease, duplication of the proteolipid protein gene PLP1 is responsible, whereas de

107 The proteolipid protein gene products DM-20 and PLP are adhe

108 survival, differentiation, and expression of proteolipid protein gene products.

109 n by oligodendrocytes expressing one copy of proteolipid protein gene secondary to selection for a fa

110 axons, and subsequently expressed the myelin proteolipid protein gene, initiating remyelination.

111 fect disease induced after immunization with proteolipid protein immunodominant peptide plus MBP.

112 aging correlated with myelin-related stains (proteolipid protein immunostaining and Luxol fast blue)

113 c F1 mice, immunized 12-15 days earlier with proteolipid protein in complete Freund's adjuvant, were

114 ulates cell surface expression of the myelin proteolipid protein in cultured oligodendrocytes in unex

115 y acidic protein in Alexander disease and of proteolipid protein in hypomyelinating disorders such as

116 In vitro stimulation with proteolipid protein in the presence of rmIL-12 was assoc

117 ought to be completely replaced by the newer proteolipid proteins in the terrestrial vertebrate CNS.

118 course is well documented for both MBP- and proteolipid protein-induced EAE, and recently has been s

119 major intrinsic membrane protein of myelin, proteolipid protein, interacts with rafts in oligodendro

120 We have found that the myelin proteolipid protein is critical to regulating OPC migrat

121 issue, Yin et al. study mutant mice in which proteolipid protein is replaced by the peripheral myelin

122 ling view has been that expression of P0 and proteolipid proteins is mutually exclusive; P0, which me

123 ons of myelin-specific proteins (MBP, myelin proteolipid protein, MAG, and 2',3'-cyclic nucleotide,3'

124 Transcripts for myelin genes, such as proteolipid protein, MAG, MBP, and myelin oligodendrocyt

125 ubsequently, tissue samples were stained for proteolipid protein (myelin) and scored for cortical les

126 uced by myelin oligodendrocyte glycoprotein, proteolipid protein, myelin basic protein, and renal tub

127 expression, including myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein

128 erized myelin antigens myelin basic protein, proteolipid protein, or myelin oligodendrocyte glycoprot

129 roliferative response and IL-2 production of proteolipid protein p139-151-specific T cells were signi

130 ctive T cells was demonstrated by inhibiting proteolipid protein (p139-151)-induced EAE and finding t

131 JL/J mouse by adoptive transfer of activated proteolipid protein peptide (PLP) 139-151-specific Th1 c

132 on with Listeria monocytogenes (LM) encoding proteolipid protein peptide (PLP) amino acids 178-191 (L

133 latory signals, impaired memory responses to proteolipid protein peptide (PLP), and do not develop PL

134 ephalomyelitis induced via immunization with proteolipid protein peptide (PLP139-151) and complete Fr

135 Oral administration of proteolipid protein peptide (PLP139-151) increased MCP-1

136 zed for disease with encephalitogenic myelin proteolipid protein peptide 139 to 151, and analysis was

137 By comparing a wide age range of proteolipid protein peptide 139-151 immunized mice, we f

138 SJL mice were challenged with proteolipid protein peptide 139-151 to induce EAE and or

139 specific for MBP exon 2, MBP peptide 89-101, proteolipid protein peptide 139-151, and OVA gave stimul

140 of a CD4+, Th1, VB2+ encephalitogenic SJL/J proteolipid protein peptide 139-151-specific T cell clon

141 vere course of EAE with epitope spreading to proteolipid protein peptide 43-64.

142 ecific for the relapse epitope consisting of proteolipid protein peptide amino acids 139-151 clustere

143 odel of MS, was induced by immunization with proteolipid protein peptide in SJL/J mice.

144 During acute relapsing EAE induced by a proteolipid protein peptide of amino acids 178-191, tran

145 e are also resistant to initiation of EAE by proteolipid protein peptide PLP(178-191).

146 AR inhibited their capability to present the proteolipid protein peptide to PLP(139-151)-specific T c

147 encephalomyelitis using an encephalitogenic proteolipid protein peptide, PLP(139-151).

148 t detectable in the infiltrates of mice with proteolipid protein peptide-induced experimental autoimm

149 ectively, these results indicate that myelin proteolipid protein peptide-specific CD8+ CTL may be an

150 litis (EAE) was induced by immunization with proteolipid protein peptide.

151 ntal autoimmune encephalomyelitis induced by proteolipid protein, peptide 139-151-specific T cell lin

152 In relapsing/remitting EAE induced with proteolipid protein peptide139-151, lithium administered

153 Our data showed that an extensive array of proteolipid protein peptides could elicit autoreactivity

154 encoded by alternative transcripts from the proteolipid protein ( PLP ) gene, are major components o

155 Ig-proteolipid protein (PLP) 1 and Ig-myelin oligodendrocyt

156 ospot analysis (ELISPOT) assays, we followed proteolipid protein (PLP) 139--151-specific T cells enga

157 study, we have identified an MHC variant of proteolipid protein (PLP) 139-151 (145D) that renders PL

158 encephalitogenic epitope of a myelin antigen proteolipid protein (PLP) 139-151 in the peripheral repe

159 In this study, using the SJL proteolipid protein (PLP) 139-151 peptide EAE model, we

160 ompassing the immunodominant myelin epitope, proteolipid protein (PLP) 139-151, into the coding regio

161 Female B10.S mice are highly resistant to proteolipid protein (PLP) 139-151-induced experimental a

162 mpared the ability of anti-VLA-4 to regulate proteolipid protein (PLP) 139-151-induced R-EAE when adm

163 tides, myelin basic protein (MBP) 87-106 and proteolipid protein (PLP) 175-192, that are considered t

164 A protein complex containing the myelin proteolipid protein (PLP) and alphav integrin modulated

165 Mutated HSP proteins include myelin proteolipid protein (PLP) and axon-enriched proteins inv

166 ducts of the proteolipid protein gene (PLP), proteolipid protein (PLP) and DM20, are major components

167 a significant reduction of protein levels of proteolipid protein (PLP) and myelin oligodendrocyte gly

168 matic epitope mapping of responses to myelin proteolipid protein (PLP) as well as assaying responses

169 mutation in exon 3B of the PLP altering the proteolipid protein (PLP) but not the alternatively spli

170 ping series of 265 12-mer peptides of myelin proteolipid protein (PLP) by patients with isolated mono

171 s of myelin, myelin basic protein (MBP), and proteolipid protein (PLP) during postnatal brain develop

172 ific for the immunodominant encephalitogenic proteolipid protein (PLP) epitope (PLP139-151) as assess

173 of 13 aa with the dominant encephalitogenic proteolipid protein (PLP) epitope PLP(139-151).

174 SJL mice initiated by immunization with the proteolipid protein (PLP) epitope PLP139-151 is associat

175 nti-IL-23p19 during active disease inhibited proteolipid protein (PLP) epitope spreading and prevente

176 states in different cell compartments of the proteolipid protein (PLP) expressed in COS-7 cells.

177 ockout of myelin regulatory factor (Myrf) in proteolipid protein (PLP) expressing cells in Myrffl/fl

178 mice induced by MP4, a myelin basic protein-proteolipid protein (PLP) fusion protein.

179 The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM20 gene)

180 Overexpression or lack of expression of proteolipid protein (PLP) gene by oligodendrocytes cause

181 The proteolipid protein (PLP) gene encodes two myelin-specif

182 inhibitory effect on OLP differentiation and proteolipid protein (PLP) gene expression.

183 enes containing portions of the mouse myelin proteolipid protein (PLP) gene fused to the lacZ reporte

184 Duplications of the proteolipid protein (PLP) gene have been found in a prop

185 nt protein (EGFP) driven by the mouse myelin proteolipid protein (PLP) gene promoter have been develo

186 of the CNS, resulting from mutations in the proteolipid protein (PLP) gene.

187 mutations, deletions, or duplications of the proteolipid protein (PLP) gene.

188 mutations, deletions, or duplications of the proteolipid protein (PLP) gene.

189 Proteolipid protein (PLP) has been postulated to play a

190 areas, an increased number of OGs expressing proteolipid protein (PLP) mRNA compared with those expre

191 rade astrocytomas contained a high number of proteolipid protein (PLP) mRNA-positive cells and that t

192 ic for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139-151 (HSLGKWLGHPDKF

193 We used myelin proteolipid protein (PLP) peptide 139-151 and its analog

194 In B10.S mice immunized with myelin proteolipid protein (PLP) peptide 139-151, both PD-L1 an

195 B6) specific for the encephalitogenic myelin proteolipid protein (PLP) peptide 139-151, on the experi

196 encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 c

197 For instance, delivery of a proteolipid protein (PLP) peptide on Ig boosts the neona

198 ning of the BBB in EAE mice immunized to the proteolipid protein (PLP) peptide, PLP 139-151, with or

199 eptides derived from sequences of the myelin proteolipid protein (PLP) presented by HLA class I molec

200 nit of functional NMDARs, using an inducible proteolipid protein (Plp) promoter-driven Cre-loxP recom

201 Using an inducible proteolipid protein (Plp) promoter-driven Cre-loxP recom

202 n the oligodendroglia lineage, driven by the proteolipid protein (PLP) promoter.

203 encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) residues 139-151 (HSLGKWLGHPDK

204 To address this issue we used the proteolipid protein (PLP) sequence 139-151 (hereafter re

205 1, a chimera expressing the encephalitogenic proteolipid protein (PLP) sequence 139-151, induced devi

206 c presentation system, we demonstrate that a proteolipid protein (PLP) TCR antagonist peptide (PLP-LR

207 Like MS, EAE induced by proteolipid protein (PLP) usually follows the form of a

208 ized with the p139-151 determinant of myelin proteolipid protein (PLP) were transfected with a DNA co

209 enic mice on the SJL background specific for proteolipid protein (PLP)(139-151) develop a high incide

210 Drug treated SJL/J mice immunized with proteolipid protein (PLP)(139-151) peptide had attenuate

211 Multiple Ag peptides (MAPs) containing eight proteolipid protein (PLP)(139-151) peptides arranged aro

212 sing the HLA-DR or -DQ gene), we showed that proteolipid protein (PLP)(91-110) peptide induced classi

213 -cyclic-nucleotide 3'-phosphodiesterase, and proteolipid protein (PLP)) in primary human oligodendroc

214 -expressing cells co-expressed mRNA encoding proteolipid protein (PLP), a mature oligodendrocyte mark

215 EAE was induced in SJL mice by using proteolipid protein (PLP), and mice were treated with ei

216 allergic encephalomyelitis in SJL mice with proteolipid protein (PLP), brain ICOS mRNA and protein w

217 intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epitopes mus

218 ntaining both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP

219 e, we show that NG2+ cells express mRNAs for proteolipid protein (PLP), myelin basic protein, and 2',

220 th antibodies to myelin basic protein (MBP), proteolipid protein (PLP), myelin-associated glycoprotei

221 undrum with regard to the function of myelin proteolipid protein (PLP), one of the major proteins in

222 ge when a tetraspan membrane protein, myelin proteolipid protein (PLP), replaced the type I integral

223 Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelinat

224 hybridization with oligonucleotide probes to proteolipid protein (PLP), the major protein in central

225 Proteolipid protein (PLP), the major protein of central

226 A new role for the myelin proteolipid protein (PLP), the most abundant protein of

227 ssociated glycoprotein (MAG) but not P(0) or proteolipid protein (PLP), the structural proteins of co

228 ant of a non- glycosylated membrane protein, proteolipid protein (PLP), to examine the quality contro

229 expression of myelin basic protein (MBP) and proteolipid protein (PLP), two major myelin-specific pro

230 lization of another myelin-specific protein, proteolipid protein (PLP), was unaltered.

231 Using antibodies to proteolipid protein (PLP), we found a total of 70 cortic

232 were determined from animals immunized with proteolipid protein (PLP)-139-151 (disease agonist), PLP

233 Proteolipid protein (PLP)-139-151 is the dominant enceph

234 ism of a rTCR ligand (RTL) construct (I-A(s)/proteolipid protein (PLP)-139-151 peptide = RTL401) for

235 P1 and Ig-PLP-LR are chimeric Igs expressing proteolipid protein (PLP)-derived T cell agonist (PLP1)

236 mice, which are highly susceptible to myelin proteolipid protein (PLP)-induced experimental autoimmun

237 the human HLA-DRB1*0301 gene predisposes to proteolipid protein (PLP)-induced experimental autoimmun

238 Fixed preparations of proteolipid protein (PLP)-null mouse spinal cord show my

239 Conversely, Tsc1 deletion from proteolipid protein (PLP)-positive oligodendrocytes slow

240 (ELISPOT) assays to study, directly ex vivo, proteolipid protein (PLP)-specific memory cell reactivit

241 ) selectively modifies cytokine secretion in proteolipid protein (PLP)-specific, CD4+ T cell clones i

242 The transfer of proteolipid protein (PLP)-stimulated lymph node cells to

243 toimmune encephalomyelitis (EAE) with myelin proteolipid protein (PLP).

244 ding proteins, and, surprisingly, the myelin proteolipid protein (PLP).

245 yelin sheath, myelin basic protein (MBP) and proteolipid protein (PLP).

246 e proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP).

247 22 MS-associated proteins, including myelin proteolipid protein (PLP).

248 r ribonucleoprotein (hnRNP) H and F regulate proteolipid protein (PLP)/DM20 alternative splicing.

249 conserved G runs, G1M2 and ISE, regulate the proteolipid protein (PLP)/DM20 ratio.

250 n (Ig) chimera carrying the encephalitogenic proteolipid protein (PLP)1 peptide corresponding to amin

251 Ig-proteolipid protein (PLP)1, an Ig carrying a PLP1 peptid

252 +CD25-Foxp3- T cells specific for the myelin proteolipid protein (PLP)139-151 peptide can be converte

253 DEC205-mediated delivery of the self-peptide proteolipid protein (PLP)139-151 to DCs ameliorated clin

254 w chimeras, we show that activation of naive proteolipid protein (PLP)139-151-specific T cells in SJL

255 d multitransmembrane domain proteins, myelin proteolipid protein (PLP, 30 kDa) and DM-20 (26 kDa), fr

256 We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in the la

257 ion of 19 base pairs (bp) in intron 3 of the proteolipid protein (PLP/DM20) gene causes a neurologica

258 ed with an autoantigenic peptide from myelin proteolipid protein (PLP; PLP(139-151)) and used it to a

259 e significant homology with the major myelin proteolipid protein, PLP/DM20.

260 Proteolipid protein (PLP1) and its alternatively spliced

261 e three, and in one case, five copies of the proteolipid protein (PLP1) gene.

262 editary spastic paraplegia (HSP) type 2 is a proteolipid protein (PLP1)-related genetic disorder that

263 gene encoding the major CNS myelin protein, proteolipid protein (PLP1, previously PLP).

264 g the immunodominant encephalitogenic myelin proteolipid protein (PLP139-151) epitope.

265 T cell epitope peptides derived from proteolipid protein (PLP139-151) or myelin basic protein

266 ng a minigene for residues 139-151 of myelin proteolipid protein (PLP139-151), a pathogenic self-Ag.

267 ent of oligomerized T cell epitope of myelin proteolipid protein (PLP139-151).

268 mpassing the extracellular domains of myelin proteolipid protein (PLPECD).

269 es forming myelin basic protein (MBP)(+) and proteolipid protein-positive myelin was impaired.

270 F-beta mRNA and protein in normal as well as proteolipid protein-primed splenocytes.

271 Conversely, blockage of proteolipid protein production exacerbated myelin thinni

272 oxed conditional allele was crossed with the proteolipid protein promoter-driven inducible Cre allele

273 Our data suggest that NG2(+)/PDGFRalpha(+) proteolipid protein promoter-expressing progenitors gene

274 st cells can induce gene expression from the proteolipid protein promoter.

275 fluorescent protein under the control of the proteolipid protein promoter.

276 ytes using an inducible cre regulated by the proteolipid protein promoter.

277 led by GFP transgenically expressed from the proteolipid protein promoter.

278 Enhanced responses to proteolipid protein self peptide were associated with re

279 Finally, we show that myelin proteolipid protein-specific autoreactive T cells transd

280 Here we report that tolerized proteolipid protein-specific lymph node cells regain the

281 our study, we used the previously described [proteolipid protein/suppressor of cytokine signaling 1 (

282 enerated a transgenic mouse line [PLP/SOCS1 (proteolipid protein/suppressor of cytokine signaling 1)]

283 hed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degene

284 ocyte glycoprotein, myelin basic protein and proteolipid protein, truncated).

285 ere remarkably similar to that of the myelin proteolipid protein were previously isolated.