ライフサイエンスコーパス: proteolysis

1 w pH and reducing conditions enhanced NOTCH3 proteolysis.

2 that the ClpX/P pathway also plays a role in proteolysis.

3 iverse enzymatic toolkit for mucin-selective proteolysis.

4 iquitin ligase complexes that mediate YTHDF2 proteolysis.

5 its contributes to the biological outcome of proteolysis.

6 y are resistant to chemical denaturation and proteolysis.

7 ketones and lactate and had higher rates of proteolysis.

8 gions of large proteins without the need for proteolysis.

9 f genes involved in metabolism, particularly proteolysis.

10 nstrates enhanced susceptibility to ADAMTS13 proteolysis.

11 umin (BSA) and the factors that affected the proteolysis.

12 demonstrating complex relationships through proteolysis.

13 lum (ER)-associated degradation-governed NIS proteolysis.

14 lding of GGPP as studied by in vitro limited proteolysis.

15 PRT6 N-degron pathway of ubiquitin-mediated proteolysis.

16 ptors possess GAIN domains incapable of self-proteolysis.

17 lex that functions to recruit substrates for proteolysis.

18 FoxO-regulated ubiquitin-proteasome-mediated proteolysis.

19 ntify peptides generated by various types of proteolysis.

20 mily are ubiquitous biological regulators of proteolysis.

21 yopic pathway to trigger robust perisynaptic proteolysis.

22 djacent metalloprotease domain to facilitate proteolysis.

23 ees C and is significantly more sensitive to proteolysis.

24 fy modulators of PrP(C) expression levels or proteolysis.

25 and targets proteins for ubiquitin-dependent proteolysis.

26 f cell proteins) without affecting lysosomal proteolysis.

27 t these activities are governed by regulated proteolysis.

28 ethality through activation of mitochondrial proteolysis.

29 t high temperature and its resistance toward proteolysis.

30 ygen species (ROS) production and phagosomal proteolysis.

31 ein-coupled receptors that are activated via proteolysis.

32 ogression through spatiotemporally regulated proteolysis.

33 e first time, kinetic constants for versican proteolysis.

34 a pro-inflammatory environment and increased proteolysis.

35 tivity and protects GCase from intracellular proteolysis.

36 role for heparin in complex formation during proteolysis.

37 sion that DdcA regulates YneA independent of proteolysis.

38 elevant processes such as ROS production and proteolysis.

39 ton, presumably by targeting a substrate for proteolysis.

40 uld contribute to its regulation of parasite proteolysis.

41 l-CoA amounts, thereby linking metabolism to proteolysis.

42 t not the bulk of cell proteins or lysosomal proteolysis.

43 N-glycan biosynthesis enhanced Spike-protein proteolysis.

44 needed to provide increased stability toward proteolysis.

45 icer expression in monocytic cells, based on proteolysis.

46 AP undergoing active substrate unfolding and proteolysis.

47 models regarding different values related to proteolysis.

48 during processive steps of translocation and proteolysis.

49 which significantly slowed down the rate of proteolysis.

50 asomes, but also increase their capacity for proteolysis.

51 ucine residue (L6) to aspartic acid inhibits proteolysis.

52 se that the Ddi1 protease contributes to DPC proteolysis.

53 a helix previously thought to be removed via proteolysis.

54 bilized these inhibitors against mesotrypsin proteolysis 17- and 6.6-fold, respectively.

55 f pairs of tyrosines, and is completed by TG proteolysis(3).

56 g branch of the N-degron pathway-part of the PROTEOLYSIS 6 (PRT6)/N-degron pathway-as well as the und

57 eir migratory path using pericellular tissue proteolysis(6).

58 ins by cleavage, with the irreversibility of proteolysis allowing sustained downstream effects.

59 es, inhibit an apparently constitutive Dicer proteolysis, allowing for increased formation of miRNAs.

60 Peptides generated through proteolysis also showed incredible similarity to those r

61 0709-729 peptide in R6/2 mice prevents N-CAD proteolysis and ameliorates cognitive deficits in the mi

62 for intracellular, acidic hydrolase-mediated proteolysis and cellular degradation.

63 tic proteases (Clp) are central to bacterial proteolysis and control cellular physiology and stress r

64 an ADAM10 synthetic inhibitor reduces N-CAD proteolysis and corrects electrophysiological alteration

65 owever, the relative importance of regulated proteolysis and dephosphorylation in dictating the order

66 and ageing time on the oxidative stability, proteolysis and digestibility of fresh and long-term fro

67 material generated was resistant to trypsin proteolysis and displayed mechanical properties similar

68 have applied two gel-based approaches, pulse proteolysis and force-profile analysis, to probe the fol

69 boring a SMARCA4 allele amenable to targeted proteolysis and identify SMARCA4-dependent cell models w

70 hereas immune system response, regulation of proteolysis and iron homeostasis were dysregulated in se

71 cal Oxidation of Proteins (FPOP) followed by proteolysis and LC-ESI-MS/MS analyses.

72 In altered conditions, proteolysis and lipolysis decreased to different extents

73 derstanding of the evolution of dehydration, proteolysis and lipolysis during the maturation period t

74 R spectral bands characterising dehydration, proteolysis and lipolysis were individuated and studied

75 72.7%), with non-trivial interplays between proteolysis and lipolysis.

76 over, ECM turnover is partially dependent on proteolysis and network interactions, and slowing turnov

77 ment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain reg

78 roved technological (no moisture loss, lower proteolysis and organic acid content), texture (lower gu

79 a significant increase in genes involved in proteolysis and oxidative-reduction processes in juvenil

80 Two types of allergen bioactivity, namely proteolysis and peptidolipid/lipid binding, elicit IgE a

81 roteomics, we compare the relative extent of proteolysis and protein dephosphorylation.

82 Limited proteolysis and REMSA demonstrate the accessibility of t

83 Differential scanning calorimetry, limited proteolysis and small-angle X-ray scattering (SAXS) supp

84 ter protein are adequate to trigger complete proteolysis and that mutation of a single leucine residu

85 nal for the extracellular matrix (ECM)-based proteolysis and, consequentially, muscle cell dystrophy.

86 ion of ryanodine receptor, oxidative stress, proteolysis, and cross-sectional areas were evaluated.

87 ore, revealed by Raman spectroscopy, limited-proteolysis, and fibril disaggregation experiments, sugg

88 bility, residual toxicity, susceptibility to proteolysis, and loss of activity due to host cell, tiss

89 tion, we found that O-GlcNAcylation inhibits proteolysis, and strikingly, this stabilization occurs d

90 which includes genes involved in metabolism, proteolysis, and xenobiotic detoxification.

91 Modulators of PrP(C) proteolysis are of interest because full-length PrP(C) a

92 nsional structures while being stable toward proteolysis are of interest in biomedical research, chem

93 Plasmodium berghei ookinetes have identified proteolysis as a major biological pathway dependent on P

94 Limited proteolysis assays indicate that acetylation of Pif1 ind

95 epended on MyBP-C's N terminus as N-terminal proteolysis attenuated MyBP-C's functional capacities.

96 e, iron ion homeostasis, ubiquitin dependent proteolysis, autophagy and regulation of macroautophagy,

97 However, only the proteolysis-based strategy revealed additional fibrillog

98 r in the blood stream to evade clearance and proteolysis before interacting with the plasma membrane

99 d SpbR is normally cleared by ClpXP-mediated proteolysis before the time of chromosome segregation, i

100 of gastric peptide distribution and duodenal proteolysis between models.

101 phonuclear cells (PMNs) promote pericellular proteolysis by binding to PMN surfaces in a catalyticall

102 Following exposure to and proteolysis by caspase-3, the provector shows a 95-fold

103 compared to caspase-3 and that RNA enhances proteolysis by caspase-7 of many of these RNA-BPs.

104 ggest that the Cys-17-Cys-34 disulfide slows proteolysis by dampening conformational fluctuations in

105 er serves a protective role against unwanted proteolysis by endogenous proteases.

106 reover, whey proteins were more resistant to proteolysis by latex peptidases; however, heat pretreatm

107 Proteolysis by MMP20, however, is essential for the prev

108 Previously we showed that perisynaptic proteolysis by MMP9 mediates the enhancement of plastici

109 oblast migration and conferred resistance to proteolysis by multiple proteases.

110 e assay can be used to measure modulation of proteolysis by potential therapeutics and offer new mech

111 Regulated proteolysis by proteasomes involves ~800 enzymes for sub

112 This identifies intramembrane proteolysis by SPPL2a/b as a novel atheroprotective mech

113 -secretase complex, poised for intramembrane proteolysis, by cryo-electron microscopy.

114 Blocked immunoproteasome proteolysis, by treatment of TLR2 (Toll-like receptor 2)

115 milial AD patients, which restores lysosomal proteolysis, calcium homeostasis, and normal autophagy f

116 lluminate biochemical pathways through which proteolysis causes plaque rupture and identify substrate

117 t initial rates of iron oxide-associated BSA proteolysis, comparable to proteolysis of BSA in solutio

118 This subdomain is susceptible to proteolysis, consistent with local disorder.

119 Limited proteolysis coupled with LC-MS/MS could reveal the chang

120 structure-guided cysteine cross-linking and proteolysis-coupled gel analysis to probe the conformati

121 The kinetic proteolysis curves are measured with continuously repeat

122 Proteolysis depends upon shear-induced conformational ch

123 However, uncharacterized proteolysis during brewing followed by the secondary dig

124 Indeed, PARP-1 proteolysis efficacy is sensitive to RNase A and promote

125 The proteolysis experiments were performed using different w

126 pared to control), being salmon and sea bass proteolysis extent (40 and 33%, respectively) the most a

127 cation fork collision with DPCs causes their proteolysis, followed by translesion DNA synthesis.

128 heads, including DNA repair, metabolism, and proteolysis genes.

129 Q mutant, we observed a drastic reduction in proteolysis, hemolysis, and pigmentation that was fully

130 ), and overexpression of PPARGC1B inhibiting proteolysis imply suppression of protein degradation in

131 work has demonstrated the utility of limited proteolysis in helping to elucidate the potential biolog

132 s during ATP-driven unfolding and subsequent proteolysis in solution.

133 ovide kinetic and mechanistic description of proteolysis in terms of initial hydrolysis rate, r(0), a

134 rotease Tolkin (Tok) is responsible for Slit proteolysis in vivo and in vitro.

135 Markers of proteolysis including calpain 1 and calpain 2 remained a

136 tegically targeted Nrf2 for degradation in a proteolysis-independent manner; NS2B3 licensed Nrf2 for

137 ures, whereas spectroscopic data and limited proteolysis indicate that H6 displays poorly cooperative

138 lated disorders stem from defective end-step proteolysis inside lysosomes.

139 Ubiquitin (Ub)-mediated proteolysis is a fundamental mechanism used by eukaryoti

140 Rationale: Proteolysis is a key aspect of the lung's innate immune

141 Proteolysis is a major posttranslational regulator of bi

142 Fzo1 proteolysis is activated by metabolic stress that arises

143 We show here that when DPC proteolysis is blocked, the replicative DNA helicase CMG

144 ggest that Iduna-mediated regulation of Axin proteolysis is essential for tissue homeostasis in the D

145 N2 is only active outside meristems when its proteolysis is inhibited in response to cold exposure, a

146 Thus, intramembrane proteolysis is naturally diffusion-limited, but cells mi

147 f PRR5 is much reduced, suggesting that PRR5 proteolysis is promoted by SPY-mediated O-fucosylation.

148 ERFVII proteolysis is regulated by the N-degron pathway and med

149 rdination between protein disaggregation and proteolysis is required to survive proteotoxic stress ca

150 The effect of e-cigarettes (vaping) on proteolysis is unknown.

151 Such proteolysis is very intense and consists of the generati

152 erein, we provide a contemporary view of how proteolysis, lipid-binding activity and interactions wit

153 elderly gastrointestinal (GI) conditions on proteolysis, lipolysis and calcium and vitamins A and D3

154 Matrix proteolysis mediated by MT1-MMP facilitates the invasive

155 streamlined, high-throughput, and controlled proteolysis method was successfully established.

156 Dysregulation of SPOP-mediated proteolysis might be involved in the development and pro

157 reduced prohibitin complex disruption, OPA1 proteolysis, mitochondrial fragmentation, and apoptosis,

158 nhibited prohibitin complex disruption, OPA1 proteolysis, mitochondrial fragmentation, and apoptosis.

159 and Bif-1-deficiency protected against OPA1 proteolysis, mitochondrial fragmentation, apoptosis and

160 omics and chemometrics further revealed that proteolysis mostly hampered the oxidized peptides rather

161 Besides the expected progress of proteolysis occurring during storage, light negatively a

162 intuitive role in promoting PMN pericellular proteolysis occurring in chronic obstructive pulmonary d

163 Excessive proteolysis occurs with chronic tobacco use and is causa

164 ative rearrangement, carboxymethylation, and proteolysis of a terminal cysteine yields an amino acid-

165 istic model of TDMD in which target-directed proteolysis of AGO by the ubiquitin-proteasome pathway e

166 localized to the shoot meristem inhibits the proteolysis of an N-degron-pathway(4,5) substrate known

167 How ER retention, Golgi trafficking, and proteolysis of ATF6alpha are regulated and whether addit

168 er of E2F regulation, demonstrating temporal proteolysis of both activator and atypical repressor E2F

169 ing defect was accompanied by a delay in the proteolysis of both L1 and L2 in mutated HPV-16 PsVs.

170 AS-specific DARPin degrader induces specific proteolysis of both mutant and wild type KRAS, it only i

171 de-associated BSA proteolysis, comparable to proteolysis of BSA in solution, and very slow rates at p

172 Simultaneous detection of the proteolysis of cathepsin B on the microelectrode array f

173 ns affected by ADAMTS5 and revealed specific proteolysis of complement C3 and fibronectin associated

174 Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chr

175 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase en

176 hat dephosphorylation initiated by selective proteolysis of cyclin B drives the bulk of changes obser

177 This reveals highly-selective rapid proteolysis of cyclin B, securin and geminin at the meta

178 gibberellin (GA) response relies on targeted proteolysis of DELLA proteins mediated by a GA-activated

179 Both endosomal proteolysis of EBOV GP and binding of mAb FVM09 displace

180 ellular senescence and disrupts MMP-mediated proteolysis of ECM components such as fibronectin and co

181 In conclusion, we found that proteolysis of extracellular enamel matrix proteins by M

182 ponent of the FA core complex, and regulated proteolysis of FAAP20 mediated by prolyl cis-trans isome

183 (2020) demonstrate that proteolysis of gliomedin, which drives initial channel c

184 rface, assisting bacterial dissemination via proteolysis of host defense proteins.

185 rch was to determine the effect of pH on the proteolysis of human milk.

186 developed here for the stabilization against proteolysis of Kunitz domains, which can serve as import

187 non-redundant role for ADAM17 in TCR-induced proteolysis of L-selectin in mouse and human T cells and

188 se results, we propose that ADAM17-dependent proteolysis of L-selectin should be considered a regulat

189 The technique is based on limited proteolysis of live cells in the absence of denaturation

190 We show that spontaneous proteolysis of MADD-4B first generates a shorter N-MADD-

191 Results documented that the proteolysis of milk proteins, particularly beta-casein,

192 resence of L or S at P8 resulted in a slower proteolysis of MuV F by furin and a reduced ability to m

193 lating I(NaP) and KCC2, the calpain-mediated proteolysis of Nav and KCC2 drives the hyperexcitability

194 implicated in the formation of NETs through proteolysis of nuclear proteins leading to chromatin dec

195 Meanwhile, continued APC/C activity promotes proteolysis of other mitotic regulators.

196 aphase-anaphase transition, followed by slow proteolysis of other substrates.

197 cognized by the proteasome, leading to rapid proteolysis of Rb.

198 Controlled proteolysis of sigma(S) is regulated by RssB which maint

199 Polyubiquitination and proteolysis of SMAX1 and SMXL2 then enable growth respon

200 dk1 phosphorylation but by APC-Cdh1-mediated proteolysis of the Cdk1 activator, cyclin B1, secondary

201 Importantly, TAILS also identified proteolysis of the latent TGF-beta-binding proteins 3 an

202 PAR4 is activated by proteolysis of the N terminus to expose a tethered ligan

203 atterns of digestion rates were found due to proteolysis of the oriented and nonoriented antibodies o

204 7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1 (PARP-1

205 anonical Notch signaling relies on regulated proteolysis of the receptor Notch to generate a nuclear

206 in the CCSSD enable regulated intramembrane proteolysis of the sigma regulator, ultimately resulting

207 ialised repair complex required for upstream proteolysis of TOP1ccs and their subsequent resolution.

208 Proteolysis of transmembrane receptors is a critical cel

209 Intramembrane proteolysis of transmembrane substrates by the presenili

210 ation, and originated predominantly from the proteolysis of two storage proteins - vicilin and a 21 k

211 ctin and determined the impact of L-selectin proteolysis on T cell activation in virus-infected mice.

212 eered multivalent tethered antibody formats, proteolysis or deconjugation at the fusion or conjugatio

213 r loss of growth restraint due to excess p27 proteolysis or from an oncogenic gain of function throug

214 of compound libraries for effects on PrP(C) proteolysis or overall expression level.

215 r the degradation of matrix via endocytosis, proteolysis, or both.

216 ervations, we propose that RGMA-induced NEO1 proteolysis orchestrates NT morphogenesis by promoting N

217 al root development when the auxin-dependent proteolysis pathway fails.

218 The ubiquitin (Ub) proteolysis pathway uses an E1, E2, and E3 enzyme cascad

219 The use of two proteolysis pathways to tune levels of UmuD might reflec

220 lipid and protein oxidative stabilities and proteolysis pattern compared to control straight-dry-age

221 nerated in dry-cured ham as a consequence of proteolysis phenomenon exerted by muscle peptidases.

222 Regulation of proteolysis plays a critical role in a myriad of importa

223 We demonstrate that proteolysis plays an important role in a biological proc

224 , antitoxin bound to toxin is protected from proteolysis, preventing release of active toxin.

225 in callose accumulation, lignin deposition, proteolysis process, transcriptional activation/repressi

226 solved oxygen, riboflavin and other flavins, proteolysis products, volatile compounds, and sensory ch

227 Altogether we have characterized a novel proteolysis/proteasome-dependent pathway involved in deg

228 the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for interdisciplinary

229 e plant immune system, through the E3 ligase PROTEOLYSIS (PRT)6.

230 Further, we uncover differential proteolysis rates for E2F8 at different points within G1

231 While the functional proteolysis regulated by proteases plays a central role

232 e essential enzyme for DNA-protein crosslink proteolysis repair.

233 C, its resistance to strand cleavage and the proteolysis requirement for resolution.

234 In this context of targeted proteolysis research spurring the emergence of innovativ

235 Acute inhibition of calpains reduced this proteolysis, restored the motoneuronal expression of Nav

236 CcrM DNA methyltransferase and Lon-mediated proteolysis restrict CcrM to a specific time in the cell

237 membrane proteins by regulated intramembrane proteolysis (RIP) and regulated alternative translocatio

238 on, possibly through regulated intramembrane proteolysis (RIP), to increase intracellular cholesterol

239 events are known as regulated intramembrane proteolysis (RIP).

240 ese two functions are seemingly regulated by proteolysis: S100A9 is readily degraded, while S100A8/S1

241 nt in senescence-related processes including proteolysis, sugar transport and signaling, and sink act

242 n solution, and very slow rates at prolonged proteolysis suggest a large variability in mineral-assoc

243 the extent of beta1-regulated intramembrane proteolysis, suggesting that the plasma membrane is the

244 teric inhibitors, peptidomimetics, and novel proteolysis-targeted chimera (PROTAC) technology that ha

245 ged including modulation of auto-inhibition, proteolysis targeting chimaeras (PROTACs), use of cystei

246 f small-molecule MDM2 degraders based on the proteolysis targeting chimera (PROTAC) concept.

247 Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focu

248 apable of selectively targeting MCL1 using a proteolysis targeting chimera (PROTAC) methodology leadi

249 Proteolysis targeting chimera (PROTAC) recruits an E3 li

250 , Saraswat and colleagues identified a novel proteolysis targeting chimera (PROTAC), ARV-825 (ARV), t

251 en for ligands that bind proteins, including proteolysis targeting chimera (PROTAC)-like molecules.

252 ic depletion, pharmacological inhibition, or proteolysis targeting chimera (PROTAC)-mediated degradat

253 Based on the proteolysis targeting chimera strategy, we previously de

254 Using the proteolysis targeting chimera technology, we discovered

255 GFR degrader, MS154 (compound 10), using the proteolysis targeting chimera technology.

256 with BET protein inhibitor or degrader (BET-proteolysis targeting chimera) repressed RUNX1 and its t

257 mall-molecule ERalpha degraders based on the proteolysis targeting chimeras (PROTAC) concept.

258 ion of small molecules and peptides and even PROteolysis TArgeting Chimeras (PROTACs) and proteins.

259 Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer new ways

260 Hetero-bifunctional PROteolysis TArgeting Chimeras (PROTACs) represent a new

261 Proteolysis targeting chimeras (PROTACs) represent an ex

262 Using PROteolysis TArgeting Chimeras (PROTACs) to degrade prot

263 c protease inhibitors, and the maturation of proteolysis targeting chimeras as promising chemical too

264 Proteolysis-targeting chimaera (PROTAC) technology is an

265 Protein-degradation platforms such as proteolysis-targeting chimaeras (PROTACs)(1,2) and other

266 HP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept.

267 CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PROTAC) degraders selecti

268 the required properties for conversion into proteolysis-targeting chimera (PROTAC) degraders.

269 By using a proteolysis-targeting chimera (PROTAC) strategy that cou

270 Here, we report the use of proteolysis-targeting chimera (PROTAC) technology to red

271 improved response, we developed a series of proteolysis-targeting chimera (PROTAC) that allosterical

272 263, we converted it into DT2216, a BCL-X(L) proteolysis-targeting chimera (PROTAC), that targets BCL

273 ended to the synthesis of a proof-of-concept proteolysis-targeting chimera (PROTAC), which efficientl

274 g PNPLA3 levels by either shRNA knockdown or proteolysis-targeting chimera (PROTAC)-mediated degradat

275 C2059 combined with depletion of BRD4 by BET proteolysis-targeting chimera reduced c-Myc levels and e

276 PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifu

277 PROteolysis-TArgeting Chimeras (PROTACs) have been devel

278 Accordingly, we developed CDK4/6-targeted proteolysis-targeting chimeras (PROTACs) that inhibit CD

279 Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capa

280 e a compelling mechanism of native substrate proteolysis that is promoted by entropy-driven specifici

281 Overall, processing affected proteolysis the most (f-ratio = 5.86), while intestinal

282 -NS from DNA, the PhoP protein promoted H-NS proteolysis, thereby de-repressing foreign genes-even th

283 tabilize the Kunitz domain structure against proteolysis through disulfide engineering.

284 ) of oriented antibodies on MBs, restricting proteolysis to mainly Fab regions.

285 rity and unequivocal input/response of Notch proteolysis to screen surface receptors for other putati

286 osomal maturation, often in conjunction with proteolysis, triggers viral proteins to insert into the

287 substrate of Siah1 is ELL2, which undergoes proteolysis upon polyubiquitination.

288 ta1 subunits undergo regulated intramembrane proteolysis via the activity of beta-secretase 1 and gam

289 Proteolysis was highly affected by elderly GI alteration

290 In the standard conditions, proteolysis was not affected by processing, but lipolysi

291 ts that recapitulate replication-coupled DPC proteolysis, we show that DPCs can be degraded by SPRTN

292 to metabolism, oxidative phosphorylation and proteolysis were significantly over-represented among th

293 aVal increased the resistance of peptides to proteolysis when incorporated at the 3-position and had

294 CMA) is the most selective form of lysosomal proteolysis, where individual peptides, recognized by a

295 ent reports demonstrating optical control of proteolysis with chimeric molecules bearing photolabile

296 s of prothrombin can be monitored by limited proteolysis with chymotrypsin that attacks W468 in the f

297 inol binding site on RBP4 when adopting this proteolysis with HDX.

298 man plaques identify mechanisms that connect proteolysis with plaque rupture, including inflammation,

299 ting the Arg/N-end rule and the p97-mediated proteolysis with the replication stress response, workin

300 cologic mTORC1 inhibition restores lysosomal proteolysis without correcting cholesterol storage, impl