ライフサイエンスコーパス: proteolytic

1 cretion and identified a specific N-terminal proteolytic ACLP fragment.

2 te in most assays was related to its greater proteolytic action on main proteins (avenin, 11S- and 12

3 The proteolytic actions of this cellular endoprotease help t

4 into the lumen of the late endosome and its proteolytic activation in lipid rafts.

5 a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor prot

6 One innate immune response in insects is the proteolytic activation of hemolymph prophenoloxidase (pr

7 1P) and site-2 protease (S2P) is involved in proteolytic activation of membrane-bound transcription f

8 Proteolytic activation of phenoloxidase (PO) and the cyt

9 inical-stage mAb that prevents extracellular proteolytic activation of pro- and latent myostatin.

10 diated inhibition of apoptosis by preventing proteolytic activation of procaspase-8, we define pUL36

11 ing a mutation (Bmp7(R-GFlag)) that prevents proteolytic activation of the dimerized BMP7 precursor p

12 Coupled with receptor binding, proteolytic activation offers a new parameter to evaluat

13 , membrane-bound transcription factors whose proteolytic activation requires the cholesterol-sensing

14 orm covalent conjugation products upon their proteolytic activation.

15 o conformational changes and become prone to proteolytic activation.

16 the contributions of the nonproteolytic and proteolytic activities of Mt2 by taking advantage of Mt2

17 DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or t

18 Strains with distinctive proteolytic activities were identified.

19 L. sanfranciscensis I4) possessing different proteolytic activities were used to produce sourdoughs c

20 of MALT1 and inhibits MALT1 scaffolding and proteolytic activities.

21 we showed that FXII expresses a low level of proteolytic activity (independently of FXIIa) that may i

22 pre-UC-colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone com

23 ogenic signaling, and a postnatal phase with proteolytic activity and reduced elastic fibres.

24 contributes to promote inflammation-mediated proteolytic activity and uncovers a target for restoring

25 ns would benefit from wireless monitoring of proteolytic activity at minimal cost, e.g., sensors embe

26 context, we sought to investigate how MALT1 proteolytic activity contributes to the overall allergic

27 A significant increase in the overall ATG4 proteolytic activity in Arabidopsis was detected under n

28 h an impaired luminal acidic environment and proteolytic activity in the lysosomes.

29 sue lymphoma translocation protein 1 (MALT1) proteolytic activity in the suppression of autoimmune re

30 lays a determinant role and suggest that the proteolytic activity is not an appropriate target to mod

31 The aim of our study was to characterize the proteolytic activity of 170 Lactobacillus strains isolat

32 called the inflammasome, which unleashes the proteolytic activity of a cysteine protease caspase-1.

33 Proteolytic activity of Ddi1 requires the HDD domain and

34 of FtsH as its deletion fully eliminated the proteolytic activity of FtsH.

35 with the catalytic histidine that makes the proteolytic activity of GII.4 protease pH sensitive.

36 t failed to infect mice, suggesting that the proteolytic activity of Lon-1 is essential for bacterial

37 LT-231 potently and selectively inhibits the proteolytic activity of MALT1 in NF-kappaB-dependent ass

38 Constitutive proteolytic activity of MALT1 is associated with highly

39 The proteolytic activity of metalloproteinases is post-trans

40 Moreover, elevated proteolytic activity of MMP2 and MMP9 was linked to a 50

41 sis of a NP that sequesters and inhibits the proteolytic activity of snake venom metalloproteinases f

42 Although adhered, eosinophils exhibited no proteolytic activity on collagen matrices.

43 by transducing NF-kappaB signaling, and its proteolytic activity represents a key node for therapeut

44 showed that the purified EV-D68 2A(pro) has proteolytic activity selective against a peptide sequenc

45 ibited a better inhibitory effect on TMPRSS2 proteolytic activity than HAI-1, and recombinant HAI-2 p

46 We have identified increased fecal proteolytic activity that precedes the clinical diagnosi

47 All isolates were screened for proteolytic activity using skim milk agar-well diffusion

48 -CoV-2 trimeric spike protein increased ACE2 proteolytic activity ~3-10 fold against model peptide su

49 In addition to their cognate extracellular proteolytic activity, ADAMTS9 and ADAMTS20 thus have an

50 account growth rate, acidification capacity, proteolytic activity, cell envelope associated peptidase

51 ndolysosome, such compounds can modulate the proteolytic activity, including its processing by cystei

52 icate that the catalytic domain, but not its proteolytic activity, was required for Mt2 to suppress h

53 ears to be independent of its calpain domain proteolytic activity.

54 lolytic, cellulolytic and lipolytic, but not proteolytic activity.

55 o role in either NETosis or arming NETs with proteolytic activity.

56 transponders as a transduction mechanism of proteolytic activity.

57 wed comparable inhibitory effects on TMPRSS2 proteolytic activity.

58 interesting in food analysis, as well as non-proteolytic aminoacyl derivatives, which are well-known

59 , functional analysis showed increased fecal proteolytic and elastase activity before UC onset.

60 and function of the aortic wall by enhanced proteolytic and phagocytic activity; however, the cells

61 t factors including compartmental pH, redox, proteolytic, and proteostatic factors, and inhibited by

62 mational changes in the protein, including a proteolytic autoprocessing event.

63 by increasing the protein content and using proteolytic bacteria strain to enable the release of bio

64 of retromer Vps35 subunit reduces lysosomal proteolytic capacity as a consequence of the improper pr

65 Fzo1 degradation is mediated by a proteolytic cascade consisting of the E3 ubiquitin ligas

66 he complement system is a tightly controlled proteolytic cascade in the innate immune system, which t

67 This important and well-described proteolytic cascade is governed by numerous protease-sub

68 haperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which

69 enormous amounts of heme released during the proteolytic catabolism of erythrocytic hemoglobin.

70 d abundant in the mammalian brain, these non-proteolytic chains are underappreciated in neurons and s

71 directly translocated from PAN into the 20S proteolytic chamber, after a first, to our knowledge, su

72 essive substrate translocation into the ClpP proteolytic chamber.

73 te unfolding and translocation into the ClpP proteolytic chamber.

74 We show that proteolytic cleavage and acid pH have significant effect

75 Thus, the combination of proteolytic cleavage and the destabilizing mutation trig

76 y in trypsin-like proteases is the result of proteolytic cleavage at R15 followed by an ionic interac

77 d precursor protein (APP) through sequential proteolytic cleavage by BACE1 and gamma-secretase.

78 t manner, the depletion of ORP2 resulting in proteolytic cleavage by matrix metalloproteinases, and r

79 mbrane protein, which is further matured via proteolytic cleavage by metalloproteases such as ADAM17,

80 The untranslocated MLL1 is a substrate for proteolytic cleavage by the endopeptidase threonine aspa

81 GNPTAB activity is dependent upon proteolytic cleavage by the SKI-1/S1P protease.

82 eight extracellular proteases, we show that proteolytic cleavage by these enzymes is not a prerequis

83 As proteolytic cleavage contributes to the activation of th

84 We show that TapA is subjected to proteolytic cleavage in the colony biofilm and that only

85 tivity of IL-12 and provided protection from proteolytic cleavage in-vitro.

86 eased from the bacterial surface by specific proteolytic cleavage into the culture supernatant allowi

87 RTANCE Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection

88 d neurotrophic factor (BDNF) is generated by proteolytic cleavage of a prodomain from the proBDNF pre

89 membrane protease complex that catalyzes the proteolytic cleavage of amyloid precursor protein and No

90 In AD brain, state the sequential proteolytic cleavage of APP by beta secretase 1 enzyme (

91 Pharmacological strategies targeting the proteolytic cleavage of APP disrupt the relationship bet

92 The proteolytic cleavage of beta-amyloid precursor protein (

93 r activated phospho-Syk- and ADAM17-mediated proteolytic cleavage of CD16.

94 dent metalloprotease, is a central player in proteolytic cleavage of DPCs.

95 s, most likely via a mechanism that involves proteolytic cleavage of endothelial cell-cell adhesins s

96 CTD (TDP-43 C-terminal domain), formed upon proteolytic cleavage of full-length TDP-43 in the nucleu

97 Proteolytic cleavage of Gag results in a mature, infecti

98 elective MMP-9 inhibition to protect against proteolytic cleavage of hepatic VEGF using either MMP-9

99 ion: Liver-selective MMP inhibition prevents proteolytic cleavage of hepatic VEGF, which enhances rec

100 ement membrane in the rat testis, likely via proteolytic cleavage of matrix metalloproteinase 9.

101 generation is feasible via demonstration of proteolytic cleavage of one of the acylated analogues.

102 ch repeat (NLR) protein, is activated by the proteolytic cleavage of PBS1.

103 Surprisingly, the aptamer enhanced proteolytic cleavage of precursor p66/p66 by HIV-1 prote

104 The mature middle domain, generated after proteolytic cleavage of proSP-B, generates the striking

105 nit incorporation could be synchronized with proteolytic cleavage of the C-terminal pro-peptide that

106 Proteolytic cleavage of the cell adhesion molecule L1 (L

107 Keratinocyte migration is mediated mainly by proteolytic cleavage of the extracellular matrix and/or

108 in the HIV-1 replication cycle that requires proteolytic cleavage of the Gag polyprotein into its con

109 s to ssDNA, forming filaments that stimulate proteolytic cleavage of the LexA transcriptional repress

110 We show that proteolytic cleavage of the patient LC resulting in an i

111 Proteolytic cleavage of the S protein exposes its fusion

112 results argue that both receptor binding and proteolytic cleavage of the spike are critical factors t

113 Together, these results indicate that proteolytic cleavage of the spike, not receptor binding,

114 PARs are activated by proteolytic cleavage of their receptor N terminus by enz

115 Within mitochondria, MOCS1AB underwent proteolytic cleavage resulting in mitochondrial matrix l

116 amino acid residue at position 8 (P8) of the proteolytic cleavage site of MuV F, because this amino a

117 arm region of the prodomain distant from the proteolytic cleavage sites.

118 the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, wher

119 verifying mutant cell surface expression and proteolytic cleavage, we tested their ability to mediate

120 shed aiming at deciphering the mechanisms of proteolytic cleavage.

121 imerized with neuroligin-3, they too undergo proteolytic cleavage.

122 t Ripk3(-/-) mice, recapitulates ALI-induced proteolytic collapse of arterial architecture.

123 The proteolytic core of Clp comprises subunits from one plas

124 nce of AAA and accelerates macrophage-driven proteolytic damage of the aortic wall.

125 avage signatures of 178 proteases highlights proteolytic degeneracy wired into the SARS-CoV-2 lifecyc

126 has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspe

127 jection, protection of antigen payloads from proteolytic degradation and reduction of antigen present

128 still highly stable in aqueous media, whose proteolytic degradation could be used in these wireless

129 s are thought to remove TOP2ccs primarily by proteolytic degradation followed by DNA DSB repair.

130 Proteolytic degradation of a structurally aberrant enzym

131 nctional tPA-plasmin system causes defective proteolytic degradation of Abeta plaques in advanced sta

132 Thus, the bacterial production and proteolytic degradation of leupeptins can be associated

133 in lung destruction not only through direct proteolytic degradation of matrix proteins, but also thr

134 ptake from biofilm formation, likely through proteolytic degradation of proteinaceous components of t

135 is essential as it controls ClpCP-dependent proteolytic degradation of the essential enzyme MurA, wh

136 iciently destroyed by granzyme B, suggesting proteolytic degradation of these proteins as essential i

137 BM through which they can invade, either via proteolytic degradation or mechanical force.

138 eptors from the surface and their subsequent proteolytic degradation were the primary mechanisms resp

139 ificity of alpha-helices in proteins, resist proteolytic degradation, and may provide a novel modalit

140 mma-AA peptides were completely resistant to proteolytic degradation, boosting their potential for bi

141 sk but not low-risk HPV E7 target PTPN14 for proteolytic degradation, suggesting that PTPN14 degradat

142 g the high resistance of synthetic PvD(1) to proteolytic degradation, we claim that conditions are no

143 zymatic systems, since enzyme can be lost to proteolytic degradation.

144 human blood monocytes, indicating a specific proteolytic degradation.

145 readily designed to resist denaturation and proteolytic degradation.

146 defensins exhibit increased vulnerability to proteolytic degradation.

147 d to the LNs only within migratory DCs after proteolytic degradation.

148 ss of a structurally aberrant enzyme through proteolytic degradation.

149 nderwent in vitro simulated gastrointestinal proteolytic digestion after a wide range of thermal trea

150 continuous labeling experiment, followed by proteolytic digestion and MS analysis, generates a large

151 egumes, the simulated gastrointestinal tract proteolytic digestion induced marked changes not only in

152 ods target signature peptides resulting from proteolytic digestion of proteins of the allergenic ingr

153 includes seven stages of: (1) extraction and proteolytic digestion of proteins to peptides, (2) seque

154 HDX-MS relies on successful proteolytic digestion of target proteins under acidic co

155 dence of enamel proteome phosphorylation and proteolytic digestion that occurred in vivo during tooth

156 spectrometric analysis (HDX-MS) coupled with proteolytic digestion was used to identify the early sta

157 dation experiments demonstrated differential proteolytic digestion, as a function of thermal stabilit

158 Through the assessment of proteolytic digestion, tandem mass tag (TMT) labeling, o

159 Leucine aminopeptidase (LAP) is an essential proteolytic enzyme and potential biomarker for liver mal

160 wound care dressing is flexible cross-linked proteolytic enzyme degradation resistant.

161 The proteolytic enzyme might be a new translational target r

162 ormulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in

163 In this study, three proteolytic enzymes (pepsin, trypsin, Alcalase(R)) were

164 ark is degradation of articular cartilage by proteolytic enzymes leading to loss of joint function.

165 treatment of ex vivo porcine cartilage with proteolytic enzymes resulted in decreased AFL.

166 mass spectrometry-based proteomics utilizes proteolytic enzymes with well characterized specificitie

167 e addition of external coagulation proteins, proteolytic enzymes, or phospholipids.

168 viously loaded with trypsin and chymotrypsin proteolytic enzymes, was successfully exploited.

169 -based selectivity is a general attribute of proteolytic enzymes.

170 These proteolytic events are known as regulated intramembrane

171 Proteolytic fragmentation of polyglutamine-expanded atax

172 This approach efficiently analyzes proteolytic fragments and native proteins in a complex m

173 tform) to attempt to identify substrates and proteolytic fragments in mouse and human plaque extracts

174 pecifically respond to OS via recognition of proteolytic fragments of chloroplastic ATP synthase, ter

175 platform did not detect robust increases in proteolytic fragments of ECM proteins in either setting.

176 ography (RPLC) column reduction, the ~25 kDa proteolytic fragments were analyzed using hydrophilic in

177 We demonstrate that tagging proteolytic fragments with mass sensitivity probes in a

178 rification of the protein and removal of any proteolytic fragments.

179 composition and interactions influencing the proteolytic function of the apicoplast Clp system and de

180 a functions as an adhesin independent of its proteolytic function to suppress early neutrophil influx

181 supports a general base mechanism for Mpro's proteolytic function.

182 lso through activation of M inflammatory and proteolytic functions.

183 s and a larger set of seemingly more mundane proteolytic genes.

184 or fructosyl valine (FV), the product of the proteolytic hydrolysis of HbA1c.

185 ease and prolonged protein stability against proteolytic hydrolysis.

186 ofiling of NPC lysosomes, we find pronounced proteolytic impairment compounded with hydrolase depleti

187 in the disruption of prohibitin complex and proteolytic inactivation of the inner membrane fusion pr

188 Consistent proteolytic kinetics are measured by monitoring the deca

189 om raw or heat treated milk, with or without proteolytic L. helveticus and ripened for 120 days.

190 mammalian cell lies in properly functioning proteolytic machineries called proteasomes.

191 ell-orchestrated Clp (caseinolytic protease) proteolytic machinery consisting of two oligomeric segme

192 identify how the immunoproteasome, the main proteolytic machinery in immune cells harboring 3 distin

193 proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins.

194 d the range of biological events governed by proteolytic machinery to microbial community structure,

195 fation and proline hydroxylation within, and proteolytic maturation after exit from the Golgi.

196 ER stress inhibits proteolytic maturation of insulin proreceptors by interf

197 of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1beta (IL-1beta) a

198 e absence of VII (Ad5-VII-) are deficient in proteolytic maturation of protein VI and endosome escape

199 dification of nucleocytoplasmic proteins and proteolytic maturation of the transcriptional coregulato

200 scopy and EM, we also demonstrate that these proteolytic maturations occur after secretion of collage

201 lication-coupled manner; however, additional proteolytic mechanisms may exist to cope with the divers

202 acellular peptides derived from a variety of proteolytic mechanisms play a crucial role in subsequent

203 t and had no association with cellular/viral proteolytic mechanisms, suggesting that the CA degradati

204 importance for our understanding of how the proteolytic microenvironment is modified in epithelial-s

205 e and are prone to degradation in the acidic-proteolytic milieu of the gastrointestinal tract, leadin

206 otease binding and catalysis are determined, proteolytic network dynamics can be explored using compu

207 lations of multiple proteases working in one proteolytic network of interactions occurring in a defin

208 Thus, we identified a novel proteolytic pathway of meprin beta with ADAM proteases t

209 hysiological substrate of the Arg/N-end rule proteolytic pathway, in which UBR1 and UBR2 ubiquitin li

210 y and involves a phosphorylation-independent proteolytic pathway.

211 ce dynein-mediated trafficking of nephrin to proteolytic pathways, diminishing its recycling required

212 , both pasteurization methods led to similar proteolytic patterns, while raw HM presented a higher na

213 late the determined isotope pattern for each proteolytic peptide at each labeling time.

214 ported ~89 800 centroid measurements for 430 proteolytic peptide sequences of the Fab fragment (~78 9

215 oO-Tn utilizes solid-phase immobilization of proteolytic peptides of proteins, which modifies Tn by g

216 In contrast, proteasome-independent non-proteolytic polyubiquitin chains regulate protein scaffo

217 Mechanistic studies pinpoint multiple SREBP proteolytic processes and SREBP-regulated lipid biosynth

218 e P8 residue has a significant effect on the proteolytic processing and fusogenicity of MuV F and mig

219 intracellular calcium concentration induces proteolytic processing and secretion of interleukin (IL)

220 We demonstrate that P8 affects the proteolytic processing and the fusogenicity of MuV F.

221 phin, and proopiomelanocortin, by sequential proteolytic processing by prohormone convertases and car

222 In Huntington's disease (HD), proteolytic processing generates toxic N-terminal huntin

223 Tau protein is subjected to proteolytic processing into fragments before being secre

224 hance virion assembly, but C16/B22 increases proteolytic processing of core proteins in A549 cells co

225 anoma 2) containing inflammasome and induces proteolytic processing of cytokine precursors such as pr

226 al changes in target cells by inhibiting the proteolytic processing of full-length Drosophila Ci or m

227 ssembled via a novel mechanism that involves proteolytic processing of lipidated precursor subunits a

228 Recent reports have indicated that proteolytic processing of PGRN to smaller protein module

229 nd inhibitory profile of PLD3 and found that proteolytic processing of PLD3 is dispensable for its hy

230 Therefore post-translational proteolytic processing of polyproteins into mature pepti

231 Polypeptides generated from proteolytic processing of protein precursors, or proteol

232 ion of Abeta levels was related to increased proteolytic processing of the amyloid precursor protein.

233 ns in Hp oligomerization, glycosylation, and proteolytic processing of the Hp alpha-chain.

234 lls with proteasome inhibitors prevented the proteolytic processing of trapped TOP2ccs, suppressed th

235 Due to mechanisms such as proteolytic processing or alternative translation starts

236 terature suggests a critical role of partial proteolytic processing resulting in various truncations

237 We followed the expression, proteolytic processing, and intracellular distribution o

238 hat the plasma membrane is the site of beta1 proteolytic processing.

239 e their proximity-induced autoactivation and proteolytic processing.

240 nd that all three undergo post-translational proteolytic processing.

241 A proteolytic product, soluble TREM2 (sTREM2), is abundant

242 ic measurements to monitor the generation of proteolytic products in solution as well as the real-tim

243 we investigated the interactions between the proteolytic products of both TDP-43 and PGRN.

244 The proteolytic profile and epithelial-mesenchymal transitio

245 ociated with known lysosomal trafficking and proteolytic proteins like SQSTM1, CTSD, and LGMN.

246 Particularly, we discovered several proteolytic proteoforms of pro-opiomelanocortin and prod

247 eolytic processing of protein precursors, or proteolytic proteoforms, play an important role in diver

248 Mass spectrometry analysis of fibrinogen proteolytic reactions detected the presence of eosinophi

249 eters and following their development during proteolytic reactions is therefore essential for process

250 een proteins and soil minerals restrict such proteolytic reactions.

251 Notch proteolytic regulation is a notable exception, where int

252 hanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed re

253 mechanisms; however, the post-translational proteolytic regulation of Sestrin-2 remains unclear.

254 Proteolytic regulation of the translocases is critically

255 or growth, metastasis, integrin binding, and proteolytic regulation.

256 Protease activity is read out via proteolytic release of a membrane-anchored transcription

257 residues of the NOTCH3 N terminus activated proteolytic release of the first EGF-like repeat, sugges

258 lved in the prerequisite steps of N-terminal proteolytic release were unknown until now.

259 Surprisingly, proteolytic removal of the DR5 ectodomain can fully acti

260 fects on S100A9 proinflammatory activity and proteolytic resistance but has little effect on S100A8/S

261 s otherwise not inherent to the sequence: 1) proteolytic resistance compared to the oligopeptide alon

262 that S100A9 evolved both functions and lost proteolytic resistance from a weakly proinflammatory, pr

263 s have increased alpha-helicity and improved proteolytic resistance without any loss of disrupting ac

264 The assemblies of AVPI exhibit enhanced proteolytic resistance.

265 ermostability, but yielded reduced levels of proteolytic resistance.

266 ADAMTS9 and ADAMTS20 thus have an additional proteolytic role intracellularly, revealing an unexpecte

267 c flies, we prepared and crystallized stable proteolytic S1-like fragments containing the entire EMB

268 gradation by stimulating the recognition and proteolytic sequestration of insoluble ubiquitinated pro

269 th the aid of engineered viral proteases and proteolytic signals, we build two sets of controllable p

270 This proteolytic signature may constitute a noninvasive bioma

271 tribution and functional significance of the proteolytic signature were investigated in germ-free adu

272 ggesting a bacterial component to the pre-UC proteolytic signature.

273 proposed to involve the exposure of a second proteolytic site (S2'), cleavage of which is required fo

274 in a highly conserved region proximal to the proteolytic site.

275 t form a barrel-like structure, sequestering proteolytic sites inside its lumen.

276 The proteolytic stabilities of 1 and its analogs were determ

277 omers of N-substituted glycines) demonstrate proteolytic stability and better bioavailability than co

278 tide activators of p53 generally suffer poor proteolytic stability and low membrane permeability, pos

279 The generated mimetics showed enhanced proteolytic stability and reduced aggregation in vitro a

280 be valuable tools for bestowing rigidity and proteolytic stability on bioactive peptides.

281 tructure-activity investigation reveals that proteolytic stability, dephosphorylation, and biotin con

282 e and the retro-enantio shows a strengthened proteolytic stability.

283 Proteolytic stabilization of the peptide by chemical mod

284 ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnes

285 r successful acidification of the cheese and proteolytic strains like Lactobacillus helveticus, are a

286 ing hPm to form and provide GAS cells with a proteolytic surface.

287 cryptic protease site within a juxtamembrane proteolytic switch domain to activate transcriptional pr

288 We created a Synthetic Notch Assay for Proteolytic Switches (SNAPS) that exploits the modularit

289 We identify several new proteolytic switches among receptors with structural hom

290 screen surface receptors for other putative proteolytic switches.

291 In sum, this multifunctional proteolytic system has emerged as a regulator of mammali

292 ion involves the hyperactivation of the CAPN proteolytic system.

293 We describe multifunctional proteolytic systems that target N-degrons and C-degrons.

294 is combines in vivo genetic modifications of proteolytic systems, stabilized protease-substrate inter

295 the plasminogen activation system and other proteolytic systems.

296 ssociated Quality Control (RQC)-by mediating proteolytic targeting of incomplete polypeptides produce

297 cial taxa and directly correlated with known proteolytic taxa, such as Bacteroides vulgatus.

298 inflammatory activities concomitantly with a proteolytic 'timer' to selectively regulate S100A9.

299 marize recent evidence that disease-specific proteolytic truncations of alphasyn occur in Parkinson's

300 content through synthesis, inactivation, or proteolytic turnover influence their metabolic function.