ライフサイエンスコーパス: proteolytic activity

1 ors (NgR1) as a downstream target of MT3-MMP proteolytic activity.

2 iling different cancer cell line dynamics in proteolytic activity.

3 nction of MT1-MMP that is independent of its proteolytic activity.

4 s proposed to account for this unprecedented proteolytic activity.

5 osis in cancer cells, without affecting Skp2 proteolytic activity.

6 nate the heterogeneous and dynamic nature of proteolytic activity.

7 ated with reduced acidification and impaired proteolytic activity.

8 ating isopeptidase activities in addition to proteolytic activity.

9 t with three His zinc ligands, increases the proteolytic activity.

10 reveal significant neutrophil elastase (NE) proteolytic activity.

11 dine tags and nickel ions fully retain their proteolytic activity.

12 interactions caused the stimulation of HtrA proteolytic activity.

13 hrombin expression or inhibition of thrombin proteolytic activity.

14 ce energy transfer (FRET) pairs sensitive to proteolytic activity.

15 compensate by increasing lysosome number and proteolytic activity.

16 related to the ADAM proteases but devoid of proteolytic activity.

17 ears to be independent of its calpain domain proteolytic activity.

18 kdown is not a consequence of lacking Papp-a proteolytic activity.

19 HEXXH of InhA1 (HEYGH) was critical for its proteolytic activity.

20 pressed proteins is not due to PA's reported proteolytic activity.

21 sses biological functions independent of its proteolytic activity.

22 lolytic, cellulolytic and lipolytic, but not proteolytic activity.

23 esponses, mechanisms of vascularization, and proteolytic activity.

24 ric structure and was processed, they lacked proteolytic activity.

25 o role in either NETosis or arming NETs with proteolytic activity.

26 ys-101, Trp-103, and Glu-184 are crucial for proteolytic activity.

27 bout a drastic drop in pH leading to greater proteolytic activity.

28 th a disruption of the lysosomal dynamic and proteolytic activity.

29 t MT2 may also function independently of its proteolytic activity.

30 cleave the tripeptide S-2302, demonstrating proteolytic activity.

31 chanisms, one of which is impaired lysosomal proteolytic activity.

32 rt to lysosomes, thereby restoring lysosomal proteolytic activity.

33 tion with mature TACE, thereby licensing its proteolytic activity.

34 transponders as a transduction mechanism of proteolytic activity.

35 wed comparable inhibitory effects on TMPRSS2 proteolytic activity.

36 cific expression of Lon protein isoforms and proteolytic activity.

37 for Lon binding with DNA and effects on Lon proteolytic activity.

38 geographical origin, suggesting diversified proteolytic activities.

39 s, because its gene silencing restored their proteolytic activities.

40 sis partly depends on the fine regulation of proteolytic activities.

41 of MALT1 and inhibits MALT1 scaffolding and proteolytic activities.

42 f at least seven secreted proteins and three proteolytic activities.

43 Ps are themselves inhibitors of MMP-mediated proteolytic activities.

44 nhibition, antihypertensive, antioxidant and proteolytic activities.

45 es, Neutrase(R) and Alcalase(R), at the same proteolytic activity (1U/mL), using an enzyme/substrate

46 tive stress (4-hydroxynonenal) and increased proteolytic activity (20S proteasome, calpain-1, and cas

47 -CoV-2 trimeric spike protein increased ACE2 proteolytic activity ~3-10 fold against model peptide su

48 In addition to their cognate extracellular proteolytic activity, ADAMTS9 and ADAMTS20 thus have an

49 fluorescence signal when ActFP is cleaved by proteolytic activity after targeting toward MT1-MMP.

50 from patients with active CeD have increased proteolytic activity against gluten substrates that corr

51 Purified DEG1C exhibited high proteolytic activity against unfolded model substrates a

52 We showed differences in the proteolytic activities and expression levels of cytosoli

53 We used fluorogenic methods to measure proteolytic activities and inhibition by protease inhibi

54 Proteasome proteolytic activities and phosphokinase expression were

55 2) for His resulted in a general increase in proteolytic activity and a change in substrate specifici

56 how in this study are critical for balancing proteolytic activity and adhesive activity to achieve a

57 he importance of microenvironmental cues for proteolytic activity and also investigated the differenc

58 pre-UC-colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone com

59 EGF-SubA demonstrated potent tumor-specific proteolytic activity and cytotoxicity in glioblastoma li

60 barrier integrity by stimulating endogenous proteolytic activity and defines a previously unknown me

61 of caspase-2, as monitored by its cleavage, proteolytic activity and dimerization.

62 amaged kernels content, gluten index values, proteolytic activity and electrophoretic properties of g

63 ophagin-2 (TcAtg4.2) carries the majority of proteolytic activity and is responsible for processing A

64 on the MEK/ERK pathway and by requiring its proteolytic activity and lysine binding sites.

65 ation (PNS) substantially reduces MV-induced proteolytic activity and oxidative stress in the diaphra

66 Thus, increased proteolytic activity and PAR activation play a pathogeni

67 release combined with a local inhibition of proteolytic activity and protein expression of ADAMTS13

68 ogenic signaling, and a postnatal phase with proteolytic activity and reduced elastic fibres.

69 some of which appeared conflicting with its proteolytic activity and stability.

70 In vitro assays showed Zn-dependent proteolytic activity and substrate cleavage upstream of

71 lS. suisstrains investigated possess the IgG proteolytic activity and that piglet serum samples conta

72 contributes to promote inflammation-mediated proteolytic activity and uncovers a target for restoring

73 immunoprecipitation yielded gamma-secretase proteolytic activity and vice versa.

74 plasma-derived ADAM17 retained its specific proteolytic activity and was partly located on extracell

75 e detection of protein-protein interactions, proteolytic activities, and posttranslational modificati

76 Serratia sp. strain SCBI displays high proteolytic activity, and because secreted proteases are

77 e many clinically significant allergens have proteolytic activity, and many helminths express proteas

78 on fibrinolysis, plasmin generation, protein proteolytic activity, and plasminogen-fibrin interaction

79 und that the homologous STC2 inhibits PAPP-A proteolytic activity, and that this depends on the forma

80 Atg7 is not a direct substrate for caspase-9 proteolytic activity; and that, depending on the cellula

81 The stress-triggered induction of Oma1 proteolytic activity appears to be associated with confo

82 The three proteasome subunits with proteolytic activity are encoded by standard or immunopr

83 s may exercise significant control of ADAMTS proteolytic activity as a general principle.

84 ficiency, or prevention of NET formation and proteolytic activity as modelled in NE(-/-) mice prevent

85 the neuropil that codistributed with foci of proteolytic activity, as well as with markers of growing

86 Here, we report the development of a trans-proteolytic activity assay for Aura virus capsid proteas

87 In this study, we failed to detect proteolytic activity associated with the Ser596-containi

88 ns would benefit from wireless monitoring of proteolytic activity at minimal cost, e.g., sensors embe

89 Transgene expression resulted in increased proteolytic activity attributable to KLK5 and its downst

90 ng, liposomes containing PA supported higher proteolytic activity by factor VIIa and activated protei

91 First, CYCLO stimulated lysosomal proteolytic activity by increasing cathepsin D activity,

92 revealed significant reduction of the global proteolytic activity by several compounds.

93 have developed a robust reporter of caspase proteolytic activity, called caspase-activatable green f

94 itors of either granule function or granzyme proteolytic activity can arrest TCR-driven TEM, implying

95 r of the transformed epithelium and that its proteolytic activity can be exploited to noninvasively e

96 serum and plasma, respectively, showing that proteolytic activity capable of activating pro-FD exists

97 account growth rate, acidification capacity, proteolytic activity, cell envelope associated peptidase

98 DNA and ubiquitin binding, SPRTN can elicit proteolytic activity; cleaving DPC substrates and itself

99 To investigate how MALT1 proteolytic activity contributes to overall immune cell

100 context, we sought to investigate how MALT1 proteolytic activity contributes to the overall allergic

101 The changes in proteolytic activity correlated with increased cell elon

102 The pro-form of ADAMDEC1 does not have proteolytic activity, demonstrating that the prodomain o

103 (CP) is a serine protease that possesses cis-proteolytic activity essential for its release from the

104 , are predominantly responsible for secreted proteolytic activities exhibited by strain K279a, as wel

105 ne compound (paclitaxel) to inhibit BoNT/A's proteolytic activity experimentally with an IC50 of 5.2

106 tion also limits the half-life of separase's proteolytic activity, explaining how cohesin can be relo

107 val, and somewhat effective at inhibiting NE proteolytic activity, fails to remove the majority of hi

108 significant induction of Ctss expression and proteolytic activity following acute muscle injury or in

109 role in this process, and inhibition of its proteolytic activity has been shown to be important for

110 NA, but the role of this interaction for Lon proteolytic activity has not been characterized.

111 However, its proteolytic activity has not been studied under conditio

112 ADAMTS13 618Ala variant associated with less proteolytic activity, higher risk of chronic complicatio

113 Although it is one of the dominant cellular proteolytic activities in exponentially growing H. volca

114 tric function and to stimulate the stomach's proteolytic activities in FD.

115 Proteolytic activities in the extracellular matrix by th

116 Alterations to the proteolytic activities in the over-expressing and knock-

117 A significant increase in the overall ATG4 proteolytic activity in Arabidopsis was detected under n

118 Proteolytic activity in CNS extract, detected by a fluor

119 This method is useful for determining the proteolytic activity in different media and its effectiv

120 to directly measure Akt activity as well as proteolytic activity in individual fibroblast-like synov

121 e-like structures, which are associated with proteolytic activity in other cell types.

122 o calculate quantitative progress curves for proteolytic activity in regions of interest in the acqui

123 irect validation, we also observed increased proteolytic activity in stromal fields adjacent to melan

124 T cells, suggesting a contribution of MALT1 proteolytic activity in T cell activation and EAE develo

125 A significant decrease in the proteolytic activity in the aneurysmal tissues and vascu

126 h an impaired luminal acidic environment and proteolytic activity in the lysosomes.

127 We showed that the proteolytic activity in the supernatants of pathogenic s

128 sue lymphoma translocation protein 1 (MALT1) proteolytic activity in the suppression of autoimmune re

129 t do not significantly inhibit the caspase-9 proteolytic activity in vitro compared with the wild-typ

130 AsES exhibited proteolytic activity in vitro, and its resistance elicit

131 Recombinant HtrABb exhibits proteolytic activity in vitro, while a mutant (HtrABbS19

132 Based on these results, the proteolytic activity, in particular the thermostable fra

133 litated the detection of additional secreted proteolytic activities, including aminopeptidases and ca

134 ndolysosome, such compounds can modulate the proteolytic activity, including its processing by cystei

135 we showed that FXII expresses a low level of proteolytic activity (independently of FXIIa) that may i

136 Assessing their proteolytic activities individually has therefore proven

137 cific pattern of Lon isoform expression, Lon proteolytic activity induction, and H2O2 stress adaptati

138 female-specific Lon isoform expression, Lon proteolytic activity induction, and H2O2 stress adaptati

139 how Pro618Ala ADAMTS13 variants and related proteolytic activity interact with ACEi therapy in predi

140 Functional imaging of proteolytic activity is an emerging strategy to quantify

141 Overall, these results indicate that proteolytic activity is essential for cytotoxicity in Se

142 lays a determinant role and suggest that the proteolytic activity is not an appropriate target to mod

143 Wss1 proteolytic activity is regulated by a cysteine switch m

144 hen inhibited with PMSF, suggesting that its proteolytic activity is required to induce the defense r

145 ing the mechanism for the loss of permissive proteolytic activity is therefore a key link for improvi

146 d by epithelial/carcinoma cells in which its proteolytic activity is tightly controlled by the Kunitz

147 generated through oxidative, lipolytic, and proteolytic activities lead to the formation of several

148 erived, soluble form of Jagged-1, via ADAM17 proteolytic activity, led to Notch activation in CRC cel

149 f GNP (GNP-ActFP) for a targeting moiety and proteolytic activity ligand toward MT1-MMP.

150 form with a computational analytical method, Proteolytic Activity Matrix Analysis (PrAMA), we are abl

151 ction rates using a deconvolution technique, proteolytic activity matrix analysis (PrAMA).

152 hibitors, together with inhibitors of BoNT/A proteolytic activity, may be useful for reducing the mor

153 ycosylated, active protease and that its own proteolytic activity mediates zymogen cleavage.

154 ical inhibition affected human melanoma cell proteolytic activity; metastatic melanoma is a highly ag

155 et-muFC) to comprehensively analyze multiple proteolytic activities of a patient-derived tumor (with

156 esults provide new insight into the combined proteolytic activities of cathepsins toward substrates a

157 otease and demonstrated that they also block proteolytic activities of host furin, cathepsin B, and c

158 sults shed light on hitherto undescribed non-proteolytic activities of Mmp14 that are necessary for t

159 lective molecular recognition properties and proteolytic activities of more than two dozen membrane-b

160 the contributions of the nonproteolytic and proteolytic activities of Mt2 by taking advantage of Mt2

161 e and inducible proteasome subunits, and the proteolytic activities of the 20S and 26S proteasomes we

162 MRZ inhibits the 3 proteolytic activities of the 20S proteasome with specif

163 DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or t

164 We contrast here the proteolytic activities of these mutant PSEN alleles with

165 The aim of our study was to characterize the proteolytic activity of 170 Lactobacillus strains isolat

166 The proteolytic activity of a cancer-related enzyme cathepsi

167 called the inflammasome, which unleashes the proteolytic activity of a cysteine protease caspase-1.

168 ading and simple valveless isolation, so the proteolytic activity of a small sample (10-100 cells) ca

169 The proteolytic activity of adam13 is critical for the relea

170 anism for conversion to mucoidy in which the proteolytic activity of AlgW and its ability to compete

171 er composed of epithelial cells by intrinsic proteolytic activity of allergens may facilitate allerge

172 Proteolytic activity of allergens or their capacity to b

173 critical role in this process by sensing the proteolytic activity of allergens via protease-activated

174 ription-dependent, and MT-I/II can block the proteolytic activity of alpha-secretase and the activati

175 ioned as a sensing element for examining the proteolytic activity of an enzyme at highly acidic pH an

176 The structural features rather than the proteolytic activity of an immunoproteasome subunit are

177 The proteolytic activity of APN promotes cancer angiogenesis

178 s from bovine and goat milk subjected to the proteolytic activity of Aspergillus oryzae and Aspergill

179 This inhibition requires the proteolytic activity of AvrRpt2, is associated with redu

180 The proteolytic activity of BACE1 was unadulterated by the s

181 nt of alpha-actinin bands due to increase in proteolytic activity of calpain.

182 in the heart that we related to unregulated proteolytic activity of calpain3.

183 Proteolytic activity of cell surface-associated MT1-matr

184 It is proposed that the proteolytic activity of Clp protease counteracts GBP bin

185 Last, we show that CpaB does not abolish the proteolytic activity of CpaA against human Factor V.

186 Proteolytic activity of Ddi1 requires the HDD domain and

187 of FtsH as its deletion fully eliminated the proteolytic activity of FtsH.

188 n short, our findings identify an unexpected proteolytic activity of GDH specific to histone H3 that

189 To date, the enzymes responsible for the proteolytic activity of German cockroach allergen have n

190 with the catalytic histidine that makes the proteolytic activity of GII.4 protease pH sensitive.

191 Taken together, the enhanced proteolytic activity of Gly1629Glu can be readily explai

192 mechanisms likely have evolved to detect the proteolytic activity of helminth proteases, which may be

193 The proteolytic activity of HtrA (DegP) from Escherichia col

194 The proteolytic activity of InhA1 on established secreted vi

195 domics technologies were used to examine the proteolytic activity of kefir grains on bovine milk prot

196 The study was conducted to establish proteolytic activity of Lactobacillus acidophilus (ATCC(

197 t failed to infect mice, suggesting that the proteolytic activity of Lon-1 is essential for bacterial

198 LT-231 potently and selectively inhibits the proteolytic activity of MALT1 in NF-kappaB-dependent ass

199 Constitutive proteolytic activity of MALT1 is associated with highly

200 ts represent the first reconstitution of the proteolytic activity of MamE and show that its behavior

201 dependent protein kinase, and is mediated by proteolytic activity of matrix metalloprotease 9 (MMP9).

202 Interestingly, the proteolytic activity of mature ADAMDEC1 can be significa

203 However, only the CUB1 domain inhibited proteolytic activity of MDTCS.

204 The increased proteolytic activity of membrane-bound and secreted prot

205 The proteolytic activity of metalloproteinases is post-trans

206 We demonstrate that MIB is necessary for the proteolytic activity of MIP.

207 Moreover, elevated proteolytic activity of MMP2 and MMP9 was linked to a 50

208 These findings shift the focus from the proteolytic activity of MMP3 as the central player to it

209 h the collagenolytic function or the general proteolytic activity of MT1-MMP.

210 ctively account for 85% of the extracellular proteolytic activity of P. gingivalis at the site of inf

211 Our study identifies a previously unknown proteolytic activity of PLA2 that is specific to apoA-I

212 Tumor cells use broad spectrum proteolytic activity of plasmin to invade tissue and for

213 onoclonal antibody 10-D7 or by inhibition of proteolytic activity of plasmin-like serine proteases wi

214 The proteolytic activity of PSA towards a small peptide subs

215 The sensing mechanism was based on the proteolytic activity of S. aureus proteases on a specifi

216 KISC operates independently of proteolytic activity of separase in promoting microtubul

217 tease-inhibitory domains, which regulate the proteolytic activity of serine proteases.

218 sis of a NP that sequesters and inhibits the proteolytic activity of snake venom metalloproteinases f

219 bacterial microenvironment can modulate the proteolytic activity of SpeB in a manner that preserves

220 Surprisingly, the proteolytic activity of SPPL3 is not required for its ro

221 f apoptosis proteins on the stability and/or proteolytic activity of the caspase-8 platforms.

222 and immunoproteasome differ not only in the proteolytic activity of the catalytic sites but also in

223 e described the formerly unappreciated trans-proteolytic activity of the enzyme and for the first tim

224 Moreover, this effect was independent of the proteolytic activity of the enzyme.

225 rane domains of presenilin 1 that affect the proteolytic activity of the gamma-secretase.

226 We found that STC2 potently inhibits the proteolytic activity of the growth-promoting metalloprot

227 tophan metabolism, while also increasing the proteolytic activity of the gut microbiome.

228 t DDR1 activation is partly regulated by the proteolytic activity of the membrane-anchored collagenas

229 CoV) from the beta-CoV subgroup, require the proteolytic activity of the nsp5 protease (also known as

230 , which account for 85% of the extracellular proteolytic activity of the pathogen and are thus prime

231 These tumours also displayed elevated proteolytic activity of the primary biochemical target o

232 cise N-terminal processing releases the full proteolytic activity of the wild type analogously to chy

233 e clones, lysosomal pH was increased and the proteolytic activity of these organelles was deranged.

234 The assembly and proteolytic activity of this enzyme require the correct

235 Our data demonstrate that the proteolytic activity of thrombin negatively regulates th

236 At the molecular level, experience-dependent proteolytic activity of tissue plasminogen activator (tP

237 Experience-dependent proteolytic activity of tissue plasminogen activator (tP

238 In parallel, the proteolytic activity of tumor necrosis factor alpha-conv

239 could impair cardiomyocyte functions by the proteolytic activity of viral proteinase 2A in cases of

240 Proteolytic activity of viscera extract from hybrid catf

241 Cu(2+) inhibits the proteolytic activity of Zebrafish Hatching Enzyme 1 and

242 ing-enzyme (ACE)-inhibition, antioxidant and proteolytic activity) of camel milk fermented with indig

243 ses (MMPs) can disrupt the BBB through their proteolytic activity on basement membrane and tight junc

244 Although adhered, eosinophils exhibited no proteolytic activity on collagen matrices.

245 source of complement proteins confirmed Pic proteolytic activity on these proteins.

246 nteractions that allosterically regulate its proteolytic activity on von Willebrand factor (VWF).

247 ctis in its isolated form showed the highest proteolytic activity, particularly in the hydrolysis of

248 ate the DUB function of PL(pro), and not its proteolytic activity per se, in the inhibition of IFN-be

249 d luminal proinsulin suggests that different proteolytic activities process the two Ag forms.

250 PCD induction, inhibitor treatments of these proteolytic activities provided further evidence of larg

251 The interdependence of these proteolytic activities provides a paradigm for non-apopt

252 CLL cells in vitro with MI-2 inhibited MALT1 proteolytic activity reduced BCR and NF-kappaB signaling

253 2013) now show that MMP3, independent of its proteolytic activity, regulates murine mammary stem cell

254 by transducing NF-kappaB signaling, and its proteolytic activity represents a key node for therapeut

255 detect full-length rADAMTS13 protein and its proteolytic activity, respectively, in transgenic (Adamt

256 ne presented higher legumain and papain-like proteolytic activities, resulting in a faster initial se

257 s revealed that endopeptidases are the major proteolytic activities secreted by P. destructans, and t

258 showed that the purified EV-D68 2A(pro) has proteolytic activity selective against a peptide sequenc

259 geting therapy that negates the influence of proteolytic activity showed that the treatment could be

260 P) anchored on invasive cancer cells and its proteolytic activity simultaneously.

261 Besides the proteolytic activity, Skp2 also blocks p53-mediated apop

262 ebrafish Papp-a demonstrates conservation of proteolytic activity, specificity, and the intrinsic reg

263 ibited a better inhibitory effect on TMPRSS2 proteolytic activity than HAI-1, and recombinant HAI-2 p

264 ha or IL-1 treatment of ECs leads to caspase proteolytic activity that cleaves interleukin-1 receptor

265 of these particular strains to generate the proteolytic activity that disrupts the innate barriers t

266 the apoptosome form a holoenzyme with robust proteolytic activity that is 2-3 orders of magnitude hig

267 Allergens possess proteolytic activity that is capable of disrupting the a

268 enthes genus of carnivorous plants contain a proteolytic activity that is very useful for hydrogen/de

269 We have identified increased fecal proteolytic activity that precedes the clinical diagnosi

270 e ADAMDEC1 metalloprotease domain impact the proteolytic activity, the substrate specificity, and the

271 microvesicles (MVs; or microparticles) with proteolytic activity; the major proteases involved; and

272 y elevates proteasome subunit expression and proteolytic activity to eradicate nuclear FOXO4 proteins

273 ential for experience-dependent elevation of proteolytic activity to express juvenile-like structural

274 During metastasis, cells can use proteolytic activity to form tube-like "microtracks" wit

275 e-activated receptor activation but requires proteolytic activity toward a novel substrate.

276 78% amino acid sequence, has only a minimal proteolytic activity toward insoluble elastin.

277 de of the ADAMTS superfamily shows preferred proteolytic activity toward the hyalectan/lectican prote

278 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the all

279 le effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postgluta

280 O2-Cl(-) system, and determined its residual proteolytic activity using both a VWF A2 peptide substra

281 All isolates were screened for proteolytic activity using skim milk agar-well diffusion

282 nsing method was based on the measurement of proteolytic activity using specific proteases probes.

283 Proteolytic activity values were the highest 50 days aft

284 proteases and a series of kinetic assays for proteolytic activity was carried out, including multiple

285 Proteolytic activity was inhibited by 1,10-phenanthrolin

286 ase was the most performing, while microbial proteolytic activity was less efficient.

287 specific inhibitors, revealed that gingipain proteolytic activity was required for beta-catenin proce

288 Of note, APC proteolytic activity was required for inhibiting NETosis

289 icate that the catalytic domain, but not its proteolytic activity, was required for Mt2 to suppress h

290 Strains with distinctive proteolytic activities were identified.

291 After gluten gavage, gliadin amount and proteolytic activities were measured in intestinal conte

292 L. sanfranciscensis I4) possessing different proteolytic activities were used to produce sourdoughs c

293 The optimum pH and temperature for the proteolytic activity were 10.0 and 50 degrees C, respect

294 nerated, and six SCBI mutants with defective proteolytic activity were identified.

295 showed that albumin fraction (15-30 kDa) and proteolytic activity were negatively correlated with bre

296 y 3.5- to fivefold Plg receptors and plasmin proteolytic activity were required for phagocytosis of b

297 s such as derived from house dust mites have proteolytic activity which can induce oxidative stress i

298 e first evidence that B. burgdorferi possess proteolytic activity which may contribute to the pathoge

299 ion, we demonstrate that suppression of HtrA proteolytic activity with a newly developed inhibitor is

300 milder effects but still strongly diminished proteolytic activity, without affecting the subcellular