ライフサイエンスコーパス: proteolytic cleavage

1 nly after the thioester bond is exposed by a proteolytic cleavage.

2 t, with a novel limitation of Dkk4 action by proteolytic cleavage.

3 ubset of Wnts, but is further inactivated by proteolytic cleavage.

4 destabilization through receptor binding and proteolytic cleavage.

5 can reverse this by controlled intracellular proteolytic cleavage.

6 g protein, specifically by inhibiting CA-SP1 proteolytic cleavage.

7 ndoplasmic reticulum, disulfide bonding, and proteolytic cleavage.

8 initiates hemostasis before inactivation by proteolytic cleavage.

9 ynthesized as a zymogen that is activated by proteolytic cleavage.

10 ovarian tumor cells reduces PAR-2 N-terminal proteolytic cleavage.

11 d to the shielding of its adhesion sites and proteolytic cleavage.

12 ion, revealing a mechanistic requirement for proteolytic cleavage.

13 shed aiming at deciphering the mechanisms of proteolytic cleavage.

14 imerized with neuroligin-3, they too undergo proteolytic cleavage.

15 otein in RNA replication beyond facilitating proteolytic cleavage.

16 d deamidation, residual leader sequence, and proteolytic cleavage.

17 lipogenesis whose activity is controlled by proteolytic cleavage.

18 often were assumed to be due to nonspecific proteolytic cleavages.

19 ne leukemia virus Env protein matures by two proteolytic cleavages.

20 5 to be MUC16, it is hypothesized to undergo proteolytic cleavage, a process that is considered to be

21 rane endothelial adhesion molecule and, upon proteolytic cleavage, a soluble chemoattractant for circ

22 Cyclin D1 induced abundance of the Trop2 proteolytic cleavage activation components (PS2, TACE) a

23 we demonstrate that kidney lysate possesses proteolytic cleavage activity toward SPAK.

24 1629Glu mutation drastically accelerates the proteolytic cleavage activity, even in the absence of fo

25 ent on the ATP-binding activity of RPT6, but proteolytic cleavage additionally requires its ATPase ac

26 L in multivesicular bodies is protected from proteolytic cleavage and 2) upon secretion, delivery of

27 We show that proteolytic cleavage and acid pH have significant effect

28 ks sterol regulatory element-binding protein proteolytic cleavage and activation.

29 growth factor by a protein that enhances its proteolytic cleavage and activation.

30 form oligomeric pores in membranes following proteolytic cleavage and interaction with cell surface r

31 Based on these proteolytic cleavage and internalization mechanism, we d

32 ding stabilizes the tetramer, inhibiting its proteolytic cleavage and its dissociation.

33 ogous to mammalian RIP1 that is regulated by proteolytic cleavage and Lys-63-polyubiquitination.

34 Proteolytic cleavage and NPC1 binding at endosomal pH le

35 tive on the complexity of TLR9 regulation by proteolytic cleavage and offer potential ways to inhibit

36 The proteolytic cleavage and posttranslational acetylation m

37 osed on the surface of EVs, likely undergoes proteolytic cleavage and processed fragments of the prot

38 Its surface glycoproteins undergo proteolytic cleavage and rearrangements to permit membra

39 Proteolytic cleavage and release from the cell surface o

40 IL-1beta enhanced the proteolytic cleavage and release of COMP from tendon exp

41 aling independent of direct cell contact and proteolytic cleavage and suggest the participation of Ep

42 ed IFN-beta production by targeting NEMO for proteolytic cleavage and that the scission occurred at f

43 Thus, the combination of proteolytic cleavage and the destabilizing mutation trig

44 serine proteases through specific N-terminal proteolytic cleavage and the unmasking of a tethered lig

45 Activated hPAH is more resistant to proteolytic cleavage and thermal denaturation, suggestin

46 st to previous studies, which implicated Aap proteolytic cleavage and, specifically, the Aap B domain

47 al regions are highly protected from HDX and proteolytic cleavage and, thus, are part of the fibrilla

48 precipitation, an enhanced susceptibility to proteolytic cleavage, and a loss of viral protein activi

49 nal complexes and identify Rgma-induced Neo1 proteolytic cleavage as a key upstream signaling event.

50 Reports have identified proteolytic cleavage as a mechanism capable of releasing

51 ty, localization, and maturation, as well as proteolytic cleavage as a mediator in signaling pathways

52 of biological pathways that utilize specific proteolytic cleavage as a precision control mechanism in

53 ve disease, with unfolding, aggregation, and proteolytic cleavage as different facets of the process.

54 s, which liberate fluorescent reporters upon proteolytic cleavage, as well as acid phosphatase cytoch

55 Using in vitro O-glycosylation and proteolytic cleavage assays, a cell line deficient in O-

56 Recently, it has been postulated that proteolytic cleavage at Ala(1800) and protein kinase A p

57 tro-translated Nup98 with 2A(pro) results in proteolytic cleavage at multiple sites in vitro, indicat

58 y in trypsin-like proteases is the result of proteolytic cleavage at R15 followed by an ionic interac

59 yaluronan receptor CD44 undergoes sequential proteolytic cleavage at the cell surface.

60 mAb4C11) and the neoepitope generated after proteolytic cleavage at the prostasin/kallikrein cleavag

61 are G protein-coupled receptors activated by proteolytic cleavage at their amino termini by serine pr

62 S226A) into 5XFAD mice decreases APP and tau proteolytic cleavage, attenuates AD pathologies, and rev

63 uced as FimH fusion proteins and released by proteolytic cleavage, bound to the EGF receptor (EGFR) o

64 d precursor protein (APP) through sequential proteolytic cleavage by BACE1 and gamma-secretase.

65 We show that proteolytic cleavage by CalpA generates Cactus fragments

66 pro-IL-1beta is a complex process involving proteolytic cleavage by caspase-1.

67 The proteolytic cleavage by gamma-secretase of its C-termina

68 al IL-15Ralpha was shed by keratinocytes via proteolytic cleavage by matrix metalloproteinases upon s

69 t manner, the depletion of ORP2 resulting in proteolytic cleavage by matrix metalloproteinases, and r

70 mbrane protein, which is further matured via proteolytic cleavage by metalloproteases such as ADAM17,

71 ein-coupled receptor that is activated after proteolytic cleavage by serine proteases, including mast

72 rom its full-length 135-kDa precursor though proteolytic cleavage by serine proteases.

73 of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a

74 The untranslocated MLL1 is a substrate for proteolytic cleavage by the endopeptidase threonine aspa

75 leavage sites, thus allowing activation upon proteolytic cleavage by the respective proteases.

76 GNPTAB activity is dependent upon proteolytic cleavage by the SKI-1/S1P protease.

77 eight extracellular proteases, we show that proteolytic cleavage by these enzymes is not a prerequis

78 possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypepti

79 PAR-2 is activated via proteolytic cleavage by trypsin-like serine proteases, i

80 Among the various protease-specific types of proteolytic cleavage, cleavages by casapses/granzyme B a

81 As proteolytic cleavage contributes to the activation of th

82 rms that arise from alternative splicing and proteolytic cleavage during inflammatory responses.

83 on for CIDEB downregulation, which utilize a proteolytic cleavage event that is independent of the ce

84 that the imposition of ER stress leads to a proteolytic cleavage event that selectively removes the

85 in vivoresults in CIDEB downregulation via a proteolytic cleavage event.

86 First, that targeted, limited proteolytic cleavage events by a wide repertoire of prot

87 Alterations--such as deletion, mutation, and proteolytic cleavage events--to the extracellular ligand

88 rmation of Gag via an orchestrated series of proteolytic cleavage events.

89 d amino-acid residue(s) can be identified by proteolytic cleavage followed by liquid chromatography-m

90 Diminished levels of VAPB and its proteolytic cleavage fragment have also been reported in

91 m of 2C that then becomes fully activated by proteolytic cleavage from the adjacent 2B viroporin doma

92 for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA)

93 ugh a number of substrates for both types of proteolytic cleavage have been experimentally identified

94 The roles of proteolytic cleavage have been intensively investigated

95 ell differentiation and is activated through proteolytic cleavage in response to ligand engagement.

96 er, the role of histone variants and histone proteolytic cleavage in senescence remains unclear.

97 It is also recognized that apoE undergoes proteolytic cleavage in the brain and the resultant apoE

98 We show that TapA is subjected to proteolytic cleavage in the colony biofilm and that only

99 Proteolytic cleavage in the hinge region by tumor-associ

100 We further show that Astn2 undergoes proteolytic cleavage in the second transmembrane domain

101 tification, mass spectrometry (MS), requires proteolytic cleavage in the vicinity of a PTM to yield p

102 tly hypothesized, crucial pathogenic role of proteolytic cleavage in TTR amyloid fibrillogenesis.

103 tivity of IL-12 and provided protection from proteolytic cleavage in-vitro.

104 eased from the bacterial surface by specific proteolytic cleavage into the culture supernatant allowi

105 g to obtain and have been thought to require proteolytic cleavage into two-component subunits, gp120

106 In fact, the fate of pVIn following proteolytic cleavage is completely unknown.

107 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase a

108 by overexpressing neoICD suggests that this proteolytic cleavage is essential for neurulation.

109 ble protein posttranslational modifications, proteolytic cleavage is involved in nearly all aspects o

110 Maturation by proteolytic cleavage is known to activate the enzyme.

111 In the case of human adenovirus, this proteolytic cleavage is mediated by the virally encoded

112 Proteolytic cleavage is stimulated by an anti-alpha5/bet

113 RTANCE Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection

114 se assembly depends on a conserved, specific proteolytic cleavage leading to conformational activatio

115 dysfunction in dry eye, and that galectin-3 proteolytic cleavage may contribute to impaired ocular s

116 loss of membrane-tethered VTCN1 is linked to proteolytic cleavage mediated by the metalloproteinase n

117 level, neuronal death is accompanied by the proteolytic cleavage, misfolding and aggregation of hunt

118 t shock protein 27 (HSP27), to block the two proteolytic cleavages necessary for the formation of ful

119 Proteolytic cleavage occurs within a serine-rich, intrin

120 demonstrate that sEGFR is generated through proteolytic cleavage of a cell surface precursor of an a

121 NGF is derived by proteolytic cleavage of a large precursor protein, proNG

122 d neurotrophic factor (BDNF) is generated by proteolytic cleavage of a prodomain from the proBDNF pre

123 A proteolytic cleavage of a subunit in a multisubunit comp

124 y virus type 1 (HIV-1) virions is derived by proteolytic cleavage of a trimeric gp160 glycoprotein pr

125 Blood ACE concentrations are determined by proteolytic cleavage of ACE from the endothelial cell su

126 Further, proteolytic cleavage of alpha1C is not required for beta

127 By inducing acute cell-surface proteolytic cleavage of alpha2delta, voltage-dependent a

128 codes the alphaENaC subunit, was reduced and proteolytic cleavage of alphaENaC decreased.

129 n alters cellular bioenergetics and triggers proteolytic cleavage of AMPKalpha and HIF-1alpha express

130 membrane protease complex that catalyzes the proteolytic cleavage of amyloid precursor protein and No

131 The work strengthens the understanding of proteolytic cleavage of antibodies expressed in plants a

132 In AD brain, state the sequential proteolytic cleavage of APP by beta secretase 1 enzyme (

133 Pharmacological strategies targeting the proteolytic cleavage of APP disrupt the relationship bet

134 This interaction promotes a proteolytic cleavage of arid3a and its translocation to

135 CR, an interaction that is inhibited through proteolytic cleavage of AUF1 by the viral proteinase 3CD

136 The proteolytic cleavage of beta-amyloid precursor protein (

137 Our evidence points to proteolytic cleavage of beta-catenin by calpain as the m

138 uces detachment of existing biofilms through proteolytic cleavage of biofilm matrix components.

139 AP-binding motif of C9b, but did not require proteolytic cleavage of C9b.

140 ntimicrobial peptide LL-37 is generated upon proteolytic cleavage of cathelicidin and limits invading

141 r activated phospho-Syk- and ADAM17-mediated proteolytic cleavage of CD16.

142 This regulation is mediated by proteolytic cleavage of CD2831 and CD3246 by the zinc me

143 ols the ER-to-Golgi transport and subsequent proteolytic cleavage of CREBH in a circadian manner.

144 dent metalloprotease, is a central player in proteolytic cleavage of DPCs.

145 Moreover, inhibiting proteolytic cleavage of dystroglycan that occurs in OGD

146 Local proteolytic cleavage of EC JAM-C by neutrophil elastase

147 s, most likely via a mechanism that involves proteolytic cleavage of endothelial cell-cell adhesins s

148 HTRA1 promotes IVD degeneration through the proteolytic cleavage of fibronectin and subsequent activ

149 f the MYC oncoprotein family, generated by a proteolytic cleavage of full-length MYC.

150 CTD (TDP-43 C-terminal domain), formed upon proteolytic cleavage of full-length TDP-43 in the nucleu

151 Proteolytic cleavage of Gag by the viral protease (PR) i

152 Proteolytic cleavage of Gag results in a mature, infecti

153 Subsequent proteolytic cleavage of Gag triggers rearrangement of th

154 A treatment of Arabidopsis seedlings induced proteolytic cleavage of GAPC2 and inhibited Arabidopsis

155 he cathepsin-cleavage loop, and prevents the proteolytic cleavage of GP that is required for virus en

156 r cell and that activation of CLEC-2 induces proteolytic cleavage of GPVI and FcgammaRIIa but not of

157 elective MMP-9 inhibition to protect against proteolytic cleavage of hepatic VEGF using either MMP-9

158 ion: Liver-selective MMP inhibition prevents proteolytic cleavage of hepatic VEGF, which enhances rec

159 eceptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synap

160 n-like growth factor (IGF) signaling through proteolytic cleavage of IGF-binding proteins (IGFBPs).

161 Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG.

162 The role of the proteolytic cleavage of IL-15Ralpha in this process was

163 romoted calpain activation and increased the proteolytic cleavage of IL-1alpha.

164 transfection into 293T cells causes partial proteolytic cleavage of interferon regulatory factor 3 (

165 ty of the insulin receptor (IR) requires the proteolytic cleavage of its proform by intra-Golgi furin

166 is produced in pancreatic beta-cells through proteolytic cleavage of its prohormone.

167 ase at the onset of anaphase is triggered by proteolytic cleavage of kleisin.

168 ver prohibitin-2 deficiency caused excessive proteolytic cleavage of L-OPA1, mitochondrial fragmentat

169 ement membrane in the rat testis, likely via proteolytic cleavage of matrix metalloproteinase 9.

170 ADAM9 inhibition reduces HG-induced proteolytic cleavage of Mer tyrosine receptor kinase (Me

171 rate a crucial role for this sheddase in the proteolytic cleavage of MIC by means of silencing and ph

172 downstream signaling proteins, as well as by proteolytic cleavage of multiple substrates.

173 Here, we report isoform-specific proteolytic cleavage of neuroligin-3 in response to syna

174 generation is feasible via demonstration of proteolytic cleavage of one of the acylated analogues.

175 f PAR-2 is a substrate for testisin and that proteolytic cleavage of PAR-2 by recombinant testisin ac

176 ch repeat (NLR) protein, is activated by the proteolytic cleavage of PBS1.

177 Besides inhibiting the proteolytic cleavage of peptide substrates in vitro, it

178 unction of PLTP in the lung and suggest that proteolytic cleavage of PLTP by cathepsin G may enhance

179 Surprisingly, the aptamer enhanced proteolytic cleavage of precursor p66/p66 by HIV-1 prote

180 oluble HMW-EGF, that HMW-EGF is active, that proteolytic cleavage of pro-EGF first occurs at the C-te

181 vation of the NLRP3-containing inflammasome, proteolytic cleavage of pro-IL-1beta by caspase-1, and r

182 protein containing a CARD (ASC), to catalyze proteolytic cleavage of pro-interleukin-1beta (pro-IL-1b

183 LC3 undergoes two processing steps, the proteolytic cleavage of pro-LC3 and the de-lipidation of

184 ain (ED) binds and activates ErbB4 following proteolytic cleavage of pro-NRG1 precursor protein.

185 zation of procollagen I with FN fibrils, and proteolytic cleavage of procollagen to initiate fibril f

186 The mature middle domain, generated after proteolytic cleavage of proSP-B, generates the striking

187 Although proteolytic cleavage of recombinant human FGF21 in precl

188 The principle of detection was the specific proteolytic cleavage of redox-tagged peptides by trypsin

189 re reactive phenotype enabled by suppressing proteolytic cleavage of sIL-6R from IL-6R and downregula

190 omain that mediates SltB autoproteolysis and proteolytic cleavage of SltA.

191 It has previously been shown that proteolytic cleavage of SNAP25 by botulinum toxin A redu

192 les as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and t

193 disrupts the dimeric structure, such as the proteolytic cleavage of TDP-43 within the RRM2 that remo

194 Proteolytic cleavage of the 3L4 was found to abolish tra

195 Following proteolytic cleavage of the A domain, which has been sho

196 N(1801) motif in alpha1C is not required for proteolytic cleavage of the alpha1C C-terminus, and dele

197 lation of residues in alpha1C and C-terminal proteolytic cleavage of the alpha1C subunit.

198 Proteolytic cleavage of the amyloid precursor protein (A

199 on is the activity-dependent endocytosis and proteolytic cleavage of the amyloid precursor protein (A

200 nit incorporation could be synchronized with proteolytic cleavage of the C-terminal pro-peptide that

201 al modification of alpha-tubulin, or whether proteolytic cleavage of the C-terminal tail (CTT) of alp

202 ncrease membrane association, and subsequent proteolytic cleavage of the C-terminus.

203 Proteolytic cleavage of the cell adhesion molecule L1 (L

204 riggers negative feedback regulation through proteolytic cleavage of the channel within the core of t

205 of the P. falciparum CSP, which inhibits the proteolytic cleavage of the CSP, a key requirement for p

206 PCSK7 contributed to the mRNA expression and proteolytic cleavage of the cytokine TGFbeta1a.

207 Proteolytic cleavage of the dynamin-like guanosine triph

208 Keratinocyte migration is mediated mainly by proteolytic cleavage of the extracellular matrix and/or

209 in the HIV-1 replication cycle that requires proteolytic cleavage of the Gag polyprotein into its con

210 ard an infectious virion requires sequential proteolytic cleavage of the Gag polyprotein leading to t

211 Activity of ENaC is enhanced by proteolytic cleavage of the gamma-subunit and putative r

212 Furthermore, we observed that proteolytic cleavage of the host extracellular matrix pr

213 Host cell-mediated proteolytic cleavage of the human immunodeficiency virus

214 s to ssDNA, forming filaments that stimulate proteolytic cleavage of the LexA transcriptional repress

215 Here, we provide evidence that proteolytic cleavage of the macrophage efferocytosis rec

216 Proteolytic cleavage of the molecule induced a conformat

217 with the scaffold protein Sav1 and prevents proteolytic cleavage of the Mst1 kinase, resulting in in

218 the 29KE/31KE MA mutant displays a defect in proteolytic cleavage of the murine leukemia virus Env cy

219 s (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a

220 TLR7/8 activation leads to a furin-dependent proteolytic cleavage of the N-terminal part of FcgRIIA,

221 itself does not process VEGF-C, it promotes proteolytic cleavage of the otherwise poorly active 29/3

222 We show that proteolytic cleavage of the patient LC resulting in an i

223 Proteolytic cleavage of the peptide sequence results in

224 eptidase enhancer 1 (Pcolce), which enhances proteolytic cleavage of the procollagen C-terminal prope

225 main (PLP2) that plays a crucial role in the proteolytic cleavage of the PRRSV replicase polyproteins

226 e range of evidence, including resistance to proteolytic cleavage of the putative dimerization portio

227 We postulated that proteolytic cleavage of the reactive center loop produce

228 with a MET therapeutic antibody that induces proteolytic cleavage of the receptor at the cell surface

229 DSL ligands activate Notch by inducing proteolytic cleavage of the receptor ectodomain, an even

230 athways revealed that loss of Casp8 prevents proteolytic cleavage of the receptor-interacting protein

231 bjects also possessed statistically elevated proteolytic cleavage of the reporter relative to normal

232 Proteolytic cleavage of the S protein exposes its fusion

233 results argue that both receptor binding and proteolytic cleavage of the spike are critical factors t

234 Together, these results indicate that proteolytic cleavage of the spike, not receptor binding,

235 Low oxygen stimulates proteolytic cleavage of the SREBP homolog Sre1, generati

236 s or the phosphorylation, ubiquitination, or proteolytic cleavage of the transcription factor.

237 PARs are activated by proteolytic cleavage of their receptor N terminus by enz

238 Thus, the proteolytic cleavage of TLR3 appears to fulfill function

239 response to host DNA is the requirement for proteolytic cleavage of TLR9 in endosomes to generate a

240 Interestingly, ADAM15 mediated the proteolytic cleavage of TRIF.

241 tivated and degranulated neutrophils inhibit proteolytic cleavage of von Willebrand factor (VWF) by A

242 t chain of human FVIII (hFVIII-LC) increases proteolytic cleavage of VWF by ADAMTS13 under shear in a

243 statin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activ

244 c peptide probe requires dual (reductive and proteolytic) cleavages on both disulfide and amide bond

245 hese substrates (e.g. midkine) were prone to proteolytic cleavage only by KLK7 (and not by other skin

246 nnot be easily monitored (e.g. compared with proteolytic cleavage or amino acid phosphorylation); PDI

247 nt to initiate amyloidogenic transition, and proteolytic cleavage or removal of the C-terminal tail o

248 Following proteolytic cleavage, PAR(2) is activated through a teth

249 Differences in proteolytic cleavage patterns and chemical cross-linking

250 y to the peptide WE14, a naturally occurring proteolytic cleavage product from ChgA.

251 ncing revealed these smaller fragments to be proteolytic cleavage products and identified a limited n

252 monstrated in vitro, and the accumulation of proteolytic cleavage products in SCA7 patients and mouse

253 Expression of cyclin E proteolytic cleavage products, low-molecular weight cycl

254 n and signaling molecule or via its numerous proteolytic cleavage products.

255 ee of hydrolysis (DH) observed suggests that proteolytic cleavage rapidly occurred within the first 1

256 are an autoantibody subclass that, following proteolytic cleavage, recognize cryptic epitopes exposed

257 ic Abs across epithelia to the mucosa, where proteolytic cleavage releases the ectodomain (secretory

258 etalloprotease- and gamma-secretase-mediated proteolytic cleavage, releasing the intracellular protei

259 te immune response to this allergen-mediated proteolytic cleavage represents an ancient type of dange

260 increases open probability of the channel by proteolytic cleavage, resulted in significantly higher c

261 Within mitochondria, MOCS1AB underwent proteolytic cleavage resulting in mitochondrial matrix l

262 mbrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1).

263 m163S is activated by a series of C-terminal proteolytic cleavages resulting in diverse chemerin form

264 Mouse and human (h)TLR7 undergo proteolytic cleavage, resulting in the generation of a C

265 rulus in vivo We found evidence that defined proteolytic cleavage results in various proteoforms of i

266 2015, particularly at the hemagglutinin (HA) proteolytic cleavage site (PCS) that can affect virus ac

267 a polypeptides allowed identification of the proteolytic cleavage site of IL-15Ralpha and characteriz

268 amino acid residue at position 8 (P8) of the proteolytic cleavage site of MuV F, because this amino a

269 The presence of multibasic residues at the proteolytic cleavage site of the fusion (F) protein has

270 m and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA

271 difficulty via the insertion of a Factor Xa proteolytic cleavage site to acquire the optimal glutama

272 when ligand binding induces exposure of the proteolytic cleavage site, termed S2, within the NRR.

273 fication of 1672 unique protein N-termini or proteolytic cleavage sites from 690 unique proteins.

274 he covalently bound ligands did not mask any proteolytic cleavage sites of pepsin, trypsin or chymotr

275 arm region of the prodomain distant from the proteolytic cleavage sites.

276 s of flexible segments that are likely to be proteolytic cleavage sites.

277 an Nrf1 is also ER-associated and subject to proteolytic cleavage, suggesting a conserved mechanism o

278 The sPLA2-X protein is regulated by proteolytic cleavage, suggesting that an inflammatory en

279 epress open probability and was precluded by proteolytic cleavage that increases open probability, co

280 The proteolytic cleavage that releases ephrinA1 occurs at th

281 By non-covalent association after proteolytic cleavage, the pro-domains modulate the activ

282 Aap requires proteolytic cleavage to act as an intercellular adhesin.

283 ved in maintaining heart health that undergo proteolytic cleavage to become activated.

284 ressed as inactive proenzymes, which undergo proteolytic cleavage to become functional enzymes.

285 expressed near tumor tissue, iRGD encounters proteolytic cleavage to expose the CendR motif that prom

286 Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been imp

287 ped chromosomal cohesin complex is opened by proteolytic cleavage to release pairs of sister chromati

288 the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, wher

289 on the coupling of the sirtuin reaction to a proteolytic cleavage using internally fluorescence-quenc

290 estrate the maturation of active IL-1beta by proteolytic cleavage via caspase-1.

291 verifying mutant cell surface expression and proteolytic cleavage, we tested their ability to mediate

292 the susceptibility of their polypeptides to proteolytic cleavages were determined using peptidomic a

293 -EEE capsids exhibited a much slower rate of proteolytic cleavage when compared with CTDs of Cp183-WT

294 dding of MIC molecules that are sensitive to proteolytic cleavage, whereas the release of the short M

295 illogenesis in vitro, catalysed by selective proteolytic cleavage, which produces a high yield of gen

296 e CaV1.2 distal C-terminus is susceptible to proteolytic cleavage, which yields a truncated CaV1.2 su

297 e chaperone protein GRP78, through specific, proteolytic cleavage with the immunotoxin EGF-SubA repre

298 In addition, a secondary proteolytic cleavage within the membrane-associated SIRP

299 These peptides are produced by sequential proteolytic cleavage within the transmembrane helix of t

300 lusion, human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with