ライフサイエンスコーパス: proteolytic degradation

1 zymatic systems, since enzyme can be lost to proteolytic degradation.

2 displayed a high stability against heat and proteolytic degradation.

3 terface and predicts their susceptibility to proteolytic degradation.

4 silencing by targeting an unknown factor for proteolytic degradation.

5 ting Factors (PIFs), which induces rapid PIF proteolytic degradation.

6 dulated by phosphorylation and site-specific proteolytic degradation.

7 -1 in hindlimb ischemia may be challenged by proteolytic degradation.

8 of exponential phase RNase R and subsequent proteolytic degradation.

9 s with extra rigidity and resistance against proteolytic degradation.

10 r channel them into alternative pathways for proteolytic degradation.

11 human blood monocytes, indicating a specific proteolytic degradation.

12 " them, in vivo, for regulatory roles beyond proteolytic degradation.

13 iciently unnatural that these polymers evade proteolytic degradation.

14 e, blood-brain barrier transport, and direct proteolytic degradation.

15 RASSF2-dependent protection of MST2 against proteolytic degradation.

16 stability of StAR but offers protection from proteolytic degradation.

17 ulate, suggesting that OMA1 is attenuated by proteolytic degradation.

18 horylation, ubiquitination, and, ultimately, proteolytic degradation.

19 readily designed to resist denaturation and proteolytic degradation.

20 he transport of alpha-syn to the vacuole for proteolytic degradation.

21 gnized strategy to improve resistance toward proteolytic degradation.

22 defensins exhibit increased vulnerability to proteolytic degradation.

23 the susceptibility of alpha/beta-peptides to proteolytic degradation.

24 and prevents dTRAF2 from ubiquitin-mediated proteolytic degradation.

25 nner membrane and to protect each other from proteolytic degradation.

26 renders PAI-1 vulnerable to plasmin-mediated proteolytic degradation.

27 cause it targets NEDD8 to the proteasome for proteolytic degradation.

28 xin secretion and not attributable to solely proteolytic degradation.

29 lar ErbB3 levels by marking the receptor for proteolytic degradation.

30 d to the LNs only within migratory DCs after proteolytic degradation.

31 1 receptor domain of TLRs and promotes their proteolytic degradation.

32 poxia and VEGF can downregulate PEDF through proteolytic degradation.

33 th activates Chk1 and marks this protein for proteolytic degradation.

34 s, chemokine function is mostly regulated by proteolytic degradation.

35 s to the amino-terminus is essential for the proteolytic degradation.

36 ch more mechanically stable and resistant to proteolytic degradation.

37 otection of the enzyme from inactivation and proteolytic degradation.

38 itionally, they protect protein samples from proteolytic degradation.

39 his domain was thermally stable and resisted proteolytic degradation.

40 ress to [4Fe-4S](2+) cluster disassembly and proteolytic degradation.

41 and it does not appear to be associated with proteolytic degradation.

42 tion of a 10-amino-acid tag that signals for proteolytic degradation.

43 capacity of FGF-2 and also protects it from proteolytic degradation.

44 brane receptors and ligands to lysosomes for proteolytic degradation.

45 from increased sensitivity to cathepsin-like proteolytic degradation.

46 s (HDPs) to modulate their susceptibility to proteolytic degradation.

47 y in the cytoplasm possibly due to increased proteolytic degradation.

48 n be removed by this mechanism without prior proteolytic degradation.

49 ic properties but an enhanced sensitivity to proteolytic degradation.

50 lac promoter/operator are crucial to reduce proteolytic degradation.

51 inked network that is much more resistant to proteolytic degradation.

52 monomers with extreme resistance to heat and proteolytic degradation.

53 DR corneas may occur because of an increased proteolytic degradation.

54 ss of a structurally aberrant enzyme through proteolytic degradation.

55 portant role in the regulation of FXIIIA via proteolytic degradation.

56 aberrant and toxic proteins for refolding or proteolytic degradation.

57 amino acids (x and k), and was stable toward proteolytic degradation.

58 ity to reduce FXIIIA levels and function via proteolytic degradation.

59 1 stimulatory factor is susceptible to SpeB proteolytic degradation.

60 subsequently induced its ubiquitination and proteolytic degradation.

61 ited a significantly increased resistance to proteolytic degradation.

62 , and protects the polypeptide backbone from proteolytic degradation.

63 gainst thermal and chemical denaturation and proteolytic degradation.

64 ass of antimicrobial agents are resistant to proteolytic degradation.

65 tion factor VIII (FVIII), protecting it from proteolytic degradation.

66 elevated temperature and humidity) and from proteolytic degradation.

67 e increased in obesity, when SirT1 undergoes proteolytic degradation.

68 through active transport, and resistance to proteolytic degradation.

69 urthermore, DnaG is prone to aggregation and proteolytic degradation.

70 nstrated that the matrix protected FGF2 from proteolytic degradations.

71 Functional classes include defects in (1) proteolytic degradation, (2) ubiquitin signaling, and (3

72 l tissue on digestion, spectral evidence for proteolytic degradation after gel separation, and identi

73 nfers key advantages such as protection from proteolytic degradation, altered solubility, membrane pe

74 association was found between sensitivity to proteolytic degradation and aggregation profiles.

75 this subcomplex protects each component from proteolytic degradation and also allows their coregulati

76 Short half-lives due to rapid proteolytic degradation and an inability to cross cell m

77 eliminated from the cytoplasmic membrane by proteolytic degradation and argue against a model in whi

78 n by Akt through mutagenesis accelerates its proteolytic degradation and chromatin condensation.

79 le the problems of inclusion body formation, proteolytic degradation and disulfide bond generation th

80 of cyclotides against chemical, thermal, or proteolytic degradation and has sparked growing interest

81 a key role in protecting the A subunit from proteolytic degradation and in delivering the enzymatic

82 has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspe

83 sport pathways allude to their importance of proteolytic degradation and ion transport in maintaining

84 at the modified motif per se is resistant to proteolytic degradation and is a candidate antiinfective

85 use like most peptides, it is susceptible to proteolytic degradation and is challenging to synthesize

86 ort half-life, its susceptibility to in vivo proteolytic degradation and its propensity to in vitro a

87 MDA-MB-231 cells capable of proteolytic degradation and mesenchymal motion, invaded

88 c O-glycosylation shields bioactive ANP from proteolytic degradation and modifies potency at its cogn

89 Here, we used proteolytic degradation and mutational analysis to local

90 decreased transporter activity, followed by proteolytic degradation and possibly internalization of

91 These inhibitors resisted proteolytic degradation and rapidly inactivated PR3 in b

92 nt beta-glucuronidase and is associated with proteolytic degradation and reduced surface NaPi-2a.

93 jection, protection of antigen payloads from proteolytic degradation and reduction of antigen present

94 The complementarity of fast, specific proteolytic degradation and slower, broad transcriptomic

95 bers, phyA is subject to rapid light-induced proteolytic degradation and so accumulates to relatively

96 knowledge of tissue IGF-1 regulation through proteolytic degradation and suggest that chymase inhibit

97 estered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular h

98 y unstable proteins that were susceptible to proteolytic degradation and three (H94A, I101A, and N102

99 it was enzymatically active but sensitive to proteolytic degradation and unable to bind gangliosides,

100 results in endoplasmic reticulum retention, proteolytic degradation, and absence of adenosine 3',5'-

101 ificity of alpha-helices in proteins, resist proteolytic degradation, and may provide a novel modalit

102 ng ligands, susceptibility to cell-triggered proteolytic degradation, and remodeling.

103 accumulates due to a decrease in the rate of proteolytic degradation, and the resulting HIF-1alpha-HI

104 mulates because of a decrease in the rate of proteolytic degradation, and the resulting HIF1alpha-HIF

105 stabilize p53 protein through inhibition of proteolytic degradation, and this increase in p53 protei

106 ved that regulation of transcript clearance, proteolytic degradation, and translational rate contribu

107 tides") manifest decreased susceptibility to proteolytic degradation, and when properly designed thes

108 al class I binding oligopeptides that escape proteolytic degradation are potent crosspriming agents.

109 pecifically target either STAT1 or STAT2 for proteolytic degradation as a countermeasure for evading

110 o sequester SLBP in vivo, protecting it from proteolytic degradation as an inactive heterotetramer, o

111 ting occurs later and results from increased proteolytic degradation as well as decreased protein syn

112 mma-AA peptides were completely resistant to proteolytic degradation, boosting their potential for bi

113 active pool of PI4KIIbeta, shielding it from proteolytic degradation but also sequestering it to the

114 The down-regulation of CXCR4 was not due to proteolytic degradation but rather to transcriptional re

115 ha subunits were typically very sensitive to proteolytic degradation, but alphaT*(R238E) exhibited a

116 core complex, in the presence of O(2), from proteolytic degradation by a serine metalloprotease.

117 activation requires autophosphorylation and proteolytic degradation by caspases.

118 Proteolytic degradation by collagenase IV was observed i

119 fied elastin and significantly decreased its proteolytic degradation by elastolytic enzymes belonging

120 Prolonged activation of MORs promotes their proteolytic degradation by endocytic trafficking to lyso

121 and rendered the protein fully resistant to proteolytic degradation by gingipains.

122 the outer membrane vesicles is accessible to proteolytic degradation by proteinase K.

123 site shields the S100A9 C-terminal tail from proteolytic degradation by proteinase K.

124 in untransformed melanocytes are targeted to proteolytic degradation by the 26 S proteasome due to re

125 re the MOG40-48 epitope is protected against proteolytic degradation by the endolysosomal serine prot

126 tion of Met144 has little effect on rates of proteolytic degradation by the proteasome/Hsp90 or the s

127 ctor-alpha (HIFalpha), which is targeted for proteolytic degradation by the VHL gene product pVHL.

128 ransfected cells normally, and none suffered proteolytic degradation by trypsin.

129 itic joints occur concurrently with enhanced proteolytic degradation by up-regulated cathepsin B and

130 mic equilibrium between matrix synthesis and proteolytic degradation, by counteracting deposition of

131 Although this proteolytic degradation can be blocked by the protease i

132 stable, and exhibits increased resistance to proteolytic degradation compared with the linear peptide

133 ects of proteasome inhibition indicated that proteolytic degradation controls agonist efficacy by set

134 still highly stable in aqueous media, whose proteolytic degradation could be used in these wireless

135 This proteolytic degradation derepresses transcription of all

136 Mutations disrupting this signal blunted proteolytic degradation downstream of E3 ubiquitin ligas

137 for viral RNA synthesis, was stable against proteolytic degradation during expression.

138 s are thought to remove TOP2ccs primarily by proteolytic degradation followed by DNA DSB repair.

139 Exogenously added peptides are subject to proteolytic degradation for extended periods of time bef

140 phagosome must then balance microbicidal and proteolytic degradation functions with the generation of

141 Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely

142 -crystallin showed a significant increase in proteolytic degradation in both lens fiber and reticuloc

143 aposin C is required for GCase resistance to proteolytic degradation in the cell.

144 ion domain C terminus that is protected from proteolytic degradation in the context of the proteolipo

145 its nuclear translocation and preventing its proteolytic degradation in the cytoplasm.

146 pal E3 ubiquitin ligase responsible for Set8 proteolytic degradation in the S phase of the cell cycle

147 on across the inner membrane, and preventing proteolytic degradation, incorrect disulfide-bond format

148 Clearance of fibrin through proteolytic degradation is a critical step of matrix rem

149 Protein proteolytic degradation is an essential component to pro

150 Furthermore, TRIF-induced proteolytic degradation is extended to TLR3, TLR6, TLR7,

151 of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected.

152 bility of biologically active peptides where proteolytic degradation limits therapeutic value.

153 Proteolytic degradation may contribute to the nonrespons

154 s stabilization of certain turns and against proteolytic degradation, methods to introduce D-stereoce

155 ive regulators (e.g., PIFs) by light-induced proteolytic degradation might be sufficient to promote p

156 Proteolytic degradation of a structurally aberrant enzym

157 ion enzymes, alleviation is partially due to proteolytic degradation of a subunit of the enzyme.

158 demonstrate that antibody fragment mediated proteolytic degradation of Abeta peptide can be a potent

159 nctional tPA-plasmin system causes defective proteolytic degradation of Abeta plaques in advanced sta

160 otropic glutamate receptors, consistent with proteolytic degradation of all three Sp1-related factors

161 Proteolytic degradation of an HsEg5.NSC622124 complex re

162 d" (1, a recently described inhibitor of the proteolytic degradation of Axin) stimulated cardiomyogen

163 ecyl sulfate gel electrophoresis detected no proteolytic degradation of biotinylated IgG.

164 ds is both necessary and sufficient to cause proteolytic degradation of both ERK2 and green fluoresce

165 In addition, we analyzed photoinduced proteolytic degradation of both types of CRYs in vivo in

166 6 and E7 to antagonize BRCA1 did not involve proteolytic degradation of BRCA1.

167 tly overexpressed in PCa, is involved in the proteolytic degradation of BRCA2 in PCa cells, suggestin

168 Proteolytic degradation of cartilage glycoproteins can c

169 -MMP by glioma and fibrosarcoma cells led to proteolytic degradation of cell surface tissue transglut

170 ent endopeptidases which are involved in the proteolytic degradation of components of the extracellul

171 ation has been ascribed to the following: 1) proteolytic degradation of corneodesmosomes (CDs); 2) di

172 on injury may directly result, in part, from proteolytic degradation of cTnI, resulting in alteration

173 Progressive proteolytic degradation of cutaneous elastic fibers, tha

174 These data suggest that proteolytic degradation of CXCL12 is characteristic of b

175 that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibit

176 ese results suggest that CUL-4A mediates the proteolytic degradation of DDB2 and that this degradatio

177 IL-4 treatment led to proteolytic degradation of dimethylarginine dimethylamin

178 These data suggest that proteolytic degradation of DNA-protein cross-links may b

179 ans invades mucosal tissues by promoting the proteolytic degradation of E-cadherin in epithelial adhe

180 However, the proteolytic degradation of eIF4G alone by the human rhin

181 inhibit either ligand-induced endocytosis or proteolytic degradation of endocytosed receptors.

182 roles in the regulation of the activity and proteolytic degradation of enzymes involved in primary c

183 Internalization and proteolytic degradation of epidermal growth factor (EGF)

184 that EA and TA may be useful for preventing proteolytic degradation of existing dermal elastic fiber

185 giogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intr

186 is characterized by chronic inflammation and proteolytic degradation of extracellular matrix.

187 gical and pathological processes through the proteolytic degradation of extracellular or transmembran

188 Significantly, we found that upon proteolytic degradation of fluorescently labeled sAbeta,

189 Aided by the model, we also quantified the proteolytic degradation of GFP[AAV], GFP[ASV], and GFP[L

190 n that growth factor stimulation induces the proteolytic degradation of hSpry2 by stimulating tyrosin

191 An enhanced proteolytic degradation of hSpry2 is also observed in re

192 F-kappa B and diminished phosphorylation and proteolytic degradation of I kappa B-alpha.

193 first study to demonstrate the extracellular proteolytic degradation of IFN-gamma by ADAM17.

194 hat secretory component does not prevent the proteolytic degradation of IgA1 by IgA1 protease.

195 IGFBP-5 to bind IGF-I, but it increased the proteolytic degradation of IGFBP-5.

196 cation of NF-kappaB, and phosphorylation and proteolytic degradation of IkappaBalpha in macrophages.

197 paBalpha kinase-dependent phosphorylation or proteolytic degradation of IkappaBalpha.

198 During this process, cells initiate proteolytic degradation of internalized protein Ags into

199 ature cCF10 peptide could be formed from the proteolytic degradation of its signal peptide.

200 It is thought that irrevocable proteolytic degradation of key cell-cycle regulators mak

201 Thus, the bacterial production and proteolytic degradation of leupeptins can be associated

202 in lung destruction not only through direct proteolytic degradation of matrix proteins, but also thr

203 Proteolytic degradation of mitotic regulatory proteins f

204 that phosphorylation at Ser-8 inhibited the proteolytic degradation of monomeric Abeta by the insuli

205 AO1 on PIA-AMV was correlated with increased proteolytic degradation of MucA, and required envelope p

206 Proteolytic degradation of MYCN protein is regulated in

207 an Aurora A conformation-specific effect on proteolytic degradation of MYCN, rather than simple nano

208 er cells induced targeted ubiquitination and proteolytic degradation of nuclear and cytoplasmic free

209 t not RTK agonist-induced nuclear export and proteolytic degradation of p21Cip1 in HASMC proliferatio

210 human papillomaviruses (HPVs), which mediate proteolytic degradation of p53, the E6 protein of cutane

211 ptake from biofilm formation, likely through proteolytic degradation of proteinaceous components of t

212 n shown to play a role in assisting with the proteolytic degradation of proteins involved in competen

213 significantly before the onset of detectable proteolytic degradation of receptors ( approximately 60

214 ed geldanamycin-activated ubiquitination and proteolytic degradation of RIP1.

215 Proteolytic degradation of RPT6 was dependent on the loc

216 simple, fast, reliable method for evaluating proteolytic degradation of sarcoplasmic proteins during

217 This effect is not due to direct proteolytic degradation of secreted pheromone by the pro

218 e effects observed are modulated through the proteolytic degradation of several cytoplasmic proteins

219 transcriptional program, and light-regulated proteolytic degradation of several photoreceptors and si

220 Proteolytic degradation of Smad1 and Cbfa1 is proteasome

221 otein ligase and enhances ubiquitination and proteolytic degradation of some TLRs.

222 that is implemented at least partly through proteolytic degradation of specific signaling proteins.

223 s loop in transformed cells was dependent on proteolytic degradation of suppressor of cytokine signal

224 Degrons within AD1 do not promote proteolytic degradation of the 120-kDa Nrf1 glycoprotein

225 erivative of DM1 is subsequently released by proteolytic degradation of the antibody moiety within th

226 ransition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichi

227 Up-regulation of MMP activity, favoring proteolytic degradation of the basement membrane and ext

228 pericytes contribute to rapid and localized proteolytic degradation of the BBB during cerebral ische

229 This is in part owing to proteolytic degradation of the BH3-only family of pro-ap

230 omplex with the F-box protein Slimb mediates proteolytic degradation of the centrosomal regulatory ki

231 Our data suggest that, if coupled with proteolytic degradation of the crosslinked protein, the

232 n vitro via its ability to promote the rapid proteolytic degradation of the DNA repair protein XPB.

233 vations indicate for the first time that the proteolytic degradation of the ECM by MMPs is a necessar

234 The second step is proteolytic degradation of the ECM, led by advancing pro

235 munoreactivity was assessed before and after proteolytic degradation of the ELP partner.

236 talytic inactivation, dephosphorylation, and proteolytic degradation of the enzyme.

237 th high affinity and specificity, leading to proteolytic degradation of the ERG protein.

238 Postgermination proteolytic degradation of the essential ABI5 transcript

239 is essential as it controls ClpCP-dependent proteolytic degradation of the essential enzyme MurA, wh

240 A protease and is not coupled to 2A-mediated proteolytic degradation of the eukaryotic initiation fac

241 Proteolytic degradation of the extracellular matrix (ECM

242 eceptor (uPAR) provides a rendezvous between proteolytic degradation of the extracellular matrix and

243 Because proteolytic degradation of the extracellular matrix is a

244 atic activities suggests a mechanism of host proteolytic degradation of the extracellular matrix resu

245 n activator inhibitor-1, an inhibitor of the proteolytic degradation of the extracellular matrix.

246 bition of Rho strongly inhibited Src-induced proteolytic degradation of the extracellular matrix.

247 ue remodeling is disturbed,(3) and excessive proteolytic degradation of the joint matrices leads to j

248 esions, and occurred even with inhibition of proteolytic degradation of the matrix.

249 slation process of the oxidized mRNA and the proteolytic degradation of the modified full-length luci

250 om molecular nanofibrils and accelerates the proteolytic degradation of the molecular nanofibrils.

251 Proteolytic degradation of the murine cardiac mitochondr

252 products plus dityrosine was only seen after proteolytic degradation of the oxidatively modified hemo

253 t cryptochrome photoreaction that results in proteolytic degradation of the photopigment.

254 Proteolytic degradation of the provisional fibrin matrix

255 naling is perturbed in the CF airways due to proteolytic degradation of the receptor.

256 cycling-defective mutant B2ARs also enhanced proteolytic degradation of the wild-type B2AR after agon

257 abrogated upon light exposure by phy-induced proteolytic degradation of these PIFs, allowing the init

258 iciently destroyed by granzyme B, suggesting proteolytic degradation of these proteins as essential i

259 and model phagosomes differed, as a discrete proteolytic degradation of this SNARE was detected on my

260 role in TLR5-elicited responses by inducing proteolytic degradation of TLR5.

261 ombination of transcriptional regulation and proteolytic degradation of TrfA by ClpCP.

262 In contrast, the proteolytic degradation of tTG stimulated migration of c

263 ons on the mechanical stability and in vitro proteolytic degradation of type I collagen.

264 We report that DUX4-triggered proteolytic degradation of UPF1, a central component of

265 ve mechanisms of graft injury with roles for proteolytic degradation of uromodulin (UMOD) and several

266 eration of the blood-retinal barrier through proteolytic degradation of VE-cadherin.

267 iabetes contributes to BRB breakdown through proteolytic degradation of VE-cadherin.

268 ovirus disassembly is the cathepsin-mediated proteolytic degradation of viral outer capsid protein si

269 into the rate-limiting phosphorylation (and proteolytic degradation) of IkappaBalpha, the inhibitory

270 However, their susceptibility to proteolytic degradation often limits their utility in th

271 BM through which they can invade, either via proteolytic degradation or mechanical force.

272 the absence of Mzm1, Rip1 is prone to either proteolytic degradation or temperature-induced aggregati

273 The mechanism of this selective proteolytic degradation, or in essence how the nNOS beco

274 N-Formyl peptides are derived from proteolytic degradation/processing of bacterial and mito

275 Moreover, we observed distinct proteolytic degradation products for hcTnT and mcTnT.

276 e AR and that detection of the corresponding proteolytic degradation products in urine provides a non

277 ofolate, are direct targets of As2O3-induced proteolytic degradation, providing a mechanism for arsen

278 way by geldanamycin, an effect partly due to proteolytic degradation rather than disulfide reduction.

279 Proteolytic degradation reduces the levels of unfolded a

280 homologue shows substantial protection from proteolytic degradation relative to the Bim BH3 alpha-pe

281 itial autocleavage of IrvR and exposure of a proteolytic degradation sequence followed by Clp-depende

282 sk but not low-risk HPV E7 target PTPN14 for proteolytic degradation, suggesting that PTPN14 degradat

283 lpha/beta-peptide is far less susceptible to proteolytic degradation than is an analogous alpha-pepti

284 TTSS-dependent effectors are subject to the proteolytic degradation that appears to be rate-limiting

285 that redirects IRF3 to the endolysosome for proteolytic degradation, thus allowing HIV to avoid the

286 cell stimulation, our findings indicate that proteolytic degradation tightly couples RGS2 transcripti

287 basement membrane is rendered distensible by proteolytic degradation to allow it to be moved and remo

288 e ligand density, mechanical properties, and proteolytic degradation to study the impact of ECM prope

289 results suggest that ToxT protein undergoes proteolytic degradation to terminate virulence gene expr

290 ild and harsh acidic conditions, storage and proteolytic degradation--unlike native bFGF.

291 We systematically assessed proteolytic degradation using liquid chromatography-mass

292 A-crystallins were labeled with (125)I, and proteolytic degradation was determined using both lens f

293 aC-crystallins were labeled with (125)I, and proteolytic degradation was determined using both lens f

294 g the high resistance of synthetic PvD(1) to proteolytic degradation, we claim that conditions are no

295 lipid binding, chaperone-like function, and proteolytic degradation were systematically examined by

296 eptors from the surface and their subsequent proteolytic degradation were the primary mechanisms resp

297 des with considerable resistance to heat and proteolytic degradation, which are attractive properties

298 P49 are phosphorylated proteins that undergo proteolytic degradation with fiber cell age; however, th

299 biospecific cell adhesion and cell-mediated proteolytic degradation with independently adjustable ma

300 The internalized protein undergoes proteolytic degradation, yielding amino acids including