ライフサイエンスコーパス: proteolytic enzyme

1 based classification of peptidases (i.e. all proteolytic enzymes).

2 al metastatic effect of this multifunctional proteolytic enzyme.

3 examined the role of cathepsin B as a model proteolytic enzyme.

4 prompting speculation that it functions as a proteolytic enzyme.

5 ling during cervical ripening via release of proteolytic enzymes.

6 isease (AD), is degraded by a diverse set of proteolytic enzymes.

7 Bacteria produce a range of proteolytic enzymes.

8 f FAK, with no marked increases in genes for proteolytic enzymes.

9 ) phosphorylation and in gene expression for proteolytic enzymes.

10 cyte lysate as sources of ubiquitinating and proteolytic enzymes.

11 cyte lysate as sources of ubiquitinating and proteolytic enzymes.

12 3) up-regulate a group of genes that include proteolytic enzymes.

13 sms have evolved to regulate the function of proteolytic enzymes.

14 gammaRIII-deficient neutrophils, to secrete proteolytic enzymes.

15 ot-based enzymatic probes in the presence of proteolytic enzymes.

16 he protein requires cleavage by two distinct proteolytic enzymes.

17 through the release of cathepsin B and other proteolytic enzymes.

18 ording the discovery and characterization of proteolytic enzymes.

19 e particularly susceptible to degradation by proteolytic enzymes.

20 g force in the evolution of parasite-derived proteolytic enzymes.

21 nd proteins is resistant to cleavage by most proteolytic enzymes.

22 been developed that degrade as cells secrete proteolytic enzymes.

23 enced by matrix metalloproteinases and other proteolytic enzymes.

24 to an immobilized Ab and then digested with proteolytic enzymes.

25 eta, a cytokine that can induce secretion of proteolytic enzymes.

26 interstitial tissues by mobilizing undefined proteolytic enzymes.

27 exploring molecular recognition elements in proteolytic enzymes.

28 and selective reagents for a wide variety of proteolytic enzymes.

29 hether SCCA2 inhibited a different family of proteolytic enzymes.

30 an important opsonin (iC3b) are destroyed by proteolytic enzymes.

31 turing agents and aqueous buffers containing proteolytic enzymes.

32 antibacterial activity after treatment with proteolytic enzymes.

33 r significantly reduced upon hydrolysis with proteolytic enzymes.

34 evaluated through hydrolysis with different proteolytic enzymes.

35 ion, up-regulation, and secretion of various proteolytic enzymes.

36 d found to produce a range of glycosidic and proteolytic enzymes.

37 rointestinal environments in presence of the proteolytic enzymes.

38 -based selectivity is a general attribute of proteolytic enzymes.

39 kinetics were accelerated in the presence of proteolytic enzymes.

40 ll basement membrane can both be affected by proteolytic enzymes.

41 eases belonging to five catalytic classes of proteolytic enzymes.

42 ilatory agents, antilymphogenic therapy, and proteolytic enzymes.

43 gical macromolecules, including proteins and proteolytic enzymes.

44 ection of the protein against degradation by proteolytic enzymes.

45 e caused by activation of calpain or caspase proteolytic enzymes.

46 itin was shown to be relatively resistant to proteolytic enzymes.

47 By targeting the actions of these proteolytic enzymes, a more controlled and physiological

48 A number of proteolytic enzymes activate pro-MMP-9 in vitro, but the

49 levels for myofibrillar proteins, increased proteolytic enzyme activities, and a lower myosin/actin

50 speculate that AgrB is a novel protein with proteolytic enzyme activity and a transporter facilitati

51 We suggest, therefore, that proteolytic enzyme activity contributes to loss of exocr

52 Proteolytic enzyme activity in lipid-rich atheroma may p

53 ery of new connections between metabolic and proteolytic enzyme activity in specific tumor compartmen

54 content due in part to less fluid, aberrant proteolytic enzyme activity, decline in amylase activity

55 ressed proinflammatory responses, as well as proteolytic enzyme activity, induced by ligature.

56 ed to construct sensing assemblies to detect proteolytic enzyme activity.

57 arch industry was hydrolyzed with commercial proteolytic enzymes (Alcalase, Neutrase, Flavourzyme) an

58 ocessing seed storage protein and that other proteolytic enzymes also can process storage proteins in

59 Using trypsin as the sole proteolytic enzyme and data from a single injection per

60 Leucine aminopeptidase (LAP) is an essential proteolytic enzyme and potential biomarker for liver mal

61 trate a role for a leucine zipper motif in a proteolytic enzyme and suggest that leucine zipper motif

62 in-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate

63 tion by stimulating the expression of matrix proteolytic enzymes and by downregulating the deposition

64 nd heterotypic adhesion while also secreting proteolytic enzymes and experiencing a haptotactic gradi

65 This method is compatible with a range of proteolytic enzymes and fragmentation methods, and shoul

66 ulating the bioavailability of extracellular proteolytic enzymes and growth factors.

67 In addition, the release of proteolytic enzymes and inhibitors is imbalanced.

68 Proteins were digested with proteolytic enzymes and peptides masses determined by ma

69 mine further the expression of a spectrum of proteolytic enzymes and protease inhibitors.

70 Fab and abeta(1-40) complex was treated with proteolytic enzymes and the digested complexes were dire

71 hich requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.

72 believed to result from an imbalance between proteolytic enzymes and their inhibitors.

73 Characterization of proteolytic enzymes and their substrates presents a form

74 idolysis assay is readily adaptable to other proteolytic enzymes and their substrates.

75 The terms "proteolytic enzyme" and "peptidase" have been treated as

76 Peptidases (proteolytic enzymes) and their natural, protein inhibito

77 olved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthes

78 hat now implicates cytokines and chemokines, proteolytic enzymes, and oxidants in the inflammatory ca

79 of accurate mass data, expected cleavages by proteolytic enzymes, and postsource decay sequencing all

80 of nonionic detergents, reducing agents, and proteolytic enzymes, and successive products of the reac

81 These proteolytic enzymes are also the first in which the nucl

82 Proteolytic enzymes are essential for initiation of the

83 In this technique, samples containing proteolytic enzymes are first resolved in nonreducing SD

84 disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of

85 Proteolytic enzymes are key signaling molecules in both

86 Proteolytic enzymes are known to be associated with deve

87 Proteolytic enzymes are necessary for the mineralization

88 Recent improvements in proteolytic enzymes are reflected in the introduction of

89 ases that disrupt host tissue and that these proteolytic enzymes are regulated by multiple transcript

90 Proteolytic enzymes are required to mediate tumor cell i

91 Peptidases (proteolytic enzymes) are of great relevance to biology,

92 n be used to dissect the biological roles of proteolytic enzymes as well as to develop diagnostic and

93 ix-degrading metalloproteinases, a family of proteolytic enzymes, as mediators of collagen damage in

94 tated by the catalytic activities of granule proteolytic enzymes, assists in the targeting (storage)

95 teine proteases (PLCPs) are a large class of proteolytic enzymes associated with development, immunit

96 been developed for detecting the activity of proteolytic enzymes based on fluorescent conjugated poly

97 enzymes with the milk proteins and the main proteolytic enzymes becomes important in determining the

98 hordin are in turn regulated by the secreted proteolytic enzymes BMP1 and Xolloid.

99 Zymography detects and characterizes proteolytic enzymes by electrophoresis of protease-conta

100 atially heterogeneous biochemical network of proteolytic enzymes called blood coagulation.

101 d/or the regulation of a group of endogenous proteolytic enzymes called kallikreins.

102 Cleavage is suppressed by inhibitors of the proteolytic enzyme, calpain I.

103 Proteolytic enzyme, calpain, is a potential candidate fo

104 -/-) mice is associated with activation of a proteolytic enzyme, Calpain-1.

105 e release of cytochrome c, which activates a proteolytic enzyme cascade, resulting in specific nuclea

106 tein present in platelets but also regulates proteolytic enzyme cascades, including the blood coagula

107 cl-micelles was observed in the presence of proteolytic enzymes (cathepsin B).

108 The proteasome is a proteolytic enzyme complex essential for protein homeost

109 -40% to 86-89%, respectively with increasing proteolytic enzyme concentration.

110 etermined, in addition to genes encoding key proteolytic enzymes containing putative signal peptides.

111 ecreted virulence factors, including various proteolytic enzymes, contribute to the establishment and

112 This steroidal modulation of proteolytic enzymes could help to explain why pregnancy

113 wound care dressing is flexible cross-linked proteolytic enzyme degradation resistant.

114 modified peptides, to improve resistance to proteolytic enzyme degradation, and to modulate physico-

115 hat the CPZ-1 enzyme functions directly as a proteolytic enzyme degrading cuticular proteins before e

116 tion, and augments superoxide production and proteolytic enzyme degranulation.

117 Treatment of the pigmented cells with proteolytic enzymes, denaturant, and hot concentrated ac

118 Additionally, inhibitors of these proteolytic enzymes did not affect the biological activi

119 Because the proteolytic enzyme dispase dissociates tissues, the hypo

120 ing those that target inflammatory cells and proteolytic enzymes (eg, integrin alphavbeta3 and matrix

121 acologically active member of the sulfhydryl proteolytic enzyme family, obtained from Ananas comosus

122 The first structure of an ant proteolytic enzyme, fire ant chymotrypsin, was determine

123 Matrix metalloproteinase-9 (MMP-9), a proteolytic enzyme for matrix proteins, chemokines and c

124 y show that cathepsin L functions as a major proteolytic enzyme for the production of POMC-derived pe

125 udy, CME can be suggested as a new source of proteolytic enzymes for fish protein hydrolysis.

126 ng phage display have been widely applied to proteolytic enzymes for substrate selection and optimiza

127 cera can be used as an alternative source of proteolytic enzymes for the effective tenderising of mea

128 icular the roles of excitotoxic amino acids, proteolytic enzymes, free radicals, nitric oxide, and le

129 shown that there is an interesting group of proteolytic enzymes from carnivorous pitcher plants of t

130 The proteolytic enzymes generating short N-terminal fragment

131 of inhibitors with enhanced potency against proteolytic enzymes has many applications for the treatm

132 se" have been treated as synonymous, and all proteolytic enzymes have been considered to be hydrolase

133 For a long time, proteolytic enzymes have been employed as key tools of i

134 Proteolytic enzymes have been proposed to play a role in

135 ticular attention focuses on the impact that proteolytic enzymes have on the tumour's progression.

136 Proteolytic enzymes have shown efficacy in cancer therap

137 t following apoptosis, the caspase family of proteolytic enzymes have the potential to generate immun

138 n CcI3, with more esterolytic, lipolytic and proteolytic enzymes having signal peptides.

139 Cathepsin E (Cath E) is a proteolytic enzyme highly expressed in PDAC.

140 phosphoproteome that uses endo-Lys C as the proteolytic enzyme, immobilized metal affinity chromatog

141 oteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remod

142 During this process Ce-CPL-1 may act as a proteolytic enzyme in the processing/degradation of cuti

143 a multigene family of 56 subtilisin-related proteolytic enzymes in Arabidopsis thaliana.

144 roviding information about the activities of proteolytic enzymes in blood, which may be correlated wi

145 The abundance of proteolytic enzymes in cancer cells makes it difficult t

146 nsideration of the widespread application of proteolytic enzymes in food processing.

147 in the levels of bacterial and host-derived proteolytic enzymes in oral inflammatory exudates.

148 h of more recent developments of the role of proteolytic enzymes in physiological regulation and an o

149 proaches to study activity and substrates of proteolytic enzymes in relevant biological models, both

150 extracellular matrix barriers by mobilizing proteolytic enzymes in response to epidermal growth fact

151 ocalize various members of the MMP family of proteolytic enzymes in the Bruch's-choroid complex.

152 To assess the role of inflammatory cells and proteolytic enzymes in the development of chronic allogr

153 ges of the parasite that would be exposed to proteolytic enzymes in the digestive tract of the host.

154 e proteinases were the predominant digestive proteolytic enzymes in the guts of these insects at this

155 cs of matrix gene expression and activity of proteolytic enzymes in the lesion were evaluated.

156 The presence of proteolytic enzymes in the OMV did not contribute to cap

157 The immobilized HSA was digested by various proteolytic enzymes in the presence of normal water, whi

158 gnificantly lower and less complex levels of proteolytic enzymes, in comparison with leaf extracts, w

159 rointestinal digestion (SGID) performed with proteolytic enzymes, in vitro.

160 selectivity for HRV-14 3CP compared to other proteolytic enzymes, including chymotrypsin and cathepsi

161 Proteolytic enzymes, including fibroblast collagenase, h

162 athways but also the activity of specialized proteolytic enzymes-including proteases of the SPRTN/Wss

163 60-kDa protein was stable in the presence of proteolytic enzyme inhibitors but was gradually converte

164 were stored in artificial saliva containing proteolytic enzyme inhibitors, or pure mineral oil.

165 g, to more subtle effects on the activity of proteolytic enzymes involved in antigen processing.

166 In our search for novel proteolytic enzymes involved in MHC class I (MHC-I) pres

167 Degradation of the extracellular matrix by proteolytic enzymes is a central aspect of physiological

168 e degradation of basement membrane matrix by proteolytic enzymes is a hallmark of tumor invasion and

169 atrix (ECM) through the regulated release of proteolytic enzymes is a key process for development, mo

170 Degradation of Abeta by specific proteolytic enzymes is an important process that regulat

171 tion to this colloquium, the past history of proteolytic enzymes is briefly reviewed against the back

172 The activity of certain proteolytic enzymes is often an indicator of disease sta

173 Peptide mapping using proteolytic enzymes is one useful technique to character

174 mical evidence that cleavage by two distinct proteolytic enzymes is required for effective activation

175 hydrolysis of food proteins using commercial proteolytic enzymes is the most commonly employed proces

176 Genes in these regions include the proteolytic enzymes kallikrein (KLKB1) and Factor XII (F

177 ion is thought to be mediated by a family of proteolytic enzymes known as matrix metalloproteinases (

178 ark is degradation of articular cartilage by proteolytic enzymes leading to loss of joint function.

179 The proteins collected were identified using proteolytic enzymes, MALDI-TOF MS and MSFit database sea

180 The loss of BBB integrity by the proteolytic enzyme matrix metalloproteinase-9 (MMP-9) is

181 The results suggested that S. fusiform proteolytic enzyme may be necessary for parasite surviva

182 The proteolytic enzyme might be a new translational target r

183 Before the cleavage by its target, proteolytic enzyme MMP-2, the probe, an activatable cell

184 e knowledge that cigarette smoke induces the proteolytic enzyme MMP1 leading to destruction of the lu

185 Whole human saliva contains a number of proteolytic enzymes, mostly derived from white blood cel

186 rm ciliary ectosomes, act as carriers of the proteolytic enzyme necessary for the liberation of daugh

187 roteinase inhibitors confine the activity of proteolytic enzymes of inflammatory cells, but fail to p

188 Plasmepsins (proteolytic enzymes of the parasite) have been considere

189 Protease sensitivity analysis using six proteolytic enzymes of varying specificity showed that R

190 Current methods require proteolytic enzymes or chemical agents and typically a s

191 ement membrane barriers by either mobilizing proteolytic enzymes or deploying mechanical forces.

192 Peptidases (proteolytic enzymes or proteases), their substrates and

193 e addition of external coagulation proteins, proteolytic enzymes, or phospholipids.

194 The database has been expanded to include proteolytic enzymes other than peptidases.

195 When levels of acid and proteolytic enzymes overwhelm the mucosal defense mechan

196 ctionality of melanoidins extracted with the proteolytic enzymes papain (PE) and enzymes from B. subt

197 r governed by the capacity to degrade ECM by proteolytic enzymes, particularly matrix metalloproteina

198 l activity even after being treated with the proteolytic enzyme pepsin and heated at 60 degrees C.

199 c stationary phase for immobilization of the proteolytic enzyme pepsin.

200 on an enzyme-assisted (EA) extraction using proteolytic enzymes (pepsin or pepsin-pancreatin).

201 In this study, three proteolytic enzymes (pepsin, trypsin, Alcalase(R)) were

202 ls and subjected to hydrolysis by SGID using proteolytic enzymes (pepsin, trypsin, chymotrypsin and p

203 min inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin.

204 activating human plasminogen to generate the proteolytic enzyme plasmin.

205 Parasite proteolytic enzymes play an essential but poorly underst

206 Proteolytic enzymes play fundamental roles in many biolo

207 sp molecules because treatment of hsp71 with proteolytic enzymes, polymyxin, or ATP abrogated this in

208 these findings suggest that the response of proteolytic enzyme preparations to static or free-fall p

209 These experiments showed that proteolytic enzymes present in the apoplasm and medium c

210 lows for the exposure of procytokines to the proteolytic enzymes produced by activated neutrophils, n

211 nd phloem revealed the existence of distinct proteolytic enzyme profiles within these tissues.

212 elanoproteins classically extracted with the proteolytic enzyme pronase E (S. griserus).

213 specific removal of fast inactivation by the proteolytic enzyme pronase eliminated charge immobilizat

214 The proteolytic enzyme Pronase reduced the uptake of transfe

215 sitivity of the B cell FCXM, we utilized the proteolytic enzyme pronase to remove Fc receptors from l

216 Proteolytic enzymes (proteases) participate in a vast ra

217 proteins may occur through the activation of proteolytic enzymes rather than exclusively through tran

218 ffects involve specific receptor activation, proteolytic enzymes, reactive oxygen species, or deliver

219 cal strain-driven cell damage and downstream proteolytic enzyme release, fluid flow-driven aggrecan d

220 e extracellular matrix through production of proteolytic enzymes, release of proinflammatory factors

221 To identify the proteolytic enzyme responsible for shedding of meprin A,

222 n production and activity and determined the proteolytic enzymes responsible for corin cleavage.

223 ix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for myocardial extracell

224 Gamma-secretase is the second of two proteolytic enzymes responsible for the release of the a

225 should facilitate the identification of the proteolytic enzymes responsible for their formation.

226 treatment of ex vivo porcine cartilage with proteolytic enzymes resulted in decreased AFL.

227 e paradox of how functional loss of a single proteolytic enzyme results in an apparent increase in bo

228 ane protrusions and (b) functional for using proteolytic enzyme(s) for ECM degradation.

229 various pH values, (2) protein digestion by proteolytic enzyme(s), during which all the rapidly exch

230 le death is probably caused by the action of proteolytic enzymes secreted by neighboring fibroblasts.

231 Proteolytic enzymes secreted by the cold-adapted microor

232 -medium adhesion, and that increases in both proteolytic enzyme secretion rate and the coefficient of

233 between cell-cell and cell-medium adhesion, proteolytic enzyme secretion, cell birth and death proce

234 The protein chips with immobilized proteolytic enzymes showed the usefulness for fast in si

235 nd showed loss and gain of saliva-associated proteolytic enzymes, similar to NOD.B10-H2(b).C-Stat6(+/

236 Proteolytic enzyme studies indicate that the two histidy

237 tract plant proteins, and then hydrolysed by proteolytic enzymes such as trypsin (serine protease) an

238 in vitro by organomercurial compounds and by proteolytic enzymes such as trypsin, chymotrypsin, and s

239 eaved to some extent (ca. 50% after 24 h) by proteolytic enzymes, such as cathepsin B, cathepsin D, p

240 pared by cleaving the proteins with specific proteolytic enzymes, such as trypsin.

241 r research is aimed at the definition of the proteolytic enzyme systems in these oral streptococci wh

242 Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microb

243 Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme that degrades the extracellular matri

244 amel matrix serine proteinase 1 (EMSP1) is a proteolytic enzyme that has been isolated from the devel

245 ormulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in

246 trate that the Kell blood group protein is a proteolytic enzyme that processes big ET-3, generating E

247 of matrix metalloproteinase 9 (MMP9), a key proteolytic enzyme that regulates wound remodeling.

248 as a chaperone at low temperatures and as a proteolytic enzyme that removes denatured or damaged sub

249 synergistically increasing micro-calpain, a proteolytic enzyme that targets E-cadherin.

250 est and activation of the caspase cascade of proteolytic enzymes that accompany apoptotic cell death.

251 tive in the production of the gingipains-the proteolytic enzymes that also harbor hemagglutinin domai

252 roup of delayed response genes including two proteolytic enzymes that appear to execute the tail reso

253 Caspases are proteolytic enzymes that are closely involved in the ind

254 Caspases are proteolytic enzymes that are essential for apoptosis.

255 Dipeptidyl peptidases (DPPs) are proteolytic enzymes that are ideal therapeutic targets i

256 ovium produces proinflammatory cytokines and proteolytic enzymes that are important in the tissue deg

257 Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury and

258 exes of histone proteins and DNA coated with proteolytic enzymes that are released extracellularly to

259 and the system is subject to degradation by proteolytic enzymes that can break down its mechanical i

260 ix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components

261 Deubiquitinases (DUBs) are proteolytic enzymes that catalyze the removal of ubiquit

262 e pulmonary disease and alters expression of proteolytic enzymes that contribute to disease pathology

263 metalloproteinases (MMPs) are extracellular proteolytic enzymes that contribute to pericellular remo

264 ondrocytes characterized by the induction of proteolytic enzymes that degrade cartilage, such as matr

265 Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix pr

266 stresses may stimulate the cells to produce proteolytic enzymes that degrade the duct wall, making i

267 MMP-1, interstitial collagenase), one of the proteolytic enzymes that degrade type I collagen, in nor

268 elial and stromal cells and by production of proteolytic enzymes that facilitate the invasion of trop

269 ut some of these proteins are substrates for proteolytic enzymes that generate soluble cytokines with

270 determining the cleavage site specificity of proteolytic enzymes that involves pooled sequencing of p

271 Calpains are proteolytic enzymes that modulate cellular function thro

272 Matrix metalloproteinases (MMPs) are proteolytic enzymes that play an important role in these

273 xycycline can reach the choroid to attenuate proteolytic enzymes that remodel Bruch's membrane and pr

274 A low extracellular pH further activates proteolytic enzymes that remodel the extracellular matri

275 s and activational states of a family of ECM proteolytic enzymes, the matrix metalloproteinases (MMPs

276 atoid synoviocytes express a multiplicity of proteolytic enzymes, the primary effectors of cartilage,

277 a randomized, phase III, controlled trial of proteolytic enzyme therapy versus chemotherapy.

278 The proteolytic enzyme thrombin is produced during activatio

279 As a case study, we targeted the proteolytic enzyme thrombin, involved in blood coagulati

280 ni of two monomers (chains) were modified by proteolytic enzymes to different extents with no effect

281 Schistosomes employ proteolytic enzymes to digest host hemoglobin from inges

282 Blood-feeding parasites employ a battery of proteolytic enzymes to digest the contents of their bloo

283 In this study, we introduce antibody-guided proteolytic enzymes to enable selective sub-stoichiometr

284 The industrial preparation, modified within proteolytic enzyme, totally soluble (average 98%), was c

285 HD characterized by preferentially enhanced proteolytic enzyme translation and secretion, platelet c

286 better quality of life than those who chose proteolytic enzyme treatment.

287 ubsequent treatment of plasma membranes by a proteolytic enzyme (trypsin) causes the loss of some of

288 A can be treated with mild concentration of proteolytic enzymes (trypsin or thermolysin).

289 iris and ciliary body was digested with the proteolytic enzyme V8 protease to solubilize the protein

290 rived by treatment of insoluble MAA with the proteolytic enzyme, V8 protease.

291 andom screening on a panel of representative proteolytic enzymes was then carried out and revealed th

292 viously loaded with trypsin and chymotrypsin proteolytic enzymes, was successfully exploited.

293 te targeting' by small-molecule effectors of proteolytic enzymes, which if generally applicable may s

294 alpain is a nearly ubiquitous Ca2+-activated proteolytic enzyme whose precise physiological function

295 f proteolytic activities or perhaps a single proteolytic enzyme with broad amino acid specificity.

296 alloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity agai

297 tion of NEP represents a unique example of a proteolytic enzyme with dual action, namely, degradation

298 mass spectrometry-based proteomics utilizes proteolytic enzymes with well characterized specificitie

299 ely bind and block the catalytic activity of proteolytic enzymes with wide ranging biological functio

300 In addition, the induction of a proteolytic enzyme within the Type II pneumocyte suggest