ライフサイエンスコーパス: proteolytic fragment

1 als representing small soluble species (e.g. proteolytic fragments).

2 ting that this form of PKM is not a PKC zeta proteolytic fragment.

3 e gamma-PAK as a full-length enzyme and as a proteolytic fragment.

4 associates with the amyloid as an accessory proteolytic fragment.

5 ns have diverse effects on the levels of APP proteolytic fragments.

6 phosphorylation, 18 duplicate genes, and 44 proteolytic fragments.

7 m the lipoprotein(a) (Lp(a)) particle, or as proteolytic fragments.

8 , as evidenced by a change in the pattern of proteolytic fragments.

9 to the alpha-subunit was mapped to two large proteolytic fragments.

10 arget proteins were selectively cleaved into proteolytic fragments.

11 sistant oligomers of pig gastric AE2 and its proteolytic fragments.

12 ecular functions of differentially localized proteolytic fragments.

13 e with endoproteinase Glu-C produces several proteolytic fragments.

14 vative was identified by antibody mapping of proteolytic fragments.

15 tibody, we mapped the locations of the major proteolytic fragments.

16 st cancer cell lines were used to assess the proteolytic fragments.

17 analyses of ADAMTS-4, ADAMTS-5, and aggrecan proteolytic fragments.

18 nits of a protein complex can yield isomeric proteolytic fragments.

19 rification of the protein and removal of any proteolytic fragments.

20 -length proteins and their in situ-generated proteolytic fragments.

21 t but resulted in the secretion of two apo B proteolytic fragments (80 and 120 kD), which were found

22 17 x 10(6) M(-1)) were close to those of Fab proteolytic fragments (9.78 x 10(6) M(-1)) derived from

23 SR) of SP-B measured using the most abundant proteolytic fragment, a 10 amino acid peptide from the c

24 a precursor protein, and accumulation of its proteolytic fragment Abeta; (b) accumulations of phospho

25 Secretion of the APP-derived proteolytic fragment, Abeta, was tightly correlated with

26 ues has nuclease activity, whereas no stable proteolytic fragments accumulate from the N-terminal por

27 ed endocytosis and the transport of a 37-kDa proteolytic fragment across a membrane into the cytoplas

28 nd D44C, and to a lesser extent I43C, led to proteolytic fragments after oxidation.

29 h PS1 and PS2 are each processed into stable proteolytic fragments after their biosynthesis in transf

30 Catalytically active ADAMTS5 proteolytic fragment also suppressed angiogenesis in vit

31 pha by various methods (mass spectrometry of proteolytic fragments, amino acid analysis, molecular we

32 he amyloid-beta precursor protein and of its proteolytic fragment, amyloid-beta, associated with the

33 Using proteolytic fragments and maltose-binding protein fusion

34 This approach efficiently analyzes proteolytic fragments and native proteins in a complex m

35 e molecule in solution but is exposed on the proteolytic fragments and probably when fibronectin is i

36 ructure and folding of the repressor and its proteolytic fragments and show excellent agreement for t

37 in planar lipid bilayers and liposomes with proteolytic fragments and site-directed variants.

38 unity regulation, the (in)stability of these proteolytic fragments and the determinants regulating th

39 Analysis of ShdA binding to fibronectin proteolytic fragments and to recombinant fibronectin fus

40 have been generated against sequences in the proteolytic fragments and used to demonstrate the time c

41 n in full-length human APPswe as well as its proteolytic fragments, and ameliorates cognitive deficit

42 Using deletion mutants, proteolytic fragments, and protease protection of HIP/L2

43 nce common to all active synthetic peptides, proteolytic fragments, and recombinant constructs of Ebp

44 Using naturally occurring thymosin beta4, proteolytic fragments, and synthetic peptides, we find t

45 recursor (67 kDa) from eight non-overlapping proteolytic fragments, and the identity was confirmed by

46 accounting for the earlier observation that proteolytic fragments ( approximately 35 kDa) of lucifer

47 RNA synthetase (TrpRS) and a similar natural proteolytic fragment are potent angiostatic factors that

48 In addition, APP and its proteolytic fragments are emerging as biomarkers for neu

49 as it is from the Abeta monomer, while other proteolytic fragments are generated much more slowly.

50 Five-helix proteolytic fragments are less stable.

51 Our findings reveal that numerous proteolytic fragments are released from dying tumor cell

52 ength beta(2)m induces pathophysiology or if proteolytic fragments are sufficient for inducing this e

53 tic activity, calpain also produces a stable proteolytic fragment at 50kDa using recombinant MetAP2.

54 Following the substrate cleavage, only the proteolytic fragments bearing biotin moieties are captur

55 abeling was contained within a 20-kilodalton proteolytic fragment beginning at Ser(173) that contains

56 incorporation was contained within a 20-kDa proteolytic fragment beginning at Ser-173, with alphaTyr

57 (APP) and intracellular accumulation of its proteolytic fragment beta-amyloid play a central role in

58 d increased significantly the release of its proteolytic fragment, beta amyloid (Abeta).

59 In this study, we examined HMW1 proteolytic fragments by mass spectrometry, achieved 89%

60 ical APP processing pathway, which generates proteolytic fragments capable of inhibiting neuronal act

61 ll-length Dll1, but not its N- or C-terminal proteolytic fragment, co-immunoprecipitates with ADAM12.

62 (APP) and intracellular accumulation of its proteolytic fragments collectively known as beta-amyloid

63 Using limited proteolysis, we identified the proteolytic fragments composing the molecular "bar-code"

64 cell co-transfectants, we demonstrate that a proteolytic fragment consisting of the extravesicular do

65 The latter increase was confined to a proteolytic fragment containing the first three transmem

66 nly in the alpha subunit with 70% being in a proteolytic fragment containing the M4 transmembrane seg

67 The largest proteolytic fragment containing the putative glycosyltra

68 Purified TSP proteolytic fragments containing either the N-terminal h

69 Proteolytic fragments containing the C terminus were com

70 ays that reliably quantified the proteins or proteolytic fragments covalently bound to DNA.

71 intact polypeptides and mass spectrometry of proteolytic fragments demonstrated that the 142-kD form

72 Analysis of the labeled protein and its proteolytic fragments demonstrates that the ZTG label is

73 Based on the accumulation of proteolytic fragments derived from APC-induced cleavage,

74 The fibrils consist of proteolytic fragments derived from Pmel17, a pigment cel

75 K18, but not K8, generates a proteolytic fragment during drug- and UV light-induced a

76 d reactivity for a calpain-specific spectrin proteolytic fragment during the period of recovery from

77 a), or Lp(a-), free apo(a), and the two main proteolytic fragments, F1 and F2.

78 In addition, one of the major N-terminal Htt proteolytic fragments found in human HD tissue appears t

79 ange in micro 1 and for release of the delta proteolytic fragment from entering particles.

80 our original suggestion that zeugmatin is a proteolytic fragment from the N-terminal region of titin

81 MALDI-MS identified proteolytic fragments from ovalbumin and lysozyme, exhib

82 Proteolytic fragments from Pmel17 form fibrils upon whic

83 dependent excitatory synaptogenesis, via two proteolytic fragments generated by calpain cleavage.

84 These studies indicate that other proteolytic fragments generated by intracellular process

85 Several of the ARS molecules and their proteolytic fragments generated during inflammation and

86 nt data suggest that ARS molecules and their proteolytic fragments generated during the cell death pr

87 sely related homolog by sequence analysis of proteolytic fragments generated from the purified enzyme

88 d CaM induced alterations in the kinetics of proteolytic fragment generation during limited trypsinol

89 A similar set of proteolytic fragments has been identified in hamster GAA

90 in digests by MALDI-MS because these anionic proteolytic fragments have low ionization efficiencies.

91 erative binding (ka) of both gp32 and of its proteolytic fragment *I (which lacks 48 residues from th

92 on is supported by the observations that SUS proteolytic fragments: (i) were detected and possessed r

93 spectrometry (MALDI-MS) characterization of proteolytic fragments identified disulfide bonds between

94 Sequencing of a purified proteolytic fragment in combination with SERCA2a mutagen

95 ated Edman degradation of native CP2 and its proteolytic fragments in conjunction with mass spectrome

96 tform) to attempt to identify substrates and proteolytic fragments in mouse and human plaque extracts

97 The 66-, 36-, and 27-kDa proteolytic fragments in the membranes all start at Met1

98 ighted the generation of specific C-terminal proteolytic fragments, in particular the accumulation of

99 Peak overlap among the dozens of proteolytic fragments (including those from autolysis of

100 Proteolysis of PTPmu generates a series of proteolytic fragments, including a soluble catalytic int

101 Mass spectrometry analysis of isolated proteolytic fragments indicated at least two major cleav

102 In both reactions, the extreme N-terminal proteolytic fragment is released from fibrils as rapidly

103 -terminal sequence analysis of nAChR-subunit proteolytic fragments isolated by SDS-PAGE and/or revers

104 s to the 3'-5' exonuclease site of the large proteolytic fragment (Klenow fragment) of DNA polymerase

105 The calpain-generated proteolytic fragment, like paxillin delta, functions as

106 For proteolytic fragments linked by more than one disulfide

107 iption factor/antitoxin MrpC and its related proteolytic fragment MrpC2 are increased, inhibiting the

108 These include the production of proteolytic fragments, nuclear accumulation, and process

109 through improved insulin sensitivity, and a proteolytic fragment of adiponectin stimulates beta oxid

110 A proteolytic fragment of alpha-catenin, residues 385-651,

111 Endostatin, a proteolytic fragment of basement membrane-associated col

112 ement program, expressed a novel M(r) 75,000 proteolytic fragment of beta-catenin (beta-cat(75)).

113 ithdrawal support the conclusion that CCt, a proteolytic fragment of Ca(V)1.2, autoregulates Ca(V)1.2

114 Endostatin is a carboxyl-terminal proteolytic fragment of collagen XVIII and a potent inhi

115 Endostatin is a proteolytic fragment of collagen XVIII that potently inh

116 Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inh

117 Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclini

118 Endostatin, a proteolytic fragment of collagen XVIII, is an endogenous

119 escribed wherein SAMDI is used to identify a proteolytic fragment of cystatin C in cerebral spinal fl

120 However, an 80-kDa proteolytic fragment of ErbB-4 was found in the detergen

121 anscription is induced by D dimer, a plasmin proteolytic fragment of fibrin, supporting its role in n

122 Furthermore, application of fibronectin or a proteolytic fragment of fibronectin containing the centr

123 S. sobrinus GBP-5 may be a proteolytic fragment of GBP-3, or, alternatively, the ge

124 A stable, small (60-kD) proteolytic fragment of gp600 was isolated and localized

125 e show that the cardio-protective N-terminal proteolytic fragment of HDAC4 is enhanced in vivo in pat

126 Link protein N-terminal peptide (LPP) is a proteolytic fragment of link protein, an important cross

127 oth muscle heavy meromyosin, a double-headed proteolytic fragment of myosin lacking the COOH-terminal

128 A soluble proteolytic fragment of native MAG, dMAG, also inhibited

129 Protein sequencing of an internal 61-kDa proteolytic fragment of NTPPHase (61-kDa NTPPHase) deter

130 ulation of its more potent activator, p25, a proteolytic fragment of p35.

131 the 568 residues of PA63, the active 63-kDa proteolytic fragment of PA.

132 A proteolytic fragment of PC1 corresponding to the cytopla

133 PKM has been thought of as a proteolytic fragment of PKC.

134 Angiostatin is a proteolytic fragment of plasminogen and a potent angioge

135 Angiostatin, a proteolytic fragment of plasminogen that was first isola

136 ough the therapeutic value of angiostatin, a proteolytic fragment of plasminogen, has been recognized

137 Angiostatin, a proteolytic fragment of plasminogen, inhibits the growth

138 Angiostatin, a proteolytic fragment of plasminogen, is a potent angioge

139 Angiostatin, a proteolytic fragment of plasminogen, is a potent antagon

140 Angiostatin, a proteolytic fragment of plasminogen, is a potent endogen

141 ease-sensitive site results in an N-terminal proteolytic fragment of Pol2, called Pol2core, that cons

142 The C1 fragment represents the major proteolytic fragment of PrPC in brain and several cell t

143 inal amino acid sequencing of a 16-kDa Lys-C proteolytic fragment of the 23-kDa storage granule prote

144 e plaques is amyloid-beta peptide (Abeta), a proteolytic fragment of the amyloid precursor protein (A

145 y at single-residue resolution a 156-residue proteolytic fragment of the androgen receptor that conta

146 nctional knowledge available for the central proteolytic fragment of the cascade, C3b.

147 We report that a proteolytic fragment of the extravesicular domain of Syn

148 th this cDNA insert representing an internal proteolytic fragment of the full length 127-kDa NTPPHase

149 ariant chain-derived peptide (CLIP), a short proteolytic fragment of the invariant chain, and exhibit

150 motif(s) is located within the NH2-terminal proteolytic fragment of the protein consisting of residu

151 Increased p25, a proteolytic fragment of the regulatory subunit p35, is k

152 titer wells coated with the isolated 190-kDa proteolytic fragment of the talin rod domain.

153 f aggregated amyloid beta peptide (Abeta), a proteolytic fragment of the transmembrane amyloid precur

154 n at Thr(402) in both intact gamma-Pak and a proteolytic fragment of this kinase.

155 nits, specific labeling was contained within proteolytic fragments of 14 and 21 kDa, respectively, be

156 3A)R subunit was initially mapped to subunit proteolytic fragments of 8 kDa, containing the M4 transm

157 Thus, rat beta-pol has four distinct proteolytic fragments of 8, 6, 10, and 12 kDa, extending

158 ess, which may be initiated by IDE-generated proteolytic fragments of Abeta, was prevented by three d

159 However, smaller truncated proteolytic fragments of ACBP do, increasing the excitab

160 of proteins within virus particles detected proteolytic fragments of alpha-smooth muscle actin and m

161 identified 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins rele

162 ve different N-terminal lipid modifications, proteolytic fragments of alphao isoforms were immunoprec

163 associated with extracellular deposition of proteolytic fragments of amyloid precursor protein (APP)

164 e, because 1 month of activity decreased the proteolytic fragments of APP [for alpha-C-terminal fragm

165 mapping and N-terminal sequence analysis of proteolytic fragments of azidoATP-photolabeled GLUT1.

166 d by automated Edman degradation analysis of proteolytic fragments of both the heavy and light chains

167 direct oxidative cleavage of heme-containing proteolytic fragments of c-type cytochromes and helps to

168 Inceptins are proteolytic fragments of chloroplastic ATP synthase gamm

169 pecifically respond to OS via recognition of proteolytic fragments of chloroplastic ATP synthase, ter

170 Results showed that proteolytic fragments of chromogranin A (CgA) and chromo

171 These come in two flavors: (i) proteolytic fragments of complement proteins (C3, C4, C5

172 Several proteolytic fragments of constitutively active PKC eta a

173 Proteolytic fragments of Dau c 1 matched its T-cell-acti

174 lpha(5) integrin also reversed the effect of proteolytic fragments of denatured collagen on contracti

175 platform did not detect robust increases in proteolytic fragments of ECM proteins in either setting.

176 expression is modulated in part by specific proteolytic fragments of fibronectin (FN), which are ass

177 etitive binding assays using recombinant and proteolytic fragments of FN revealed that the cell-bindi

178 and binding of thioredoxin, we have analyzed proteolytic fragments of gene 5 protein.

179 bind to non-GPCR nuclear signaling proteins, proteolytic fragments of GPCRs capable of ligand-indepen

180 our group have implicated calpain-dependent proteolytic fragments of menin, the product of the MEN1

181 id disease associated with the deposition of proteolytic fragments of mutant (D187N/Y) plasma gelsoli

182 Proteolytic fragments of myosin, S1 and HMM, were exchan

183 V8 proteolytic fragments of nitrated TH were analyzed by ma

184 these proteins as full-length nucleolin and proteolytic fragments of nucleolin.

185 from porcine plasma, and sequencing of four proteolytic fragments of pICA revealed that each of the

186 These full-length and proteolytic fragments of PKC eta in the detergent-insolu

187 Using ceramide overlay assays with proteolytic fragments of PKCzeta and vesicle binding ass

188 ied fractions of plasma fibrinogen, purified proteolytic fragments of plasma fibrinogen, recombinant

189 In melanosome precursor organelles, proteolytic fragments of Pmel17 form insoluble, amyloid-

190 RG was localized to the H/P domain by use of proteolytic fragments of rbHPRG and was further confirme

191 c inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) a

192 Two proteolytic fragments of streptokinase were examined, a

193 by transforming growth factor-beta generated proteolytic fragments of talin-1 that matched the degrad

194 Sequence analysis of three internal proteolytic fragments of the 97-kDa polypeptide revealed

195 Amyloid beta-proteins (A beta) are proteolytic fragments of the beta-amyloid precursor prot

196 binding class II molecules, we have studied proteolytic fragments of the I chain generated both by n

197 ified by amino-terminal sequence analysis of proteolytic fragments of the Na,K-ATPase alpha-subunit a

198 Proteolytic fragments of the nucleotide form of DnaA pro

199 Proteolytic fragments of the poly-glutamine-containing N

200 ed to determine the deuterium content of all proteolytic fragments of the protein.

201 Amyloid-beta peptides are proteolytic fragments of the transmembrane amyloid precu

202 In contrast, 16- to 17-kDa proteolytic fragments of these hormones have antiangioge

203 LC-MS/MS analysis of the proteolytic fragments of this complex mapped the cross-l

204 pondin-1 (TSP1) based on activities of large proteolytic fragments of TSP1 or peptides containing TSP

205 xpression of OLE1 is activated by N-terminal proteolytic fragments of two homologous endoplasmic reti

206 Proteolytic fragments of type II collagen, a major compo

207 cked the inhibitory effect of chromogranin A proteolytic fragments on nicotinic-stimulated catecholam

208 in D3, preceding A1, and corresponded to the proteolytic fragment originally identified as the GP Iba

209 eavage site and formation of a unique 22-kDa proteolytic fragment (p22).

210 Nonetheless, in the latter fractions, proteolytic fragments, presumably corresponding to cleav

211 inal, the noncovalent interactions among the proteolytic fragments produced by papain and chymotrypsi

212 d the N-terminal amino acid sequences of the proteolytic fragments produced by the processing events.

213 These proteolytic fragments provide a useful set of reference

214 tions and under agitation the residue 49-127 proteolytic fragment rapidly and completely self-aggrega

215 Using a proteolytic fragment release (PFR) assay, we detected an

216 We speculated that detection of proteolytic fragments released from apoptotic cells into

217 was used to identify the time course of the proteolytic fragments released from the proteasome.

218 lly relevant chemotherapeutics and monitored proteolytic fragments released into the media.

219 ir pH-activity profiles mimicked that of the proteolytic fragments reported earlier.

220 CH, PSH and AMA in relation to levels of APP proteolytic fragments reported from AD-associated mutati

221 (5) CV2 binds even more strongly to Chordin proteolytic fragments resulting from Tolloid digestion o

222 ion kinetics in the presence of gp32 and its proteolytic fragments reveal three types of kinetic beha

223 ification and sequencing of the radiolabeled proteolytic fragments revealed that each of Ssa1p's thre

224 nt fusion protein was similar to that of the proteolytic fragment seen in NMU cells transformed with

225 wever, MALDI signals from the phosphorylated proteolytic fragments sometimes increase dramatically wh

226 (C364S) prevented the generation of smaller proteolytic fragments, suggesting that the processing mi

227 itions, to generate structurally informative proteolytic fragments that are analyzed by mass spectrom

228 sin generates reproducible patterns of large proteolytic fragments that are consistent with the forma

229 calmodulin is initially degraded into large proteolytic fragments that are released from the proteas

230 he high prevalence of endogenous CgA and CgB proteolytic fragments that function in chromaffin secret

231 ke other LCAT enzymes it is cleaved into two proteolytic fragments that share the residues of the cat

232 ide assays and sequencing of radiolabeled L1 proteolytic fragments, the phosphorylation site was dete

233 he delinking of the frozen topoisomerase (or proteolytic fragments thereof) from the DNA substrate, w

234 the functions of human myocilin and its two proteolytic fragments, these proteins were expressed in

235 proteolysis and the ability of the resulting proteolytic fragments to form multiply charged negative

236 , we noted evidence for cross-linking of AE2 proteolytic fragments to higher-order oligomeric forms.

237 Using TSP proteolytic fragments to map the binding site, we showed

238 illary channel followed by separation of the proteolytic fragments using capillary electrophoresis (C

239 lial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen.

240 The stable 9-kDa proteolytic fragment was identified as the highly conser

241 The released approximately 20-kDa proteolytic fragment was thought to be degraded.

242 y folded as its pattern of stable C-terminal proteolytic fragments was identical to that of native br

243 s in the predicted N-terminal and C-terminal proteolytic fragments, we demonstrate that the BEHAB/bre

244 pproximately 76 and approximately 56 kDa IDE proteolytic fragments were active toward the physiologic

245 reduction, the obtained approximately 25 kDa proteolytic fragments were analyzed by reversed phase li

246 ography (RPLC) column reduction, the ~25 kDa proteolytic fragments were analyzed using hydrophilic in

247 with Abeta40 and Abeta42, and the resulting proteolytic fragments were assessed via immunoprecipitat

248 Interestingly, alpha-actinin-4 and talin-1 proteolytic fragments were detected in brain death but n

249 Proteolytic fragments were identified using the informat

250 In contrast, LEKTI precursors and proteolytic fragments were not detected in differentiate

251 ormation and degradation of the six produced proteolytic fragments were significantly different, howe

252 and subjected to protease digestion, and the proteolytic fragments were subjected to mass spectroscop

253 pes, and the concomitant release of a 70-kDa proteolytic fragment, which correlated with a reduced ab

254 tase 1B (PTP1B) corresponding to the calpain proteolytic fragment, which indicates that calpain modul

255 The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyl

256 oth endogenous and added SecA yield the same proteolytic fragments, which are distinct from those obt

257 onic functionalities permits detection of 22 proteolytic fragments, while analysis using a stainless

258 lastic A-band part of the protein, and for a proteolytic fragment with 100-nm contour length from the

259 DE approximately 76 and approximately 56 kDa proteolytic fragments with a synthetic fluorogenic subst

260 We demonstrate that tagging proteolytic fragments with mass sensitivity probes in a

261 -2, -3, -7, -9, and -12 resulted in similar proteolytic fragments with MMP-7 and -12 being the most

262 ied by gel analysis of fluorescently labeled proteolytic fragments with the aid of Western blotting w