ライフサイエンスコーパス: proteolytic processing

1 without affecting its Golgi localization and proteolytic processing.

2 are fully concealed and independent of their proteolytic processing.

3 is activated during ageing and mediates APP proteolytic processing.

4 n destruction complex by gingipain-dependent proteolytic processing.

5 SIRT2 deletion increased TUG acetylation and proteolytic processing.

6 ation status of beta-catenin but resulted in proteolytic processing.

7 nriched, truncated NRG1 protein resistant to proteolytic processing.

8 GTPase OPA1, whose activity is regulated by proteolytic processing.

9 e their proximity-induced autoactivation and proteolytic processing.

10 l flexibility may thus change the pattern of proteolytic processing.

11 ndolysosomal compartments and its subsequent proteolytic processing.

12 onstrating E-cad overexpression and specific proteolytic processing.

13 sing RNAi that TC10alpha is required for TUG proteolytic processing.

14 play altered gamma-secretase-dependent Notch proteolytic processing.

15 ocally in tissues and is itself regulated by proteolytic processing.

16 ms, but there is little information on TWEAK proteolytic processing.

17 452) is essential for the initiation of DSPP proteolytic processing.

18 e availability of APP for secretase-mediated proteolytic processing.

19 that these mutant proteins were impaired in proteolytic processing.

20 ting in AMIGO2 silencing and changes in PTK7 proteolytic processing.

21 oteins and activated by the inflammasome via proteolytic processing.

22 nd that all three undergo post-translational proteolytic processing.

23 upling entry into the endocytic pathway with proteolytic processing.

24 post-translation modifications, isoforms and proteolytic processing.

25 terminus and 65 kDa carboxy terminus, after proteolytic processing.

26 endoplasmic reticulum (ER) to the Golgi for proteolytic processing.

27 via inhibition of CA-SP1 cleavage during Gag proteolytic processing.

28 rhomboid family protease required for SREBP proteolytic processing.

29 hat the plasma membrane is the site of beta1 proteolytic processing.

30 1 and a type 2 orientation are generated by proteolytic processing.

31 the secreted precursor protein, DfsB, after proteolytic processing.

32 he channel from entering a state that allows proteolytic processing.

33 s to facilitate LC-MS/MS characterization of proteolytic processing, a major form of posttranslationa

34 ubunits are modified post-translationally by proteolytic processing, acetylation, and/or ubiquitylati

35 isive role in controlling the outcome of APP proteolytic processing and Abeta generation.

36 The presented DISC1 mechanism of APP proteolytic processing and Abeta peptide generation, whi

37 n type III NRG1 that disrupt intramembranous proteolytic processing and abolish intracellular domain

38 enzyme that is internalized and subjected to proteolytic processing and activation in lysosomes.

39 CIRL in the GPS domain inhibit intracellular proteolytic processing and also result in the absence of

40 s of lacritin is multifunctional by dose and proteolytic processing and appears to play a key role in

41 P combination enhances mature glycosylation, proteolytic processing and cell-surface expression of al

42 -GX sPLA2 is a substrate for furin and PCSK6 proteolytic processing and define a novel mechanism for

43 e P8 residue has a significant effect on the proteolytic processing and fusogenicity of MuV F and mig

44 iquitination is associated with irreversible proteolytic processing and inactivation of Bag6.

45 This is followed by proteolytic processing and mobilization of the transcrip

46 intracellular calcium concentration induces proteolytic processing and secretion of interleukin (IL)

47 e absence of Hh, Cos2 and Kif7 contribute to proteolytic processing and silencing of the Hh-regulated

48 However, the location(s) of proteolytic processing and subsequent secretion of APP f

49 We demonstrate that P8 affects the proteolytic processing and the fusogenicity of MuV F.

50 wnstream target genes through the control of proteolytic processing and the transcriptional activatio

51 the inner membrane before the FtsH-dependent proteolytic processing and translocation of the toxic tR

52 mal degradation pathway and autophagy on the proteolytic processing and turnover of C99.

53 the expanded PolyQ region can be produced by proteolytic processing and/or aberrant splicing.

54 We followed the expression, proteolytic processing, and intracellular distribution o

55 ar those that perturbed particle production, proteolytic processing, and particle-associated IN level

56 udy the biosynthesis, cell-surface delivery, proteolytic processing, and release of soluble EGFR liga

57 atures of Env involved in protein stability, proteolytic processing, and virus assembly and entry, th

58 ment LG3 is generated at increased levels by proteolytic processing as long as 3 days after ischemia.

59 oteinases as being primarily responsible for proteolytic processing (as opposed to degradation) durin

60 the viral fusion (F) protein, which requires proteolytic processing at a basic cleavage site in order

61 ose bioactivity is closely regulated through proteolytic processing at its C terminus.

62 Proteolytic processing at N- and C-terminal sites of the

63 We demonstrate that native BB0323 undergoes proteolytic processing at the C-terminus, at a site afte

64 Chymotrypsin zymogen is activated by proteolytic processing at the N terminus, resulting in s

65 th both nucleocapsid and matrix domains, and proteolytic processing at the spacer peptide 1|nucleocap

66 one or together with YXXPhi, did not prevent proteolytic processing but increased cell surface expres

67 ts suggest a direct relationship between APP proteolytic processing, but not amyloid-beta, in GSK-3be

68 in the lymphovascular embolus, E-cad and its proteolytic processing by calpain and other proteases ha

69 demonstrate that TREM2 undergoes sequential proteolytic processing by ectodomain shedding and intram

70 t a 25-kDa fragment, probably resulting from proteolytic processing by eta-secretase.

71 o assessed the affect of lattice assembly on proteolytic processing by exogenous PR.

72 nimum of two events are required for fusion, proteolytic processing by furin-like proteases and expos

73 are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein co

74 myloid precursor protein (APP) is subject to proteolytic processing by gamma-secretase within neurona

75 n shedding by alpha-secretase and subsequent proteolytic processing by gamma-secretase.

76 Structural changes in DeltaGag upon proteolytic processing by HIV-1 protease, monitored by N

77 Proteolytic processing by matrix metalloproteinase-20 (M

78 fensins protects the mature peptides against proteolytic processing by MMP-7.

79 y deleted, provided that the requirement for proteolytic processing by PLP1 was offset by an alternat

80 phin, and proopiomelanocortin, by sequential proteolytic processing by prohormone convertases and car

81 le-pass transmembrane protein that undergoes proteolytic processing by secretases to generate the pat

82 In addition to the proteolytic processing by secretases, APP is also metabo

83 epatitis C virus (HCV) core protein requires proteolytic processing by two host proteases: signal pep

84 ene expression levels and post-translational proteolytic processing can be controlled.

85 inding consistent with P. gingivalis-induced proteolytic processing causing the increase in TCF/LEF p

86 Since changes in lectican abundance and proteolytic processing did not accompany the synaptic pr

87 for insulin enhancement of SREBP-1c mRNA and proteolytic processing diverge after mTORC1.

88 we showed that regulation of FANCC involved proteolytic processing during apoptosis.

89 inent yet previously uncharacterized role of proteolytic processing during platelet storage.

90 an unanticipated role of IN for polyprotein proteolytic processing during virion morphogenesis.

91 We demonstrate that this novel proteolytic processing event depends on a two-step casca

92 PKA is known to be required for the proteolytic processing event that generates the represso

93 thways and physiologic processes to specific proteolytic processing events is a major challenge in si

94 ination cycling specifically regulates later proteolytic processing events required for destruction o

95 DD8 is translated as a precursor protein and proteolytic processing exposes a C-terminal glycine requ

96 otch with membrane-anchored ligands triggers proteolytic processing, first by Adam10 and then preseni

97 the context of a polyprotein that undergoes proteolytic processing for NS5 maturation.

98 ins than in controls, while genes related to proteolytic processing (for example, LGMN, CTSZ) were hy

99 Site-specific mutagenesis to prevent proteolytic processing generated a full-length enzyme th

100 In Huntington's disease (HD), proteolytic processing generates toxic N-terminal huntin

101 Although proteolytic processing goes to completion, the rate of c

102 peptide derived from VGF (non-acronymic) by proteolytic processing, has been shown to modulate energ

103 49) and His(151) to asparagine decreased APP proteolytic processing, impaired APP endoplasmic reticul

104 -mediated shedding and highlight the role of proteolytic processing in prion disease.

105 r mass of NCED3, indicative of altered NCED3 proteolytic processing in the chloroplast.

106 Toll-like receptor (TLR) 9 requires proteolytic processing in the endolysosome to initiate s

107 for p38 MAPK phosphorylation fail to undergo proteolytic processing in the Golgi apparatus and drive

108 redistribution toward the basolateral side, proteolytic processing in the membranes, and excretion i

109 a requirement for Taspase 1-dependent TFIIA proteolytic processing in the mouse testis to enable TRF

110 xpressed and is subject to posttranslational proteolytic processing in the retina, brain, and kidney.

111 t evidence that chemerin undergoes extensive proteolytic processing in vivo, underlining the importan

112 at most mutations do not disrupt expression, proteolytic processing, incorporation into virus, or rec

113 at several levels, including transcription, proteolytic processing, inhibition of enzymatic function

114 Proteolytic processing inside producing cells is a novel

115 cate that annexin A1 externalization and its proteolytic processing into a chemotactic peptide repres

116 cytokines lack a signal peptide and require proteolytic processing into an active molecule.

117 Tau protein is subjected to proteolytic processing into fragments before being secre

118 disease, has a complex biology that includes proteolytic processing into potentially toxic fragments,

119 orm of DMP1 is an inactive precursor and its proteolytic processing is an activation step essential t

120 Together, our data demonstrate that proteolytic processing is an important event that allows

121 Proteolytic processing is dispensable for hydrolytic sul

122 Taken together, our data indicate that TLR3 proteolytic processing is essential for its function, an

123 e we introduce a molecular probe, which upon proteolytic processing is retained at the site of enzyme

124 lizes to the inner core but, associated with proteolytic processing, is also present on the outer cor

125 eavage of the transit peptide and additional proteolytic processing, mature HMR, which begins from Ly

126 sibility that targeting aberrant splicing or proteolytic processing may present attractive therapeuti

127 Therefore, the two-step proteolytic processing may represent a regulatory mechan

128 Tal(2009) and Tal(901-1) can undergo proteolytic processing mid-protein at the glycine-rich s

129 ddition to changes in PrPC glycosylation and proteolytic processing, net reductions in PrPC occur in

130 sponsive transcription factor PacC, and PacC proteolytic processing occurred normally during calcium

131 Proteolytic processing of 38-kDa CTGF occurs during corn

132 We show that transcript abundance as well as proteolytic processing of a borrelial protein required f

133 Pg/NIaPro, NIb, and CP, all derived from the proteolytic processing of a large polyprotein, and an ad

134 ral proteins were thought to derive from the proteolytic processing of a polyprotein encoded in a sin

135 Proteolytic processing of alpha2delta then permits volta

136 We report the novel regulation of proteolytic processing of amyloid precursor protein (APP

137 In the brain, neurons produce Abeta by the proteolytic processing of amyloid precursor protein (APP

138 myloid beta (Abeta) peptide derived from the proteolytic processing of amyloid precursor protein (APP

139 Proteolytic processing of amyloid precursor protein (APP

140 beta-Amyloid peptides (Abeta), derived from proteolytic processing of amyloid precursor protein (APP

141 embrane aspartyl protease that catalyzes the proteolytic processing of APP and other plasma membrane

142 This sequestration significantly delayed the proteolytic processing of APP by secretases and the prot

143 ral and dynamic features are critical in the proteolytic processing of APP by the gamma-secretase enz

144 Here, we investigated expression and proteolytic processing of APP during differentiation of

145 proteins is required for the P2X7R-dependent proteolytic processing of APP leading to sAPPalpha relea

146 Proteolytic processing of ataxin-7 by caspase-7 generate

147 IFN-stimulated proteolytic processing of ATF6 and ERK1/2-mediated phosp

148 IFN-gamma-induced proteolytic processing of ATF6 and phosphorylation of C/

149 nduced expression of DAPK1 IFN-gamma-induced proteolytic processing of ATF6 and phosphorylation of C/

150 Importantly, active proteolytic processing of AtMCP2d proteins dependent on

151 We then investigated the proteolytic processing of Bet v 1 by endosomal extracts

152 In addition, proteolytic processing of cadherin extracellular and cyt

153 causing altered febrile responses, increased proteolytic processing of caspase-1, and more rapid infl

154 In cells, F1L inhibits apoptosis and proteolytic processing of caspases induced by overexpres

155 I3C directly inhibits the elastase-mediated proteolytic processing of CD40, which alters downstream

156 SPPL2A deficiency blocked the proteolytic processing of CD74 MHC II invariant chain in

157 n, and DNA replication and reveal widespread proteolytic processing of cellular proteins to generate

158 hance virion assembly, but C16/B22 increases proteolytic processing of core proteins in A549 cells co

159 s a polytopic membrane protein that inhibits proteolytic processing of CREB3L1 (cAMP response element

160 Proteolytic processing of CTGF in HCF cultures, normal a

161 This study addresses the role of proteolytic processing of CTGF in human corneal fibrobla

162 In addition to liver, the enhanced proteolytic processing of CtsB was also observed in brai

163 anoma 2) containing inflammasome and induces proteolytic processing of cytokine precursors such as pr

164 t D213A substitution effectively blocked the proteolytic processing of DMP1 in vivo.

165 13A-Tg mice) to test the hypothesis that the proteolytic processing of DMP1 is an activation step ess

166 These findings indicate that the proteolytic processing of DMP1 is essential to the forma

167 t D452A substitution effectively blocked the proteolytic processing of DSPP in vivo.

168 These results indicate that the proteolytic processing of DSPP is an activation step ess

169 We believe that the proteolytic processing of DSPP is an essential activatio

170 ere we report that phosphorylation-regulated proteolytic processing of EIN2 triggers its endoplasmic

171 to lymphatic vessels stimulated release and proteolytic processing of endothelium-derived Reelin.

172 ly on ameloblast-ameloblast interactions and proteolytic processing of extracellular matrix proteins

173 al changes in target cells by inhibiting the proteolytic processing of full-length Drosophila Ci or m

174 We hypothesized that proteolytic processing of gammaENaC occurs in the human

175 of Hh signaling, is down-regulated, and the proteolytic processing of Gli3 is compromised.

176 we had provided evidence of tissue-specific proteolytic processing of histone H3 in White Leghorn ch

177 ells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressivel

178 dition, A3G and Mov10 overexpression reduced proteolytic processing of HIV-1 Gag.

179 edly, T124N/T174I IN substitutions inhibited proteolytic processing of HIV-1 polyproteins Gag and Gag

180 Our understanding of proteolytic processing of Htt has thus far focused on th

181 Proteolytic processing of human host cell factor 1 (HCF-

182 regulated in large part by the extracellular proteolytic processing of hyaluronan-bound proteoglycan.

183 ediated knockout of caspase b, which acts by proteolytic processing of il1beta, results in increased

184 activate the inflammasome complex and drive proteolytic processing of inflammatory cytokines; howeve

185 ermed "inflammasomes," which are involved in proteolytic processing of interleukin-1beta (IL-1beta) a

186 ote T cell activation was due to inefficient proteolytic processing of internalized ICs.

187 ng through the other branches of the UPR, or proteolytic processing of its close homolog ATF6beta or

188 cum AMB-1, was recently shown to promote the proteolytic processing of itself and two other biominera

189 ode of growth is associated with an abnormal proteolytic processing of L1 and N-cadherin, two ADAM10

190 ssembled via a novel mechanism that involves proteolytic processing of lipidated precursor subunits a

191 Heat shock-induced proteolytic processing of Lsb1 is crucial for prion main

192 impaired lysosomal acidification, decreased proteolytic processing of lysosomal enzymes, reduced deg

193 trostudies showing that FAP mediates ordered proteolytic processing of matrix metalloproteinase (MMP)

194 Post-translational proteolytic processing of mature chemokines is a key, ye

195 We show here that proteolytic processing of Msb2p was induced by underglyc

196 SP1-specific antibodies shown to inhibit the proteolytic processing of MSP1 that occurs at invasion.

197 abnormalities, and pcd mice display altered proteolytic processing of Nna1 interacting proteins.

198 ubsequent study suggested that site-specific proteolytic processing of Nrf1 by the proteasome yields

199 Here we investigated proteolytic processing of NRG1 type III and demonstrate

200 ression and the subcellular distribution and proteolytic processing of NRG1-IVNV isoforms were also d

201 aracterized the synaptic consequences of the proteolytic processing of Nrxns in cultured hippocampal

202 min-related protein 1) at Ser637 and altered proteolytic processing of OPA1 (optic atrophy 1).

203 Recent reports have indicated that proteolytic processing of PGRN to smaller protein module

204 Proteolytic processing of PKCalpha by calcium-activated

205 Recently, we showed that calpain-mediated proteolytic processing of PKCalpha in ischemic myocardiu

206 nd inhibitory profile of PLD3 and found that proteolytic processing of PLD3 is dispensable for its hy

207 f the 4 gene and a presumptive change in the proteolytic processing of polyproteins 1a and 1ab.

208 Therefore post-translational proteolytic processing of polyproteins into mature pepti

209 ic function, we address the relevance of the proteolytic processing of presynaptic neurexins (Nrxns)

210 e that mature L-SMase arises from C-terminal proteolytic processing of pro-aSMase and suggest that im

211 or activation of Met signaling that bypasses proteolytic processing of pro-HGF.

212 nt molecular protein complex which initiates proteolytic processing of pro-IL-1beta and pro-IL-18 int

213 scription whereas inflammasomes regulate the proteolytic processing of pro-IL-1beta.

214 d profound effects on MHC-I presentation and proteolytic processing of proinsulin.

215 Polypeptides generated from proteolytic processing of protein precursors, or proteol

216 Nalpha acetylation, protein maturation, and proteolytic processing of proteins in human platelets.

217 m open reading frame repression requires the proteolytic processing of PTEF by PfCalpain.

218 drive the amyloid cascade in AD and that the proteolytic processing of RanBP9 may be an attractive th

219 valent modification in controlling the later proteolytic processing of receptors.

220 h is essential for viral replication through proteolytic processing of RNA replicase machinery.

221 Adenovirus maturation involves proteolytic processing of seven precursor proteins.

222 Adenovirus assembly concludes with proteolytic processing of several capsid and core protei

223 these studies, it has become recognized that proteolytic processing of signaling molecules by certain

224 n collagen fibril assembly is the C-terminal proteolytic processing of soluble procollagen precursors

225 CMV infection was also found to increase the proteolytic processing of SREBP-2, a transcription facto

226 notion that proper vacuolar trafficking and proteolytic processing of storage proteins require endom

227 Proteolytic processing of synaptic adhesion components c

228 Interestingly, the observed proteolytic processing of Tal(2009) and Tal(901-1) facil

229 Because cathepsins are known to influence proteolytic processing of Tg in vivo, we examined in thi

230 effects of elastase on receptor activation, proteolytic processing of the adhesion protein ICAM-1, N

231 Abeta is generated by the proteolytic processing of the amyloid precursor protein

232 in Alzheimer's disease (AD), is generated by proteolytic processing of the amyloid precursor protein

233 There is compelling evidence that the proteolytic processing of the amyloid precursor protein

234 Alzheimer's disease (AD) is associated with proteolytic processing of the amyloid precursor protein

235 Proteolytic processing of the amyloid precursor protein

236 ion of Abeta levels was related to increased proteolytic processing of the amyloid precursor protein.

237 Proteolytic processing of the amyloid-beta precursor pro

238 re in that its maturation requires extensive proteolytic processing of the astrovirus capsid protein

239 Maturation of HAstV requires proteolytic processing of the astrovirus CP both inside

240 gene and represent products of intracellular proteolytic processing of the CIRL precursor.

241 pitope presentation at a step other than the proteolytic processing of the epitope.

242 Proteolytic processing of the flavivirus polyprotein is

243 hybridization and immunostaining and confirm proteolytic processing of the FRFamide precursor by mass

244 that in skeletal muscle, insulin stimulates proteolytic processing of the GLUT4 retention protein, T

245 Apparently, proteolytic processing of the HIV-1 Env precursor decrea

246 Remarkably, proteolytic processing of the HIV-1 Env precursor result

247 ns in Hp oligomerization, glycosylation, and proteolytic processing of the Hp alpha-chain.

248 Proteolytic processing of the laminin-gamma2 chain is a

249 When L2 expression was repressed, proteolytic processing of the major core proteins and th

250 We have demonstrated proteolytic processing of the matrix proteoglycan, versi

251 , insulin rapidly and selectively stimulates proteolytic processing of the nascent SREBP-1c by enhanc

252 Proteolytic processing of the nuclear factor (NF)-kappaB

253 Proteolytic processing of the pigment cell-specific Mela

254 but there was no change in the abundance or proteolytic processing of the prominent lecticans brevic

255 Proteolytic processing of the protein leads to a number

256 omplex array of glycosylation substrates and proteolytic processing of the transcription factor host

257 Proteolytic processing of the viral nonstructural polypr

258 inhibitor and exhibit a significant delay in proteolytic processing of the viral replicase polyprotei

259 ctivate KLKs because of gingipain K-mediated proteolytic processing of the zymogenic proform of KLK13

260 ation of collagen metabolism by uPA-mediated proteolytic processing of transforming growth factor (TG

261 Immunoblots demonstrated that proteolytic processing of TRAP5b and the cytoskeletal pr

262 lls with proteasome inhibitors prevented the proteolytic processing of trapped TOP2ccs, suppressed th

263 ressed, exo-cystein-protease involved in the proteolytic processing of various other lysosomal enzyme

264 To determine whether peptides derived from proteolytic processing of VGF participate in nociceptive

265 ivity of endosomal proteases or delaying the proteolytic processing of virions.

266 Due to mechanisms such as proteolytic processing or alternative translation starts

267 to the trans-Golgi network (TGN) to prevent proteolytic processing or by directing newly produced Ab

268 processed by TDP2 unless they first undergo proteolytic processing or denaturation.

269 signaling proteins IKKbeta and IKKgamma, the proteolytic processing p105 and p100 and NF-kappaB DNA b

270 cell culture model to investigate huntingtin proteolytic processing; previous studies of these cells

271 Contrary, in PNS glia, but not in neurons, proteolytic processing produced a two-chain SorCS2 isofo

272 at axonal entry and secretion of APP and its proteolytic processing products traverse different pathw

273 ined with the appropriate enzymes to analyze proteolytic processing rates in the presence or absence

274 Here we demonstrate that proteolytic processing regulates the biological activity

275 Subsequent proteolytic processing releases the toxic compound insid

276 terature suggests a critical role of partial proteolytic processing resulting in various truncations

277 that Sonic hedgehog (Shh) is solubilized by proteolytic processing (shedding) of lipidated peptide t

278 eavage fragments produced by pathogen-driven proteolytic processing should be further characterized t

279 Multiple proteolytic processing sites in Glass bottom boat (Gbb),

280 We demonstrate that HERV-K ENV undergoes a proteolytic processing step and triggers membrane fusion

281 w here that Fat is subject to a constitutive proteolytic processing, such that most or all cell surfa

282 hundreds of peptides in different levels of proteolytic processing that may provide a range of biolo

283 r knowledge, the first example of tail fiber proteolytic processing that results in a heterogeneous p

284 e site of protein VI that profoundly impacts proteolytic processing, the generation of infectious par

285 this study, we demonstrate that, after hTLR7 proteolytic processing, the liberated amino (N)-terminal

286 A proteolytic processing then transforms the proenzyme int

287 cked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability t

288 Da proenzyme and then undergoes biosynthetic proteolytic processing to active approximately 30 kDa LO

289 Whether TLR3 requires similar proteolytic processing to become competent for signaling

290 Nrf1 was reported to require proteolytic processing to enter the nucleus [3].

291 LOX protein and then undergoes extracellular proteolytic processing to form approximately 30 kDa LOX

292 ized the necessity of appropriate C-terminal proteolytic processing to generate the likely physiologi

293 rmore, both increased CAMP secretion and its proteolytic processing to LL-37 are required for antimic

294 ly transcription factors and prevents Ci/Gli proteolytic processing to repressor forms.

295 This proteolytic processing, unusually extensive for an envel

296 hereas certain NLRs trigger their subsequent proteolytic processing via caspase 1.

297 A1 during secondary necrosis coincided with proteolytic processing within its unique N-terminal doma

298 microfibrils is a multistep process in which proteolytic processing within the C-terminal globular re

299 Activation of TLR9 for signaling requires proteolytic processing within the ectodomain by endosome

300 sm of aSMase maturation involving C-terminal proteolytic processing within, or in close proximity to,