ライフサイエンスコーパス: protoporphyrin IX

1 or heme oxygenase-1 inhibitors (1400W or tin protoporphyrin IX).

2 ndent conversion of protoporphyrinogen IX to protoporphyrin IX.

3 rotoporphyrinogen IX to the fully conjugated protoporphyrin IX.

4 chondria, with ferrochelatase adding iron to protoporphyrin IX.

5 the carbon bearing the peroxyl group and the protoporphyrin IX.

6 re blocked by the HO-1 inhibitors Zn- and Sn-protoporphyrin IX.

7 osynthesis by insertion of ferrous iron into protoporphyrin IX.

8 rmediates from 5-aminolevulinic acid through protoporphyrin IX.

9 hetic pathway by inserting ferrous iron into protoporphyrin IX.

10 y ferrochelatase inserting ferrous iron into protoporphyrin IX.

11 is the enzyme feedback inhibited by hemin or protoporphyrin IX.

12 latase-catalyzed insertion of magnesium into protoporphyrin IX.

13 tic pathway, catalyzes Fe(2+) chelation into protoporphyrin IX.

14 hares a biosynthetic pathway with haem up to protoporphyrin IX.

15 results in elevated intracellular levels of protoporphyrin IX.

16 roxypropyl)-5-(1-methylbutyl)barbituric acid)protoporphyrin IX.

17 is is the insertion of iron into the ring of protoporphyrin IX.

18 ectron oxidation of protoporphyrinogen IX to protoporphyrin IX.

19 by both hemin (ferric protoporphyrin IX) and protoporphyrin IX.

20 tizers verteporfin, temoporfin, S3AlOHPc, or protoporphyrin IX.

21 due near the propionate carboxyl function of protoporphyrin IX.

22 catalyzes the insertion of a Mg(2+) ion into protoporphyrin IX.

23 atalyzes the insertion of an Mg(2+) ion into protoporphyrin IX.

24 we determined the binding site for magnesium protoporphyrin IX.

25 -propionato coordination dimers of iron(III) protoporphyrin IX.

26 like red chlorophyll catabolite or exogenous protoporphyrin IX.

27 and was strikingly similar to ferrous (Fe2+) protoporphyrin-IX.

28 Synthetic beta-haematin (FeIII-protoporphyrin-IX)2 is chemically, spectroscopically and

29 ition of heme oxygenase via injection of tin protoporphyrin IX (20 micromol/kg intraperitoneally) res

30 order of magnitude higher than that with Mn protoporphyrin IX (3.3 x 10(6) M(-1) s(-1)), the dissoci

31 imals with the heme oxygenase inhibitor zinc protoporphyrin IX (50 micromol/kg IP) markedly decreased

32 ficial protein specifically accumulated zinc protoporphyrin IX, a rare cofactor that is not used by n

33 Treatment of the animals with tin protoporphyrin-IX, a global HO inhibitor, or HO-1 small

34 Protoporphyrin IX accumulated in the dysplastic epitheli

35 We report here that protoporphyrin IX accumulates in the mutant embryos, sug

36 Moreover, protoporphyrin IX accumulation in flumioxazin-treated WT

37 eterocyclic herbicide S-23142 causes massive protoporphyrin IX accumulation, resulting in membrane de

38 the Ccm system, and the negative effects of protoporphyrin IX accumulation.

39 changes, but had increased ductular reaction protoporphyrin-IX accumulation, and MDB-preventive K18 i

40 hexylester, EMT6 cells accumulated abundant protoporphyrin IX, an endogenous photosensitizer formed

41 Interestingly, cobalt protoporphyrin IX, an HO-1 inductor, increased the paras

42 Furthermore, zinc protoporphyrin IX, an inhibitor of HO activity, abrogate

43 MGd used in combination with tin protoporphyrin IX, an inhibitor of HO1, resulted in syne

44 and HO-1 and systemic administration of tin-protoporphyrin-IX, an HO inhibitor, abolished these anti

45 EM14C-deficient cells was ameliorated with a protoporphyrin IX analog, indicating that TMEM14C primar

46 ctron donor in solution was examined between protoporphyrin IX and 1-methyl-2-oxomesoheme XIII.

47 ing of photosensitizers in milk (riboflavin, protoporphyrin IX and a chlorophyllic compound) by front

48 uted cytochrome b5 may dissociate to free Mn-protoporphyrin IX and apocytochrome b5.

49 ed Michaelis-Menten kinetics with respect to protoporphyrin IX and BchH.

50 gle-channel activity only in the presence of protoporphyrin IX and blue light.

51 n identified in avian eggshells: rusty-brown protoporphyrin IX and blue-green biliverdin IXalpha.

52 ae, forms a stoichiometric complex with iron protoporphyrin IX and catalyzes the oxygen-dependent con

53 It is suggested that protoporphyrin IX and chlorophyll are responsible for ox

54 BfrB binds iron-free protoporphyrin IX and coproporphyrin III, whereas BfrC d

55 port other cyclic planar porphyrins, such as protoporphyrin IX and coproporphyrin.

56 ical, we isolated and characterized the iron protoporphyrin IX and heme a from the reactions of CN(-)

57 ochrome oxidase, suggesting a defect between protoporphyrin IX and heme a.

58 , and N-bromosuccinimide) and was blocked by protoporphyrin IX and hemoglobin but not by Congo red.

59 an accumulation of the chlorophyll precursor protoporphyrin IX and in attenuation of FR-regulated gen

60 of PMA are prevented by the HO inhibitor tin protoporphyrin IX and in cultures from mice with deletio

61 he last enzyme in the heme pathway, chelates protoporphyrin IX and iron to form heme and is mutated i

62 RR data on the binding of free-base protoporphyrin IX and its metalated complexes (Fe(III),

63 rkness drastically increased the level of Mg-protoporphyrin IX and Mg-protoporphyrin IX monomethyl es

64 to be dose dependent and specific for heme; protoporphyrin IX and other heme structural analogs did

65 HO-1 inhibition with tin-protoporphyrin IX and silencing with RNA interference re

66 ssion, and markedly increased levels of free protoporphyrin IX and zinc protoporphyrin are generated

67 lirubin and abolished by incubation with tin protoporphyrin-IX and knock down of nuclear factor-E2-re

68 ators of heme synthesis (succinylacetone and protoporphyrin IX) and cellular iron content (holotransf

69 Proteins containing heme, iron(protoporphyrin IX) and its variants, continue to be one

70 nit of Mg-chelatase, as well as a substrate (protoporphyrin IX) and product (Mg-protoporphyrin IX) of

71 xpression is inhibited by both hemin (ferric protoporphyrin IX) and protoporphyrin IX.

72 ctron-transfer reorganization energies of Zn(protoporphyrin IX) and Zn(octaethylporphyrin) are determ

73 plicated DeltaPsim changes in PCD: ceramide, protoporphyrin IX, and the hypersensitive response elici

74 Heme is a complex of iron with protoporphyrin IX, and the iron-containing structure of

75 ressed BchH proteins contained tightly bound protoporphyrin IX, and they were susceptible to inactiva

76 ed photosensitizers verteporfin, temoporfin, protoporphyrin IX, and trisulfonated hydroxyaluminum pht

77 pi-acceptor compounds (e.g., 1,4-dipyridine, protoporphyrin IX), aromatic compounds (e.g., 1,4-dihydr

78 and identified the chlorophyll precursor Mg-protoporphyrin IX as a key signalling molecule.

79 not show any change in the structure of the protoporphyrin IX as indicated by its MALDI mass spectru

80 oli hemA mutant to employ exogenous hemin or protoporphyrin IX as sole sources of porphyrin.

81 BchD, and BchI) that inserts magnesium into protoporphyrin IX as the first committed step of (bacter

82 1) catalyzes the insertion ferrous iron into protoporphyrin IX as the last step in heme biosynthesis,

83 tentiated by the HO inhibitors, zinc and tin protoporphyrin-IX as well as by the CO scavenger, hemogl

84 Our previous study has shown that endo-Protoporphyrin IX based SDT (ALA-SDT) could induce apopt

85 titrations demonstrated that both hemin and protoporphyrin IX bind to NikA with similar affinity.

86 nd the Roussin's red salt ester (mu-S,mu-S')-protoporphyrin-IX-bis(2-thioethyl ester)tetranitrosyldii

87 of sheared SMCs with the HO-1 inhibitor, tin protoporphyrin-IX, blocked the antiaggregatory effect of

88 e of human ferrochelatase with the substrate protoporphyrin IX bound as well as a higher resolution s

89 Activation of protoporphyrin IX by noninvasive, magnetic resonance-gui

90 s the ATP-dependent insertion of Mg(2+) into protoporphyrin IX catalyzed by the multisubunit enzyme m

91 onomethyl ester oxidative cyclase (bchE), Mg-protoporphyrin IX chelatase (bchD), and phytoene dehydro

92 Patients with EPP may overproduce protoporphyrin IX, chiefly in developing erythrocytes.

93 en intraperitoneal injections of cobalt(III) protoporphyrin IX chloride (CoPP), which up-regulates HO

94 rats were treated with HO-1 activator cobalt protoporphyrin IX chloride (Copp; 25 mg/kg body weight)

95 For this catalyst and iron protoporphyrin IX chloride, Fe(PPIX)Cl, two distinct and

96 The suppressive effect of HO-1 induction by protoporphyrin IX cobalt chloride (CoPP; a classical ind

97 ated, respectively, by varying the hemin (or protoporphyrin IX) concentration in the medium and by ad

98 Here, we demonstrate that cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnP

99 Cobaltic protoporphyrin IX (CoPP) is a synthetic heme analog whic

100 HO-1 expression by administration of cobalt protoporphyrin IX (CoPPIX) to the graft donor restored g

101 with induction of HO-1 expression by cobalt protoporphyrin IX (CoPPIX).

102 Administration of HO-1 inhibitor tin protoporphyrin IX dichloride in infected BALB/c mice led

103 Tin protoporphyrin IX did not affect heme oxygenase-1 expres

104 , and that of the methoxide adduct of ferric protoporphyrin IX dimethyl ester (FeIIIPPIXDME).

105 strates 4-fluorostyrene, vinylferrocene, and protoporphyrin IX dimethyl ester were then coupled (in d

106 zation of the beta-positions of deutero- and protoporphyrin IX dimethyl esters.

107 ations were carried out on both deutero- and protoporphyrin IX dimethyl esters.

108 The HO-1 inducer cobalt protoporphyrin IX diminished proinflammatory cytokine le

109 Furthermore, upregulation of HO-1 by cobalt protoporphyrin IX diminished the production of TNF-alpha

110 r human methemoglobin, linking hemin (ferric protoporphyrin IX) disassociation and apoprotein unfoldi

111 retreatment with aminolevulinic acid or with protoporphyrin IX dramatically increased the light sensi

112 A was found to comigrate with both hemin and protoporphyrin IX during gel filtration.

113 inhibition of HO by a specific inhibitor, Sn-protoporphyrin IX, enhanced chemotaxis.

114 Treatment with the HO-1 inhibitor zinc protoporphyrin IX exacerbated the inflammatory response

115 in, a detoxified, crystalline form of ferric protoporphyrin IX (Fe(3+)-PPIX) produced by the parasite

116 er bonds between the vinyl groups of heme b (protoporphyrin IX-Fe) and the thiol groups of cysteines

117 ocytochromes and the vinyl groups of heme b (protoporphyrin IX-Fe).

118 x +Fe4+=O) and compound II (Fe4+; formally (protoporphyrin-IX)Fe4+=O) were detected.

119 believed to result from accumulation of iron protoporphyrin IX (FePPIX) derived from erythrocytic hem

120 iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (EC 4.99.1.1).

121 at is capable of ultrasensitive detection of protoporphyrin IX fluorescence in vivo, together with in

122 In vivo animal studies reveal that protoporphyrin IX fluorescence is strongly correlated wi

123 ity levels of Hexaminolevulinic Acid-induced Protoporphyrin IX fluorescence.

124 These transfectants still require hemin or protoporphyrin IX for growth but produce porphyrin when

125 he ability of B. fragilis to utilize heme or protoporphyrin IX for growth was greatly reduced in a De

126 fen, and by replacement of heme by manganese protoporphyrin IX (forming MnPGHS-1).

127 stant S. aureus and M. smegmatis was gallium protoporphyrin IX (Ga-PPIX).

128 n of transcription by hemoglobin and (cobalt protoporphyrin IX) globin but not by apoglobin or other

129 articularly striking is the structure of the protoporphyrin IX group, which is distorted from planari

130 manganese protoporphyrin IX instead of iron protoporphyrin IX has been investigated by resonance Ram

131 rm whale myoglobin reconstituted with cobalt protoporphyrin IX have been determined by x-ray crystall

132 eins that contain cysteine thiolate-liganded protoporphyrin IX heme prosthetic groups.

133 l genetic systems that allow the use of iron-protoporphyrin IX (heme) have been described for the pat

134 here that the endogenous small molecule iron protoporphyrin IX (hemin) and several related porphyrin

135 associated with heme transport since cobalt-protoporphyrin IX-hemopexin, which binds to the receptor

136 Experiments with protoporphyrin IX in a glioma rodent model demonstrate i

137 e accumulation of the photosensitizing agent protoporphyrin IX in areas of plaque psoriasis by monito

138 vo heme oxygenase enzyme inhibition with tin protoporphyrin IX in common bile duct ligation animals w

139 cy of ferrochelatase (FECH), accumulation of protoporphyrin IX in erythrocytes, skin, and liver, and

140 ragilis does not synthesize the tetrapyrrole protoporphyrin IX in order to form heme that is required

141 Mixed-metal hybrids, with zinc protoporphyrin IX in place of heme on both alpha or both

142 xidase (MP) and 2-methylimidazole ligated Fe protoporphyrin IX in the 10 ns to 10 ms time window.

143 Magnesium chelatase inserts Mg2+ into protoporphyrin IX in the chlorophyll and bacteriochlorop

144 s accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alte

145 yl phenotype of laf6 and the accumulation of protoporphyrin IX in the mutant can be recapitulated by

146 es the oxidation of protoporphyrinogen IX to protoporphyrin IX in the penultimate step of heme and ch

147 -aminolevulinic acid, the level of magnesium-protoporphyrin IX increased 60-fold in the PS I-less/chl

148 the characteristic fluorescence emission of protoporphyrin IX increases in intensity within the 6-h

149 f cytochrome b5 reconstituted with manganese protoporphyrin IX instead of iron protoporphyrin IX has

150 es results in a decreased ability to convert protoporphyrin IX into heme, leading to protoporphyria,

151 Protoporphyrin IX iron complex (heme) is an important co

152 s-histidyl N delta 1/N epsilon 2-coordinated protoporphyrin IX iron.

153 e and its biosynthetic intermediates such as protoporphyrin IX is a complex and highly coordinated pr

154 Insertion of ferrous iron into protoporphyrin IX is catalyzed by ferrochelatase (EC 4.9

155 ct of the ferrochelatase-catalyzed reaction, protoporphyrin IX is fluorescent, and therefore the prog

156 The ATP-dependent insertion of Mg(2+) into protoporphyrin IX is the first committed step in the chl

157 Hemin (iron protoporphyrin IX) is a crucial component of many physio

158 Heme (iron protoporphyrin IX) is a well-known prosthetic group for

159 biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX fer

160 Replacement of the heme group by mangano protoporphyrin IX largely preserves the cyclooxygenase a

161 elevated serum ferritins, elevated red cell protoporphyrin IX levels, and adult-onset neurodegenerat

162 nt with this, we observed increased cellular protoporphyrin IX levels, reduced mitochondrial heme a a

163 nd Q189R was reduced to that of free Fe(III) protoporphyrin IX levels, whereas Q189N catalyzed more r

164 Holocytochrome b5, the protein with iron protoporphyrin-IX liganded to His-39 and His-63, contain

165 Protoporphyrin IX may accumulate, with resultant toxicit

166 ealed accumulation of very high levels of Mg-protoporphyrin IX methyl ester and only traces of protoc

167 me which converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methion

168 th the next enzyme in the pathway, magnesium protoporphyrin IX methyltransferase (BchM).

169 Sll1214 and the Chl biosynthesis enzymes Mg-protoporphyrin IX methyltransferase and protochlorophyll

170 mutation in the bchM gene that codes for Mg-protoporphyrin IX methyltransferase, the enzyme which co

171 cystis genome should similarly code for a Mg-protoporphyrin IX methyltransferase.

172 Accumulation of magnesium-protoporphyrin IX (Mg-Proto), an intermediate in chlorop

173 oroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated interme

174 liana) knockout ntrc reveals lower magnesium protoporphyrin IX (MgP) and MgPMME steady-state levels,

175 m S-adenosyl-L-methionine (SAM) to magnesium protoporphyrin IX (MgP) forming MgP monomethylester (MgP

176 f Mg(2+)-mesoporphyrin IX (MgMPIX) or Mg(2+)-protoporphyrin IX (MgPPIX) located in the heme pocket of

177 teristics of PGHS reconstituted with mangano protoporphyrin IX (Mn-PGHS) to those of the native heme

178 -2) and in PGHS-1 reconstituted with mangano protoporphyrin IX (MnPGHS-1), but the EPR spectra of the

179 ability of a DeltabluB strain to convert Mg-protoporphyrin IX monomethyl ester (MPE) into protochlor

180 Surprisingly, Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase,

181 sed the level of Mg-protoporphyrin IX and Mg-protoporphyrin IX monomethyl ester in the PS I-less/ch/L

182 d strain containing reporter plasmids for Mg-protoporphyrin IX monomethyl ester oxidative cyclase (bc

183 izes 3,8-divinyl protochlorophyllide from Mg-protoporphyrin IX monomethyl ester, Ho1 oxidatively clea

184 reduced amounts of Crd1/CHL27 accumulate Mg-protoporphyrin IX monomethyl ester, the substrate of the

185 e only proton donating/accepting site, using protoporphyrin IX-monomethyl esters (PPIX(MME)) and N-me

186 the chlorophyll biosynthesis intermediate Mg-protoporphyrin IX monomethylester (Mg-proto MME), consis

187 RC stimulates in vitro activity of magnesium protoporphyrin IX monomethylester (MgPMME) cyclase, most

188 nin), coproporphyrinogen III oxidase, and Mg-protoporphyrin IX monomethylester cyclase.

189 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and I

190 As neither protoporphyrin IX nor coproporphyrin export improved wit

191 ytochrome b5 into the apoprotein and free Mn protoporphyrin IX occurs with a first-order rate constan

192 ubstrate (protoporphyrin IX) and product (Mg-protoporphyrin IX) of Mg-chelatase.

193 ted ion channels to human subjects, applying protoporphyrin IX or its precursor aminolevulinic acid.

194 adjacent metalloporphyrin, +1 for iron(III) protoporphyrin IX or neutral for zinc(II) protoporphyrin

195 Ca(2+) inhibited sGC stimulated by protoporphyrin IX or YC-1 suggesting that inhibition was

196 xidizes to the hexacoordinate hemin (Fe(III)-protoporphyrin IX) or hemichrome form (hemiHtsA) with an

197 The hexacoordinate heme (Fe(II)-protoporphyrin IX) or hemochrome form of holoShp (hemoSh

198 ts; gallium (Ga) or zinc (Zn) complexed with protoporphyrin IX (PP) or mesoprotoporphyrin IX (MP) tha

199 lic disease that causes excess production of protoporphyrin IX (PP-IX), the final biosynthetic precur

200 Hepatic accumulation of protoporphyrin-IX (PP-IX) in erythropoietic protoporphyr

201 pical photosensitizing agents and subsequent protoporphyrin IX (PPIX) accumulation in photodynamic th

202 nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX) and polyethylene glycol (PEG) w

203 drug simvastatin (SV) and a photosensitizer protoporphyrin IX (PpIX) due to the n-n stacking of the

204 Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular loc

205 clinical use of a natural fluorophore called protoporphyrin IX (PpIX) for image-guided surgical resec

206 grow on media containing the heme precursor protoporphyrin IX (PPIX) in place of heme.

207 ayed metabolism of 5-ALA and accumulation of protoporphyrin IX (PpIX) in the high fluorescence area.

208 at the hemoglobin (Hb) metabolites hemin and protoporphyrin IX (PPIX) interact with the BZ site on th

209 Protoporphyrin IX (PPIX) is considered a conserved endog

210 FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual

211 We also describe BcTSPO-mediated protoporphyrin IX (PpIX) reactions, including catalytic

212 nation, ALA/Hf-MOL enhanced ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and

213 (PCD) triggered by Pseudomonas syringae and protoporphyrin IX (PPIX) treatment.

214 nd the iron, copper, and zinc derivatives of protoporphyrin IX (PPIX) with similar affinities, and ap

215 The level of endogenous photosensitiser, protoporphyrin IX (PPIX), can be enhanced in the cells b

216 is based upon the intracellular synthesis of protoporphyrin IX (PpIX), which absorbs light and target

217 Photodynamic therapy (PDT) with protoporphyrin IX (PpIX), which is endogenously derived

218 ng effects of reovirus therapy combined with protoporphyrin IX (PpIX)-mediated photodynamic therapy o

219 lation of the heme biosynthesis intermediate protoporphyrin IX (PPIX).

220 of the tissue in to a photosensitizer called protoporphyrin IX (PPIX).

221 nic acid (ALA) to induce the accumulation of protoporphyrin IX (PpIX).

222 accumulation of the phototoxic intermediate protoporphyrin IX (PPIX).

223 and iron pathways, associated with elevated protoporphyrin IX (PPIX).

224 ing for NSCLC surgery using the well-studied protoporphyrin IX (PPIX)/5-aminiolevulinic acid (5-ALA)

225 ccumulation of the PDT-activated ALA product protoporphyrin-IX (PpIX) up to 10-fold, mainly by alteri

226 capable of binding the metalloporphyrin zinc protoporphyrin IX ((PPIX)Zn) have been synthesized.

227 the bound, light-activated chromophore, zinc protoporphyrin IX, (PPIX)Zn.

228 wing the direct fluorescent determination of protoporphyrin IX produced.

229 are features of the iron heme active site: a protoporphyrin IX prosthetic group is linked to the prot

230 wn laf6 seedlings also showed an increase in protoporphyrin IX (Proto IX), Mg-proto, Mg-proto MME and

231 ulinic acid (ALA) causes cells to accumulate protoporphyrin IX (Proto) and heme.

232 Structural determinations of Co(3+)-protoporphyrin IX-reconstituted muCOX-2 with alpha-linol

233 d docosahexaenoic acid (DHA) bound to Co(3+)-protoporphyrin IX-reconstituted murine COX-2 to 2.1, 2.4

234 in the cyclooxygenase active site of Co(3+) protoporphyrin IX-reconstituted ovine PGHS-1 (Co(3+)-oPG

235 Hemin, but not protoporphyrin IX, restored bacterial growth in iron-lim

236 I) protoporphyrin IX or neutral for zinc(II) protoporphyrin IX resulted in a loss of 70 mV [Fe(III)PP

237 lyzes the insertion of ferrous iron into the protoporphyrin IX ring.

238 Irradiation of aminolevulinic acid/protoporphyrin IX-sensitized cells with 10 J cm(-2) of 5

239 Thus, mangano protoporphyrin IX serves as a useful tool to evaluate th

240 In contrast, HO-1 agonists hemin and cobalt protoporphyrin IX significantly increased DAF protein ex

241 HO-1 induction with metalloporphyrin cobalt protoporphyrin IX significantly reduces the loss of body

242 (+) We observed that HO inhibition using tin protoporphyrin IX (SnPP) decreased heme-iron recycling i

243 and absence of neurohumoral inhibitors (tin protoporphyrin IX [SnPP IX] for CO synthesis, N(omega)-n

244 was induced in vivo by treatment with cobalt protoporphyrin IX, starting at week 5 or 12 of mice life

245 run-off assays showed that the sGC activator protoporphyrin IX stimulates transcription of the gamma-

246 istent with a high-spin hexacoordinate MnIII protoporphyrin IX structure that converted to a high-spi

247 with BchM in Escherichia coli overproducing protoporphyrin IX suggests that the chelatase is the rat

248 Protoporphyrin IX synthesis in TMEM14C-deficient erythro

249 ee chelatase complexes insert magnesium into protoporphyrin IX, the activities range by a factor of 1

250 conversion of protoporphyrin IX to magnesium protoporphyrin IX, the first committed step of chlorophy

251 Studies of the binding of MnIII protoporphyrin IX to apocytochrome b5 indicated that the

252 vating Mg-chelatase, the enzyme that commits protoporphyrin IX to chlorophyll biosynthesis.

253 catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme.

254 y in ferrochelatase, which chelates iron and protoporphyrin IX to form heme.

255 hat catalyzes chelation of ferrous iron into protoporphyrin IX to form heme.

256 mpaired (by replacement of heme with mangano protoporphyrin IX to form MnPGHS-1 and -2).

257 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme).

258 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme).

259 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX.

260 ynthesis, the insertion of ferrous iron into protoporphyrin IX to form protoheme, is catalyzed by the

261 catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme.

262 valent cobalt, zinc, nickel, and copper into protoporphyrin IX to form the corresponding metalloporph

263 zyme catalyzes in vivo Fe(2+) chelation into protoporphyrin IX to give heme.

264 Zea mays) are deficient in the conversion of protoporphyrin IX to magnesium protoporphyrin IX, the fi

265 hyltransferase, the enzyme which converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester us

266 lei Pharmacological administration of cobalt protoporphyrin IX to mice resulted in an enhanced bacter

267 inclusion bodies and reconstituted with iron protoporphyrin IX to obtain the ferric form of the holop

268 lyze the insertion of the imported iron into protoporphyrin IX to produce heme.

269 Concomitantly, upon cobalt protoporphyrin IX treatment, there is a significant upre

270 HCR24 and HO-1 small interfering RNA and tin-protoporphyrin-IX treatment abolished these effects.

271 ells with HO-1 small interfering RNA and tin-protoporphyrin-IX treatment did not inhibit the (A-I)rHD

272 ologic induction of HMOX-1 in vivo by cobalt protoporphyrin-IX treatment eradicated intestinal inflam

273 he physiological substrates ferrous iron and protoporphyrin IX under strictly anaerobic conditions.

274 The crystal structure of Co3+-protoporphyrin IX V349A/W387F oPGHS-1 in a complex with

275 ggesting that the protein matrix rather than protoporphyrin IX was attacked by the cyanyl radical.

276 f the endogenously generated photosensitiser protoporphyrin IX was measured with quantitative fluores

277 ible drug-induced precipitation of iron(III) protoporphyrin IX was postulated to account for this.

278 ose, weighted to the absorption spectrum for protoporphyrin IX, was calculated.

279 ion of the fluorescent tetrapyrrole product, protoporphyrin IX, was detected using a fluorescence pla

280 Hemin and protoporphyrin IX were found to form a complex with acri

281 measurement of oxidative stress markers and protoporphyrin-IX were performed.

282 cid ring A and 5-aminolevulinic acid-induced protoporphyrin IX, were studied.

283 catalyzes the insertion of a Mg(2+) ion into protoporphyrin IX, which can be considered as the first

284 alpha or the beta subunits replaced by zinc protoporphyrin IX, which is unable to bind a ligand and

285 or the transport and correct distribution of protoporphyrin IX, which may act as a light-specific sig

286 of PGHS-1 reconstituted with heme or mangano protoporphyrin IX with a lipid hydroperoxide, 15-hydrope

287 Although PfHO bound heme and protoporphyrin IX with modest affinity, it did not catal

288 akly electron-polarizing 2,4-vinyl groups of protoporphyrin IX with strongly electron-polarizing acet

289 the negative controls, while rose bengal or protoporphyrin IX with visible light were the positive c

290 transfer from flavin to the lower potential protoporphyrin IX, with an unfavorable free energy, can

291 We observed that BchM uses protoporphyrin IX without bound metal as a substrate.

292 eroxide (EtOOH), compound I (Fe5+; formally (protoporphyrin-IX) x +Fe4+=O) and compound II (Fe4+; for

293 tion of heme oxygenase1 (HO-1) activity with protoporphyrin IX zinc(II) blocked MLP nuclear accumulat

294 hat cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly

295 Zinc protoporphyrin IX (ZnPP) is known to accumulate in most

296 Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue th

297 atment of ganglia with the HO inhibitor zinc protoporphyrin-IX (ZnPP) (10 microm) completely and irre

298 The zinc(II)-protoporphyrin IX (ZnPPIX) fluorophore binds to G-quadru

299 complex with a heme analog, zinc-substituted protoporphyrin IX (ZnPPIX).

300 lated when HO-1 activity was blocked by zinc protoporphyrin IX (ZnPPIX).