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2 y CD6, selected for binding to the NA of the prototypic A(H1N1)pdm09 virus, A/California/07/2009, pro
5 ased in patients with alcoholic hepatitis, a prototypic acute-on-chronic condition; and its expressio
7 re, we reveal that integrin alphaIIbbeta3, a prototypic adhesion receptor, can be activated by variou
13 ed by airway challenge to subtilisin induces prototypic allergic lung inflammation, characterized by
14 shown to be important to the ability of the prototypic alphaherpesvirus herpes simplex virus 1 (HSV-
15 B-cell pool is enriched for cells expressing prototypic ANA heavy chains in these mice in a non-autoi
17 clude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct r
18 he peptide library was then used to identify prototypic and quantotypic peptides to proceed with MRM
21 GABAergic GPe projection neuron, so-called 'prototypic' and 'arkypallidal' neurons, that have differ
22 ry T cells (Tregs) are generally regarded as prototypic anti-inflammatory cells that maintain immune
25 t interact with the glycoproteins (GPs) of a prototypic arenavirus and hantavirus and show that the l
26 he generation of recombinant versions of the prototypic arenavirus LCMV encoding codon-deoptimized vi
30 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
31 Here, we investigated the ability of the prototypic arenavirus lymphocytic choriomeningitis virus
32 ursor (GPC) loci within the S segment of the prototypic arenavirus lymphocytic choriomeningitis virus
33 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
34 We recoded the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus
35 nce indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus
36 ence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus
38 nce indicates that the worldwide-distributed prototypic arenavirus, lymphocytic choriomeningitis viru
47 mes for two primordial T-cell lineages and a prototypic B-cell lineage were already present in the la
50 e show that murine cytomegalovirus (MCMV), a prototypic beta-herpesvirus, harnesses the UPR to regula
53 n a century of use in clinical practice, the prototypic binding site for this class of drugs within p
54 CR3 and MUT4, were designed and tested, and prototypic bispecific Abs directed against CD5 and HLA-D
57 ugs: 1) metformin and 2) cimetidine; and two prototypic cationic substrates, 3) 1-methyl-4-phenylpyri
65 hat Chitinase 3-like-1 (Chi3l1), a conserved prototypic chitinase-like protein, is induced by Strepto
67 issue focused on eosinophilic esophagitis, a prototypic, chronic, allergic disease, which provided a
68 ies with the M3 muscarinic receptor (M3R), a prototypic class A GPCR, that the M3R is able to form mu
71 yne 1,3-dipolar Huisgen's cycloaddition, the prototypic click reaction, presents a promising opportun
77 (AhR) is activated in cells infected with a prototypic coronavirus, mouse hepatitis virus (MHV), res
83 nalysis of resting-state fMRI measurements-a prototypic data modality that exhibits variable levels o
89 present the mechanistic analysis of PglC, a prototypic dual domain PGT from Campylobacter concisus U
93 hage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose
94 acterization of these enzymes along with the prototypic enzyme Sfp from Bacillus subtilis demonstrate
95 encodes a member of the reticulon family of prototypic ER-shaping proteins, in families with spastic
97 -damaging agent mitomycin C, argue that this prototypic eukaryotic member of the MORC superfamily has
98 nal dimers of the purine transporter UapA, a prototypic eukaryotic member of the ubiquitous nucleobas
99 suppressor genes by homozygous deletion is a prototypic event in the cancer genome, yet such deletion
102 by insulin receptor activation provides the prototypic example of a homeostasis response dependent o
106 hereditary cardiomyopathies are discussed as prototypic examples of single-gene disorders, including
107 profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclero
108 Our results provide insights into how a prototypic flavivirus, yellow fever virus (YFV-17D), dif
110 ependent long-term depression (NMDAR-LTD), a prototypic form of synaptic plasticity, is accompanied b
111 ince early in life, have been considered the prototypic forms of genetic defects of T-cell developmen
112 py of the minor rs12459419T allele decreases prototypic full-length CD33 expression by approximately
114 upratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respect
115 the beta2-adrenergic receptor (beta2-AR), a prototypic G-protein coupled receptor (GPCR), using epin
117 emdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammagl
120 reatments with alpha-galactosylceramide, the prototypic glycolipid ligand of iNKT cells, result in an
121 ha(2B)-adrenergic receptor (alpha(2B)-AR), a prototypic GPCR, and directly interact with the receptor
122 alpha2B-adrenergic receptor (alpha2B-AR), a prototypic GPCR, and studied the underlying mechanisms.
123 al understanding and many approved drugs for prototypic GPCRs, most GPCRs still lack well-defined bio
125 arkinsonian mice abnormal, temporally offset prototypic GPe and STN neuron firing results in part fro
126 onnectivities, a network of arkypallidal and prototypic GPe neurons comprises a neural substrate capa
131 in an experimental endocarditis model, using prototypic healthcare- and community-associated MRSA par
132 ollicular helper T cells (TFH cells) are the prototypic helper T cell subset specialized to enable B
133 e causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that repli
136 by a mechanism similar to that shown by the prototypic HJ resolvase, Escherichia coli RuvC protein,
141 Here, we characterized the interaction of a prototypic human antibody that acquires binding potentia
144 te a functional human immune system, develop prototypic human virus-specific CD8(+) T cell responses
148 mong the specific upregulated genes were the prototypic inflammatory IL (interleukin) IL1B (interleuk
149 ponse to pathogens through activation of the prototypic inflammatory transcription factor NF-kappaB.
151 d to be markedly more potent than the parent prototypic inhibitor in the inhibition of eIF4E/eIF4G in
152 on of a series of rigidified mimetic of this prototypic inhibitor in which the phenyl in the 2-(4-(3,
157 ytic necessity for the first time, using the prototypic invertebrate representative twitchin (UNC-22)
158 g protein 1) transcription factor c-Jun is a prototypic JNK target and important regulator of hepatoc
161 he La module is at present restricted to the prototypic La protein, which acts as an RNA chaperone bi
164 wined with VEGFR2 surface recognition by its prototypic ligand VEGF-A and its noncanonical ligand gre
166 terodimeric cell surface receptors that bind prototypic ligands on neighboring cells or in the extrac
168 Tc17 cells express high levels of multiple prototypic lineage-defining transcription factors (eg, R
171 op an enhanced functional profile beyond the prototypic M1, characterized by an even more potent proi
172 and expression of a set of genes involved in prototypic macrophage functions was quantified using rea
174 Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialyl
176 solved by the identification of Skint-1, the prototypic member of a novel B7-related multigene family
180 the angiotensin II type 1 receptor (AT1R), a prototypic member of the G protein-coupled receptor supe
184 While corticotrophin releasing factor is the prototypic member of this class, recent work has identif
188 acterial endotoxin, lipopolysaccharide, is a prototypic microbe-derived inflammatory signal that cont
189 the exposure to mating pheromone activates a prototypic mitogen-activated protein kinase (MAPK) casca
191 in promoted cardiomyocyte proliferation in a prototypic model of apical resection-induced cardiac reg
194 designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine sp
196 mparatively effective to vaccination against prototypic mutation-generated neoantigens, potentiated t
198 suppressor, is required for the entry of the prototypic negative-strand RNA virus, including influenz
199 eral sclerosis, Parkinson's disease, and the prototypic neuroinflammatory disease multiple sclerosis
201 dopamine-intact rats, molecularly identified prototypic neurons fired at relatively high rates and wi
202 rganization, as actioned by arkypallidal and prototypic neurons with specialized molecular, structura
203 s fired at lower rates and regularities than prototypic neurons, and the two cell types could be furt
204 ro was slower and more variable than that of prototypic neurons, which tallied with arkypallidal neur
206 d Mvarphis, yet the binding of p65/RelA (the prototypic NF-kappaB family member) was reduced at IL-6
207 The efficacy of glycolipids, such as the prototypic NKT cell antagonist alpha-galactosylceramide
208 rotein of vesicular stomatitis virus (VSV, a prototypic NNS RNA virus) to examine participation of th
210 d to 10-50% of normal the levels of mRNA for prototypic Nrf2-regulated enzymes, including the glutama
211 Toward this end, fur was deleted in the prototypic NTHi clinical isolate, 86-028NP, and we asses
212 e most common viruses found in humans and is prototypic of a persistent viral infection characterized
213 nt study, we investigated the ability of the prototypic Old World arenavirus lymphocytic choriomening
215 onceptually, some of these changes behave as prototypic oncogenic addiction loops, being ideal biomar
217 Epidermolysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease induced by
218 sh larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon.
219 , especially during cortical activation, (2) prototypic parvalbumin-expressing GPe neurons are excess
221 studied the minimal fusion requirements of a prototypic phlebovirus, Uukuniemi virus, in an in vitro
224 constants among single-site variants of the prototypic plant enzyme soybean lipoxygenase-1 substitut
227 te conformation of GLIC, currently used as a prototypic pLGIC, and opens new avenues to study the sig
232 tructurally nonrelevant modifications of the prototypic proinflammatory cytokine IL-1beta during an i
235 he single-molecule level the activity of the prototypic proton-pumping P-type ATPase Arabidopsis thal
237 ical transformation is rapidly emerging as a prototypic, redox-based post-translational modification
238 angiopoietin/Tie ligand/receptor system is a prototypic regulator of vessel remodeling and maturation
239 developed a fusion protein consisting of two prototypic regulatory cytokines, interleukin 4 (IL4) and
241 approach, we have generated and validated a prototypic reverse diagnosis catalog for the MMR gene Mu
242 ggested that formation of a complex with the prototypic RNase H inhibitor beta-thujaplicinol is slow,
245 these cells share common hallmarks with the prototypic SCs in somite-derived muscles, they distincti
250 ction relationships of Antigen 43 (Ag43a), a prototypic self-associating AT protein from uropathogeni
251 n this disease are small bile ducts, and the prototypic serologic response includes antimitochondrial
253 ctive agent in this in vitro cell assay, the prototypic sigma 1 receptor agonist (+)-pentazocine was
254 of the beta-2 adrenergic receptor (B2AR), a prototypic signaling receptor, between sequence-dependen
255 NALE: Hypertrophic cardiomyopathy (HCM) is a prototypic single-gene disease caused mainly by mutation
256 at clearly was morphologically distinct from prototypic SIV encephalitis and human immunodeficiency v
258 e of yeast mgt1Delta rad52Delta cells to the prototypic Sn1-type methylating agent N-methyl-N'-nitro-
259 medial amygdala (MeA) has been implicated in prototypic social behaviors such as aggression, the circ
260 ost-interacting effector proteins from these prototypic strains has led to the discovery of novel pos
262 fections is based on the study of one or two prototypic strains that have provided deep insight into
264 t Fbw7-dependent regulation of cyclin E, its prototypic substrate, and to examine the consequences of
266 6 log(10) inactivation of EBOV/Mak dried on prototypic surfaces by EDS or formulations of NaOCl (>=
267 Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, is a debilitatin
269 es elicited by T cells via engagement of the prototypic T cell costimulatory receptor CD28 by the cog
270 and conventional DCs, we found that CD28, a prototypic T cell stimulatory receptor, was highly expre
272 affinity maturation of antibodies against a prototypic T-dependent B. burgdorferi protein, Arthritis
273 c Escherichia coli bundle-forming pilus is a prototypic T4P assembled and powered by BfpD, a conserve
274 involved in this process; disruption of the prototypic target-derived neurotrophic factor NGF leads
276 behavior of T cells with specificity for the prototypic TEIPP antigen, the "self" TRH4 peptide/Db com
277 increased transcripts and expression of the prototypic TH1 genes Eomesodermin, IFN-gamma, T-box tran
278 N is essential for host resistance against a prototypic Th1 pathogen, Toxoplasma gondii, and for the
280 effector functions that are inhibited by the prototypic Th2 cytokine IL4 and the TGFbeta superfamily
285 een revealed where proteins described in the prototypic Tn7 element are fused or otherwise repurposed
287 used single-channel optical analysis of the prototypic transmembrane beta-barrel alpha-hemolysin (al
288 quantification concatamer (QconCAT) carrying prototypic tryptic peptides of UCH-L1 was used as an int
289 We sought to evaluate the effect of the prototypic type 2 cytokines IL-4 and IL-13 on human neut
291 reactive V3 NAbs elicited by vaccination and prototypic V3 NAbs derived from natural infections in hu
292 of core and complete vRNAP complexes of the prototypic Vaccinia poxvirus (Grimm et al., 2019; in thi
294 is also reported to be less sensitive to the prototypic viral antagonist human immunodeficiency virus
295 ised against E7 from human papillomavirus, a prototypic viral oncoprotein and a model intrinsically d
296 ciency virus type 1 (HIV-1) Vpu protein, the prototypic viral tetherin antagonist, in rescuing HIV-1
297 The positive-stranded RNA genome of the prototypic virulence-attenuating hypovirus CHV-1/EP713 c