ライフサイエンスコーパス: protrusion

1 to the plasma membrane of uropod, a rear-end protrusion.

2 e do not translate into faster lamellipodium protrusion.

3 uple actin networks to the membrane to drive protrusion.

4 en precede migration in the direction of the protrusion.

5 es the shape and expansion properties of the protrusion.

6 naling in actin polymerization-mediated edge protrusion.

7 es that required Micro-Stent trimming due to protrusion.

8 ling localized actin polymerization and cell protrusion.

9 coupling between integrin tension and actin protrusion.

10 amics, often resulting in traveling waves of protrusion.

11 scosity-adhesion length, and a rate of actin protrusion.

12 ension and harnessing network growth to cell protrusion.

13 diated the recruitment of Exo70 to bacterial protrusions.

14 ation by locally promoting the retraction of protrusions.

15 ell junctions and lined with microvilli-like protrusions.

16 ho-FAK and phosphopaxillin, located in small protrusions.

17 hat form between the distal tips of adjacent protrusions.

18 ns as opposed to bulbous, irregularly shaped protrusions.

19 , an RNA-binding protein that is enriched in protrusions.

20 in within the nano-architecture of dendritic protrusions.

21 t structural features compared to other cell protrusions.

22 hat they appear as almost radial finger-like protrusions.

23 actin polymerization alone does not initiate protrusions.

24 egrin complex, driven by actin-rich membrane protrusions.

25 f the small GTPase Rap1 in vesicles and cell protrusions.

26 el of the capsid, HL2476 binds to the 3-fold protrusions.

27 of SCAR, decreasing cell area and number of protrusions.

28 ontrol the membrane wrapping of cell surface protrusions.

29 mbrane tension, which suppresses spontaneous protrusions.

30 urface protrusions and the gaps between such protrusions.

31 rom the cell edge, in coordination with cell protrusions.

32 neuronal processes, astrocytes, endfeets, or protrusions.

33 esion complexes between the tips of adjacent protrusions.

34 , and that PACSIN2 specifically localizes to protrusions.

35 r close to the basal plasma membrane in cell protrusions.

36 i that mediates adhesion between neighboring protrusions.

37 of cells to generate specialized cup-shaped protrusions.

38 leators and builds Arp2/3-dependent lamellar protrusions.

39 dispersed acetylated alpha-tubulin and rare protrusions.

40 ernal morphology, albeit featuring extensive protrusions.

41 ontrolling where and when cells initiate new protrusions.

42 s with the cell edge induce local actin-rich protrusions.

43 thers the membrane and thus resists outgoing protrusions.

44 to directly participate in the formation of protrusions.

45 gments, and the decrease of microtubule-rich protrusions.

46 gs, RP-mRNAs localize to the actin-rich cell protrusions.

47 ed fusion, but occasionally we observed long protrusions (~12 um).

48 trated that in the majority of events, short protrusions (~3 um) between two closely apposed cells in

49 ndria were found in high numbers within cell protrusions, a finding validated by mitochondrial staini

50 Protrusions act as hotspots of translation for RP-mRNAs,

51 d by an interplay between microtubule-driven protrusion, actomyosin-driven retraction, and CD44-media

52 echanisms-'push-pull' (forming a finger-like protrusion, adhering to an ECM node, and pulling the cel

53 Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critic

54 owed the observation of peculiar subcellular protrusions along tanycyte processes and at their endfee

55 g spinal neurons transiently extend two long protrusions along the basal surface of the spinal cord b

56 ament, produce mini-cells and have branching protrusions along their length.

57 accentuated at filopodia and thin arborized protrusions, an expression pattern associated with decre

58 ted event that is initiated by cell membrane protrusion and actin reorganization.

59 est that critical residues at the three-fold protrusion and at the interface of the five-fold axis of

60 brane-proximal F-actin (MPA) during membrane protrusion and cell migration.

61 e at the leading edge that controls membrane protrusion and cell motility.

62 This mechanism controls the protrusion and contraction dynamics fundamental to cell

63 role for LASP1 in actin-based lamellipodial protrusion and establish LASP1 as a positive regulator o

64 ctin nano-architecture that enables podosome protrusion and mechanosensing.

65 s within the membrane to increase lipid tail protrusion and promote stalk formation and then acts to

66 discover that mitochondria enrich within the protrusion and provide localized ATP that fuels F-actin

67 xtend from the Plus3 domain along the Pol II protrusion and RPB10 to the polymerase funnel.

68 teriorates as a result of continuous conical protrusion and the consequent altered corneal curvature.

69 , PRG DH/PH also induced filopodia-like cell protrusions and activated Cdc42.

70 uring wound repair: microtubules extend into protrusions and along cell-cell boundaries as cells stre

71 s an actin stabilizer that promotes membrane protrusions and enables bridging of ECM gaps.

72 promotes the biogenesis of TNT-like cellular protrusions and facilitates the cell-cell transport of m

73 localization resulted in abnormal dendritic protrusions and growth cone dynamics.

74 ter probe reveals the presence of nanoscopic protrusions and invaginations of lower lipid order in pl

75 ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP h

76 We show that T-Plastin widens and lengthens protrusions and is specifically enriched in active protr

77 mation of zinc carboxylates, which can cause protrusions and mechanical failure.

78 es of the actin bundler T-Plastin to promote protrusions and migration when adhesion is spatially-gap

79 (PCP) organizes the orientation of cellular protrusions and migratory activity within the tissue pla

80 n Microscope (FESEM) analysis reveal surface protrusions and morphology modification of the SnSe NSs

81 -1 (Prom1/CD133) is known to be localised to protrusions and plays a pivotal role in migration and th

82 les involved in the formation of actin-based protrusions and podosomes, was also impaired both in vit

83 ultrastructure with the loss of cell surface protrusions and poor aggregation, resulting in increased

84 the front where Rac1/Rho oscillations drive protrusions and retractions.

85 ction of Laminin expression leads to smaller protrusions and shorter distances between differentiatin

86 s cells developed prominent invadopodia-like protrusions and showed increased matrix degradation and

87 cally low MPA density directs local membrane protrusions and stabilizes cell polarization during cell

88 rference inhibited the formation of Listeria protrusions and subsequent cell-to-cell spread of bacter

89 on modes associated with anisotropic surface protrusions and the gaps between such protrusions.

90 sistent motility promotes collisions between protrusions and ultimately clustering and consolidation

91 s, MF OCs appeared small and round, with few protrusions, and carried the mutations and chromosomal a

92 filament to drive the formation of membrane protrusions, and ends with the formation of a highly con

93 vity, enhanced PI3K distribution to cellular protrusions, and increased AKT activation in invadopodia

94 These protrusions are morphologically distinct from the well-o

95 egulate the assembly and morphology of these protrusions are poorly understood.

96 the morphogenesis of microridges, elongated protrusions arranged in elaborate maze-like patterns on

97 ate the efficient generation of uniform cell-protrusion arrays (more than 5000 cells with protrusions

98 approaches to expand the utility of TNT-like protrusions as a delivery system for regenerative medici

99 ates together, resulting in more cylindrical protrusions as opposed to bulbous, irregularly shaped pr

100 During protrusion, as membrane tension increases, velocity slow

101 Actin filaments are cortical within the protrusion, as opposed to TNTs, in which filaments run d

102 fibroblasts yielded more frequent and larger protrusions, as well as increased lysosomal and mitochon

103 variable accretion rate of the muddy deltaic protrusion at Camau; it was < +1 km(2)/year before 1400

104 Protrusion at the cell front has been extensively studie

105 P2X4 receptors, Ca(2+) influx, and pseudopod protrusion at the front.

106 capable of high-throughput isolation of cell protrusions at single-cell precision for profiling subce

107 ed enveloping layer (EVL) integrity and cell protrusions at the blastula stage.

108 d live cell imaging to show that actin-based protrusions at the leading edge initiate macrophage fusi

109 oduction, cell-matrix adhesion, and cellular protrusions at the leading edge of migrating cells.

110 Listeria generate actin-rich tubular protrusions at the plasma membrane that propel the bacte

111 he point of closure, and produce cytoplasmic protrusions, before rearranging to form two continuous e

112 Prolapse was defined as any vaginal segment protrusion beyond the hymen or reported prolapse surgery

113 phages that are equipped with "balloon-like" protrusions (BLPs) inserted in the epithelium, which sam

114 s extend a long, basally oriented filopodial protrusion, building a de novo path along which their nu

115 apical, centripetally polarised leading edge protrusions but remain attached to the basal lamina, dep

116 s the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional

117 nts and microtubules create diverse cellular protrusions, but intermediate filaments, the strongest a

118 Numerous RNAs are enriched within cellular protrusions, but the underlying mechanisms are largely u

119 There, we propose RGBARG shapes the protrusion by expanding Rac activation at the rim while

120 unresolved question is whether generation of protrusions by Listeria involves stimulation of host pro

121 barriers by use of small actin-rich membrane protrusions called invadopodia.

122 icate is through long, actin-rich membranous protrusions called tunneling nanotubes (TNTs), which all

123 -monomer-binding protein profilin 1 dictates protrusion character at the cell edge.

124 A new study now finds that protrusion collapse, induced by Semaphorin-5C-Plexin-A i

125 rom amoeboid-like, during which actin filled protrusions come and go, to keratocyte-like, characteriz

126 Interestingly, these protrusions contact different neural cells in the brain

127 opy, we finally observed that these tanycyte protrusions contain ribosomes, mitochondria, diverse ves

128 veals McTNs are dynamic, CD44-coated tubular protrusions containing microtubules and actin filaments,

129 oupled to ECM signaling that is modulated by protrusion/contraction.

130 nd edge coordinates cells, while actin-based protrusions contribute to cell crawling and seamless wou

131 localized at the tip of lamellipodia and its protrusion coordinated with F-actin at the leading cell

132 These protrusions correlate with the capacity to migrate and e

133 analysis revealed that the formation of cell protrusions could be effectively suppressed by inhibitin

134 findings, we propose a mechanism of adhesion-protrusion coupling in cell motility that involves dynam

135 Cellular protrusions create complex cell surface topographies, bu

136 Clustering of protrusion-derived RNAseq datasets defined a core 192-nt

137 e pulmonary trunk and the dorsal mesenchymal protrusion (DMP).

138 ta indicate that beta-Pix-dependent cellular protrusions drive and coordinate collective migration of

139 tin-membrane release plays a similar role in protrusions driven by intracellular pressure.

140 Filopodia, dynamic membrane protrusions driven by polymerization of an actin filamen

141 and rotates, enabling the tRNA to bypass 50S protrusions during accommodation into the peptidyl trans

142 n of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo.

143 ure lamellipodia to high-pressure lobopodial protrusions during three-dimensional (3D) migration.

144 havior by examining the relationship between protrusion dynamics and establishment of PCP and directe

145 While NMIIA-KD affects protrusion dynamics and increases cell directionality, N

146 cts significantly decreased repair rates and protrusion dynamics in both control subjects and patient

147 inct and dynamic pools of myosin II regulate protrusion dynamics within and between collectively migr

148 ols cell morphology and EGF-induced membrane protrusion dynamics.

149 suggesting that the exocyst complex promotes protrusion elongation.

150 Because Sh1 membrane protrusions eluded detection for decades, it is possible

151 Filopodia are actin-filled protrusions employed by cells to interact with their env

152 anized into a ring or ruffle of actin-driven protrusion encircling a non-protrusive interior domain.

153 BAR protein PACSIN2 promote L. monocytogenes protrusion engulfment during spread, and that PACSIN2 sp

154 Protrusion-enriched RNAs encode factors linked to cancer

155 sion to study the behavior and importance of protrusion-enriched RNAs.

156 face a fundamental challenge: while multiple protrusions explore different paths, the cell needs to a

157 long-term muddy sedimentation that left the protrusion exposed to wave erosion.

158 These protrusions express Delta protein, consistent with the h

159 man cells also use Arp2/3-dependent lamellar protrusions for motility and phagocytosis, this work sup

160 protrusion arrays (more than 5000 cells with protrusions) for a series of cell types.

161 Although podosome protrusion forces have been quantified, the magnitude, s

162 To study how protrusions form, we focused on the morphogenesis of mic

163 e exocyst complex, which are needed for cell protrusion formation and matrix metalloproteinases secre

164 that Fz7 signaling is required for ppl cell protrusion formation and migration and that spatiotempor

165 ocyst regulators Rab8 and Rab11 in bacterial protrusion formation and spread.

166 Unexpectedly, we observed normal protrusion formation and therapeutic efficacy following

167 Inhibiting protrusion formation by Arp2/3 protein blocks invaginati

168 xperiments show that loss of vangl2 disrupts protrusion formation cell-autonomously while fibronectin

169 tive, single-cell precision analysis of cell protrusion formation during cell migration that is regul

170 Here we demonstrate that efficient protrusion formation in polarized epithelial cells invol

171 Apical protrusion formation of nascent HCs and planar polarity

172 utic drugs to evaluate their effects on cell protrusion formation with single-cell precision could be

173 uronal growth cone development and dendritic protrusion formation, and we noted that ZBP1 and PAT1 co

174 tory M2-like M(IL-4/IL-10) affected TNT-like protrusion formation, intercellular transport and, ultim

175 ether these data suggest that an actin-based protrusion formed at the leading edge initiates macropha

176 copy, we further found that fusion-competent protrusions formed at sites enriched in podosomes.

177 where distinct types of actin-based membrane protrusions formed.

178 Dendritic spinules are thin protrusions, formed by neuronal spines, not adequately r

179 tion of ezrin's affinity for actin modulates protrusion frequency and efficiency.

180 olume, with the emergence of filopodial-like protrusions from synaptic boutons of the Ib input.

181 omosomes typically contain a 3' ssDNA G-rich protrusion (G-overhang).

182 llular mitochondrial trafficking during cell protrusion generation is not well-understood amidst a la

183 We further find that the restriction of protrusion growth to one site does not always respond to

184 tural integrity within the Listeria membrane protrusions hampers the microbes from spreading from Cyp

185 lar protrusion, which we term cell-substrate protrusion, has similar width range and cytoskeletal fea

186 However, spine-like protrusions have been reported in C. elegans (Philbrook

187 asymmetric structures with varying degree of protrusion heights from the membrane.

188 cleating protein necessary for lamellipodial protrusion, impaired durotactic migration.

189 Disruption of these axon-like protrusions impairs cell migration in culture and inhibi

190 Filopodia are actin-rich protrusions important for sensing and responding to the

191 tilize the CCR5 receptor maps to a predicted protrusion in the envelope V3 loop, this viral determina

192 e consistent with a role for lung macrophage protrusions in antigen presentation.

193 ells and suggest a new model for the role of protrusions in collective direction sensing in vivo.

194 ed by growth factor, which drive actin-based protrusions in human epithelial cells.

195 gnal across cell-cell boundaries to suppress protrusions in neighboring cells and that Plexin A is th

196 ecules reorganize around the protein's small protrusions in structurally ordered waters that are char

197 ckdown of mis12 increased the filopodia-like protrusions in this region.

198 tion in the root, how the growth of cellular protrusions induces local tension, and how the cell wall

199 Thus, our findings suggest that protrusion initiation might be governed by a universal r

200 letion of actin-membrane links is needed for protrusion initiation.

201 e and displacing RNA, while a unique helical protrusion inserts into the main channel, prying the bet

202 l via tunneling nanotube (TNT)-like cellular protrusions, interacts with dysfunctional mitochondria i

203 or microtubes (TMTs)," or "cytonemes," these protrusions interconnect cells in dynamic networks.

204 late sarcomere disassembly and cardiomyocyte protrusion into the injured area, respectively.

205 yocyte dedifferentiation, proliferation, and protrusion into the injured area.

206 n complexes to remodel their apical membrane protrusions into organized functional arrays.

207 The formation and activity of cell protrusions involve the localization of molecules and or

208 rised targeting of diverse mRNAs to cellular protrusions is a hallmark of cell migration.

209 The formation of these protrusions is controlled by multiple neuronal factors i

210 d; however, only the directionality of basal protrusions is recovered, and migration is not rescued.

211 Our highly controlled protrusion isolation method opens a new avenue for the s

212 astatic cancer cells use actin-rich membrane protrusions, known as invadopodia, for efficient ECM deg

213 lower repair rates and reduced lamellipodial protrusion length and velocity than those from control s

214 ould have relevance for the role of cellular protrusions like microvilli.

215 Inside of membrane protrusions, lipid cluster-mediated interaction draws lo

216 ed signaling pathways that coordinate conoid protrusion, microneme secretion, and actin polymerizatio

217 ized Ca(2+) mobilization at the site of cell protrusion/migration.

218 wild-type cells undergo a reduction in bleb protrusions near late gastrulation accompanied by a VANG

219 ene expression with upregulation of cellular protrusion/neuritogenic pathways, concurrently causing r

220 tion of the cytoskeleton and actin-dependent protrusion of a rigid penetration hypha(3).

221 facilitates Rock and Roll by delaying apical protrusion of its nascent HCs but it does not determine

222 apillomacular bundle and areas of fibrillary protrusion of sRNFL above the internal limiting membrane

223 Protrusion of sRNFL through the ILM was present in 76.2%

224 the streak, cells changed shape and extended protrusions of distinct size and abundance depending on

225 ormed by three rows of stiff microvilli-like protrusions of graduated heights, the short, middle-size

226 indicated that exocytosis is up-regulated in protrusions of Listeria in a manner that depends on the

227 ctional role of RNA localization at cellular protrusions of migrating mesenchymal cells, using as a m

228 d by previously unobserved, thin, membranous protrusions of the adjacent somatic gonad cell pair (Sh1

229 cation of interacting residues at the 3-fold protrusions of the capsid, including R483, which forms t

230 ze and architecture of the TNT-like cellular protrusions of the distal tip cell (DTC), the germline s

231 lateral and median ganglionic eminences, two protrusions of the ventral telencephalon from which the

232 Dendritic spines are small protrusions on dendrites that endow neurons with the abi

233 Dendritic spines are tiny membranous protrusions on the dendrites of neurons.

234 n-membrane linker ezrin is depleted prior to protrusion onset and that perturbation of ezrin's affini

235 quired for the maturation of nascent FAs and protrusion orientation toward a chemoattractant.

236 Complete invadopodia maturation depends on protrusion outgrowth and the targeted delivery of the ma

237 Bleb-type cellular protrusions play key roles in a range of biological proc

238 arked induction of CK2-containing filopodial protrusions possessing budding viral particles.

239 cally distinct from the branched actin-based protrusion program but shares some of the same core comp

240 omponents, revealing a processive bleb-based protrusion program that is mechanistically distinct from

241 Bone protrusions provide stable anchoring sites for ligaments

242 We find that changes in the protrusion rate at the cell front are instantaneously co

243 g at the presence of aragonite at the dorsal protrusion region of the Eudicella gralli head, in line

244 initiate extracellular matrix (ECM)-directed protrusions, release from the epithelium, and migrate th

245 mechanisms governing the formation of these protrusions remain poorly defined.

246 control the assembly and morphology of these protrusions remain poorly understood.

247 s, local microtubule depolymerization within protrusions remote from the microtubule organizing cente

248 mbrane remodeling proteins promote bacterial protrusion resolution.

249 slip dynamics resulting in periodic waves of protrusion/retraction and propagating waves along the ce

250 induces the biogenesis of TNT-like cellular protrusions, "Rhes tunnels," through which Rhes moves fr

251 Furthermore, nascent membrane protrusions selectively extended outward from areas wher

252 ssel injury sites and respond with filipodia protrusion, shape change, and surface area expansion to

253 , namely forming a gap in dsDNA and creating protrusion sites in ssDNA for generating a hybrid DNA co

254 row-derived macrophages (BMDMs) formation of protrusions, some of which displayed characteristics of

255 ng centre pass the largest pore, cytoplasmic protrusions still lingering in smaller pores are retract

256 Cells move via leading-edge protrusion, substrate adhesion, and retraction of the ce

257 They are associated with plasma membrane protrusions, such as primary cilia, as well as extracell

258 ne expression profiling of the isolated cell protrusions suggested that mitochondria were found in hi

259 cyst proteins reduced the length of Listeria protrusions, suggesting that the exocyst complex promote

260 e, which drives formation of an F-actin-rich protrusion that physically breaches and displaces BM.

261 rface fibers, but features 30 A-long surface protrusions that are formed by loops of the major capsid

262 cteria remodel the host plasma membrane into protrusions that are internalized by neighboring cells.

263 nd miR-205-dependent suppression of cellular protrusions that are required to initiate collective inv

264 tion pattern is regulated by transient basal protrusions that deliver temporally controlled lateral i

265 border, waves may initiate the formation of protrusions that elongate and eventually pinch off to fo

266 Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are im

267 ermeates the spindle poles and forms dynamic protrusions that extend well beyond the spindle.

268 Invadopodia are dynamic protrusions that harbor matrix metalloproteinases for pe

269 ament functions, and identify microridges as protrusions that integrate actin and intermediate filame

270 ants that exclusively use CXCR4 have V3 loop protrusions that interfere with CCR5 receptor interactio

271 Invadopodia are cell protrusions that mediate cancer cell extravasation but t

272 Membrane blebs are specialized cellular protrusions that play diverse roles in processes such as

273 Filopodia are actin-filled membrane protrusions that play essential roles in cell motility a

274 lls in culture and in vivo can grow cellular protrusions that resemble axons.

275 n the cell membrane, with spherical membrane protrusions that resemble plasma membrane blebbing.

276 ormed the Actin- and Cortactin-rich invasive protrusions that were important for breaching the extrac

277 rmation of Arp2/3 and formin-dependent actin protrusions that wrapped around the particle.

278 While RAB13 RNA is enriched at peripheral protrusions, the expressed protein is concentrated perin

279 Cell migration is driven by local membrane protrusion through directed polymerization of F-actin at

280 activation induced the formation of cellular protrusions tipped with MHC class I protein.

281 ce and final structure for the surface metal protrusion to be metal-dependent, but point to an equiva

282 coordinate extension and retraction of their protrusions to avoid fragmenting.

283 Cells extend invadopodia protrusions to create channels in the nanoporous BM thro

284 ons are adsorbed on the outer surface of the protrusions to form a 30 angstrom layer instead of enter

285 lymerization as a driving mechanism for cell protrusion, upregulated actin polymerization alone does

286 dius, matching the dimensions of the surface protrusions used by T cells to interrogate their targets

287 A (CypA) is hijacked by Listeria at membrane protrusions used for cell-to-cell spreading.

288 Structural features in these protrusions vary between cellular systems, including tub

289 antagonistic Rac-Rho signaling, Rac-mediated protrusion (via activation of Arp2/3 actin nucleation) a

290 Further, AP-1B labeling in cell protrusions was distinct from labeling for the endocytic

291 wNP; however, the effect of S aureus on cell protrusions was more sustained over time in patients wit

292 fusion and when rare fusion events occurred, protrusions were not observed.

293 sions and is specifically enriched in active protrusions where F-actin is devoid of non-muscle myosin

294 yosin accumulates transiently at the base of protrusions, where it functions to retract them.

295 phospho-Y155 RLC is prominently featured in protrusions, where it prevents NMII assembly.

296 A second class of tubular protrusion, which we term cell-substrate protrusion, has

297 erm cells have long polarized filopodia-like protrusions, which are absent in beta-Pix mutants.

298 Invading cancer cells extend cell protrusions, which guide cancer-cell migration and invas

299 We find tubular protrusions, which we classify as TMTs, in a pancreatic

300 ancer cell migration is often guided by cell protrusions, whose formation and activity involve subcel

301 We show precise isolation of cell protrusions with high purity at single-cell precision fo