ライフサイエンスコーパス: provide therapeutic benefit

1 AERD), and IL-5 inhibition has been shown to provide therapeutic benefit.

2 yte survival and enhancing myelination could provide therapeutic benefit.

3 ts may act to modulate neural structures and provide therapeutic benefit.

4 and, as a consequence, targeting M-ILK could provide therapeutic benefit.

5 n, and strategies to activate expression may provide therapeutic benefit.

6 L-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit.

7 via enhanced regulatory T cell activity may provide therapeutic benefit.

8 m with AURKA inhibitors has the potential to provide therapeutic benefit.

9 ers of gene-modified cells are sufficient to provide therapeutic benefit.

10 to hasten the resolution of inflammation and provide therapeutic benefit.

11 multiple tumor types and targeting Bcl-2 may provide therapeutic benefit.

12 rferon gamma (IFNgamma), a cytokine that can provide therapeutic benefit.

13 lear whether systemic inhibition of IKK will provide therapeutic benefit.

14 development and selection of agents that may provide therapeutic benefit.

15 al compounds that affect aggregation and may provide therapeutic benefit.

16 aling or excitation-contraction coupling can provide therapeutic benefit.

17 ggesting that enhancing STAT3 activation may provide therapeutic benefit.

18 d at preserving cardiomyocyte survival could provide therapeutic benefits.

19 Replacing Nemo through gene therapy might provide therapeutic benefits.

20 sition in the skin by dietary fish oil could provide therapeutic benefits.

21 diabetic stem/progenitor cell functions may provide therapeutic benefits.

22 nally restoring the physiologic gradient may provide therapeutic benefits.

23 es geared toward inhibiting inflammation may provide therapeutic benefits.

24 kers prevent T-tubule remodeling and thereby provide therapeutic benefits.

25 s from their pathophysiological fate and may provide therapeutic benefits.

26 nd in some instances metabolic interventions provide therapeutic benefits.

27 This method could provide therapeutic benefit against an intractable disea

28 omes by activating TRPML1 or BK channels may provide therapeutic benefit against latent HIV-1 infecti

29 nistration of low-dose PMO25 in SMA mice can provide therapeutic benefit and phenotypic rescue, presu

30 aled corticosteroids for control, colchicine provides therapeutic benefit as measured by maintenance

31 st, ENaC inhibition via exogenous agents may provide therapeutic benefit, as has long been proposed.

32 guinea pig and rhesus monkey EVD models, 3A6 provides therapeutic benefit at high-viremia advanced di

33 Certain medications carry a risk by providing therapeutic benefits at the expense of misuse

34 MPs have innate antioxidant properties that provide therapeutic benefit both in vitro and in vivo.

35 nt with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence o

36 argeting Lp(a) production and catabolism may provide therapeutic benefit, but little is known about L

37 utant Huntingtin messenger RNA (mRNA) should provide therapeutic benefit, but normal Huntingtin likel

38 ANKL can alter thymic output and potentially provide therapeutic benefit by enhancing anti-tumor immu

39 Therefore, dasatinib may provide therapeutic benefit by preventing the growth and

40 NAc-Hep or similar heparin derivatives might provide therapeutic benefits by diminishing bleeding com

41 immunization with anti-CAPS antibodies might provide therapeutic benefit for AD.

42 king memory and that targeting GABA(B)Rs may provide therapeutic benefit for age-related impairments

43 inst tumors, and targeting these cells might provide therapeutic benefit for cancer patients.

44 dria with an uncoupling agent is unlikely to provide therapeutic benefit for DPN, DKD, or DR in T2D.

45 f the 12/15LO pathway in the vessel wall may provide therapeutic benefit for early vascular inflammat

46 ion of multiple targets will be necessary to provide therapeutic benefit for GBM patients.

47 , and these approaches have the potential to provide therapeutic benefit for numerous other cancers,

48 leukemia and that antagonizing Survivin may provide therapeutic benefit for patients with acute leuk

49 icrodystrophin may be dosed safely and could provide therapeutic benefit for patients with DMD.

50 ll molecules targeting CaMKIV activation may provide therapeutic benefit for patients with IBD.

51 PBN inhibition of RPE65 catalytic action may provide therapeutic benefit for such retinal diseases.

52 ition of InsP3-mediated Ca2+ signaling could provide therapeutic benefit for the patients afflicted w

53 Thus, NLRP3 inhibitors could potentially provide therapeutic benefit for these disorders.

54 reclinically, inhibition of MAGL is known to provide therapeutic benefits for a number of neurologica

55 development of melanoma immunotherapy, could provide therapeutic benefits for cancer treatment.

56 scade responding to bacterial lipotoxins may provide therapeutic benefits for CF patients.

57 The HTR2B agonist may provide therapeutic benefits for constipation associated

58 itochondrial function in muscle, which might provide therapeutic benefits for diseases associated wit

59 ggests that modifying the gut microbiome may provide therapeutic benefits for ID and ASD patients.

60 This could provide therapeutic benefits for patients with cholestat

61 Selective inhibition of TYRO3 may provide therapeutic benefits for treating thrombosis and

62 Radiation therapy (RT) provides therapeutic benefits for patients with glioblas

63 cells (MSCs) are ongoing for the purpose of providing therapeutic benefit for a variety of human dis

64 or accelerating hematopoietic recovery, thus providing therapeutic benefits for patients after clinic

65 Targeting TET2 in CAR T cells provides therapeutic benefit; however, TET2's role in ex

66 une homeostasis that could be manipulated to provide therapeutic benefit in autoimmune diseases.

67 d also destroy malignant prostate tissue and provide therapeutic benefit in cancer patients.

68 inhibitors such as palbociclib are likely to provide therapeutic benefit in combination with BRAF inh

69 orally administered PPARgamma agonists could provide therapeutic benefit in demyelinating disease.

70 biogenesis and fatty acidbeta-oxidation and provide therapeutic benefit in diseases associated with

71 Nomacopan has been shown to provide therapeutic benefit in experimental autoimmune u

72 inical work suggests that NHE inhibition may provide therapeutic benefit in heart failure also.

73 GCase, can effectively reduce alpha-syn and provide therapeutic benefit in human midbrain neurons.

74 , suggesting that targeting mast cells could provide therapeutic benefit in human osteoarthritis.

75 (LNA)-modified antimiR (LNA-antimiR-34) can provide therapeutic benefit in mice with preexisting pat

76 ther clinical examination of this therapy to provide therapeutic benefit in OA.

77 pected underlying infections and appeared to provide therapeutic benefit in our cohort of patients wi

78 purposing of sirolimus plus nintedanib might provide therapeutic benefit in patients with HHT.

79 cement of multiple proteostasis branches may provide therapeutic benefit in PD.

80 cement of multiple proteostasis branches may provide therapeutic benefit in PD.

81 These data suggest that Src inhibition may provide therapeutic benefit in PKD.

82 ism by which NAC may act on ROS and PTP1B to provide therapeutic benefit in SSc.

83 positive allosteric modulation of DUBs could provide therapeutic benefit in the 2 major cardiovascula

84 o the fetal central nervous system (CNS) and provide therapeutic benefit in the motor neuron disease

85 D-NAM) in early human clinical trials, might provide therapeutic benefit in the mouse FXS model.

86 ive, high-affinity A(2B) AdoR antagonist may provide therapeutic benefit in the treatment of asthma.

87 cal inhibition of the DOT1L/AF10 complex may provide therapeutic benefits in an array of malignancies

88 ugh direct targeting of the cancer cells may provide therapeutic benefits in CLL by encouraging a cyt

89 gression and suggest that targeting US28 may provide therapeutic benefits in GBM treatment.

90 Targeting phospholamban may provide therapeutic benefits in human heart failure.

91 Anti-VEGF agents also provide therapeutic benefits in proliferative diabetic r

92 Inhibition of calpain 2 might therefore provide therapeutic benefits in the treatment of cancer.

93 le inhibitors of ceramide biosynthesis might provide therapeutic benefits in VCP and related neurodeg

94 challenge in an infectious disease model and provided therapeutic benefit in a mouse cancer model.

95 AC1903 also provided therapeutic benefit in a rat model of hypertens

96 ally, pharmacologic inhibition of ROR-gammat provided therapeutic benefit in mouse models of intestin

97 ing of differently folded states of SOD1 has provided therapeutic benefit in mutant SOD1 transgenic m

98 nterference mediated silencing of ATXN1 mRNA provides therapeutic benefit in mouse models of the dise

99 nd that targeting its central component (C3) provides therapeutic benefit in nonhuman primates (NHPs)

100 Autonomic neuromodulation provides therapeutic benefit in ventricular tachycardia

101 These results suggest that MC stabilization provides therapeutic benefits in sepsis by inhibiting ex

102 to kill both leukemic and solid tumor cells, providing therapeutic benefit in vivo.

103 S MPs enabled sustained release of EPO-R76E, providing therapeutic benefits including reduction in in

104 If demonstrated effective clinically, it may provide therapeutic benefit not only in hemorrhagic stro

105 cells, and its antiproliferative effects may provide therapeutic benefits of local administration of

106 ion raises some safety concerns, it can also provide therapeutic benefit; the direct intrathymic inje

107 ideal drug for sickle cell anemia (SCA) and provides therapeutic benefit through multiple mechanisms

108 These findings suggest that GSI may provide therapeutic benefit to a subset of ERBB2-positiv

109 inhibition of calpains has the potential to provide therapeutic benefit to cancer patients, there ar

110 se results indicate that acidified water may provide therapeutic benefit to CLN3 Batten disease patie

111 these oxygen-based therapies are unlikely to provide therapeutic benefit to DMD patients.

112 uggest that strategies to maintain HSP72 may provide therapeutic benefit to enhance mitochondrial qua

113 that small molecule inhibitors of CRTC2 may provide therapeutic benefit to individuals with autoimmu

114 es that attenuate the CREB-CRTC2 pathway may provide therapeutic benefit to individuals with type 2 d

115 ounds that enhance cryptochrome activity may provide therapeutic benefit to individuals with type 2 d

116 cological targeting of beta(1) integrins may provide therapeutic benefit to overcome tumor cell resis

117 alone or in combination with paclitaxel, may provide therapeutic benefit to patients diagnosed with A

118 reventing this myosin isoform "switch" could provide therapeutic benefit to patients with heart failu

119 h paradoxical MAPK pathway activation and to provide therapeutic benefit to patients with RAS mutant

120 se results suggest that ISR modulation could provide therapeutic benefit to PMD patients.

121 ggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by

122 , antibody-mediated neutralization of IL-1Ra provided therapeutic benefit to Mtb-infected B6.Sst1(S)

123 adiponectin (APN), a pleiotropic adipokine, provides therapeutic benefit to prevent AngII-induced ad

124 ng may cultivate interoceptive awareness and provide therapeutic benefit when implemented within ment

125 HGF to its active form has the potential to provide therapeutic benefit where HGF/Met activity is as

126 The use of heat-killed probiotics may provide therapeutic benefit while minimizing adverse eff

127 BTK inhibition may provide therapeutic benefit within the CNS by targeting

128 all, we found that tmSCF-based therapies can provide therapeutic benefits without off target effects.