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1 t a cis-acting 12-nucleotide sequence in the proximal 3' UTR of MTCH2 is the necessary signal for SCR
3 sub-regions supporting control of concrete, proximal actions and motor-distal, cerebellar sub-region
4 n of the p.Y783 residue is essential for the proximal activity of wild-type PLCgamma1, but we provide
7 e expression by reducing H3K27ac on promoter-proximal and -distal elements of negative regulators of
8 oscale organization of GluN2B-NMDARs between proximal and distal dendritic segments, whereas the topo
10 f white matter microstructure to measures of proximal and distal motor function in patients after hem
12 beled using retrograde tracers injected into proximal and distal regions of colon or bladder, followe
16 e epithelial cells differentiate into mature proximal and distal tubules, whereas expression of the r
18 l coronary segments (DeltaFFR(eng)-FFR(dis), proximal and middle 0.04+/-0.03 versus distal segments 0
19 tly more pronounced with stenoses located in proximal and middle as compared with distal coronary seg
20 ccurs mostly when the stenosis is located in proximal and middle coronary segments and the FFR value
21 rofiled the transcriptomes of cells from the proximal and non-proximal tubules of healthy and fibroti
30 ities of most spine populations on basal and proximal apical dendrites, as well as firing rates and o
35 ation of "causal" genetic variants and their proximal biological consequences; placing variants withi
38 um imaging of melanopsin mutants including a proximal C-terminus truncation (at residue 365) and prol
39 t CA3 cells in aged rats were hyperactive in proximal CA3, but possibly hypoactive in distal CA3, com
43 FAK branch synergizes with inhibition of the proximal cascade, providing a blueprint for combination
44 kinase from inner centromeres to kinetochore proximal centromeres and the core of chromosome arms.
45 ignments, we quantify the similarity between proximal cofactor-binding folds and show that they are d
47 on, adjacent normal tissue region, and tumor proximal collagen stroma region were imaged, revealing t
52 tities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material in
54 6 is a ciliary protein that localizes to the proximal compartment of the primary cilium, where it reg
55 ptors and STAT2 is critical for the receptor proximal complex assembly and reciprocal transphosphoryl
59 AP were successfully ablated from within the proximal coronary sinus (CS) guided by recorded potentia
61 atase domains: comprising an active membrane proximal (D1) domain and an inactive distal (D2) pseudop
62 ated by EPHB2 at tyrosine 310, which bridges proximal Dectin-induced EPHB2 activity to downstream CAR
64 ncer who had symptomatic or incidental acute proximal deep-vein thrombosis or pulmonary embolism to r
65 be evoked by both focal stimulation near GC proximal dendrites and by activating sensory inputs in t
66 yer (EPL); (2) axodendritic synapses onto GC proximal dendrites via their axon collaterals or termina
69 r types of FLAIR-HAs defined by location (at proximal/distal middle cerebral artery (MCA), within/bey
71 sentation as PE (particularly if concomitant proximal DVT), a positive d-dimer test after stopping an
73 se data indicate that vertical inhibition of proximal EGFR signaling should be pursued as a potential
76 wed that OsPIP1;3 majorly accumulated on the proximal end of the endodermis and the cell surface arou
77 invagination of the cell membrane around the proximal end of the flagellum, which is an important org
80 red transcriptional cell state, leading to a proximal enterocyte population enriched for genes within
82 e connection between ectodomain and membrane-proximal external region (MPER) by reference to the publ
83 ment with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocki
84 ouble stranded DNA molecules bind across the proximal face of the Hfq hexamer as parallel, straight r
85 hexamer and passes over the uridine-binding proximal-face pore, whereas the remaining DNA duplexes i
86 compared across trabecular sections from the proximal femora of three groups (n = 10 each): ageing no
87 ffered regarding the landmark levels for the proximal femoral reference axis and included measurement
90 ion has been reported in patients undergoing proximal forearm transplantations (PFTs), reports of lon
91 at this combination of target engagement and proximal functional readout will prove useful to the stu
92 d treatment, interactions between distal and proximal GBSs and the TSS correlated with KLF9 induction
94 regeneration, and assigned these regions to proximal genes with corresponding expression changes by
95 quencing data, we identified variants in two proximal genes: FTSJ3, encoding an RNA methyltransferase
97 lear receptor NR4A1/Sp1 complex bound to the proximal germinal center (GC)-rich region of the PD-L1 g
98 nhances calcitonin hormone affinity with the proximal GlcNAc residue mediating this effect through an
101 TC-NER on the transcription start site (TSS)-proximal half of the +1 nucleosome is largely independen
102 es were measured in cells collected from the proximal half of the small intestine of Hnf4alphagamma(D
103 ently, recruitment of TIP60 and ATM, two key proximal HDR factors, is substantially impaired at DNA b
104 C1 carboxylate group of 2OG is trans to the proximal histidine (His134) of the 2-His-1-carboxylate f
105 osteoporotic (hip, pelvis, spine, wrist, and proximal humerus) fractures individually and any fractur
107 ain extent, accessibility for self-performed proximal hygiene is associated to the peri-implant condi
109 duodenum and ulcerations in the jejunum and proximal ileum covered by fibrin; histological report sh
110 around the trigeminal root were respectively proximal in 82.7% (67/81) and superior in 59.3% (48/81).
113 ovenous malformations (AVMs) (n = 5/24), and proximal interruption of pulmonary artery (n = 2/24).
114 s that can be primed towards more colonic or proximal intestinal lineages in serum-free defined condi
115 (3) [1,25(OH)(2)D(3)]-activated genes in the proximal intestine associated with active calcium transp
116 In 12 public hospitals, patients with a proximal intracranial occlusion in the anterior circulat
117 dilated intrahepatic biliary tree with left proximal intrahepatic hyperdensities, as well as a 3 cm
118 t parameters were included in this analysis: proximal isovelocity surface area (PISA)-derived regurgi
120 gatively charged amino acids in the membrane-proximal juxtamembrane domain of substrates make them re
121 as well as TET2 and TET3 was observed within proximal KIR promoters in CD56(bright) NK cells cultured
122 subsequent interaction- and light-dependent proximal labeling of a model protein-protein interaction
123 dividuals with no polyp, proximal small SPs, proximal large SPs, and distal SPs were 4.7 (95% CI, 4.0
124 distinct steps, including docking, merger of proximal leaflets (stalk formation), and formation of a
125 oportion of left main, 2-vessel disease with proximal left anterior descending or 3-vessel disease co
126 ates both in the crustacean terga and in the proximal leg segments, suggesting that the evolution of
129 monary embolism, and a minority of them have proximal limb-threatening deep vein thrombosis (DVT).
131 f obtaining reliable MTR measurements in the proximal lumbar plexus of healthy volunteers using MRN t
132 f obtaining reliable MTR measurements in the proximal lumbar plexus, opening up the possibility of st
133 ctor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periureth
134 Furthermore, we show that mouse distal and proximal luminal cells are most similar to human acinar
138 ted with higher odds of excellent outcome in proximal M1 (OR = 3.26; 95% CI = 1.67-6.35; p = 0.0006)
139 splayed the highest percentage match (45% of proximal marker genes [TPM threshold =15]), with pig kid
142 g, covalent inhibitors irreversibly modify a proximal nucleophilic residue on the protein via reactio
144 acks methylation on the first and second cap-proximal nucleotides (cap1, m7GpppNm, and cap2, m7GpppNm
146 l or descending) colon but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1
147 athetic prevertebral ganglion innervated the proximal or distal colon, with processes closely opposed
149 g (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition with antisense morpholi
150 a genes accumulated most heavily at promoter-proximal pause (PPP) sites located ~60 nucleotides downs
151 ecruitment of Pol II and entry to a promoter-proximal paused state, and also to promote Pol II's tran
152 am information directing ubiquitous promoter-proximal pausing and downstream nucleosome location.
154 ions, we reconstituted human RNAPII promoter-proximal pausing in vitro, entirely with purified factor
155 ated with active transcription, and promoter-proximal pausing of RNA polymerase II (Pol II) is a crit
156 tilize Spt4-Spt5 (DSIF) to regulate promoter-proximal pausing, a transcription-regulatory mechanism t
158 ed piRNA precursors associated with promoter-proximal Pol II, resulting in termination of transcripti
159 orrelated with the preferential selection of proximal polyA sites by the 3'end processing complex.
160 ctor FY (WDR33), thus linking activities for proximal polyadenylation of the antisense transcripts to
161 o shorter mRNA isoforms due to usage of more proximal polyadenylation signals (PASs) in introns and l
167 ding of pICln (but not vice versa) to the AR proximal promoter region, suggesting that PRMT5 recruits
170 ially contained NF-Y-binding motifs in their proximal promoters, and notably enriched genes related t
171 rotein with BioID biotin ligase and identify proximal proteins that are biotin tagged on both their e
173 ic ganglia, as well as a transition zone and proximal pull-through resection margin where ENS was pre
174 's NADH-binding and CoQ-binding modules, the proximal-pumping module and the plant-specific gamma-car
175 xpansive PFA lesions without stenosis in the proximal PV sites, compared with more confined and often
178 e, multiple recurrence, advanced recurrence, proximal recurrence, and distal adenoma recurrence with
179 at residue 365) and proline mutation of this proximal region (H377P, L380P, Y382P) delayed melanopsin
182 Loss of DNA methylation at Pdcd1's promoter-proximal regulatory regions is highly correlated with it
183 t subgroups of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that
185 in the reabsorption of filtered phosphate in proximal renal tubules, thereby critically contributing
186 tegrator complex as a terminator of promoter-proximal RNA polymerase II during piRNA biogenesis.
187 Here, we report that widespread promoter-proximal RNA polymerase II pausing in resting macrophage
189 s did not reveal major structural changes at proximal sciatic nerve branches or distal toe nerve fasc
191 btained such counts with confocal imaging of proximal sections of the mouse penis after paraffin embe
192 gion of human DDR1 and found that the kinase-proximal segment, JM4, is an important regulator of kina
193 tes of apical and basal segments, along with proximal segments on both apical and basal dendrites, an
197 ase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, re
199 rates of CRC for individuals with no polyp, proximal small SPs, proximal large SPs, and distal SPs w
200 re after the first colonoscopy (HR for small proximal SPs 2.6; 95% CI, 1.7-3.9 and HR for large proxi
202 let is a short indeterminate branch with two proximal sterile bracts (glumes) followed by a variable
204 here these epigenetic reader proteins couple proximal stimuli to chromatin, acting at super-enhancer
208 1 targets tyrosine phosphosites that mediate proximal T cell receptor signaling, cytoskeletal organiz
209 that combining extracellular and cytoplasmic proximal tagging with a biophysical binding assay increa
212 p into the OA distal third versus medial and proximal thirds (P = 0.04) and a mean catheter diameter-
214 tinction phases, we further demonstrate that proximal threats impaired extinction efficacy via persis
215 ients with COVID-19 (95% CI: 70%, 99.8%) had proximal thrombi compared with 47% of control patients (
216 e characterized by a gene expression profile proximal to bone marrow neutrophils (Cd177, Lcn2, Fpr1),
217 veal binding regions that in many cases, are proximal to cardiolipin-protein interacting regions.
219 ous trophoblasts and a gradual decrease from proximal to distal cell columns as cytotrophoblasts diff
221 Accordingly, TORC1 can phosphorylate Fab1 proximal to its PI3P-interacting FYVE domain, which caus
224 leocytoskeletal connections, Par3 clustering proximal to nuclear lamina folds, and retrograde movemen
227 have reported viral integration sites (VISs) proximal to structural or functional regions of the huma
228 ) coordination sphere in the N42C Az mutant, proximal to the (larger) substrate-electrode, to which t
229 nd interrogation of modifications within and proximal to the A-triad that are associated with disease
230 te of EphA2 on EBV gH/gL is at least in part proximal to the EBV gL glycosylation site, which in part
233 f a tryptophan substitution at position 471, proximal to the GAC catalytic site, to examine the confo
234 red a small heterocyclic scaffold that binds proximal to the Gna1 active site and can be optimized to
235 h, the majority of tagged collagen localises proximal to the injury, within the overlying epicardial
237 Nevertheless, the CDR3beta loop anchored proximal to the MR1 A'-pocket and mediated direct contac
238 toproteolysis-inducing (GAIN) domain that is proximal to the N terminus of the G protein-coupling sev
239 tion of a traditionally unreactive C-H bond, proximal to the nitrogen atom, into a versatile chemical
240 GSIS by both limiting the amount of insulin proximal to the PM and preventing or breaking interactio
241 These experiments also suggest water is proximal to the selectivity filter of KirBac1.1 in the o
243 sible esophageal columnar mucosa; 2) 5-10 mm proximal to the squamocolumnar junction and 3) 5-10 mm d
244 We have recently discovered that mutations proximal to the substrate binding site of glycosyltransf
245 G-quadruplexes, EXO1 resects the nascent DNA proximal to these structures to facilitate fork progress
246 tegration events, VIS clusters, DNA elements proximal to VISs and virus-host interactions involved in
248 ferents, crypt innervation exhibited a muted proximal-to-distal decrease in control mice and a smalle
249 ) the candidate role of reactive oxygen as a proximal trigger for the onset of polyploidy, (c) the re
253 gether, these results suggest that DsbA-L in proximal tubular cells promotes TIF via activation of th
254 hy (DN). However, the role and regulation of proximal tubular DsbA-L for renal tubulointerstitial fib
259 Additional frequent findings included renal proximal tubular injury, focal pancreatitis, adrenocorti
261 ken together, our studies suggest that renal proximal tubular P2X4 activation exacerbates ischemic AK
264 l model of protein reabsorption in the human proximal tubule (PT) using Michaelis-Menten kinetics and
265 The results demonstrate a primary renal proximal tubule cell AT(2)R natriuretic defect in SHR th
267 location to apical plasma membranes of renal proximal tubule cells, internalization/inactivation of N
269 ation, and chromatin accessibility in kidney proximal tubule epithelial cells (PTECs) derived from su
270 ion of YAP (yes-associated protein) in renal proximal tubule epithelial cells (RPTC) in patients with
271 pressed at the basolateral membrane of renal proximal tubule epithelial cells, mediates the renal exc
274 ing number of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropa
275 ation of nearly 150 differentially expressed proximal tubule lncRNAs during fibrosis suggests they ma
280 heir reciprocal interaction were upstream of proximal tubule YAP activation in diabetic kidneys.
282 By inhibiting glucose reabsorption in the proximal tubule, these agents promote glycosuria, thereb
283 l reabsorption is augmented by growth of the proximal tubule, which (alongside sodium-glucose cotrans
284 cement of remaining podocytes, activation of proximal tubule-like parietal epithelial cells identifie
289 criptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys t
291 G45 to be effectively effluxed out of normal proximal tubules through P-glycoprotein transporter whil
292 S), is predominantly presented in podocytes, proximal tubules, distal convoluted tubules, and the api
293 hain deposition disease (n = 5), light chain proximal tubulopathy (n = 2), and light chain cast nephr
296 wever, their inactivation allows scanning to proximal V(H)s, where additional CBEs activate rearrange
297 ong-distance regulation of the Ealpha on the proximal Valpha genes, and its deletion impaired the Tcr
298 0 mV was sufficient to deplete the membrane-proximal vesicle pool, while triggering rapid stepwise m
299 on of the input within the dendritic branch (proximal vs distal), (2) the strength of the input patte