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1 r binding and a stalk domain at the membrane-proximal region.
2 twenty six (ETS) binding elements within the proximal region.
3 rved Smad binding site in the Tbx20 promoter proximal region.
4 t only in the context of the TAPNAC promoter proximal region.
5 h at least one mismatch occurring in the PAM proximal region.
6 aded volume, and tended to return toward the proximal region.
7 RSS-associated sites are located in the D(H)-proximal region.
8 this is an NPLY(747) motif and the membrane-proximal region.
9 of polymerase elongation within the promoter-proximal region.
10 enes with Pol II stalled within the promoter-proximal region.
11 erminus at a site designated as the membrane proximal region.
12 uctural variation relative to the centromere-proximal region.
13 nsible for the constitutive occupancy at the proximal region.
14 responsive element (CRE) in the PII promoter-proximal region.
15 ration and invasion at the integrin receptor-proximal region.
16 , but paused or stalled, within the promoter-proximal region.
17 of severe recombination suppression over its proximal region.
18 rosophila have Pol II paused in the promoter proximal region.
19 , opposite to that commonly seen at promoter-proximal regions.
20 pausing, but it is confined to extremely 5' proximal regions.
21 erable barrier to Pol II elongation past TSS-proximal regions.
22 containing domains tend to occur in promoter-proximal regions.
23 ges primarily localizing to the Fis1 arm and proximal regions.
24 fibres in the distal regions of the leg than proximal regions.
25 r transcription factors Sp1 and AP2 in their proximal regions.
26 ue to the loss of chromatin accessibility in proximal regions.
27 petitive elements differs between distal and proximal regions.
28 alization of BRG1 and CHD7 at distal but not proximal regions.
29 RNA genes, in both their bodies and promoter-proximal regions.
30 he 300 nm granule diffused into the bleached proximal regions.
31 y (distal) region toward the high-frequency (proximal) region.
32 ferase assays demonstrated that not only the proximal region (-1300/-7) of the UGT1A1 promoter, but a
34 an unstructured region to surmount the noisy proximal region, a homomeric polyprotein marker, a carri
35 ed cis-regulatory cassette located in the 3' proximal regions adjacent to the HoxA and HoxB complexes
37 GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured a
38 ion of the distal enhancer from the promoter-proximal region allows for two independent chromatin sta
40 chnical problems, including the noise of the proximal region, ambiguous single-molecule identificatio
41 flowers, which have a ridged cuticle in the proximal region and a smooth cuticle in the distal regio
42 e-specific manner to the mouse and human TSS proximal region and also to high-affinity sites recogniz
43 ':3' ratio of pol II density in the promoter-proximal region and caused Ser5 hyperphosphorylation of
44 mismatches in PAM-distal region than to PAM-proximal region and the high specificity and efficiency
46 PII to overcome its stalling in the promoter-proximal region and to engage in efficient transcription
47 shment of DNA damage-induced cohesion at DSB-proximal regions and cohesion-associating regions (CARs)
48 ression levels and cytosine modifications in proximal regions and gene bodies, suggesting epigenetic
49 facultative heterochromatin in the telomere-proximal regions and H3K27me1 is diagnostic for constitu
50 d Ser5 phosphorylated Pol II around promoter-proximal regions and within the first 20 to 30 kb of gen
51 gene conversion events at the site of a DSB (proximal region) and at a surrounding region ~1 kb away
52 omoter region and subsequently to a promoter proximal region, and FACT and Asf1 are both required for
53 e chromatin architecture around the promoter-proximal region, and that loss of Pol II stalling at the
54 and beta(3) TMs, the intracellular membrane-proximal regions, and the whole cytoplasmic tails, to th
55 ted the effects of trinucleotides in the AUG-proximal region (APR) (i.e. positions -3 to -1 upstream
56 react with the HIV-1 envelope gp41 membrane proximal region are also polyspecific autoantibodies tha
57 s, our results revealed that the lincRNA TSS proximal regions are associated with the characteristic
60 er, and 17-mer peptides of the gp41 membrane-proximal region, at 2.0-, 2.1-, and 2.2-A resolutions, r
61 ta signaling controls Sox9 expression in the proximal region, because Sox9 expression is delayed in c
63 nalysis and identified almost 1,400 promoter-proximal regions bound by DMRT1 in the juvenile mouse te
64 deficient alleles are still recruited to DSB-proximal regions but are defective in tethering sister c
65 are almost exclusively placed at centromere-proximal regions but it remains unclear if there is func
66 of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclea
67 bundant not only in centromere- and telomere-proximal regions, but also throughout the euchromatic ar
68 presynaptic dendrites preferentially target proximal regions, but such actions differ significantly
69 nked to a conformationally flexible template-proximal region by a bulge that severely kinks the entir
70 r events are malleable and can be shifted to proximal regions by altering the growth temperature.
71 anscription is tightly regulated at promoter-proximal regions by intricate dynamic processes includin
72 d/or by conformational signals from membrane proximal regions, can reposition a remote domain that in
73 nesis of strain 1244 pilin residues of the C-proximal region common to the group I proteins showed th
75 multiple cis-regulatory elements including a proximal region containing a cAMP-responsive element (CR
76 n is controlled by an intron enhancer plus a proximal region containing a HesC site as predicted from
79 ty of individuals have a 3 Mb deletion whose proximal region contains the presumed disease-associated
80 that co-expression of this I-II loop or its proximal region (Delta1-Cav3.2; Ser(423)-Pro(542)) toget
81 mutations in all three AML1 sites of the URE proximal region demonstrated that AML1 regulates PU.1 bo
82 ignificant difference in mass scaling in the proximal region distinguished long from local projection
83 x DNA binding promote DNA bending in the PAM-proximal region during early steps of Cas9/guide RNA-DNA
85 ible structure that, along with the membrane proximal region, forms a flexible scaffold for cytoplasm
86 ermini, including the FP, the fusion peptide-proximal region (FPPR), the membrane-proximal external r
87 the functional PPAR-responsive element to a proximal region from -135 to -123 of the LPCAT3 promoter
88 ion and that this interaction requires the N-proximal region from either amino acids 1 to 31 or amino
89 ariant exons into the extracellular membrane proximal region generates the variant isoforms (CD44v).
90 at residue 365) and proline mutation of this proximal region (H377P, L380P, Y382P) delayed melanopsin
91 s by deletion mutagenesis suggested that the proximal region had a highest core promoter activity whi
92 heme oxygenase-1 promoter in addition to one proximal region, HS-1, which we have shown previously to
93 es extensive phosphorylation of the membrane proximal region in a hierarchical fashion at both consen
95 fraction of P-TEFb is recruited to promoter-proximal regions in a catalytically inactive state bound
97 (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitr
98 , affects transcription through the promoter proximal region, including this nucleosome, remains larg
99 ation within the first cluster on a membrane-proximal region increases tyrosine phosphorylation of ty
100 ated the FRET rate significantly at membrane proximal region, indicating C2AB-Ca(2+) promotes the tra
101 A polymerase-II in the distal as well as the proximal region, indicating that the distal region may b
102 CP-1 expression, was not required for distal-proximal region interactions, suggesting that it plays a
104 two regions, on proximal and distal 15q; the proximal region is notable because recombination among t
105 fragment that does not include the conserved proximal region is sufficient to promote transgene expre
107 reas all bNAbs directed against the membrane proximal region lost neutralizing activity after DC-medi
108 g analyses suggest that several of the lumen proximal regions may be important for cpTatC-cpTatC inte
109 ed by a portion of the HIV Env gp41 membrane proximal region (MPER) and is cross-reactive with the HI
110 e interaction between talin and the membrane-proximal region (MPR) in the beta-integrin cytoplasmic d
111 teraction of talin with an integrin membrane-proximal region (MPR) that is critical for integrin acti
112 ear the -1.1 kb essential PRE, and also to a proximal region near -130 bp that contains PRE half-site
114 rearrangements in the FP and fusion peptide proximal region occur around M530, which remains anchore
115 Recombination initiation in interstitial and proximal regions occurs later than distal events, is not
116 ty of Cas1-Cas2 integrase outside the leader-proximal region of a CRISPR array suggests that this pol
117 ed RNA polymerase II binding to the promoter proximal region of a majority of expressed genes, sugges
120 residues 28 to 39 of the N-terminal membrane-proximal region of chECL1 constitute the minimal domain
121 animals indicating a strong influence of the proximal region of Chr10 in the development of tolerance
122 cal congenic genotypes (B6D2, D2B6) with the proximal region of chromosome 10 (Chr10) introgressed in
123 Nek8/NPHP9 localizes to centrosomes and the proximal region of cilia in dividing and ciliated cells,
124 ed and Fuzzy localized to the basal body and proximal region of cilia, and cilium formation was compr
126 identify conserved residues in the membrane-proximal region of CNIHs that contribute to AMPAR bindin
128 ) of histone H3 in the promoter and promoter-proximal region of defense genes WRKY6 and PDF12, but no
129 at ODA10 in flagella localizes strictly to a proximal region of doublet number 1, which completely la
130 to transcription arrest within the promoter-proximal region of Drosophila hsp70 and that transcript
131 -beta signaling are present in the quiescent proximal region of ducts in an androgen-replete animal a
132 ree bNAbs directed against the gp41 membrane proximal region of Env (2F5, 4E10, and 10E8) and three g
133 plicing enhancer (ESE) element within the 5'-proximal region of exon 2 that facilitates both exon inc
134 ion for hypermethylated CpG sites within the proximal region of gene promoters, including some genes
139 stal region of IL-1alpha promoter and to the proximal region of IL-1beta promoter upstream of the tra
140 ze highly conserved epitopes in the membrane-proximal region of influenza virus hemagglutinin (HA) ha
144 is consistent with the proposal that the 5'-proximal region of miRNAs is critical for target mRNA re
146 , and 4B, which cooperatively unwind the cap-proximal region of mRNA and later also assist 43S comple
147 1, and 1A, and tRNA(Met)(i) attach to the 5'-proximal region of mRNA and then scan along the 5' untra
148 ion of p21 by MCGA3 was mediated through the proximal region of multiple Sp1 sites regardless of p53-
152 Like a subset of normal cells located in the proximal region of prostatic ducts, the early neoplastic
153 ell cycle, and Sca-1(+) cells cluster in the proximal region of prostatic tubules where replication-q
154 due peptide, which had been modeled on the C-proximal region of strain 1244 pilin, served as a PilO s
156 cocious collateral branches emerge along the proximal region of the axon shaft typically devoid of br
157 and further highlight the importance of the proximal region of the axoneme in generating flagellar b
160 residues (Arg(310)-Arg(311)) in the membrane-proximal region of the C-terminal tail plays a pivotal r
163 distal region and bins of low density in the proximal region of the chromosome arms, with the excepti
164 nent SAS-6 localized to basal bodies and the proximal region of the ciliary axoneme, and depletion of
166 is preferentially integrated into the leader-proximal region of the CRISPR array, guided by the leade
170 -positive multipotent cells in the posterior-proximal region of the epiblast, but the mechanisms that
171 a fully developed initial segment, the most proximal region of the epididymis, male infertility resu
172 ingly, we showed that Fli1 binds to the most proximal region of the ERalpha promoter, and dissociates
173 t the localization of Agg2p and Agg3p to the proximal region of the flagella may be important for int
175 C with more MT growth in the distal than the proximal region of the GC during repulsion, and knockdow
176 orphism (RFLP) analysis of the PCR-amplified proximal region of the gene encoding cytadherence access
179 cterized factors that recognize the promoter-proximal region of the germ cell-specific TFIIA alpha/be
180 for a single amino acid within the membrane-proximal region of the GluA2 cytoplasmic tail, and sugge
181 833, Ser836, and Ser840) within the membrane proximal region of the GluK5 C-terminal domain that, in
182 ach was demonstrated to present the membrane-proximal region of the HIV-1 envelope glycoprotein.
183 NELF causes Pol II to pause in the promoter-proximal region of the hsp70 gene in Drosophila melanoga
184 g RNA Polymerase II (Pol II) in the promoter-proximal region of the hsp70 gene in Drosophila, before
186 homology modeling, we hypothesized that the proximal region of the I-II loop may form a helix-loop-h
187 ese early events was dependent on a membrane proximal region of the IgG1 cytoplasmic tail not previou
188 oth THi and TLo cells, but only bound to the proximal region of the IL-17 promoter in TLo cells.
191 mplex signaling component, p65, binds to the proximal region of the IL22 promoter and promotes transc
193 Absorption of dietary cholesterol in the proximal region of the intestine is mediated by Niemann-
194 the absorption of dietary cholesterol in the proximal region of the intestine, a process that is bloc
195 e TpoR is entirely conferred by the membrane-proximal region of the intracellular domain that include
197 igration, MgcRacGap also concentrates in the proximal region of the leading process, and inhibition o
201 that Nelf-b was associated with the promoter-proximal region of the majority of expressed genes, yet
202 ugh intramembranous ossification whereas the proximal region of the mandible undergoes endochondral o
204 In summary, our findings suggest that the proximal region of the melanocortin-4 receptor (MC4R) C
205 These residues are located in the membrane-proximal region of the N terminus of chECL1, suggesting
206 ic receptor-binding site was identified at a proximal region of the N-terminal tail of the HCN4 chann
210 es that structural integrity at the membrane proximal region of the PhoQ sensor domain promotes metal
211 with high affinity and specificity to the 5' proximal region of the PPR53-dependent 23S rRNA, suggest
212 We mapped the sub-QTL for body weight in the proximal region of the previously mapped QTL, ranging fr
213 e cell line is regulated by sequences in the proximal region of the promoter and requires transcripti
214 ly directed luminal cell movement toward the proximal region of the prostate duct was able to best re
215 hat the AR/beta-catenin complex binds to the proximal region of the prostate-specific antigen promote
216 that all malignant neoplasms arise from the proximal region of the prostatic ducts, the compartment
217 at separates the distal pocket from the more proximal region of the protein and is thought to control
218 Leu(611), Arg(683), or Phe(694) in the hinge proximal region of the pseudokinase domain resulted in a
219 nding sites showed the importance of the PAM-proximal region of the sgRNA guiding sequence and that d
221 hat the CDE and CHR response elements in the proximal region of the Survivin promoter are involved in
223 ys found that Pax6 binds endogenously to the proximal region of the tartrate acid phosphatase (TRAP)
227 0 is involved in patterning the veins in the proximal region of the wing blade and that CG17278 and C
229 ment-binding protein-binding site within its proximal region of the ZO-1-promoter, whereas induced Ju
230 (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these res
231 red for CGRP-mediated internalization, and a proximal region of twelve residues (from G388 to W399),
232 ivation of the glucocorticoid receptor (GR), proximal regions of activated and repressed genes are re
233 (cenhaps) in humans that span the centromere-proximal regions of all metacentric chromosomes, includi
234 g experiments demonstrate that both membrane-proximal regions of alphaIIb and beta3 CTs are involved
235 and IFIT1B showed very high affinity to cap-proximal regions of cap0-mRNAs (K1/2,app approximately 9
236 scaffolding protein Girdin localizes to the proximal regions of centrioles and regulates BB position
237 e genes within the genome are located in the proximal regions of chromosomes which undergo low/very l
240 g up proper Pol II occupancy at the promoter-proximal regions of developmentally regulated genes and
241 The BACE1 cleavage sites at the membrane-proximal regions of L1 (between Tyr(1086) and Glu(1087))
242 y genes are known to lie within interstitial/proximal regions of low recombination, creating a limita
243 ions between lipid bilayers and the membrane-proximal regions of membrane-associated proteins play im
244 ive transcription elongation at the promoter-proximal regions of OriLytL-K7 lytic genes, leading to t
246 erved pyrimidine-rich 5' untranslated region proximal regions of SOS1 that are missing in Arabidopsis
252 teracts, directly or indirectly, with origin-proximal regions of the chromosome, arguing that the ori
253 ession has on Wg signaling in the distal and proximal regions of the disc and makes a number of quant
254 The homologous motifs in the distal and proximal regions of the human HAMP promoter act in a man
257 ap antibody and HBGA carbohydrate binding to proximal regions of the norovirus capsid, showing that e
258 ality of Ca(2+) channels is regulated within proximal regions of the same organelle is unresolved.
259 ny, thus behaving similarly to comparable 5'-proximal regions of the SCoV 5' UTR as shown by others.
260 that nucleotides at both PAM-distal and PAM-proximal regions of the sgRNA are significantly correlat
262 on and spreading of variant repeats from the proximal regions of the telomeres and that the consequen
265 rmally oriented PCP and, in all but the most proximal regions of the wing, uniform ds rescues the ds
267 d RNA polymerase II (pol II) in the promoter-proximal region on both sides of the transcription start
268 quence element (PSE) and TATA element in the proximal region, plus a distal region with octamer (OCT)
269 ive lincRNA TSS regions predicted by the TSS proximal region prediction model based on genomic and ep
270 ent inter-arm interactions within centromere-proximal regions, providing structural constraints cruci
271 predicted motifs, such as motifs enriched in proximal regions rarely overlapped with motifs enriched
275 x separate positions examined throughout the proximal region reveal a pattern of recent turnover driv
276 s of the chromosome, arguing that the origin-proximal region segregates via an MreB-dependent mechani
277 se higher order features to cluster promoter-proximal regions, showing that five major patterns of me
278 es whether crossovers can be shifted to more proximal regions simply by elevating growth temperature.
280 -binding motif, CAATTTTATTAA, located in the proximal region spanning bp -210 to -221 upstream of the
282 ique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compa
283 bound to sites in the ompF and ompC promoter proximal regions that overlap but were distinct from Omp
284 Thus, despite extensive conservation in the proximal region, the importance of these elements may be
285 f the receptor, suggesting that the membrane-proximal region, the transmembrane helix and the kinase
286 ing digestion and nutrient absorption in the proximal region to be separate from the vast microbial p
287 ch other at multiple parts from the membrane-proximal region to the membrane-distal region, relying o
289 m controlling 7SK snRNP delivery to promoter-proximal regions to facilitate "on-site" P-TEFb activati
291 mislocalization of H3K4me3 from the promoter-proximal regions to the gene bodies and intergenic regio
292 s histone acetylation levels in the promoter-proximal region via the Rpd3L deacetylase and NuA3 acety
293 these higher order features across promoter-proximal regions, we are able to construct a powerful ma
296 genes were bound by STAT5 in their promoter proximal regions, whereas upstream binding had minor bio
297 regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA p
298 ished that two large domains in the membrane-proximal region, which include the previously defined Bo
299 s exhibited RFLPs following digestion of the proximal region with restriction endonuclease MboI or Rs