ライフサイエンスコーパス: proximally

1 e of the fin, significant growth also occurs proximally.

2 and accumulate abnormal and degraded oocytes proximally.

3 hile the Bmp4 expression domain was expanded proximally.

4 six, the weakness was greater distally than proximally.

5 ms was virtually zero distally and very high proximally.

6 h several recognizable elements concentrated proximally.

7 he vein, focal activity seemed to occur more proximally.

8 naldehyde dehydrogenase 2 (Raldh2) expressed proximally.

9 rker D3S3691 distally and by the gene ATP2B2 proximally.

10 lected the arterial occlusion occurring more proximally.

11 tal end that give rise to meiotic cells more proximally.

12 ated in the leading edge and galectin-3 more proximally.

13 val, with a worse outcome as the tumor moves proximally.

14 nd toward a worse outcome as the tumor moves proximally.

15 at is severalfold greater than that observed proximally.

16 polymerizing drugs than the polymer situated proximally.

17 while atrial progenitors are positioned more proximally.

18 es the distal lower limbs before progressing proximally.

19 r intrinsic mitochondrial oxidative capacity proximally.

20 efficacy and safety most optimally balanced proximally.

21 P = 0.003, respectively), all being greater proximally.

22 rsal V2a cells have higher synapse densities proximally.

23 fasciculation syndrome more frequently arise proximally.

24 istally and bigeminal and trigeminal rhythms proximally.

25 ast distally and the extraembryonic ectoderm proximally.

26 fined to the 3.3-kb repeats but extends both proximally (42 kb) and distally to include the telomere.

27 reduced this innervation to a greater degree proximally (91-93%) than distally (65-72%), resulting in

28 ircumferential involvement was more frequent proximally, a similar pattern to native atherosclerosis.

29 receptor antagonists) should be avoided, and proximally acting agents (e.g., acetazolamide and loop d

30 t of expression QTL that uncouple genes from proximally acting regulatory networks, creating 'co-expr

31 and CSF-1R were coexpressed in RCCs and TECs proximally adjacent to RCCs.

32 Proximally, all V2a neurons have axonal distributions th

33 ACS-1 did not proximally alter EGF receptor or integrin signaling, but

34 d they always contacted relay cell dendrites proximally among retinal terminals (the retinal recipien

35 at the rate of regeneration is more rapid in proximally amputated appendages compared with distal amp

36 enchymal stem cells (mBMSCs) to regenerate a proximally amputated digit tip.

37 s rarely approached within 4 mm of the lumen proximally and 2.5 mm more distally.

38 ure, for which the critical zone occurs more proximally and at an imageable spatial scale.

39 ing sites, the sB-loop and 3' spacer, reside proximally and bind a single PCBP2.

40 ing the oral INCs, we found that they extend proximally and continue beyond the arm, through the arm'

41 The hip capsule inserts proximally and continuously to the acetabular rim perios

42 a 7-cM (4.3-Mb) interval flanked by D19S928 proximally and D19S425 distally.

43 further defined RMD-1 between markers D6S186 proximally and D6S227 distally.

44 ene that is differentially expressed between proximally and distally amputated limbs.

45 Perturbations evoked proximally and distally propagate along the loop, rendez

46 haracterizes complex circuits involving both proximally and distally regulating transcription factors

47 Residual nodal disease was observed proximally and distally to the clinical target volume in

48 fin spine develops in the fold, growing both proximally and distally, and sensory innervation, which

49 Subsequently it spreads proximally and distally, covering the entire afferent su

50 ters away from the synaptic input site, both proximally and distally, dendritic calcium transients ar

51 and flanked by "wings" W1 and W2 positioned proximally and distally, respectively, to the transcript

52 ial regulatory targets, acting both receptor proximally and distally, that can terminate or amplify t

53 noncancerous lesions are equally distributed proximally and distally.

54 ng atypical cadherin Flamingo localizes both proximally and distally.

55 siological TGF-beta signaling gradient (high proximally and low distally) and its functional correlat

56 tine nucleus stimulation restored StartReact proximally and proximal reaction times to loud stimuli c

57 e found that hsh is flanked between D3Mit187 proximally and S100a4 distally.

58 Clusters arise first dorsally and proximally and spread over the entire intestine within 2

59 cleic-acid translocases, may bind substrates proximally and, coupled with ATP hydrolysis, translocate

60 and regulators of the TFIID pathway located proximally, and (5) distinct mobilization of SAGA- versu

61 to have the V600E BRAF mutation, be located proximally, and occur in older individuals (in univariat

62 and the cytoplasmic protein Prickle localize proximally, and the seven-pass transmembrane spanning at

63 ucleotide diversity was high distally, lower proximally, and very low nearest the centromere.

64 comprised of a Cu(II)-centered core with two proximally appended tripeptide arms emanating outward.

65 ostructure, where dissimilar metal atoms are proximally arranged.

66 ia phospholipase C activation, PKC acts more proximally as an upstream activator of PKD.

67 he left side were merged with the right side proximally as stationary and distally as moving objects.

68 key roles in cell-cell communication, acting proximally as well as systemically.

69 scle weakness that was greater distally than proximally, as well as respiratory insufficiency, cardio

70 anxiety and substance use disorders were not proximally associated with suicidality.

71 l value, and that this value signal was most proximally associated with task performance.

72 However, if mouse cells are implanted either proximally at stage 21 or into the limb tip at stage 24,

73 Pegcetacoplan inhibits complement proximally at the level of C3 and is highly effective in

74 of the extrahepatic bile duct were measured proximally at the porta hepatis, at the middle above the

75 poneurotic fibers and Muller's muscle attach proximally at the superior tarsal border.

76 er two INCs, paired aboral INCs, also extend proximally beyond the arm's base with trajectories sugge

77 Here, we show that proximally biased human-derived kidney organoids provide

78 providing an explanation for the origins of proximally biased limb defects.

79 ecruited from a pool of polymerases that are proximally bound to the replisome and continuously reple

80 ably due to the necessity for interaction of proximally bound transcription factors, while a facilita

81 activator such as E2F or actively represses proximally bound transcription factors.

82 ning a p53 response element which is located proximally (bp -168 to -57) to the transcription start s

83 ese, hIK1-like immunoreactivity was detected proximally but not distally to injury, whereas neurofila

84 ing successive evaginations that "zipper" up proximally, but at their leading edges are free to make

85 ith two nearly orthogonal stems, each capped proximally by a G x G mismatch pair, binding the AMP lig

86 didate region of approximately 20 cM flanked proximally by D15S983 and distally by D15S127 on human c

87 of deletion flanked distally by D1S2713 and proximally by D1S2134, which spans 1.5 cM within 1p32.

88 has been mapped to a region of 1q41 flanked proximally by D1S217 and distally by D1S439.

89 ve FOP gene within a 36-cM interval bordered proximally by D4S1625 and distally by D4S2417.

90 n mouse chromosome 7 in the interval defined proximally by hemoglobin beta (Hbb), D7Mit38, D7Mit2l7,

91 roximately 2.1 Mb recurrent deletion flanked proximally by LCR22-4 and distally by either LCR22-5 or

92 PLP is restricted proximally by limiting its mRNA and protein to the earli

93 a minimal region of common deletion flanked proximally by marker GSN on 9q33.

94 al ectodermal ridge, both Fgfs and Bmps, and proximally by retinoic acid signaling.

95 ic stage 13 at the chelicera tip, progresses proximally by the end of embryonic development and exten

96 1H), T(33H), and T(36H), which extended more proximally, caused male sterility when heterozygous with

97 Conversely, more proximally charged residues of the collagen receptor tha

98 Although proximally continuous with villous cytotrophoblast (CTB)

99 he distal ligand binding properties of these proximally detached Hbs.

100 tern of focal and noncircumferential disease proximally, diffuse and circumferential disease distally

101 There is also a small proximally directed progression of NF-M expression.

102 hers to argue for two overlapping components proximally displaced from the OCJ: an extrinsic crural s

103 a DSB using short dispersed repeats located proximally, distally, or even on separate molecules rela

104 populations (LumA, LumD, LumL, and LumV), a proximally enriched luminal population (LumP) that is no

105 An anti-PD-1 antibody that bound membrane proximally excluded CD45, triggered Src homology 2 domai

106 n cancer are mediated by enzymes, which most proximally exert their function through their activity.

107 cription factor that largely binds promoters proximally, exhibits an extremely stable chromatin dwell

108 nd expression of marker genes, including the proximally expressed hepatocyte nuclear factor/forkhead

109 One of these rearrangements is a D4Z4 proximally extended deletion (DPED) allele, where not on

110 ate distinct signaling pathways that diverge proximally following receptor activation but converge di

111 ce open, the gastroesophageal junction moved proximally for the duration of the transient lower esoph

112 Proximally, Foxo3a is regulated by different pathways in

113 segments (ROS) that are continuously formed proximally from connecting cilia (CC) and phagocytized d

114 ring a 1.82-Mb chromosomal segment extending proximally from p.

115 ses a 16-21 nucleotide RNA segment extending proximally from the 3' end of the chain.

116 10 cm distally from the midthigh, and 10 cm proximally from the midthigh).

117 The enlargement extended proximally from the point of nerve transection to a leve

118 murine cardiac conduction system, extending proximally from the sinoatrial node to the distal Purkin

119 posterior edge of the pectoral disc; radials proximally fused to each other; pelvic girdle extremely

120 Searching for a proximally generated diffusible factor capable of activa

121 The large bundles that are present proximally gradually split into smaller bundles as the a

122 CT2 is the most proximally identified gene on chromosome 16p to date.

123 to include cysteine pairs that are presented proximally if the cage state assembles.

124 Thus, alphaIIbbeta3 interacts proximally, if not directly, with tyrosine kinases in a

125 We see these divergent effects of proximally immobilized cations also in single-molecule m

126 h starts in the rectum and generally extends proximally in a continuous manner through part of, or th

127 rapies available, but approaches that target proximally in disease pathogenesis hold great promise.

128 he coding sequences in monocots is localized proximally in regions of very low and even negligible re

129 ations affecting a residue (R4) located more proximally in S(4) caused activation of gating-pore curr

130 regulate their expression, is not displaced proximally in the absence of definitive endoderm.

131 icantly reduced, suggesting SLAP-2 functions proximally in the antigen receptor signaling cascade.

132 ly, and greater muscular thickness was found proximally in the intervention group.

133 aphical area, with the increase being larger proximally in the jejunum than distally in the ileum.

134 ter denervation and more commonly originated proximally in the jejunum, but the velocity of migration

135 sorted into separate but adjacent fascicles proximally in the limb, long before they reached the mus

136 MA) and ionomycin, suggesting that SLAP acts proximally in the TCR signaling pathway.

137 ost mesenchyme and can also be detected more proximally, in between the forming skeletal elements.

138 in the stratum 3, with divergence increasing proximally, indicates gradual recombination cessation, p

139 A4.1 proximally inhibits beta(1) integrin-dependent adhesion

140 e developing limb skeleton, and one situated proximally, initiating transcription in neural epitheliu

141 promoter sequences that have the property of proximally interfering with upstream enhancer elements i

142 PN in VAdc receive massive inhibitory input proximally intermingled with some presumably excitatory

143 distal proliferative zone and differentiate proximally into hypertrophic chondrocytes.

144 ead to a lower peak airway pressure measured proximally, intratracheal peak airway pressure was uncha

145 relapse indicating that this lesion type is proximally involved in AML evolution.

146 mans, some recovery of strength and movement proximally is evident.

147 d D4Z4 heterochromatinization, which spreads proximally, leading to overexpression of FSHD genes in c

148 We show that the proximally localised core polarity protein Strabismus ac

149 d computational methods, which indicate that proximally localized catalyst components cooperatively s

150 We also establish recruitment by proximally localized Inturned to be a putative mechanism

151 t a model whereby, prior to hair initiation, proximally localized Mwh inhibits actin polymerization r

152 ose detected at index colonoscopy, and to be proximally located (odds ratio, 2.24; P < .001).

153 ons have a high risk for malignancy, whereas proximally located 0-Is or 0-IIa granular lesions have a

154 Large or proximally located adenomas are important indicators of

155 bind more efficiently upstream of strong or proximally located BPs and downstream of weak or distall

156 e neuropeptide Substance P, which stimulated proximally located CD301b(+) DCs through the Mas-related

157 to distal dendrites and segregated from the proximally located CoA synapses.

158 We recently reported that deletion of three proximally located conserved areas (Area I-II-III) from

159 lateral dendrites decremented less than the proximally located GABA conductance, and was more effect

160 SSA/P were proximally located in (10/11) 90% of patients aged under

161 is required for motor axons to progress from proximally located intermediate targets to distally loca

162 We find that deletion of proximally located loops 8 and 9 in the 32 kDa catalytic

163 Mutation of these residues as well as proximally located lysine 980 results in suppression of

164 ought to propel themselves with specialized, proximally located muscles that retract and rotate the f

165 Proximally located neurons in the distal part of the sub

166 hat patients with SSPE mimic those with more proximally located PE in regards to their risk profile a

167 of thromboembolic disease compared with more proximally located pulmonary embolism (PE).

168 with CRISPR/Cas9-edited rs1198588 or a rare proximally located SZ risk variant showed altered MIR137

169 that of large-artery atherosclerosis in more proximally located vessel beds.

170 type, TP53 wild type, poorly differentiated, proximally located, occur at lower stages, and have the

171 All membrane-anchored, proximally located, oncogenic Ras isoforms can promote R

172 to 20+/-2 nl/min; P<0.05) despite unchanged proximally measured, single-nephron GFR (SNGFR) (42+/-5

173 Signaling is proximally mediated by Src family tyrosine kinases, the

174 mains unclear which psychological mechanisms proximally motivate individuals to reciprocate.

175 gion contains mixed acidic and basic patches proximally (N-terminal), whereas it is largely acidic di

176 ainly distal PN dendrites, but some synapsed proximally next to large F1 boutons.

177 everal highly homologous copies located more proximally on chromosome 16.

178 ayer 5 synapses were larger and located more proximally on dendrites than were unlabeled synapses.

179 CF terminals in the KO were localized more proximally on PC dendrites, as indicated by VGLUT2(+) im

180 e placed in the standard position as well as proximally on the leg and the forearm.

181 echnical difficulty if a clamp can be placed proximally on the portal vein.

182 ng Cdk5 activity causes the domain to shrink proximally or disappear altogether.

183 ted kidney; the partially obstructed kidney, proximally or distally obstructed, with mild to severe o

184 Fasciculation potentials (FPs) may arise proximally or distally within the peripheral nervous sys

185 OEs leads us to propose a H-bond between the proximally oriented His207 ring and the carboxylate of A

186 pressure waveform resulting in an additional proximally originating deceleration wave during systole.

187 that begin in distal dendrites and progress proximally over time.

188 al (PCr/inorganic phosphate) was also higher proximally (P < 0.001).

189 CTR, and promotes redistribution of promoter-proximally paused Pol II into gene bodies.

190 , through the controlled release of promoter-proximally paused Pol II into productive RNA synthesis.

191 tential interconnected functions of promoter-proximally paused Pol II.

192 e presence of constitutively bound, promoter-proximally paused Pol IIs at some E2-regulated promoters

193 nd Egr2, immediate-early genes with promoter-proximally paused polymerases, but does not affect expre

194 Efficient release of promoter-proximally paused RNA Pol II into productive elongation

195 We observe that the proximally paused RNA polymerase further fine-tunes the

196 monstrate that GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (

197 Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules t

198 azoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termina

199 Release of promoter-proximally paused RNA polymerase II (RNAPII) is a recent

200 ing elongation factor that releases promoter-proximally paused RNA polymerase II, as a genetic intera

201 tegrator predominantly engages with promoter-proximally paused RNAPII to trigger premature terminatio

202 escent sensor for the selective detection of proximally phosphorylated protein sites, suitable for ap

203 Specifically, proximally phosphorylated residues are hallmarks of cert

204 nd maleimide groups of neighboring molecules proximally placed in an arrangement suitable for their t

205 tory duct that results in obstruction of the proximally placed seminal vesicle.

206 The result was a large area of proximally pointing hairs in this region.

207 ws high structural diversity, in contrast to proximally polyadenylated COOLAIR.

208 short DOG1 protein isoform produced from the proximally polyadenylated DOG1 mRNA is a key player in t

209 rocessing complex required for production of proximally polyadenylated functional DOG1 transcript.

210 This is corroborated by the finding that the proximally polyadenylated short DOG1 mRNA is translated

211 ylation of its C-terminal domain and remains proximally positioned at the promoter for hours.

212 ntext of the complete viral genome, however, proximally positioned enhancer sequences are unable to c

213 cancer-causing genes are unexpectedly often proximally positioned in the chromosome and share loci w

214 Proximally positioning P4 enhancer factor-binding sequen

215 Thus, NO and CO act proximally, presumably as heme ligands binding to the ox

216 injury mortality (SIM) with mortality from 3 proximally ranked top 10 causes of death: diabetes, infl

217 d, proximally reduced, and both distally and proximally reduced (p < 0.01 for each compared to contro

218 nnervation in FMS: normal, distally reduced, proximally reduced, and both distally and proximally red

219 urogranin, suggesting that CSF Lec-PF levels proximally reflect neurodegeneration as well as the amou

220 threat-detection and -response systems that proximally regulate autonomic induction of the CTRA.

221 levels, suggesting that CD2+ leukocytes may proximally regulate IL-20.

222 We identify regions consisting of tandem or proximally repetitive short DNA sequences, including som

223 lly large backward compression wave, whereas proximally, severe left ventricular outflow tract obstru

224 eceded at a one-half theta cycle interval by proximally targeted Schaffer collateral activity, tempor

225 t ascending inputs activate mainly or solely proximally targeting, parvalbumin-containing "fast-spiki

226 es, and monophasic decays, consistent with a proximally terminating synapse.

227 yed interval, they were more likely to occur proximally than a comparable number of meiotic crossover

228 ercise ischaemia, still led to larger k(PCr) proximally than distally (P = 0.013).

229 (29H), T(32H), and T(34H) that extended less proximally than T(30H) permitted male fertility when opp

230 ns exhibit cytoplasmic extradenticle whereas proximally the protein is nuclear.

231 As autophagosomes move distally to proximally, they undergo maturation and become increasin

232 Injured cortical axons were eliminated proximally through a two-phase retraction process, which

233 of conduction block in the inferior pathway proximally, thus extending the length of the retrograde

234 y condensation of water-soluble silicic acid proximally to biomolecular interfaces throughout the org

235 nt pre-mRNAs cause U1 and Malat1 to localize proximally to chromatin at active genes, demonstrating t

236 PC1 acts proximally to CPE in the pathway of post-translational p

237 ured from up to four patched neurons located proximally to each other.

238 haracterized hESC enhancers, and are located proximally to genes expressed in hESCs and the epiblast.

239 cted to the feet and toes but extending more proximally to involve the legs and hands with time.

240 e sequences imposing variegation are located proximally to Ly49 genes.

241 Many epithelial cancers develop proximally to microbial communities, which are physicall

242 ere applied such that control data collected proximally to mutants were assigned the maximal weight,

243 They initially localized proximally to mutating B cells, secreted interleukin 21

244 Moreover, transcription factors that bind proximally to one another share patterns of dysregulatio

245 f promoter escape by removing downstream DNA proximally to positions 40/42.

246 Placement of the microcatheter proximally to rete allowed trans-catheter perfusion of t

247 ings support a model in which LuxR/HapR bind proximally to RNA polymerase to drive transcription init

248 esmotic incisura volume at 1, 3, 5 and 10 cm proximally to the ankle joint.

249 ein kinase ArnS (Saci_1181) which is located proximally to the archaellum operon was identified.

250 layer of parallel collagen fibers attaching proximally to the base of the medial epicondyle of the h

251 w that molecular convergence is concentrated proximally to the binding pockets but also appears dista

252 Remaining chromaffin vesicles lined up proximally to the cell membrane in preparation for exocy

253 The tail hub connects proximally to the dodecameric portal protein and head-to

254 Whereas a tag from RepA protein crosslinked proximally to the flexible N domains, the ssrA sequence

255 ta-globin gene family during ontogeny reside proximally to the genes and immediately 5' to the human

256 yosin heavy chain promoter (alphaMHC) placed proximally to the human iPLA2gamma coding sequence that

257 phorylation of a cluster of residues located proximally to the m7Gppp cap-binding DM15 region is part

258 e, we propose that the purinosome is located proximally to the mitochondrial transporters SLC25A13 an

259 ed in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 reg

260 at drives membrane invagination is nucleated proximally to the plasma membrane, opposite to the orien

261 at a bacterial RNA polymerase that is paused proximally to the promoter can associate with the pionee

262 Rgg binds to DNA proximally to the speB promoter (PspeB) to activate tran

263 s of subthalamic deep brain stimulation both proximally to the stimulation site and distally through

264 sting that proteasome binding positions Ubp6 proximally to the substrate translocation channel.

265 l pathway, which has been found to innervate proximally to the SVZ, causes motor and cognitive impair

266 be in 'cis' to, i.e., overlapping or located proximally to the target gene.

267 s ligament (IOL) coursed obliquely to attach proximally to the tibia and insert distally in the fibul

268 rprisingly, transcription does initiate, but proximally to the UAS, regardless of its location.

269 hermore, melanomas are more likely to appear proximally to their neighboring neoplasms than to nevi.

270 lobally by lncRNAs, especially those located proximally to their regulatory targets, in a specific bi

271 t the site of impulse initiation in the cell proximally toward the soma and neurites receiving synapt

272 4 h depolarization, lengthened and relocated proximally toward the soma.

273 to the transmural incision either propagated proximally toward the stimulation site and collided with

274 Attempts to trace excitability measures proximally towards the site of block were unsuccessful,

275 Transcriptional profile of proximally transformed mosaic wing epithelium and functi

276 Dispersal was most probably proximally triggered by the planktic revolution, the fal

277 to those of the most advanced lesion removed proximally (up to the junction of the splenic flexure an

278 This result suggests that Z-DNA formation proximally upstream of a promoter is sufficient to demar

279 e signaling molecule(s) at the same level or proximally upstream of the MAPKKK level.

280 d(CG)n dinucleotide repeat sequence located proximally upstream of the TATA box enhances transcripti

281 Proximally, ureteral strictures and symptomatic retrocav

282 VH-TCFAs that remained VH-TCFAs located more proximally (values are median [interquartile range]) (16

283 e performed parallel to the popliteal tendon proximally was added to our routine study in patient kne

284 use chylomicron production is most efficient proximally we examined whether CD36 function is importan

285 muscle exhibits a greater oxidative capacity proximally, we tested whether the spatial variation in p

286 In the mesenchyme Dlx2 is expressed proximally, whereas in oral epithelium it is expressed d

287 ranch density and shifts their location more proximally, while Arl8B overexpression leads to increase

288 mped and the right iliac vein was controlled proximally with a double wrapped vessel-loop to contain

289 distally with PVA particles (300-500mum) and proximally with coils (2-3mm).

290 accharides and/or chitin that are associated proximally with lipid membrane constituents.

291 y along the apical dendrite and, on average, proximally with respect to OSN synapses.

292 These observations place Barx1 proximally within a Wt1 pathway of spleen development an

293 ta are consistent with a Src kinase activity proximally within DAP12 signaling, DAP12 also appears to

294 ed homeobox genes expressed distally but not proximally within the arches.

295 we examine new roles for lipid species made proximally within the ER and locally at the NE to contro

296 Gastric acidity extended more proximally within the LES in the large WC group, compare

297 CD39(+) exhausted T cells are abundantly and proximally within the parenchyma.

298 that affect the turnover of repeats located proximally within the telomeric DNA are poorly defined.