ライフサイエンスコーパス: pubertal

1 ntials were recorded from hippocampus of pre-pubertal (~28-32 PND) and pubertal (~35-44 PND) female w

2 hippocampus of pre-pubertal (~28-32 PND) and pubertal (~35-44 PND) female wild-type or alpha4-/- mice

3 Kidney disease in males, pubertal abnormalities in females, ovarian primordial fo

4 Pubertal abnormalities, testis disease, obesity, and ova

5 ly during pregnancy, modeling the effects of pubertal ACEs we also reported in women.

6 g kisspeptin, a key neuropeptide involved in pubertal activation and fertility.

7 ncy, and physical sexual dysfunction in male pubertal, adolescent, and young adult cancer survivors.

8 In 678 post-pubertal adolescents (52% males, M(SD) age = 16.8 (0.2)

9 In males and female post-pubertal adolescents, SPISE had a very good and good dia

10 lecular programming that had occurred during pubertal adversity experience.

11 ng of DNA accessibility in the PVN following pubertal adversity.

12 ated with supradiaphragmatic radiotherapy at pubertal ages.

13 There is little high-quality evidence on the pubertal alterations of energy expenditure and intake, a

14 Neonatal estrogen exposure, causing pubertal alterations, enhanced hypothalamic Mkrn3 and su

15 essionals involved in the management of post-pubertal and adult patients with medulloblastoma, for pa

16 diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.

17 there was a significant interaction between pubertal and adult testosterone, such that testosterone

18 ological deprivation of NO in prepubertal to pubertal animals stiffens the extracellular matrix and i

19 ministration of senktide to female rats with pubertal arrest due to chronic undernutrition rescued VO

20 Pubertal blockade has implications for fertility preserv

21 to be small and primarily confounded by pre-pubertal BMI and/or mediated through adult adiposity.

22 zed that rapidly deteriorating health of pre-pubertal boys with DMD could be due to diminished anabol

23 ot experience endogenous testosterone during pubertal brain development, and then received either tes

24 itional oxidative challenge in preweaning or pubertal but not in young adult Gclm KO mice reduces the

25 and that this increase can be blocked by pre-pubertal, but not post-pubertal, gonadectomy.

26 o systemic hormonal regulation that triggers pubertal changes.

27 Pre-pubertal children show a relative resistance to death fr

28 ood adiposity with vascular phenotype in pre-pubertal children.

29 However, the pubertal decrease in seizure-like discharges was not see

30 ons disrupts growth in both sexes and causes pubertal delay in females.

31 h downstream effects including malnutrition, pubertal delay, low muscle mass and physical inactivity.

32 versus 1.7% in those >/=14 years; P<0.001), pubertal development (9.5% of children with incomplete v

33 r to adult height and reported more advanced pubertal development (P < 0.04).

34 Neural responses to rewards, pubertal development (self-report and testosterone level

35 inin B (NKB) neurocircuits are essential for pubertal development and fertility.

36 types associated with the loss of JARID1B in pubertal development and pregnancy.

37 2) to test whether individual differences in pubertal development and risk-taking behavior were contr

38 onto cingulate pyramidal neurons during peri-pubertal development and that this increase can be block

39 These sex-specific associations with pubertal development are consistent with endocrine-disru

40 ly, we discuss stress-mediated regulation of pubertal development as a case study of how an evolution

41 e critical to understanding the way in which pubertal development drives neural and psychological cha

42 ventromedial PFC increased with both age and pubertal development during self-evaluations in the soci

43 m studies of telomere shortening or advanced pubertal development following circumscribed ELA experie

44 Male pubertal development had no strong association with acet

45 ction control changes as a function of human pubertal development in 14-year-old adolescents (n = 47)

46 and consequent physical maturation linked to pubertal development in adolescence are thought to affec

47 sure to several PFASs and various aspects of pubertal development in boys and girls.

48 ollution in utero and during early life with pubertal development in Hong Kong, China, an area with a

49 d long-term effects on adolescent growth and pubertal development in rural Gambian children.

50 etween maternal smoking during pregnancy and pubertal development in sons and daughters.

51 The timing of pubertal development is driven in part by genetic factor

52 in humans, of which sex-specific effects on pubertal development may be an indicator, is less clear.

53 This study indicates that pubertal development reopens a window of opportunity for

54 d adult height, Tanner staging, score on the Pubertal Development Scale), neuroendocrine function (di

55 posure to acetaminophen during pregnancy and pubertal development using data from 15,822 boys and gir

56 Incomplete pubertal development was the only independent predictor

57 Data on pubertal development were collected biannually from the

58 ment of almost all studied markers of female pubertal development with increasing number of weeks of

59 uggests sex-specific associations of altered pubertal development with prenatal exposure to PFASs.

60 activity results primarily in the absence of pubertal development with prenatal sex development being

61 weight, height, body weight, Tanner stage of pubertal development, axial length, and spherical equiva

62 vior participation, child self-esteem, child pubertal development, child and adult perception of thei

63 ed during the VWM task, controlling for age, pubertal development, gender, IQ, and intracranial volum

64 ect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, an

65 that are L-R independently regulated during pubertal development, including genes that regulate lumi

66 ional injury risk behavior were self-esteem, pubertal development, parent monitoring, and parent perc

67 ovaries, with subsequent lack of spontaneous pubertal development, primary amenorrhea, uterine hypopl

68 al phases of ductal expansion, which, unlike pubertal development, proceeds independent of hormonal i

69 d that all aspects of male health, including pubertal development, testosterone production, and sexua

70 ) for age at menarche, a milestone in female pubertal development.

71 subcortical to prefrontal structures during pubertal development.

72 posure to organochlorine pesticides (OCP) on pubertal development.

73 cts of BPA on the oviduct, the placenta, and pubertal development.

74 ing the stromal-epithelial cross-talk during pubertal development.

75 entrations that may affect mammary gland and pubertal development.We evaluated the relation of dairy

76 and delineate candidate factors controlling pubertal differentiation.

77 n and that its alterations may contribute to pubertal disorders linked to metabolic stress and negati

78 further research into hormonal influences on pubertal energy balance and subsequent effects on obesit

79 study was to summarize existing evidence on pubertal energy expenditure and intake in healthy nonobe

80 (KS), which is characterized by anosmia and pubertal failure due to hypogonadotropic hypogonadism.

81 hylation blocked both events and resulted in pubertal failure.

82 the neurokinin B receptor (TACR3) result in pubertal failure.

83 Pre-pubertal female pigs, age 35 d, were fed a high-energy d

84 Yet, acute LH responses to senktide in pubertal females were preserved, if not augmented, under

85 can be blocked by pre-pubertal, but not post-pubertal, gonadectomy.

86 Data were dichotomized into prepubertal and pubertal groups and compared through the use of standard

87 pathway linking earlier puberty with reduced pubertal growth (P = 4.6 x 10(-5)) and short adult statu

88 ural Gambia also illustrate that an extended pubertal growth phase allows very considerable height re

89 dulate growth hormone (GH) secretion and the pubertal growth spurt via undefined central pathways.

90 ed in children who have not yet finished the pubertal growth spurt.

91 rgy flux override conventional mechanisms of pubertal growth to promote the storage of excess energy

92 release) override conventional mechanisms of pubertal growth to promote the storage of excess energy

93 bone mass (the amount attained at the end of pubertal growth) and from the amount of bone lost subseq

94 IGF-1) production and/or release relative to pubertal growth.

95 skeletal mineralization and strength during pubertal growth.

96 Tissues from pre- and post-pubertal heifers and mature mice were collected and the

97 In pediatric NASH, practical obstacles, pubertal hormonal changes, and stringent safety requirem

98 Pre-pubertal hormone treatment also accelerates maturation o

99 We find that pre-pubertal hormone treatment drives an early increase in i

100 We next used pre-pubertal hormone treatment to model early puberty onset,

101 prenatal hormone-independent as well as the pubertal hormone-dependent branching of the mammary epit

102 ity, and (2) underlining a critical role for pubertal hormones and individual differences in risk-tak

103 We hypothesized that pubertal hormones could regulate maturation of the front

104 breeding species to investigate the role of pubertal hormones in adolescent development.

105 experiments have directly tested the role of pubertal hormones in cortical maturation.

106 developmental windows of neural plasticity; pubertal hormones may trigger the opening of an adolesce

107 The influence of pubertal hormones on brain network development and cogni

108 of the contributions of biospecimens (e.g., pubertal hormones), neural alterations, and environmenta

109 in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute

110 as to investigate the programming effects of pubertal immune challenge in response to a homotypic str

111 The pubertal increase in Kiss1 expression was accompanied by

112 ouse penis through puberty suggests that the pubertal increase of cortical magnification of the penis

113 4 subunit expression strongly influences the pubertal increase of delta subunits at the plasma membra

114 llular activity may underlie Kiss1 action in pubertal initiation and female reproduction.

115 roportion of menarche loci are important for pubertal initiation in both sexes.

116 known about these variants' relationship to pubertal initiation or tempo.

117 sults contribute to our understanding of the pubertal initiation program in both sexes and indicate t

118 ts in the BMI growth rate around the time of pubertal initiation were apparent starting after 1973.

119 nt on kisspeptin-expressing neurons to allow pubertal initiation, a phenomenon observed across specie

120 However, a subgroup of (pre)pubertal knockout mice (runts) exhibits a pronounced mal

121 -pituitary-gonadal axis during paediatric or pubertal life may result in delayed puberty.

122 Despite being recommended for all pubertal male patients, sperm banking is not universally

123 wing 41% and 25% greater absolute intakes in pubertal males and females, respectively.

124 ele et al. (2017) establish a model for post-pubertal mammary branching morphogenesis in which positi

125 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contrib

126 he predictions of this theory on datasets of pubertal mammary gland tips and embryonic kidney tips, a

127 In this Series paper, we discuss pubertal markers, epidemiological trends of puberty init

128 oids), by pregnant women was associated with pubertal maturation (height, weight, body mass index for

129 investigated the causal relationship between pubertal maturation and asthma through Mendelian randomi

130 gest that NKB-NK3R signaling plays a role in pubertal maturation and that its alterations may contrib

131 right after birth, upon weaning, and during pubertal maturation into adulthood.

132 nergistic effect of overweightness and early pubertal maturation on asthma risk (OR = 1.08; 95% CI: 1

133 the joint effect of overweightness and early pubertal maturation on asthma.

134 Adolescents with more advanced pubertal maturation showed greater aPFC activity when co

135 Early pubertal maturation significantly increased the risk of

136 with timing of the daughter's transition to pubertal maturation stage 2 or above for development of

137 e results of MR analysis revealed that early pubertal maturation was associated with active asthma (O

138 increased risk of developing high TC, while pubertal maturation was associated with an elevated risk

139 Early pubertal maturation was defined as reaching a certain pu

140 Pubertal maturation, indexed by testosterone levels, shi

141 ents of the same age, but with less advanced pubertal maturation, showed greater pulvinar and amygdal

142 gnificantly (P < 0.0001) linked to timing of pubertal maturation.

143 ertal mice showed greater survival than post-pubertal mice (76.3% vs. 28.6%), despite exhibiting a si

144 ough H3K27me3, and deletion of Ezh2 in early pubertal mice results in premature cellular senescence,

145 intra-peritoneal injection of endotoxin, pre-pubertal mice showed greater survival than post-pubertal

146 ly became evident at twenty hours, when post-pubertal mice showed prolonged elevation of serum cytoki

147 d cap cells, present in terminal end buds of pubertal mice.

148 monthly differences in age at attaining the pubertal milestones according to intrauterine cumulative

149 differences (in months) at attaining various pubertal milestones, including Tanner stages, per 10 dai

150 ters provided information on a wide range of pubertal milestones-including Tanner stages, axillary ha

151 Pre-pubertal models are lacking.

152 studies revealed Eap1 mRNA abundance in peri-pubertal mouse hypothalamus.

153 ng/ml (2.23, 5.05) in those classed as early pubertal (n = 460, P</=0.001).

154 For females classified as post-pubertal (n = 848) at the time of assessment median (IQR

155 hin double mutant (mdx-dm) mice to mimic pre-pubertal nadir androgen condition resulted in premature

156 In this review, we focus on pubertal, neural, and social changes across the duration

157 djusted by TEQs, was associated with earlier pubertal onset [TV = -8.3 months (95% CI:-16.2, -0.3)] a

158 owest TEQ quartile was associated with later pubertal onset [TV = 11.6 months (95% CI: 3.8, 19.4); G2

159 sity are recommended to prevent future early pubertal onset and asthma occurrence.

160 an (VNO) into the brain asserting control of pubertal onset and fertility.

161 ds [and their toxic equivalents (TEQs)] with pubertal onset and maturity among Russian boys enrolled

162 hroughout pregnancy might help prevent early pubertal onset and subsequent negative health outcomes.

163 pubertal serum dioxin concentration and male pubertal onset defined by genitalia staging, although no

164 to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies.

165 elopmental switches, including the timing of pubertal onset in humans.

166 indicate that although mechanisms regulating pubertal onset in males and females may largely be share

167 at sites extrasynaptic to GABAergic input at pubertal onset in tissue of wild-type (WT) mice.

168 er molecular responses to dioxin exposure or pubertal onset influence the association between peripub

169 recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD from a latent cla

170 ously, as well as a significant delay in the pubertal onset of estrous cycles compared with control a

171 Pubertal onset was based on testicular volume and on gen

172 Pubertal onset was defined as TV > 3 mL, G2, or P2.

173 their axonal extension to the ME, timing of pubertal onset, and fertility in these mice.

174 r plasmalemmal delta subunit localization at pubertal onset, electron microscopic-immunocytochemistry

175 In humans, this plasticity includes age of pubertal onset, hormone levels and age at menopause.

176 At pubertal onset, plasmalemmal localization of the delta s

177 changes in GnRH secretion are essential for pubertal onset.

178 ent organic pollutants (POPs) in relation to pubertal onset.

179 pubertal serum dioxin concentration and male pubertal onset.

180 peripubertal serum dioxin concentration and pubertal onset.

181 ippocampal pyramidal cells of female mice at pubertal onset.

182 sponse to hormone fluctuations that occur at pubertal onset.

183 gated the mechanism by which MKRN3 regulates pubertal onset.

184 R, operates as repressor of Mkrn3 to control pubertal onset.

185 , most studies address either developmental, pubertal, or adulthood exposures, with few investigation

186 difference (months) in age at achieving the pubertal outcomes across tertiles of PFAS concentrations

187 ence transposons but, after birth, most post-pubertal pachytene piRNAs map to the genome uniquely and

188 age BMI Z-scores (0.95+/-1.98) compared with pubertal participants (n = 45; 1.92+/-0.60), but this re

189 In pubertal participants this was not observed (SDS, 0.06;

190 In rodent models, stress in the pre-pubertal period impairs adult hippocampal neurogenesis (

191 Additionally, the adoptive transfer of pre-pubertal peritoneal cells improved the survival of post-

192 of post-pubertal recipient mice, while post-pubertal peritoneal cells or vehicle did not.

193 rences were detected between prepubertal and pubertal/postpubertal children.

194 secretion from the CNS is a hallmark of the pubertal process.

195 KRN3 prevents premature manifestation of the pubertal process.

196 after reproductive maturity, indicating that pubertal processes that occur after SE assembly and ERal

197 Notably, we identify a common pre-pubertal progenitor for Leydig and myoid cells and delin

198 for a highly vulnerable population, whereby pubertal programming of the PVN results in aberrant HPA

199 anguineous family that results in failure of pubertal progression, indicating that functional kisspep

200 d to adapt a model of chronic colitis to pre-pubertal rats and test if a polymeric diet rich in TGF-b

201 duces a schizophrenia-like phenotype in post-pubertal rats.

202 gonadal male monkeys in association with the pubertal reactivation of gonadotropin secretion.

203 ritoneal cells improved the survival of post-pubertal recipient mice, while post-pubertal peritoneal

204 protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity ca

205 dentify peritoneal cells as mediators of pre-pubertal resistance.

206 r the back skin or scrotal skin of castrated pubertal rhesus macaques and matured to produce function

207 lopmental trajectory is likely linked to the pubertal rise and premenopausal fall of estradiol levels

208 We found that in primary pre-pubertal Sertoli cells and in adult Sertoli line, TLR4\N

209 Furthermore, pre-pubertal Sertoli cells exhibit two distinct transcriptio

210 d seizure-like discharges in over 60% of pre-pubertal slices, but only in 7% of pubertal slices, wher

211 0% of pre-pubertal slices, but only in 7% of pubertal slices, where the coastline length was reduced

212 lls but is reduced substantially during post-pubertal spermatogenesis.

213 ivation was uniquely associated with delayed pubertal stage (beta = -.21).

214 celerated DNAm age (beta = .18) and advanced pubertal stage (beta = .28), whereas deprivation was uni

215 uring infancy was negatively associated with pubertal stage and breast development, whereas among 2,1

216 erent growth phases with clinically assessed pubertal stage at approximately age 11 years (as indicat

217 maturation was defined as reaching a certain pubertal stage earlier than the median age for that stag

218 pubertal stage showed a significant group by pubertal stage interaction: within-individual increases

219 ging metrics: DNA methylation (DNAm) age and pubertal stage relative to chronological age.

220 or sex and between-individual differences in pubertal stage showed a significant group by pubertal st

221 Each session assessed pubertal stage via nurse examination and cortisol reacti

222 Pubertal stage was Tanner 4 for pubic hair and penile si

223 interaction: within-individual increases in pubertal stage were associated with increases in cortiso

224 adjusting for birth weight, gestational age, pubertal stage, age, ethnicity, socioeconomic position,

225 iated with accelerated DNAm age and advanced pubertal stage, but exposure to deprivation (e.g., negle

226 In multivariable analysis, advanced pubertal stage, greater height Z-score, difficulty walki

227 ntake were examined with adjustment for age, pubertal stage, physical fitness, socioeconomic status,

228 longitudinal data, adjusted for baseline and pubertal stage, showed that the zinc group had significa

229 es substantially vary with weight status and pubertal stage.

230 in childhood were negatively associated with pubertal stage.

231 dels were adjusted for age, sex, season, and pubertal stage.

232 s association with body mass index (BMI) and pubertal stage.

233 and was significantly different across three pubertal stages (p < 0.0001).

234 ods of life, especially in the embryonic and pubertal stages, in which gene reprogramming may be asso

235 until age 17-18 years, a physician performed pubertal staging [genitalia (G), pubarche (P), and testi

236 res were made every 1-2 y until age 21-25 y; pubertal status and menarche data were collected.

237 is difference persisted regardless of sex or pubertal status at diagnosis.

238 included demographic (sex, age, weight, and pubertal status), clinical, and family measures.

239 confounders [+5.1% L/min; country, sex, age, pubertal status, and BMI (adjusted P < 0.001) or fat mas

240 ation network, controlling for sex, age, and pubertal status, and found a similar pattern for rsFC wi

241 ree groups were matched for age, gender, and pubertal status, and obese children with NAFLD were matc

242 dy weight, which vary according to age, sex, pubertal status, and population ancestry in the pediatri

243 race-ethnicity, socioeconomic status, Tanner pubertal status, percentage body fat, physical activity,

244 ifference by sex persisted after considering pubertal status.

245 rence persisted after further adjustment for pubertal status.

246 of age, sex, racial and ethnic identity, and pubertal status.

247 l hippocampal function and AHN following pre-pubertal stress (PPS) is unknown.

248 a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for

249 eural systems modulating this behavior using pubertal Syrian hamsters (Mesocricetus auratus) as an ad

250 Post-pubertal testicular germ-cell tumours (TGCTs) can presen

251 stage and become adult Leydig cells in post-pubertal testis.

252 Pubertal testosterone also decreased neuronal number in

253 la, suggesting a possible mechanism by which pubertal testosterone decreases volume in this subregion

254 The results show that pubertal testosterone has long-term organizational effec

255 In conclusion, pubertal testosterone organizes the medial amygdala in a

256 he medial amygdala such that the presence of pubertal testosterone resulted in 1) decreased volume of

257 in males that did not experience endogenous pubertal testosterone.

258 support higher absolute BMR/RMR and TDEE in pubertal than in prepubertal adolescents.

259 ation of BLL with IGF-1 was stronger for mid-pubertal than prepubertal boys (p = 0.04).

260 polychlorinated biphenyl concentrations with pubertal timing among Russian boys.

261 scribed inverse relationships between female pubertal timing and obesity.

262 the neuroendocrine control of reproduction, pubertal timing and the female ovulatory cycle.

263 egulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk r

264 try, physical activity by accelerometry, and pubertal timing by age at peak high velocity.

265 ared, the relationship between body mass and pubertal timing in boys may be complex and requires furt

266 regions showed slower growth during typical pubertal timing in girls with TS relative to typically d

267 increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasi

268 ted that there is a critical body weight for pubertal timing in girls, most studies have focused on B

269 ciated with central or overall adiposity and pubertal timing in girls.

270 alling, among novel mechanisms that regulate pubertal timing in humans.

271 Any effect of pubertal timing on vascular and cardiac structure and fu

272 weight is a more robust inverse predictor of pubertal timing than prepubertal BMI in boys.

273 weight is a more robust inverse predictor of pubertal timing than prepubertal BMI in boys.

274 Further, while many identified pubertal timing variants associate with age at menarche,

275 bstitutes, infection rates, underweight, and pubertal timing) differ between these settings.

276 eight velocity (PHV; an objective measure of pubertal timing) were included.

277 sity up to 14 years independent of sex, age, pubertal timing, and activity.

278 intelligence quotient, socioeconomic status, pubertal timing, and aerobic fitness (maximal oxygen vol

279 Given the health impact of altered pubertal timing, further investigation across the life c

280 We assessed the relationship of pubertal timing, in both men (n = 672) and women (n = 71

281 of offspring outcomes, including changes in pubertal timing, intelligence quotient, and mental healt

282 ally active chemicals could plausibly affect pubertal timing, so we are investigating this in the Bre

283 have been found in humans with disorders of pubertal timing.

284 ns of lipid-standardized concentrations with pubertal timing.

285 ession in the liver, affecting body mass and pubertal timing.

286 constitutes a feedback mechanism to regulate pubertal timing.

287 also might be involved in the regulation of pubertal timing.

288 orted an inverse association between BMI and pubertal timing.

289 egarding early-life determinants influencing pubertal timing.

290 Many loci were associated with other pubertal traits in both sexes, and there was substantial

291 r 11 000 European samples with data on early pubertal traits, male genital and female breast developm

292 n associative region that matures during the pubertal transition and is implicated in decision making

293 Longitudinally, the age at pubertal transition was consistently older with greater

294 ift in phenotype, from GHRH to Kiss1, during pubertal transition.

295 rences in endocrine function observed during pubertal transition.

296 on variants in the coordinated timing of the pubertal transition.

297 ere the expression of Tacr3 increased across pubertal transition.

298 he somatotropic and gonadotropic axes during pubertal transition.SIGNIFICANCE STATEMENT Late maturing

299 turational growth before or early in typical pubertal years.

300 of height growth that was evident before the pubertal years.