ライフサイエンスコーパス: puberty

1 erence standard for identifying the onset of puberty.

2 lated to body weight gain from infancy until puberty.

3 atric or pubertal life may result in delayed puberty.

4 ls and relevant to the biological control of puberty.

5 nd innervation of the mouse penis throughout puberty.

6 tiate and propagate spermatogenetic waves at puberty.

7 Kiss1-/- mice that do not go through normal puberty.

8 n system, which is an important regulator of puberty.

9 ypothalamic Mkrn3 protein and delayed female puberty.

10 also be involved in changes to the onset of puberty.

11 alian orthologs Kisspeptin and KISS1R induce puberty.

12 AR is required for X-zone regression during puberty.

13 ory peptides are the ultimate gatekeepers of puberty.

14 accurately reflect blood levels during mini-puberty.

15 eclining physical functions before attaining puberty.

16 have reduced mammary ductal outgrowth during puberty.

17 Bs) that form at ductal tips at the onset of puberty.

18 ation, ductal outgrowth and branching during puberty.

19 le to TS genetic and hormonal effects during puberty.

20 nclear whether this inequality changes after puberty.

21 ior in NMRs given the opportunity to undergo puberty.

22 ed a size increase of this protrusion during puberty.

23 ding of internal calendar time from birth to puberty.

24 to fast skeletal growth during childhood and puberty.

25 sence of AgRP neuron leptin signaling delays puberty.

26 y dynamic reorganization of the brain during puberty.

27 different trajectories, before the onset of puberty.

28 static cancer, endometriosis, and precocious puberty.

29 ngthened with age and the transition through puberty.

30 tion control-related disorders emerge during puberty.

31 releasing hormone to determine initiation of puberty.

32 valuated for interactions with age, sex, and puberty.

33 heir relative size increased markedly during puberty.

34 ess AIRE (mRNA and protein) than males after puberty.

35 communities on skin profoundly shift during puberty.

36 differences in the nasal region arise during puberty.

37 s the polymorphic variant may resolve around puberty.

38 rt for transgender children below the age of puberty.

39 significantly lower adjusted BMR/RMR during puberty.

40 xin-like, have been linked to alterations in puberty.

41 f the decreased seizure-like activity during puberty.

42 th, with the majority of oocytes lost before puberty.

43 eld genetic instrumental variables for early puberty.

44 ex postnatally, is virtually extinguished at puberty.

45 n mammals, genitals undergo major changes in puberty.

46 rse is required, particularly at the time of puberty.

47 al changes and key factors accompanying male puberty.

48 ly to achieve their final size at the end of puberty.

49 mete generation, ovulation cycle, and age at puberty.

50 signal that prevents premature initiation of puberty.

51 receptor in GHRH neurons only delayed female puberty.

52 may contribute to the skeletal growth during puberty.

53 orphic bone structure emerges largely during puberty.

54 tween March 2016 and March 2019 for signs of puberty.

55 for the imaging confirmation of the onset of puberty.

56 ptin-expressing neurons by MKRN3 to initiate puberty.

57 d prior to estrogen exposure at the onset of puberty.

58 alternative single mature population during puberty.

59 These include enhanced at puberty 1 (EAP1), which contributes to the initiation of

60 rowth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency

61 zed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years).

62 nt, Ptprb expression is downregulated during puberty, a period of extensive ductal outgrowth and bran

63 ovaries and reduced follicle numbers during puberty/adulthood; as similar changes were found for F2

64 Thus, exposure to an immune challenge during puberty affects immune function later in life, which cou

65 hrough the early, middle, and late stages of puberty (all p < 0.0001).

66 re, in adult mice previously stressed during puberty, allopregnanolone administration was sufficient

67 e that genetic deletion of Arc/Arg3.1 before puberty alters synaptic function and prefrontal cortex a

68 kout restores developmental transcription at puberty, alters luminal epithelial homoeostasis, yet rem

69 y have a physiological role for the onset of puberty and a genetic basis for sexual maturation in hum

70 eroid increases and fluctuations during peri-puberty and across the reproductive lifespan influence t

71 changes in GnRH expression are essential for puberty and adult fertility.

72 reproductive system of the offspring in pre-puberty and adulthood included reduced AGD index and gon

73 These changes begin during puberty and are generally more aggravated in the knockou

74 000 testicular cells from four boys spanning puberty and compared them to those of infants and adults

75 the rate of mammary gland development during puberty and highlights potential therapeutic targets.

76 ce of considering biological factors such as puberty and hormonal changes as areas of unique vulnerab

77 Males pretreated with LPS during puberty and in early adulthood displayed an attenuated h

78 Studies on early puberty and incident asthma have reported inconsistent r

79 steroids in GHRH neurons modulate growth and puberty and indicate that GHRH/Kiss1 dual-phenotype neur

80 (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing ho

81 rent understanding of the molecular basis of puberty and its disease states.

82 ow-up should try to establish the effects of puberty and later dietary or social transitions on these

83 tered brain development, delayed or advanced puberty and long-term reproductive consequences, such as

84 dual-phenotype neurons modulates growth and puberty and may orchestrate the sex differences in endoc

85 anaphylactic responses that emerge prior to puberty and persist into adulthood, 2) reduced severity

86 ting common effects of pituitary hormones on puberty and pigmentation.

87 particularly robust in mammary tissue during puberty and pregnancy, accounting for 34-40% of detected

88 to HDR defects in mammary epithelium during puberty and pregnancy, including in different epithelial

89 rganizational effects of ovarian hormones at puberty and provide a potential mechanism by which gonad

90 on the effects that the age of onset of male puberty and rates of spermatogenesis have likely had in

91 hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a c

92 perform working memory tasks reliably during puberty and show modest improvement in adulthood.

93 ease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age.

94 morphogenesis to form branching ducts during puberty and terminate in secretory alveoli during lactat

95 : The male predominance in prevalence before puberty and the "sex-shift" towards females after pubert

96 The onset of puberty and the female ovulatory cycle are important dev

97 t puberty will allow for selection on age at puberty and traits correlated with sow lifetime producti

98 hey show sexual dimorphism, major changes in puberty and typically more pronounced species difference

99 eous disease characterized by delayed/absent puberty and/or infertility.

100 ary individuals to block their transition to puberty and/or use gender-affirming hormone therapy (GAH

101 venile-to-adult transitions in both mammals (puberty) and holometabolous insects (metamorphosis).

102 f parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood ove

103 increased susceptibility to mortality after puberty, and identify peritoneal cells as mediators of p

104 e scanning data were matched on gender, age, puberty, and intelligence (N = 172).

105 speptin has emerged as a major stimulator of puberty, and makorin RING finger protein 3 (MKRN3) as an

106 ins, including brain structure and function, puberty, and social and environmental factors.

107 nship between obesity and onset and tempo of puberty, and the consequences of early puberty on obesit

108 include maintenance of growth, navigation of puberty, and transition to adult services for long-term

109 onhuman primates early in life, decreases as puberty approaches, and is independent of sex steroid ho

110 enced adverse childhood events (ACEs) around puberty are at the greatest risk for neuropsychiatric di

111 Mycobiome shifts during puberty are likely due to alterations in sebaceous gland

112 e mechanisms underlying social inhibition of puberty are not well understood.

113 eased in monkey hypothalamus at the onset of puberty as determined by chromatin immunoprecipitation.

114 ns, (iii) in both species males that reached puberty as juveniles had higher body mass, on average, t

115 adipokine adiponectin decrease in men during puberty, as well as in the obese state.

116 me, a syndrome of growth failure and delayed puberty associated with massive liver enlargement from g

117 Additionally, we found that pregnancy- and puberty-associated accentuation of vascular risk, also s

118 cularly devastating for young girls reaching puberty, because it irreversibly affects their physical

119 Schizophrenia typically onsets after puberty but is often preceded by observable childhood ne

120 Mechanistically, prevention of puberty by hormonal blockade or acceleration of puberty

121 erty by hormonal blockade or acceleration of puberty by oestrogen treatment led to increased or decre

122 d children were prospectively followed after puberty by using a newly standardized MeDALL Core Questi

123 omatosensory cortex, suggesting that earlier puberty can advance cortical maturation in a regionally

124 molecular mechanism whereby adversity during puberty can enact lasting transcriptional control that m

125 Taking non-overweight and non-early puberty children as the reference group, we observed a s

126 om 15,822 boys and girls in the longitudinal Puberty Cohort, nested within the Danish National Birth

127 mples ([Formula: see text] and 445) from the Puberty Cohort, nested within the Danish National Birth

128 elated to changes in body composition during puberty combined with changes in the reproductive system

129 mice) induced no changes in body length, but puberty completion was also delayed in females.

130 uberty onset was similar in both groups, but puberty completion was delayed in GHRH(DeltaERalpha) fem

131 c, CRH overexpression during early-life (pre-puberty, CRHOEdev) in double-mutant mice (Camk2a-rtta2 x

132 Changes occurring during puberty determine their height, bone health, insulin res

133 g changing levels of gonadal steroids during puberty directly modulate the somatotropic axis.

134 Females pretreated with LPS during puberty displayed lower IL-1beta, TNF-alpha, and IL-6 mR

135 arge cohort of familial self-limited delayed puberty (DP).

136 ion of breeding females and gilts that reach puberty earlier tend to stay in the herd longer and be m

137 oped additional brief paroxysmal episodes in puberty, either dystonic/dyskinetic or "shivering" attac

138 Earlier puberty, especially in girls, is associated with physica

139 Insect metamorphosis and mammalian puberty exhibit similar design principles, but the conse

140 Results show that, until puberty, female and male pelves exhibit only moderate se

141 Conversely, after puberty, females are more prone to major depressive diso

142 The ages of puberty, first sexual intercourse and first birth signif

143 neurogenesis and volume increase, peaking at puberty followed by selective elimination and myelinatio

144 ines recommend offering a halt of endogenous puberty for patients with early gender dysphoria, in who

145 00-2003, provided half-yearly information on puberty from the age of 11 years.

146 At puberty, gonadal steroids have stimulatory effects on th

147 s during childhood before its reawakening at puberty had been enigmatic.

148 Because early puberty has been linked to diseases later in life, ident

149 Earlier age of puberty has detrimental consequences for many aspects of

150 Studies in patients with abnormal puberty have illuminated the identity of the signals; ki

151 Likewise, stress exposures during puberty have stronger proximal effects on girls, includi

152 With the onset of puberty, however, the female trajectory diverges substan

153 sm through which diet-induced obesity during puberty imposes its long-lasting effects on sleep-wake b

154 The onset of puberty in adolescents and whether it is related to obes

155 ocorticoid exposure influences the timing of puberty in animal models, but the human relevance of tho

156 in MKRN3 in patients with central precocious puberty in association with the decrease in MKRN3 expres

157 opment in ChCs, but increases rapidly before puberty in BCs, with an earlier time course in deeper-la

158 iking properties matured before the onset of puberty in both cell types, but following cell type-spec

159 ure to tobacco smoke might advance timing of puberty in boys and girls.

160 mming lean mass and IGF-I around the time of puberty in boys, but not to adiposity development.

161 associated with higher mean age at onset of puberty in boys.

162 Data regarding the onset of puberty in children receiving mammalian target of rapamy

163 GABAergic inhibition increases at puberty in female mice due to expression of extrasynapti

164 ly established that chronic adversity around puberty in female mice significantly altered their HPA a

165 phy and bone age in identifying the onset of puberty in girls at the Clinica Las Americas in Medellin

166 tudies show a shift towards earlier onset of puberty in girls who are obese; however, the situation i

167 tes mellitus (GDM) was associated with early puberty in girls.

168 maller number of mutations accumulate before puberty in macaques.

169 in the uterotrophic assay and did not alter puberty in male and female rats or mammary gland develop

170 terochrony in the timing of endocrinological puberty in male cubs.

171 ved from the X-zone that should disappear at puberty in male mice and during the first pregnancy in f

172 lly understood, and whether earlier onset of puberty in obese girls is based on the activation of the

173 Puberty in pigs is usually defined as the female's first

174 We also adjusted for puberty in the body composition regression model.

175 ssociations previously identified for age at puberty in the pig and loci for age at menarche in human

176 behavioral response inhibition mature after puberty, in tandem with structural changes in the prefro

177 developmental and structural changes during puberty, including proliferation and maturation of somat

178 larger mean age differences for the combined puberty indicator in the middle tertile [girls: PFOS: [F

179 breast, genital development, and a combined puberty indicator.

180 varies between individuals and the timing of puberty initiation is associated with several health out

181 pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby

182 es the normal GnRH-fuelled run-up to correct puberty initiation, and interfering with this process di

183 results indicate that MKRN3 acts to prevent puberty initiation, at least in part, by repressing KISS

184 hildhood, and its reactivation culminates in puberty initiation.

185 .86) and 0.86 (0.79-0.94), respectively (sex-puberty interaction P = .089).

186 -0.81 and 0.81, 0.64-1.02, respectively (sex-puberty interaction P = .327).

187 e after puberty onset (0.89, 0.74-1.04); sex-puberty interaction: P < .001.

188 cortex in monkeys as they transitioned from puberty into adulthood and compared activity at differen

189 ctivity in monkeys as they transitioned from puberty into adulthood.

190 Puberty is a critical period of development marked by se

191 The timing of puberty is a highly polygenic childhood trait that is ep

192 Because age at puberty is a predictive factor for sow longevity and lif

193 Puberty is a time of rapid growth and changing energy re

194 ption can increase asthma risk and that male puberty is a time window of particular importance for of

195 Early puberty is associated with adverse health outcomes, but

196 Puberty is characterized by dynamic tissue remodeling in

197 The timing of puberty is highly variable and is associated with long-t

198 The only available treatment for POI during puberty is hormone replacement therapy (HRT), which deli

199 identification of modifiable causes of early puberty is of interest.

200 The initiation of puberty is orchestrated by an augmentation of gonadotrop

201 that the rate of mutation accumulation after puberty is similar between macaques and humans, but that

202 The most promising link between obesity and puberty is the adipokine leptin and its interaction with

203 th early gender dysphoria, in whom impending puberty is unacceptable for their psychosocial health an

204 equired for mammary gland development during puberty, it is not clear whether its overexpression alte

205 The present work shows that obesity during puberty leads to persistently dysregulated patterns of s

206 After puberty, male mice recover, but female corticalization i

207 (boys) was associated with lower mean age at puberty marker onset.

208 The other earlier puberty markers were unrelated to sleep duration.

209 Puberty marks the end of childhood and is a period when

210 indicated that the neuroendocrine control of puberty may be regulated by a hierarchically organized n

211 Puberty may induce the establishment of adult mutation a

212 rgely shaped by transitional periods such as puberty, menopause and pregnancy, while daily fluctuatio

213 ale JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litte

214 po of puberty, and the consequences of early puberty on obesity.

215 ect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (r

216 hift towards a sex-balanced prevalence after puberty onset (0.89, 0.74-1.04); sex-puberty interaction

217 idity showed the strongest sex effect before puberty onset (female-male-OR 0.55, 0.46-0.64) and a con

218 hronic RFRP neuronal activation delayed male puberty onset and female reproductive cycle progression,

219 nutritional imbalance may therefore suppress puberty onset and fertility in an individual.

220 signaling in AgRP neurons is sufficient for puberty onset and normal adult fecundity in both sexes w

221 in-releasing hormone (GnRH) neurons regulate puberty onset and sexual reproduction by secreting GnRH

222 AgRP neurons are required and sufficient for puberty onset and subsequent fertility.

223 first time that GnRH agonist treatment after puberty onset exerts sex-specific effects on social- and

224 and as multimorbid diseases before and after puberty onset in longitudinal cohort data.

225 No significant differences in male puberty onset or adult fecundity in either sex were obse

226 The age of puberty onset varies between individuals and the timing

227 Timing of puberty onset was similar in both groups, but puberty co

228 ty and the "sex-shift" towards females after puberty onset were strongest in multimorbid patients who

229 re-pubertal hormone treatment to model early puberty onset, a phenomenon increasingly observed in gir

230 tine should be closely monitored for growth, puberty onset, and potential pituitary deficiency.

231 in RFRP neuronal activity led to changes in puberty onset, fertility, and stress responses, includin

232 es were morbidly obese and exhibited delayed puberty onset, no evidence of estrous cycles, and minima

233 development, showing dramatic changes after puberty onset, yet few experiments have directly tested

234 opment of hypothalamic kisspeptin neurons or puberty onset.

235 ten affected than boys both before and after puberty onset: 0.71, 0.63-0.81 and 0.81, 0.64-1.02, resp

236 girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males

237 This study examined whether puberty opens a window of opportunity to recalibrate the

238 At the onset of puberty, ovarian hormones increase inhibitory tone in th

239 highly specific for identifying the onset of puberty, particularly in patients aged <= 8 years.

240 rapid increases in albumin excretion during puberty precede the development of microalbuminuria and

241 s of hormonal activation and flux, including puberty, pregnancy, and perimenopause.

242 this study show that exposure to LPS during puberty programs the peripheral and central immune respo

243 This dysphoria may worsen as puberty progresses.

244 d of dramatic developmental transitions-from puberty-related changes in hormones, bodies, and brains

245 These puberty-related effects may combine with other nonpubert

246 other potential factors such as growth- and puberty-related hormones.

247 Six puberty-related single-nucleotide polymorphisms (combine

248 and the programming effects of stress during puberty remain unknown.

249 Maintenance of refinement beyond puberty requires a brief, early exposure to light to sta

250 Although the SEs were formed before puberty, SE-associated genes acquired optimal ERalpha-de

251 re mediated ERalpha inactivation during late puberty specifically in extrahypothalamic neurons (N-ERa

252 bidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific se

253 s and childhood growth in 940 girls from the Puberty Study of the Breast Cancer and Environment Resea

254 constant innervation of mouse penis through puberty suggests that the pubertal increase of cortical

255 Puberty suppression by gonadotropin-releasing hormone ag

256 During puberty, the mouse mammary gland develops into a highly

257 During puberty, the serum levels of growth hormone (GH) and its

258 Following puberty, the synthesis of androgens by the adrenal gland

259 with increased interest in the other sex at puberty, these early emerging biases might help explain

260 hich contributes to the initiation of female puberty through transactivation of the GnRH promoter.

261 imals, and no other members exhibit signs of puberty throughout their lives unless they are removed f

262 ntal stages (prenatal time, early childhood, puberty time and adulthood).

263 es with the greatest number (4,164 genes) at puberty time.

264 findings highlight the relationships between puberty timing and health outcomes, and demonstrate the

265 echanisms include an unexpected link between puberty timing and natural hair colour, possibly reflect

266 ndependent of body mass index (BMI), between puberty timing and risks for breast and endometrial canc

267 yses show a genetic association between male puberty timing and shorter lifespan.

268 the complexity of the genetic regulation of puberty timing and support causal links with cancer susc

269 ublished evidence on the association between puberty timing and type 2 diabetes (T2D) or impaired glu

270 ancestry, we found that variants that delay puberty timing are associated with a longer parental lif

271 sample MR, we assessed the effect of earlier puberty timing based on 203 single nucleotide polymorphi

272 ind moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76

273 demonstrate the value of genetic studies of puberty timing in both sexes.

274 ate, understanding of the genetic control of puberty timing is based largely on studies in women.

275 Earlier male puberty timing is genetically correlated with several ad

276 nd to estimate the potential contribution of puberty timing to the burden of T2D in the United Kingdo

277 trait genome-wide association study for male puberty timing with an effective sample size of 205,354

278 es have investigated the association between puberty timing, particularly age at menarche (AAM), and

279 and identify 76 independent signals for male puberty timing.

280 ght of global secular trends towards earlier puberty timing.

281 are potential mediators linking the onset of puberty to obesity.

282 se cells change their properties during late puberty to young adulthood, when bone growth and accrual

283 imary spongiosa of long bone in mice at late puberty undergo normal programmed senescence, characteri

284 During puberty, undifferentiated spermatogonia sequentially exp

285 ch is essential for ductal elongation during puberty, upregulates CCR1 expression on macrophages.

286 -30, with a prominent role in the control of puberty via Mkrn3 repression.

287 Delayed puberty was only noted in the transfer group (27%, p = 0

288 use children have less sebaceous skin before puberty, we compared the fungal communities of primary c

289 or energy intake (EI) for >/=2 categories of puberty were included.

290 During puberty, when young people are completing their educatio

291 ovisceral attacks that typically start after puberty, whereas patients with homozygous dominant AIP (

292 causes increased collagen deposition during puberty, which results in impaired Hippo signaling and r

293 current, reduced activity in 8.5 mM K(+) at puberty, while blockade of alpha5-GABARs had no effect.

294 boy, with a diagnosis of CAH and precocious puberty, who was referred to our department for an ultra

295 Genetic markers associated with age at puberty will allow for selection on age at puberty and t

296 f each clinically assessed marker of earlier puberty with self-report sleep duration in adolescence.

297 time, we assessed the association of earlier puberty with sleep duration observationally and with val

298 genes involved in regulation of the onset of puberty would allow for the improvement of reproductive

299 ition during pregnancy, early childhood, and puberty would avoid not only obesity, but also accelerat

300 ations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevale