ライフサイエンスコーパス: pulposus

1 of sciatica secondary to a herniated nucleus pulposus.

2 ho are suspected of having herniated nucleus pulposus.

3 ion and reduced Bgm1 in degenerating nucleus pulposus.

4 ss and the resulting prolapse of the nucleus pulposus.

5 tervertebral disc, especially in the nucleus pulposus.

6 ed to measure CCN3 expression in the nucleus pulposus.

7 the intervertebral disc, called the nucleus pulposus.

8 tiation and function of cells of the nucleus pulposus.

9 ed to measure CTGF expression in the nucleus pulposus.

10 regulator of CTGF expression in the nucleus pulposus.

11 ory protein, TonEBP, in cells of the nucleus pulposus.

12 e was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-derived sh

13 Cells of the nucleus pulposus and annulus fibrosus of rat disc tissue express

14 raphy-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs

15 he other Notch receptors in both the nucleus pulposus and annulus fibrosus.

16 long forms of alpha1(IX) from bovine nucleus pulposus and articular cartilage.

17 d pro-angiogenic phenotype in bovine nucleus pulposus and cartilage endplate cells at the gene level.

18 tracted from the anulus fibrosus and nucleus pulposus, and of these aggrecan preparations following e

19 d yet unstained samples resolved the nucleus pulposus, annulus fibrosus and constituent lamellae, and

20 ed significant deteriorations in the nucleus pulposus, annulus fibrous and at the interfaces after 2

21 hibitory than that isolated from the nucleus pulposus, but enzymic pretreatments to reduce the glycos

22 lls inactivated Wnt signaling in the nucleus pulposus by 95%, degenerated the IVD to levels similar t

23 isk structures (annulus fibrosus and nucleus pulposus) by cartilage and bone tissues, with cells stai

24 ease may restore NOTCH signaling and nucleus pulposus cell function.

25 tivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.

26 a subtype of locally residing human nucleus pulposus cells (NPCs), generated by certain conditions i

27 romoter activity was observed in rat nucleus pulposus cells after TGFbeta treatment.

28 n promoter activity was seen both in nucleus pulposus cells and in N1511 chondrocytes.

29 y to mimic the cellular behaviour of Nucleus Pulposus cells exposed to a 3D multifactorial biochemica

30 re used to measure ANK expression in nucleus pulposus cells from rats and humans.

31 d the suppression of CCN2 by CCN3 in nucleus pulposus cells further the paradigm that these CCN prote

32 ptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis.

33 Adenovirus-mediated gene transfer to nucleus pulposus cells may be the initial stage of a new form of

34 Adaptive response to hypoxia in nucleus pulposus cells of the intervertebral disc is regulated b

35 rough controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc.

36 mical staining, annulus fibrosus and nucleus pulposus cells of young-adult IVD expressed osterix, but

37 l the PHDs is maintained in isolated nucleus pulposus cells regardless of the disease state.

38 Since nucleus pulposus cells reside under conditions of hypoxia, we de

39 sion of HIF-1alpha and HIF-2alpha in nucleus pulposus cells resulted in a significant suppression of

40 cally in disc tissue, and numbers of nucleus pulposus cells staining positive for ADAMTS 4, 5, 9, and

41 expression in Smad3-null mice and in nucleus pulposus cells transduced with lentiviral short hairpin

42 Above 330 mosmol/kg, cultured nucleus pulposus cells up-regulated target genes TauT, BGT-1, an

43 pendent changes in ANK expression in nucleus pulposus cells were minimal.

44 g cellular aging and inflammation in nucleus pulposus cells while increasing collagen type II and agg

45 ies include loss of reticular-shaped nucleus pulposus cells, disorganization of annulus fibrosus lame

46 sults of this study indicate that in nucleus pulposus cells, HIF-2 and HIF-1 modulate their own trans

47 Here, we show that in nucleus pulposus cells, hypoxia robustly induces PHD3 expression

48 ed GlcAT-1 promoter activity only in nucleus pulposus cells, suggesting a cell type-specific regulati

49 oter activity and expression only in nucleus pulposus cells.

50 suppressed its promoter activity in nucleus pulposus cells.

51 ent decrease in the proliferation of nucleus pulposus cells.

52 nd that this regulation is unique to nucleus pulposus cells.

53 HIFs on GlcAT-1 promoter function in nucleus pulposus cells.

54 human studies focusing primarily on nucleus pulposus cells.

55 rget gene for HIF-1 and HIF-2 in the nucleus pulposus cells.

56 s indicate that the matrix of bovine nucleus pulposus contains only the short form of alpha1(IX) that

57 e notochord from the surrounding the nucleus pulposus, especially in murine models.

58 (IX)COL3 domain purified from bovine nucleus pulposus gave a different sequence to that of the long a

59 easing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +/- 1.3; grade 5, 16.5 kPa +/

60 as human annulus fibrosus (hAF) and nucleus pulposus (hNP).

61 of the annulus fibrosus and into the nucleus pulposus in 21 (46%) and ten (22%) samples, respectively

62 , function, and fate of cells of the nucleus pulposus in the intervertebral disk.

63 robust expression of GlcAT-I in the nucleus pulposus in vivo.

64 The nucleus pulposus is an aggrecan-rich hydrated tissue that permit

65 The cells of the nucleus pulposus (NP cells) have adapted to this environment via

66 at govern the maintenance of healthy nucleus pulposus (NP) and annulus fibrosus (AF) have not been fu

67 ors of cells that populate the adult nucleus pulposus (NP) and are an important source of secreted si

68 tion of proinflammatory molecules by nucleus pulposus (NP) and other disc cells.

69 Cells of the adult nucleus pulposus (NP) are critically important in maintaining ov

70 cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specific marke

71 Here, bovine nucleus pulposus (NP) CD44 cells were sorted and compared by gen

72 The nucleus pulposus (NP) cells adapt to their physiologically hyper

73 regulation of ADAMTS-4 expression in nucleus pulposus (NP) cells and its role in aggrecan degradation

74 in regulating HIF-1 activity in the nucleus pulposus (NP) cells and the control of this regulation b

75 tor LPS and IL-1 in bovine and human nucleus pulposus (NP) cells by assessing matrix-degrading enzyme

76 ments and combined therapy on bovine nucleus pulposus (NP) cells by assessing proteoglycan (PG) accum

77 Nucleus pulposus (NP) cells cultured with UCNPs are viable both

78 Human nucleus pulposus (NP) cells derived from nondegenerated and dege

79 We show that TonEBP deletion in nucleus pulposus (NP) cells does not affect their survival or ag

80 Monolayer cultures of nucleus pulposus (NP) cells from the intervertebral discs (IVD)

81 extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.

82 However, in nucleus pulposus (NP) cells of the healthy intervertebral disc,

83 Nucleus pulposus (NP) cells of the intervertebral disc are essen

84 Nucleus pulposus (NP) cells reside in a physiologically hyperosm

85 ls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (

86 Bovine nucleus pulposus (NP) cells were treated with BMP-7 and IGF-1.

87 SOX9 binding to the Ctgf promoter in nucleus pulposus (NP) cells.

88 pendent catabolic gene expression in nucleus pulposus (NP) cells.

89 control NOTCH signaling activity in nucleus pulposus (NP) cells.

90 set of genes characterizing immature nucleus pulposus (NP) cells.

91 form a regulatory network in hypoxic nucleus pulposus (NP) cells.

92 F)-alpha degradation and activity in nucleus pulposus (NP) cells.

93 l knockout of PTH 1 receptors in the nucleus pulposus (NP) did not abolish the treatment effects of P

94 Spontaneous mineralization of the nucleus pulposus (NP) has been observed in cases of intervertebr

95 neration by regenerating the central nucleus pulposus (NP) hold significant promise, but key challeng

96 Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases,

97 The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstra

98 The nucleus pulposus (NP) of the intervertebral disc develops from t

99 VD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibrocartila

100 late (EP) annulus fibrosus (AF), and nucleus pulposus (NP) with varying ciliary length.

101 the following annotated partitions: nucleus pulposus (NP), outer annulus fibrosus (oAF), inner AF (i

102 osus (AF), transition zone (TZ), and nucleus pulposus (NP), respond to osmotic stress with altered bi

103 reach their target cells inside the nucleus pulposus (NP), the central gelatinous region of the inte

104 roteoglycan and water content in the nucleus pulposus of intervertebral discs.

105 tiation; and directly by forming the nucleus pulposus of intervertebral discs.

106 roteins (MMP-13 and ADAMTS-5) in the nucleus pulposus of the disc.

107 From nucleus pulposus of the intervertebral disc (in which the bulk c

108 , and it becomes embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturat

109 al swelling pressures in the central nucleus pulposus of the intervertebral disc generate prestrain i

110 Their pre-diagnoses were 'herniated nucleus pulposus' or 'lumbar disc herniation' or 'back pain' and

111 r third of the annulus fibrosus, the nucleus pulposus, or both was seen in four (25%) of 16 biopsy sa

112 n unconfirmed diagnosis of herniated nucleus pulposus, outcome at 2-year follow-up was no better in p

113 d afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.83) regi

114 lus fibrosus regions and modestly in nucleus pulposus regions.

115 (n = 8) from the anulus fibrosus and nucleus pulposus regions.

116 rains located in the posterior disc (nucleus pulposus) regions.

117 Analysis of human nucleus pulposus samples indicated a trend toward increasing CTG

118 es occupied in type IX collagen from nucleus pulposus showed that usage of the short alpha1(IX) trans

119 Additionally, nucleus pulposus structures, heretofore unknown in birds, are in

120 ineered IVD composed of a gelatinous nucleus pulposus surrounded by an aligned collagenous annulus fi

121 ertebral discs, normally composed by nucleus pulposus surrounded by the annulus fibrosus, were often

122 ycans and increased hydration in the nucleus pulposus that culminated in higher stiffness of the IVD.

123 Nucleus pulposus, the central zone of the intervertebral disc, i

124 s GlcAT-I expression in cells of the nucleus pulposus through a signaling network comprising both act

125 Finally, analysis of human nucleus pulposus tissue showed that while ANK was expressed in n

126 We conclude that in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expressio

127 As in cartilage, type IX collagen of nucleus pulposus was heavily cross-linked to type II collagen an

128 we detected Bgm1 in human and mouse nucleus pulposus, with prominent intracellular expression in not