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1 rmalities (including ectropion and accessory puncta).
2 localization of the SNF1 activator Std1 into puncta.
3 uced autophagic vacuoles (AVs) and less LC3B puncta.
4 annel (VGCC) puncta colocalized with Bassoon puncta.
5 Sorting 35) in the cytoplasm as fast-moving puncta.
6 es reveal local Ca(2+) influx at STIM1-Orai1 puncta.
7 astrocytic cells and fibers and connexin 43 puncta.
8 on from the TGN to cytoplasmic endosome-like puncta.
9 antigen 1 (LANA-1; ORF73) and LANA-1 nuclear puncta.
10 puncta within the colonies but fewer VGluT-1 puncta.
11 icant reduction in the size of surface GluR2 puncta.
12 autophagic vacuoles expressing RFP and EGFP puncta.
13 ulation of axon-derived material in discrete puncta.
14 , which prevents autophagy, contained no RFP puncta.
15 ors toward the recipient cell body in motile puncta.
16 er and by colocalization of Bruchpilot-short puncta.
17 of newly formed spines acquired PSD-95-eGFP puncta.
18 -2/HER2 from the cell surface to cytoplasmic puncta.
19 ll dendrites to reach ectopic ribbon-protein puncta.
20 concentrated into perinuclear and peripheral puncta.
21 puncta and decreased the number of PSD95-GFP puncta.
22 distribution of VGluT2-immunoreactive (-ir) puncta.
23 4Pm preferentially localized to cytoplasmic puncta.
24 increased VGAT (vesicular GABA transporter) puncta.
25 g11 is required for concentrating Atg32 into puncta.
26 n of endogenous light chain 3 (LC3)-positive puncta.
27 ith independently formed, Arp2/3-based actin puncta.
28 nd reduced the formation of ATG16L1 membrane puncta.
29 and recruitment to the Atg12-5-16L1-positive puncta.
31 ast, individual gephyrin-immunoreactive (IR) puncta, a postsynaptic scaffolding protein at inhibitory
32 n spine density and PSD-95-positive synaptic puncta, a reduction of persistent spines, and impaired l
33 NM2C is found in a dense, isotropic layer of puncta across the subapical domain, which transects the
35 sulted in a markedly increased number of EdU puncta, allowing efficient quantification of HIV-1 rever
37 . elegans CAMSAP protein PTRN-1 localizes to puncta along neuronal processes, stabilizes MT foci, and
40 re associated with decreased peripheral Rab5 puncta and a reduced number of early endosome antigen 1
41 LC3-II/LC3-I ratio increased as did GFP-LC3 puncta and acidic vesicles; p62 levels decreased in a ly
44 e, is normally cytosolic but concentrates in puncta and at sites of polarized growth during intense o
45 a and Rab14 colocalize in both intracellular puncta and at the plasma membrane and that Rab14 express
46 at the WIP sites reduces Dvl accumulation in puncta and attenuates beta-catenin signaling, whereas it
48 2/3 pyramidal neurons could induce gephyrin puncta and dendritic spine formation via GABA type A rec
51 ncluding formation of multiple aberrant Atg8 puncta and drastically impaired autophagosome biogenesis
53 ACE inhibition, result in the loss of axonal puncta and in the accumulation of unprocessed proforms i
54 ble levels along the Z-disk, in a pattern of puncta and linear segments consistent with the STIM1 loc
55 tin modulates the turnover of NET3C at these puncta and microtubules regulate the exchange of VAP27 a
56 r glutamate transporter 1-positive [VGlut1+] puncta and postsynaptic density protein 95-positive [PSD
57 d deficiency of GABA perisomatic bouton-like puncta and processes in the KF nucleus; (ii) blockade of
58 activity as measured by density of VGLUT2(+) puncta and Purkinje cell firing rate respectively, in co
59 found that the number of Atg12/16L1-positive puncta and recruitment of the Atg12-5-16L1 complex to Wi
63 tent accumulation of TDP-43 into cytoplasmic puncta and that our hit compounds can reduce this accumu
64 of IPMK increases the number of nuclear TFEB puncta and the co-localization of TFEB with Mediator and
65 lso caused the accumulation of Atg5-positive puncta and the formation of multilamellar structures.
66 cells revealed that both localize to nuclear puncta and the shorter isoform displays higher nuclear l
67 lbino RPE cells have fewer small connexin 43 puncta, and a larger fraction of phosphorylated connexin
70 es, as indicated by VGLUT2(+) immunoreactive puncta, and computational modeling demonstrated that the
71 and muNS resulted in disruption of normal SG puncta, and in cells lacking G3BP1, MRV replication was
73 Optn was recruited to Atg12-5-16L1-positive puncta, and interacted with Atg5 and also with Atg12-5 c
75 outons were defined as PV/GAD65 dual-labeled puncta, and PVBC inputs were defined as a PVBC bouton th
80 esponding to distal dendrites while gephyrin puncta are enriched on neuronal somata and in the medial
81 urthermore, the distributions of gephyrin-IR puncta are heterogeneous and appear as clusters along th
84 a control, we demonstrated that our synaptic puncta assay is at least 10-fold more sensitive to the t
86 gy, we show that cadherin-10 forms nanoscale puncta at excitatory and inhibitory synapses, maintains
87 ound that the N723S mutant had more immobile puncta at neuronal processes compared to Mint2 wild type
90 Z-line protein, colocalizes with F-actin in puncta at the cytoplasmic face of nuclei before sarcomer
92 usions localized as transient MotA-dependent puncta at the membrane when induced at subinhibitory lev
93 activation induces the formation of CRACR2a puncta at the plasma membrane, which initially associate
94 demonstrate that NET3C and VAP27 localize to puncta at the PM and that NET3C and VAP27 form homodimer
96 ere we find that the endogenous LC3-positive puncta become larger in cells where autophagosome format
97 ot overlapping with gap junctions, and forms puncta before the clusters of gap junction channels appe
98 es in a punctate pattern, with >95% of these puncta being indistinguishable from the plasma membrane
99 Y-LIKE in a subcellular complex localized to puncta both at the tip of the growing infection thread a
100 phospho-defective STIM1-Y361F mutant formed puncta but failed to recruit Orai1, thereby preventing.
101 ditions, nephrons expressed few EGFP and RFP puncta, but ischemia-reperfusion injury (IRI) led to dyn
103 y is low the slGFP that is concentrated into puncta can be liberated from puncta and subsequently deg
105 uinea pigs, counts of immunostained synaptic puncta can recover with increasing post-exposure surviva
106 orn mice and adult human skin, we report LC3 puncta coincident with misshaped nuclei within the granu
107 of putative podosome precursors: actin-rich puncta coinciding with matrix degradation sites and cont
108 e in rotavirus-infected cells and that STIM1 puncta colocalize with the PM-localized Orai1 SOCE calci
111 NLL1 as well as DYNLL2 localised to cilia in puncta, consistent with IFT particles, and physically in
117 f GABA and exhibited an increase in gephyrin puncta density, suggesting increased postsynaptic GABAA
118 ides in either the nucleus or in cytoplasmic puncta, depending on levels of the plant hormone salicyl
120 ges from uniform nano-, meso- and microscale puncta (distinct protein droplets) to multilayered ortho
123 fy the number of colocalized mature synaptic puncta for the assessment of synaptic changes in live ne
124 Our multi-labeling studies reveal that nNOS puncta form multiprotein complexes with NMDA receptors,
127 akes multiple interactions that support Dnm1 puncta formation and may be essential after this step, s
129 ted calcium entry (SOCE) by decreasing STIM1 puncta formation near the plasma membrane upon calcium d
131 S-glutathionylation and calcium-independent puncta formation of the ER calcium sensor STIM1 underlie
132 ) as a biosensor to assess STIM1 activation (puncta formation) by rotavirus infection and NSP4 expres
133 ics describing IP3-receptor, DTS-plasmalemma puncta formation, SOCE via assembly of STIM1 and Orai1,
134 substantively different from those for Orai1 puncta formation, suggesting that ion selectivity and ga
135 stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton
139 onversion; reduced ATG14L, ATG12, and WIPI-1 puncta formation; and significantly decreased Vps34 acti
142 Orai1 channels gated by CAD, and small Orai1 puncta gated by STIM1, exhibit repetitive fluctuations i
143 into extracellular matrix (ECM) as discrete puncta has been documented in various tissue and cell bi
145 ependent mode of TAX1BP1 recruitment to NBR1 puncta, highlighting that TAX1BP1 recruitment and cluste
146 we show that TgDrpC localizes to cytoplasmic puncta; however, in dividing parasites, TgDrpC redistrib
148 e investigated the distribution of VGluT2-ir puncta in all layers of macaque monkey primary visual co
149 hat synthesizes nitric oxide (NO), occurs as puncta in apparently all neurons in the central nucleus
150 light chain 3 (LC3) form II (LC3-II) and LC3 puncta in Atg5-competent BMMs but not in Atg5-deficient
152 multimeric assemblies, MORC-1 forms nuclear puncta in cells and can also form phase-separated drople
153 e point mutations eliminate the formation of puncta in cells and have been shown previously to elimin
157 ous Rab7 led to the appearance of large TrkA puncta in enlarged Rab5-early endosomes within the cytop
159 ss of PSD95-positive excitatory postsynaptic puncta in hippocampal area CA1 compared with sham-immuni
160 many aspects, the distribution of VGluT2-ir puncta in human was qualitatively similar to that of the
162 itro and is localized within distinct motile puncta in L. japonicus root hairs and in Nicotiana benth
163 tracer also colocalized with GAD-67-positive puncta in labeled fibers, which in some cases made close
168 ed fluorescence and accumulation of pure red puncta in skeletal muscle, which were completely amelior
169 ein light chain 3 form 2 (LC3-II) or GFP-LC3 puncta in the absence and presence of the lysosome inhib
170 abeled ribosomes are detected as fluorescent puncta in the axons and synaptic terminals of specific n
172 sing this approach, we observed distinct EdU puncta in the cytoplasm of infected cells within 12 h po
173 unit of NF-kappaB is rerouted to perinuclear puncta in the cytoplasm, which are synonymous with viral
176 gers B12 and B14 to reorganize into discrete puncta in the ER membrane called foci, structures postul
177 cant increase in synaptophysin immunolabeled puncta in the hippocampal subregion, CA1, in APPSWE /PS1
178 postinfection and subsequent accumulation of puncta in the nucleus, which remained stable through 5 d
179 ranches and post-synaptic density protein 95 puncta in the peri-infarct cortex 6 weeks after treatmen
180 orescence recovery signal is concentrated to puncta in the spatial Fourier domain, with substantial i
181 al axon collateral branches with presynaptic puncta in the spinal cord and enhanced recovery of forel
182 densities in layer 4C, patches of VGluT2-ir puncta in the supragranular layer (2/3), lower but clear
183 in vitro data, MEC-10, but not MEC-6, formed puncta in TRN neurites that colocalize with MEC-4 when M
185 gephyrin puncta, with the number of gephyrin puncta increasing to match that of PSD-95 puncta at the
186 3-II and SQSTM1 and also potentiated GFP-LC3 puncta index in GFP-LC3-transfected hippocampal neural s
187 ed inflammasomes and increased light chain 3 puncta indicative of autophagosomes in glomeruli from do
188 well as increased VGlut2- and PSD95-positive puncta, indicative of increased excitatory synapses.
189 hagocytosis), quantification of LC3-positive puncta is considered as a gold-standard assay for assess
190 rightness of different neurites and synaptic puncta is heterogeneous due to the variation of antibody
192 anslocation of the ULK complex to autophagic puncta, is repressed during mitosis, even when mTORC1 is
193 se-reared animals had larger VGlut1-positive puncta, larger profiles in electron micrographs, and mor
196 ing calcineurin activity impairs STIM1/ORAI1 puncta-like formation and cytoskeleton organization.
197 ity of perisomatic excitatory and inhibitory puncta, longer axonal initial segments (AISs), and highe
199 protein light chain 3 (LC3) and p62, GFP-LC3 puncta, monodansylcadaverine (MDC) staining, and transmi
203 nimals revealed alterations in autophagosome puncta number reflecting those phenotypes seen in vitro.
205 and-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics tha
207 increases in bronchial epithelial cells with puncta of both total ubiquitin and K63-ubiquitin, centra
208 s accumulate as unprocessed proforms, axonal puncta of CRD-NRG1 and NRG3 are comprised of processed p
209 well as accumulation of pure red fluorescent puncta of damaged mitochondria targeted for mitophagy.
211 on of autophagy as a significant increase in puncta of LC3(+) autophagosomes, endogenous levels of LC
212 24 h) caused an Mdm2-dependent loss of NMDAR puncta on a timescale similar to adaption of NMDAR funct
216 cortactin, which is present in F-actin-rich puncta on MT1-MMP-positive endosomes and regulates corta
220 ound a decrease in the density of inhibitory puncta on their perisomatic region but not on the PV+ pe
221 nd postsynaptic density 95-positive (PSD95+) puncta, on PV interneurons was lower in postpubertal rel
222 At the embryonic stage, we found that PSD-95 puncta outnumber gephyrin puncta, with the number of gep
223 ynaptic density protein 95-positive [PSD95+] puncta) per surface area of parvalbumin-positive (PV+) o
224 ys after IRI, whereas the high levels of RFP puncta persisted, indicating autophagy initiation at day
225 n of these particles into sharply delimited "puncta" positioned upon raised membrane subdomains.
226 hereas the density of PV-immunoreactive (IR) puncta (presumed PVBC boutons) increases during adolesce
228 reduced spine density and increased synaptic puncta, providing quantitative measures of risk for deve
229 derived from the patients show reduced WIPI2 puncta, reduced LC3 lipidation and reduced autophagic fl
230 hagy and caused accumulation of p62-positive puncta reminiscent of the p62 pathology observed in C9AL
234 eir chaperones are sequestered into multiple puncta specifically during early-stage Rpt ring assembly
235 postsynaptic density (PSD95) immunoreactive puncta suggesting that they receive synaptic input from
236 liferation decreased in cells containing RFP puncta, suggesting that autophagic cells are less likely
237 umulation of LC3 reporter RFP+ GFP+ (yellow) puncta, suggesting that HIV-1 infection triggers autopha
238 nd an increase in the density of presynaptic puncta, suggesting that reduced arborization is accompan
239 cell-target cell contact, formation of viral puncta-target cell conjugation, transfer of viral puncta
241 for the formation of cytoplasmic proteasome puncta that accumulate when autophagosome formation is b
243 iation and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs cons
244 eptide cargo form DIMM-dependent fluorescent puncta that are coassociated by super-resolution microsc
248 11-Atg32 interactions concentrate Atg32 into puncta that are thought to represent sites of mitophagy
249 ted in distribution of this protein as large puncta that co-localized with IVC markers, including fru
251 emonstrated that nuclear TFEB forms distinct puncta that colocalize with the Mediator complex and wit
255 cortex, where it is organized into nanoscale puncta that influence the size of their associated PSDs.
257 g region (LIR) to traffic into ATG8-positive puncta that often initiate from three-way ER tubule junc
259 , in human cancer cells, BRD4S forms nuclear puncta that possess liquid-like properties and that colo
260 resistant version, which localized to active puncta that promote lysosomal-mediated stimulator of int
261 These studies showed that GORK assembles in puncta that reversibly dissociated as a function of the
262 doplasmic reticulum (ER) store, organizes as puncta that trigger store-operated Ca(2+) entry (SOCE) v
263 ectopically expressed Nrbf2 formed cytosolic puncta that were positive for isolation membrane markers
264 ndocytic collar"); and small, rapidly moving puncta that were seen trafficking long distances in near
265 cell wall with trapping within intracellular puncta; this deletion was accompanied by reduced virulen
266 -stranded DNA binding protein I3 in multiple puncta throughout the interior of factories, which were
267 sion of Mybphl in the atria, and in discrete puncta throughout the right ventricular wall and septum,
268 rons, NHE6 was found to localize to discrete puncta throughout the soma and neurites, with noticeable
270 in how mRNA molecules can be passed from one puncta to another, forming a relay that directs mRNAs to
271 ecrease in the number of presynaptic Bassoon puncta, together with a reduction of PSD-95 levels at de
275 dition a greater number of perisomatic GAD67 puncta was observed suggesting a potential increase in p
276 lthough the arrangement of Orai1 channels in puncta was substantially unstructured, a portion of chan
277 napses per OHCs, defined as postsynaptic SK2 puncta, was reduced in aged OHCs of all strains apart fr
282 activation, spines that were endowed with SP puncta were much more likely to expand than SP(-) spines
285 In the mouse retina, Cx50-immunoreactive puncta were predominantly localized on large axon termin
287 g signals of endogenous Kv2.1, Nir2, and VAP puncta were spatially correlated in cultured neurons.
288 izes with mCherry-Rab8A in perinuclear small puncta, whereas GFP-MyoVa-CT collapses the GTPase into e
289 there was a sparse distribution of VGluT2-ir puncta, whereas in macaque, there was a dense distributi
290 tidase from the apical membrane to subapical puncta, whereas multidrug resistance protein 2 distribut
291 sion led to an increased density of synaptic puncta, while isoform 2 ameliorated the calcium signalli
292 opy and colocalization of ubiquitin-positive puncta with lysosomal-associated membrane proteins 1 and
293 de a robust engineered platform for creating puncta with new, phase-separation-mediated control of bi
296 found that PSD-95 puncta outnumber gephyrin puncta, with the number of gephyrin puncta increasing to
297 e-lapse imaging reveals that alpha-actinin-1 puncta within actomyosin bundles move more quickly than
298 tion of thrombospondin-1 or thrombospondin-5 puncta within cell-derived ECM is controlled by a novel,
299 ght induces Vipp1 coalescence into localised puncta within minutes, with net relocation of Vipp1 to t
300 aled large numbers of synaptophysin-positive puncta within the colonies but fewer VGluT-1 puncta.