ライフサイエンスコーパス: purge

1 iation due to classically theorized 'genetic purging'.

2 ed into conscious awareness and needed to be purged.

3 t deleterious mutations are less effectively purged.

4 alpha-hypersensitive Fancc-/- stem cells are purged.

5 ies intruded into awareness and needed to be purged.

6 able to multiple cycles of nitrogen/ethylene purges.

7 om Monitor, for binge eating with or without purging.

8 lera is distinct, with pronounced diarrhoeal purging.

9 n, and consequently their escape from thymic purging.

10 viors-binge eating, dietary restriction, and purging.

11 ar menstrual cycles, without binge eating or purging.

12 utations and leading to their more efficient purging.

13 rent under short-circuit condition) in an Ar-purged 0.02 M K(2)SO(4) solution.

14 In contrast to purging, 10-year progression-free survival (PFS) was 48%

15 d with an immune deficiency is not likely to purge a persistent infection using endogenous mechanisms

16 We focus this perspective on PURGE, a water suppression technique, and PROJECT presat

17 Ribosome-associated quality control (RQC) purges aberrant mRNAs and nascent polypeptides in a mult

18 ents receiving FBT (16 [39%]) were binge-and-purge abstinent compared with those receiving SPT (7 [18

19 may also benefit populations by efficiently purging accumulated damage and rejuvenating newborn cell

20 hances the effectiveness of population-level purging across generations.

21 ire recipient dendritic cells to effectively purge an established persistent viral infection.

22 Purge and cold-trap with crushed ice serving as condensa

23 fected by irradiation, increasing (p < 0.05) purge and cooking loss regardless of the dose used.

24 isotopic composition using a continuous flow purge and cryogenic trap system coupled to an isotope ra

25 e, flushing, static extraction time, solvent-purge and sample weight.

26 ymph nodes, which impaired their capacity to purge and suppress autoreactive T cells.

27 chosen: solid phase micro extraction (SPME); Purge and Trap extraction and solvent assisted flavour e

28 chromatography-olfactometry for SPME and for Purge and Trap extracts, or by sniffing for the aqueous

29 matoes were characterized and compared using purge and trap gas chromatography-mass spectrometry (PT-

30 Here we describe a cryogenic purge and trap system coupled to continuous flow compoun

31 The measurements were made by a modified purge and trap technique developed in our laboratory on

32 by combining the high enrichment capacity of purge and trap with aqueous phenylation derivatization.

33 hromium reactor has been incorporated into a purge and trap-CSIA method that is suitable for CSIA of

34 reflect overdominance, potentially reducing purging and increasing allele persistence probability.

35 at EVs and exosomes could play a role in the purging and intercellular transfer of excess free RNAs,

36 there appeared to be an interaction between purging and stress-induced physiological damage.

37 ater reductions in symptoms of binge eating, purging, and eating disorders compared with standard car

38 A dynamic headspace purge-and-trap (DHS-P&T) methodology for the determinati

39 e methodology is based on the application of purge-and-trap extraction followed by gas chromatography

40 ersus the nonpurgeable fraction by combining purge-and-trap extraction with SPE.

41 DBPs explained almost the entire AOX in the purge-and-trap extracts, but <16% in the SPE extracts de

42 The purgeable DBP fraction enriched with the purge-and-trap method exerted a lower oxidative stress r

43 Our measurements were made using a purge-and-trap method that employs benchmark chemicals t

44 he fully automated method is based on heated purge-and-trap preconcentration and gas chromatography/m

45 sed between the restricting and binge eating/purging anorexia nervosa subtypes over time; one-third c

46 loacetonitriles and approximately 60-90% for purged AOX from tap water.

47 In this study, we report a fill-and-purge approach to the layer-by-layer fabrication of bioc

48 ed with wetland sediment and suspended in N2-purged artificial groundwater.

49 In a tumor purging assay, in which tumor:bone marrow cell mixtures

50 prepared via melt-quench method in an argon-purged atmosphere.

51 ive chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been s

52 l investigation including the possibility of purged autologous hematopoietic cell transplants.

53 d serum autoantibody and reduced capacity to purge autoreactive immature and transitional B cells.

54 rk, thus disabling an essential platform for purging autoreactive T cells from the repertoire.

55 , we report a novel alternative approach for purging autoreactive T cells that spares beneficial immu

56 es natural selection to fix 'good genes' and purge 'bad genes', then mating patterns encouraging comp

57 efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatm

58 een female adolescents with binge eating and purging behaviors (i.e., bulimia nervosa or anorexia ner

59 were randomly assigned to undergo autologous purged bone marrow transplantation (ABMT) or to receive

60 l effective population size limits efficient purge by natural selection.

61 xyl radical generation when the solution was purged by air.

62 qually throughout the genome and are rapidly purged by natural selection from gene-rich regions becau

63 uman gene pool, but have been systematically purged by natural selection from genes and other functio

64 ve positively selected thymocytes from being purged by negative selection remains unclear.

65 t the residual CML LSC pool can be gradually purged by the glitazones, antidiabetic drugs that are ag

66 we conclude that methods aimed at enhancing purging by intentional inbreeding should not be generall

67 iridium strip resistance heater in an argon-purged chamber.

68 ymmetry is soon broken: The best cooperators purge cheaters and continue to grow, whereas the best ch

69 ced via life cycles that either embraced, or purged, cheating types.

70 tes and product isolation can be overcome by purging CO(2) from the system.

71 volvement of a downregulation mechanism that purges contents from conscious awareness.

72 ting cell-intrinsic immunity, in addition to purging CSCs.

73 Moreover, systemic Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes, supp

74 echanisms, which generate genetic diversity, purge deleterious mutations, and contribute to their abi

75 g linkage limits the ability of selection to purge deleterious mutations.

76 een proposed that this could be exploited in purging deleterious alleles from threatened inbred popul

77 ign of epistasis can speed up the process of purging deleterious mutations in eukaryotic organisms.

78 leviating effects of clonal interference and purging deleterious mutations.

79 Under stringent selection, they efficiently purge destabilizing amino acid changes.

80 rvosa (BN), binge eating disorder (BED), and purging disorder (PD).

81 partial- or full-criteria bulimia nervosa or purging disorder and 2.9% had partial or full-criteria b

82 Future studies on the psychobiology of purging disorder are needed to understand the propensity

83 wever, more data are needed to determine how purging disorder differs from bulimia nervosa.

84 Findings support further consideration of purging disorder for inclusion in the classification of

85 Purging disorder is a clinically significant disorder of

86 Participants with purging disorder reported significantly greater postpran

87 Recent data suggest that purging disorder, a recently characterized form of eatin

88 We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded

89 eral hypotheses, including a bottleneck that purged diversity in the German isolates, variation in mu

90 es that could independently suppress EAE, we purged draining lymph node cells from MOG-immunized, iTr

91 large and deleterious alleles may have been purged during bottlenecks.

92 extrinsic manner by infiltrating phagocytes purging dying cells.

93 Our results show that genetic purging efficiently removes the inbreeding load of both

94 However, purging endogenous 24,25-dihydrolanosterol, lanosterol,

95 ent densities greater than 1 mA in an oxygen-purged environment.

96 crossed equilibrium collapses sharply to the purged equilibrium genetic variance.

97 In the GAM a second stable equilibrium, the purged equilibrium, exists for any positive selfing rate

98 Pretransplantation rituximab in vivo purging, even in rituximab-naive patients, failed to imp

99 ion system has been demonstrated with a tank-purging experiment and has been directly compared with a

100 factors (sample weight, extraction time, and purge flow) on extraction efficiency has been studied an

101 ilation air (VA) flow rate, temperature, and purging fluids.

102 A purge-free controlled living polymerization method, acti

103 We report here the employment of a purge-free controlled/"living" polymerization reaction,

104 A sample of CaL spent sorbent, purged from a 200 kWth pilot facility, was tested as a r

105 To determine whether LCMV could be purged from a novel target selection in the absence of a

106 a memory that has entered the aware state be purged from consciousness if it is not currently desired

107 The CO(2) is continuously purged from solution and collected by two sequential min

108 logic analysis confirmed that the cells were purged from surviving mice after ganciclovir treatment.

109 lls have reduced fitness and are efficiently purged from the bone marrow.

110 tion still needs to be loaded, unloaded, and purged from the cell culture during the measurements.

111 nce but inhibits biofilm formation, had been purged from the genome.

112 infrequently, and deleterious mutations are purged from the population by purifying selection.

113 erance induction because individual TRAs are purged from the total repertoire secondary to a decline

114 ls specific for alpha345NC1 hexamers are not purged from their repertoire.

115 s controlling whether TEs are preferentially purged from, or are retained by, genetic drift or positi

116 tant effect of oxidation of Fe(2+) under air purge gas that occurs prior to dehydroxylation and leads

117 The imposed heating rate, type of purge gas, type of comminution and sample mass all influ

118 ees C and 50 mbar(abs) without dilution by a purge gas, yielding a purity exceeding 94.4%.

119 n of the heating vessel and flow rate of the purge gas.

120 late oxygen concentration via the control of purging gas flow.

121 Moreover, acute induction of EphA2 may purge genetically susceptible cells, thereby uncovering

122 nt with sex and meiosis being mechanisms for purging genomic parasites.

123 Global epigenetic reprogramming is vital to purge germ cell-specific epigenetic features to establis

124 e purged group versus 36% (30-42) in the non-purged group (p=0.77); 5-year overall survival was 50% (

125 d group compared with 51% (44-57) in the non-purged group (p=0.81).

126 oidal obstructive syndrome (12 of 177 in the purged group and 17 of 191 in the non-purged group), acu

127 non-purged group, and 180 patients from the purged group and 192 from the non-purged group received

128 SC were collected from 229 patients from the purged group and 236 patients from the non-purged group,

129 ng both induction (87 of 242 patients in the purged group and 93 of 243 patients in the non-purged gr

130 creased cardiac function (four of 242 in the purged group and five of 243 in the non-purged group) an

131 p) and 12 during consolidation (eight in the purged group and four in the non-purged group).

132 ecreased cardiac function (one of 177 in the purged group and four of 191 in the non-purged group).

133 roup), acute vascular leak (11 of 177 in the purged group and nine of 191 in the non-purged group), a

134 n 15 patients during induction (eight in the purged group and seven in the non-purged group) and 12 d

135 and elevated creatinine (five of 242 in the purged group and six of 243 non-purged group) and during

136 erall survival was 50% (95% CI 43-56) in the purged group compared with 51% (44-57) in the non-purged

137 s from the purged group and 192 from the non-purged group received transplant.

138 -free survival was 40% (95% CI 33-46) in the purged group versus 36% (30-42) in the non-purged group

139 group) and consolidation (131 of 177 in the purged group vs 145 of 191 in the non-purged group).

140 ght in the purged group and seven in the non-purged group) and 12 during consolidation (eight in the

141 rged group and 93 of 243 patients in the non-purged group) and consolidation (131 of 177 in the purge

142 f 242 in the purged group and six of 243 non-purged group) and during consolidation were sinusoidal o

143 the purged group and five of 243 in the non-purged group) and elevated creatinine (five of 242 in th

144 in the purged group and 17 of 191 in the non-purged group), acute vascular leak (11 of 177 in the pur

145 the purged group and nine of 191 in the non-purged group), and decreased cardiac function (one of 17

146 ight in the purged group and four in the non-purged group).

147 in the purged group vs 145 of 191 in the non-purged group).

148 the purged group and four of 191 in the non-purged group).

149 e purged group and 236 patients from the non-purged group, and 180 patients from the purged group and

150 The binge eating/purging group showed significantly greater activation th

151 gnetite stoichiometries (0.29 < x < 0.50) in purged headspace reactors and unpurged low headspace rea

152 histone deacetylase inhibitors (HDACis) may purge HIV in the latent viral reservoir.

153 to reactivation, raising the possibility of purging HIV-1 by redox modulators without triggering det

154 sing random genomic deletions in CRISPR loci purges immunological controls on long-lived viral sequen

155 r are needed to understand the propensity to purge in the absence of binge eating.

156 a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with h

157 decline in mTEC(high) cell pool size, which purges individual tissue-restricted peripheral self-anti

158 agents (LRAs) with targeted immunotherapy to purge infected cells.

159 flecting potential roles of recombination in purging introgression.

160 ter myeloablative therapy, but the effect of purging is unknown.

161 h the population in beneficial mutations and purge it from deleterious mutations.

162 This Q-tube gas purging kit assisted-protocol features safe due to easy

163 nd loci are critical, and negative selection-purging large-effect mutations in these regions-leaves b

164 However, the development of HDACI to purge latent HIV-1 requires knowledge of the HDAC isofor

165 n of a combinatorial therapeutic approach to purge latent HIV-1.

166 ectively blocks viral replication but cannot purge latent provirus.

167 ly as part of a "shock-and-kill" strategy to purge latent reservoirs of HIV.

168 CR pathways can be dissected and utilized to purge latent virus.

169 h deleterious mutations are more efficiently purged later during HIV infection when the larger effect

170 Cl 13 infection in TLR7(+/+) mice failed to purge LCMV Cl 13 infection in TLR7(-/-) mice, demonstrat

171 MHC I could be therapeutically corrected, we purged LCMV carrier mice of their persistent infection u

172 tion in solid tumors, including nitrogen gas-purged lysis buffer, the addition of proteasome inhibito

173 ories of strong versus weak sexual selection purge mutation load and resist extinction differently.

174 REGRES) and performed genetic backcrosses to purge mutations not required for Cit(+) from an evolved

175 diting is believed to play the major role in purging newly formed B cell compartments of autoreactivi

176 (500 muL) with high sensitivity, no need for purging, no added oxidant, and a limit of detection of 5

177 ntercellular competition) can delay aging by purging nonfunctioning cells.

178 te (>/=3.0 L) to severe (>/=5.0 L) diarrheal purge, occurred in 39 of 66 (59.1%) placebo controls but

179 otherapy (N=34) had stopped binge eating and purging (odds ratio=13.40, 95% confidence interval [CI]=

180 hotherapy group had stopped binge eating and purging (odds ratio=4.34, 95% CI=1.33-14.21; p=0.02).

181 This treatment was equivalent to a purge of nitrogen used to remove oxygen and thus minimis

182 n the thymus, the T lymphocyte repertoire is purged of a substantial portion of highly self-reactive

183 rated hydrocarbons, the ion source should be purged of air to remove nitrogen and water and fill it w

184 CD34-selected PBSCs and a defined dose of TM purged of CD45RA+ TN.

185 ynthesis pathway in Saccharomyces cerevisiae purged of its endogenous glycogen-metabolic enzymes.

186 gococcal vaccines may be more efficacious if purged of subversive immunogens such as H.8.

187 tions were responsible for the enigmatic ice purges of the last ice age.

188 In particular, the purging of autoreactive T cells and the development of i

189 es how sublethal antibiotics can trigger the purging of bacteria by the zebrafish.

190 hydrogenation can be greatly accelerated by purging of CO(2) or trapping with nucleophilic secondary

191 d sets of loci by outcrossing, the efficient purging of deleterious recessive alleles with selfing an

192 g NK cells was evident, suggesting selective purging of dividing cells.

193 n and gene-rich regions, consistent with the purging of foreign alleles more tightly linked to incomp

194 ultaneous fixation of beneficial alleles and purging of genetic load.

195 ole for this sensor of genomic stress in the purging of genetically compromised CNS cells, we find th

196 However, purging of immature and mature self-reactive T and B cel

197 ulations, we evaluate the effects of genetic purging of inbreeding load in small populations, assumin

198 As complementation delays the purging of less-fit mutations, coinfection may be detrim

199 Immunomagnetic purging of PBSC for autologous stem-cell transplantation

200 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

201 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

202 ous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from

203 of minimal residual disease through in-vivo purging of stem cells may translate into more durable re

204 ystems of pinch valves and suction pumps for purging of sweat as a reset mechanism to coincide with h

205 ature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN)

206 resistance to CDC, probably by facilitating purging of the C5b-9 complexes by endocytosis and exo-ve

207 s simplex virus thymidine kinase), to enable purging of the cells when desired, and a bioluminescence

208 Third, some purging of the deleterious recessive alleles that underp

209 g a stirred aqueous solution with continuous purging of the headspace above the solution.

210 ction of remission involved selective T-cell purging of the pancreas and draining pancreatic lymph no

211 pted for transmission spectroscopy in vacuum-purged optics, we show that minute spectral shifts induc

212 ystem (in a 1:1 ratio) to receive either non-purged or immunomagnetically purged PBSC.

213 al (OS) was not improved by either rituximab purging or maintenance.

214 Infrequent binge eating or purging or overeating without a loss of control were rep

215 prove outcome, perhaps because of incomplete purging or residual tumour in patients.

216 uctural purposes, because they have not been purged out by evolution, but at the same time they put p

217 eleterious mutations have been ineffectively purged, owing to limited recombination in the cassava ge

218 signed using a factorial design to rituximab purging (P+; 375 mg/m(2) once per week for 4 weeks) or o

219 y reseed the viral reservoirs it is meant to purge, particularly under conditions of suboptimal drug

220 ed to treatment: 243 patients to receive non-purged PBSC and 243 to received purged PBSC.

221 Non-purged PBSC are acceptable for support of myeloablative

222 eive either non-purged or immunomagnetically purged PBSC.

223 receive non-purged PBSC and 243 to received purged PBSC.

224 For purging, PBSC were mixed with carbonyl iron and phagocyt

225 erapies to reanimate the immune response and purge persistent viruses have been largely unsuccessful.

226 ed under different storage conditions (argon purging, pH variation) using Conjugated Dienes and Thiob

227 ed enzyme-based oxygen scavenging systems or purging procedures.

228 t cause gene expression changes appear to be purged rapidly by purifying selection.

229 not occur when groups reproduced via a cheat-purging regime.

230 Then, efficacy of purging (removal of CD138(-)20(+) and CD138(+) cells) wa

231 erived HSC must be characterized, methods to purge residual teratoma-forming cells from differentiate

232 xpression while obviating a cleanup phase to purge residual traces of vector.

233 These peptidic arrays are used to purge self-reactive T cells, thereby averting autoimmuni

234 lays a fundamental and unanticipated role in purging self-reactive immature and transitional B cells

235 en unable to purge the mutation burden; such purging should be a key target in future cassava breedin

236 dly neutralizing antibodies in HIV-reservoir-purging strategies.

237 ed to assess the in vivo efficacy of latency-purging strategies.

238 vant in vivo models that can be used to test purging strategies.

239 Here we report a sequential purging strategy targeting mature and immature clonogeni

240 We used our ex vivo purging strategy to treat frozen aphereses from 16 patie

241 is of anorexia nervosa (restricting or binge-purging subtype) and a demonstrated history of chronicit

242 Purifying selection is thought to purge TE insertions from the genome, and TE sequences ar

243 was more effective in relieving binging and purging than psychoanalytic psychotherapy and was genera

244 tness correlations facilitate stress-induced purging that increases the average fitness of survivors

245 n and cross-presentation by dendritic cells, purge the developing T cell repertoire of autoimmune spe

246 Clinical strategies aim to purge the latent CD4+ T cell reservoir by activating vir

247 Efforts to purge the latent reservoir have focused on reactivating

248 d immune surveillance strategies designed to purge the latent viral reservoir.

249 e heterozygous state but have been unable to purge the mutation burden; such purging should be a key

250 les in regulating anti-DNA B cells: it helps purge the peripheral repertoire of autoreactive cells, y

251 r ability to produce antiviral cytokines and purge the persistent infection.

252 ill permitting the antiviral memory cells to purge the persistent infection.

253 tency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent virus in restin

254 therapeutic antiviral T cells can completely purge the persistently infected brain without causing bl

255 ly, slow-dividing stem cells proliferate and purge the population of the fast-dividing - older - cell

256 cess against freshly disaggregated tumors to purge the repertoire, in combination with in vivo biopan

257 might help the field identify strategies to purge the reservoir in vivo When used wisely, in vitro m

258 likely require novel clinical approaches to purge the reservoir of latently infected cells from a pa

259 To purge the reservoir, pharmacological reactivation of lat

260 erance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones.

261 roaches both to curtail CMV infection and to purge the virus from organ transplants.

262 lowing the population bottleneck has largely purged the ancient polymorphisms from the current popula

263 all on millennial climate perturbations that purged the deep sea of sequestered carbon dioxide via a

264 ChaC1(CtoS) purged the ER of glutathione eliciting the expected kine

265 ns aimed at modulating immune activation and purging the HIV reservoir.

266 ellular miRNAs could be a novel approach for purging the HIV-1 reservoir.

267 l reservoir is one of the major obstacles in purging the immune system of HIV.

268 Current approaches to purging the latent reservoir involve pharmacologic induc

269 need to be answered to adopt strategies for purging the latent viral reservoirs.

270 n to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cel

271 frequencies that decreased upon irradiation, purging the population of subclonal variants.

272 the disease, modified by the anti-FcmuR CAR, purged their autologous CLL cells in vitro without reduc

273 perience, suggesting that selection acted to purge these regions of archaic alleles that disrupted th

274 he development of strategies to activate and purge these reservoirs.

275 A major therapeutic challenge is to purge this reservoir.

276 to critical value, [Formula: see text], the purging threshold, which approximately equals the mean f

277 idirectional transcription and over time are purged through mutation or retained to enable new functi

278 Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit h

279 Acid is added, and the WOR is purged to measure dissolved CO(2) or inorganic carbonate

280 ia nervosa or anorexia nervosa, binge eating/purging type);14 with anorexia nervosa, restricting type

281 g of stress affects ID and the potential for purging using inbred and outbred Drosophila melanogaster

282 n of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematic

283 We test the purge valve in the production of polyhydroxybutyryl biop

284 Here we design a simple purge valve module for maintaining NADP(+)/NADPH balance

285 The molecular purge valve provides a step towards developing continuou

286 IV that needs to be eliminated to completely purge virus from antiretroviral drug-treated patients.

287 The memory cells purged virus from the periphery as well as the CNS, but

288 However, some focal evidence of allele purging was detected including a suggestive QTL for litt

289 tigation-derived waste (IDW; development and purge water from monitoring wells) obtained from 13 diff

290 Self-reported binge eating and/or purging were used to indicate presence of DEB.

291 analyses (1606 AN restricting; 1445 AN binge-purge) were performed.

292 in ID are consistent with intragenerational purging, whereas for abiotic stressors, there appeared t

293 itness recovery is due to 'intragenerational purging' whereby fitness correlations facilitate stress-

294 he nonpurgeable DBPs enriched with SPE after purging, while contributions of both fractions to bacter

295 Analysis of aqueous morpholine solutions purged with different gas-phase NO and NO(2) concentrati

296 (-1) when the measurement cell was sealed or purged with filtered air, relative standard deviations >

297 reaction is accelerated when the solution is purged with O2 gas at 1 atm.

298 emoved from the aqueous reaction mixture via purging with an inert gas, allowing for the preparation

299 ppa(1)-N(O)SR), which reversibly loses NO on purging with an inert gas.

300 ffered from low efficiencies while requiring purging with inert gases, use of additives, and irradiat