ライフサイエンスコーパス: purging

1 iation due to classically theorized 'genetic purging'.

2 dependent 'curative' mechanisms (i.e. viral purging).

3 om Monitor, for binge eating with or without purging.

4 ar menstrual cycles, without binge eating or purging.

5 th self-induced vomiting as the sole form of purging.

6 ee survival if the graft has undergone tumor purging.

7 viors-binge eating, dietary restriction, and purging.

8 mphasis on the emerging technique of in vivo purging.

9 th complete abstinence from binge eating and purging.

10 ing novel conditioning regimens or by tumour purging.

11 ive procedure to achieve complete tumor cell purging.

12 , most engaged in recurrent binge eating and purging.

13 total body irradiation and bone marrow (BM) purging.

14 onoamine activity when they are bingeing and purging.

15 onset of extreme dieting, binge eating, and purging.

16 eful for cancer gene therapy and bone marrow purging.

17 ing new approach towards ex vivo bone marrow purging.

18 cells were detectable by PCR after TALL-104 purging.

19 f positive stem cell selection as a means of purging.

20 effects in homozygosis allowing for genetic purging.

21 ic process of infection, endogenization, and purging.

22 utations and leading to their more efficient purging.

23 reaction selectivity with and without CO(2) purging.

24 lera is distinct, with pronounced diarrhoeal purging.

25 n, and consequently their escape from thymic purging.

26 ccupant was reduced by 39-43% with scheduled purging 1-2 times per day.

27 In contrast to purging, 10-year progression-free survival (PFS) was 48%

28 After 8H9-based purging, a 2- to 3-log reduction in contaminating Ewing'

29 may also benefit populations by efficiently purging accumulated damage and rejuvenating newborn cell

30 hances the effectiveness of population-level purging across generations.

31 t multimutated HSV-1 vector, as a biological purging agent for breast cancer in the setting of stem c

32 iller T-cell line (TALL-104) as a new marrow purging agent in a clinical setting.

33 ons for the use of shiga toxin as an ex vivo purging agent in autologous stem cell transplantation.

34 ther explored for their potential as ex vivo purging agents of autologous hematopoietic stem cell tra

35 r deleterious alleles but was ineffective in purging alleles with minor fitness effects and did not a

36 cal strategies including gene therapy, tumor purging and graft engineering.

37 of 10(5) CFU, 8 of 10 volunteers experienced purging and had a positive stool culture for V. cholerae

38 reflect overdominance, potentially reducing purging and increasing allele persistence probability.

39 at EVs and exosomes could play a role in the purging and intercellular transfer of excess free RNAs,

40 provides a tool to evaluate modifications of purging and stem cell collection procedures that may be

41 there appeared to be an interaction between purging and stress-induced physiological damage.

42 , which show interesting patterns of genomic purging and the Hill-Robertson interference.

43 le preparation, eliminating preconcentration/purging and/or water management steps.

44 ater reductions in symptoms of binge eating, purging, and eating disorders compared with standard car

45 before and after ex vivo immunomagnetic bead purging, and results were compared to immunocytological

46 pplications such as gene therapy, tumor cell purging, and stem cell transplantation.

47 sed between the restricting and binge eating/purging anorexia nervosa subtypes over time; one-third c

48 Inbreeding depression and genetic purging are important processes shaping the survivabilit

49 ver, suggesting that the fitness benefits of purging are rarely appreciable.

50 mary symptoms, out-of-control overeating and purging, are poorly understood.

51 In a tumor purging assay, in which tumor:bone marrow cell mixtures

52 rk, thus disabling an essential platform for purging autoreactive T cells from the repertoire.

53 , we report a novel alternative approach for purging autoreactive T cells that spares beneficial immu

54 The change in inbreeding depression due to purging averaged across the 119 populations is <1%, howe

55 es for stem cell transplantation, tumor cell purging before autologous transplantation, and ex vivo c

56 consolidation therapy as a method of in vivo purging before marrow collection.

57 efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatm

58 take without the presence of binge-eating or purging behavior.

59 een female adolescents with binge eating and purging behaviors (i.e., bulimia nervosa or anorexia ner

60 inued to engage in recurrent binge eating or purging behaviors (incidence rate, 0.026 cases per perso

61 shes among individuals with binge eating and purging behaviors.

62 current episodes of binge eating but without purging behaviors.

63 nd chronicity); the same outcomes related to purging, binge eating and body weight status; as well as

64 rs in cancer gene therapy as a mechanism for purging bone marrow cells of possible breast cancer cont

65 we conclude that methods aimed at enhancing purging by intentional inbreeding should not be generall

66 ucture and the outcomes of genetic drift and purging by sequencing the genomes of 429 bull kelp (Nere

67 A cutoff point based on reduction of purging by session 6 usefully differentiates patients wh

68 killing by ganciclovir can be exploited for purging cancer cells from hematopoietic stem cell popula

69 ns regarding clinical efficacy of ODN marrow purging cannot be drawn from this small pilot study.

70 n captive breeding programmes and shows that purging cannot be relied upon to remove deleterious alle

71 tes and product isolation can be overcome by purging CO(2) from the system.

72 eters (purged inbreeding, and opportunity of purging coefficients).

73 These results demonstrate a new approach for purging contaminated cellular products of Ewing's sarcom

74 or a compromise between these strategies and purging could be beneficial in the long term.

75 ting cell-intrinsic immunity, in addition to purging CSCs.

76 een proposed that this could be exploited in purging deleterious alleles from threatened inbred popul

77 cause natural selection is less efficient at purging deleterious alleles that are only expressed late

78 ign of epistasis can speed up the process of purging deleterious mutations in eukaryotic organisms.

79 opulations via de novo variants, possibly by purging deleterious mutations or by revealing fitness be

80 tion of organisms to new environments and in purging deleterious mutations.

81 ectiveness of lateral gene transfer (LGT) at purging deleterious mutations.

82 leviating effects of clonal interference and purging deleterious mutations.

83 tion and genomic breeding of clonal crops by purging deleterious variants while integrating beneficia

84 ed triplet-state pathways using Cs(+) and Ar purging demonstrated that 6PPDQ does not decompose signi

85 A designed adsorption-purging-desorption system based upon Cu@FAU is establish

86 Smart purging devices, which purge only after a certain period

87 Risk reductions achieved by purging devices, which reduce water age, were also quant

88 rvosa (BN), binge eating disorder (BED), and purging disorder (PD).

89 partial- or full-criteria bulimia nervosa or purging disorder and 2.9% had partial or full-criteria b

90 significantly elevated in participants with purging disorder and bulimia nervosa compared with contr

91 Future studies on the psychobiology of purging disorder are needed to understand the propensity

92 Participants with purging disorder demonstrated significantly greater post

93 wever, more data are needed to determine how purging disorder differs from bulimia nervosa.

94 Findings support further consideration of purging disorder for inclusion in the classification of

95 Purging disorder is a clinically significant disorder of

96 Participants with purging disorder reported significantly greater postpran

97 Recent data suggest that purging disorder, a recently characterized form of eatin

98 nation of low weight and multiple methods of purging distinguishes among individuals with binge eatin

99 llele frequencies; i.e., there is no genetic purging during the experiment.

100 extrinsic manner by infiltrating phagocytes purging dying cells.

101 have an unexpected anti-tumorigenic role in purging early tumours through cell competition, thereby

102 ze of PAVs and fitness advantages due to the purging effect of gene loss.

103 , consistent with the hypothesized diversity-purging effects of an evolutionarily recent Wolbachia sw

104 Assessment of purging efficacy with additional samples from NB patient

105 Our results show that genetic purging efficiently removes the inbreeding load of both

106 However, purging endogenous 24,25-dihydrolanosterol, lanosterol,

107 Pretransplantation rituximab in vivo purging, even in rituximab-naive patients, failed to imp

108 e transporters are likely involved, possibly purging excess metabolites as part of homeostasis.

109 ction (PCR) for bcl2/IgH rearrangement after purging experienced longer freedom from recurrence than

110 ion system has been demonstrated with a tank-purging experiment and has been directly compared with a

111 ilation air (VA) flow rate, temperature, and purging fluids.

112 However, despite dilution and purging for the damaging mutation load in Southern India

113 Similarly, purging frequency in the previous 28 days declined from

114 late oxygen concentration via the control of purging gas flow.

115 nt with sex and meiosis being mechanisms for purging genomic parasites.

116 The binge eating/purging group showed significantly greater activation th

117 term culture-initiating cells suggested that purging had been accomplished at a primitive cell level

118 al clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm

119 to reactivation, raising the possibility of purging HIV-1 by redox modulators without triggering det

120 There may be a benefit to graft purging in autologous transplantation.

121 t these patterns reflect stronger, long-term purging in smaller-island populations.

122 a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with h

123 onal consideration of antibody-based in vivo purging in subsequent clinical trials.

124 Additional gene purging included mitochondrial BCAA aminotransferase (BC

125 flecting potential roles of recombination in purging introgression.

126 However, detecting purging is challenging in practice, in part because ther

127 No purging is detected in Ammotragus lervia (N(e) = 4), in

128 9) where, due to the larger population size, purging is slower and detection is expected to require m

129 ter myeloablative therapy, but the effect of purging is unknown.

130 This Q-tube gas purging kit assisted-protocol features safe due to easy

131 nd loci are critical, and negative selection-purging large-effect mutations in these regions-leaves b

132 These results suggest that purging latent cells from infected individuals on highly

133 t merits consideration as a new strategy for purging latent HIV proviruses from their cellular reserv

134 nervosa with the use of multiple methods of purging; LC3, restricting AN without obsessive-compulsiv

135 may contribute to lymphoma relapse, and that purging may be beneficial for patients undergoing autolo

136 the use of monoclonal antibodies as in vivo purging mechanisms and nonmyeloablative and radioimmunoc

137 s to develop a viral-directed enzyme prodrug purging method that specifically targets neuroblastoma c

138 Therefore, effective purging methods are needed.

139 Current purging methods are useful when fewer than 1% tumor cell

140 ic cells, it overcomes a limitation of other purging methods that result in delayed reconstitution of

141 Different purging methods to obtain sources of stem cells free of

142 After purging, Myb mRNA levels declined substantially in appro

143 diting is believed to play the major role in purging newly formed B cell compartments of autoreactivi

144 (500 muL) with high sensitivity, no need for purging, no added oxidant, and a limit of detection of 5

145 After ex vivo purging, none of the BM cells was immunocytology-positiv

146 ntercellular competition) can delay aging by purging nonfunctioning cells.

147 g-term recovery (>1 year with no bingeing or purging, normal weight, and regular menstrual cycles) fr

148 otherapy (N=34) had stopped binge eating and purging (odds ratio=13.40, 95% confidence interval [CI]=

149 hotherapy group had stopped binge eating and purging (odds ratio=4.34, 95% CI=1.33-14.21; p=0.02).

150 onality impairment, thus contributing to the purging of archaic introgression in YARS2.

151 In particular, the purging of autoreactive T cells and the development of i

152 We analysed data on the purging of B cells by use of antibodies in the setting o

153 es how sublethal antibiotics can trigger the purging of bacteria by the zebrafish.

154 ion of the inbreeding depression and genetic purging of biological fitness in pedigreed populations.

155 n of hematological malignancies, and ex vivo purging of cancer cells in autologous transplantation.

156 and effective approach for the detection and purging of carcinoma cells in hematopoietic stem cell pr

157 Receptor editing contributed to the purging of cells displaying anti-GPI BCRs, and significa

158 a promising technology for rapid tumor cell purging of clinical progenitor cell preparations.

159 Therefore, 8H9-based purging of clinical samples is predicted to reduce tumor

160 hydrogenation can be greatly accelerated by purging of CO(2) or trapping with nucleophilic secondary

161 The results suggest that the purging of deleterious alleles has had some influence on

162 le population, despite genomic signatures of purging of deleterious alleles via natural selection.

163 compensation can effectively counteract the purging of deleterious alleles within consanguineous pop

164 happened in all populations, consistent with purging of deleterious load.

165 ng without compromising the benefits of past purging of deleterious mutations.

166 d sets of loci by outcrossing, the efficient purging of deleterious recessive alleles with selfing an

167 g NK cells was evident, suggesting selective purging of dividing cells.

168 n and gene-rich regions, consistent with the purging of foreign alleles more tightly linked to incomp

169 n of modern birds (Neoaves) has entailed the purging of genes including SLC3A2, SLC7A5, -7, -8, -10,

170 ultaneous fixation of beneficial alleles and purging of genetic load.

171 ole for this sensor of genomic stress in the purging of genetically compromised CNS cells, we find th

172 oss-of-function mutation load, likely due to purging of highly deleterious recessive mutations.

173 vant cell separation problems, including the purging of human breast cancer cells from normal T-lymph

174 However, purging of immature and mature self-reactive T and B cel

175 parameter more relevant to selection and the purging of inbreeding depression than previous measures.

176 ulations, we evaluate the effects of genetic purging of inbreeding load in small populations, assumin

177 find that the bundling effect increases the purging of introgressed DNA by between 1.2-fold (in a ba

178 poor outcome was predicted by a reduction in purging of less than 70% by treatment session 6, allowin

179 As complementation delays the purging of less-fit mutations, coinfection may be detrim

180 c NK cells was an effective means of ex vivo purging of leukemia-contaminated bone marrow and that th

181 ctor WT1 is an ideal target for CTL-mediated purging of leukemic progenitor cells in vitro and for an

182 concerted evolution with the acquisition and purging of lineage-specific pseudogenes.

183 apse), the source of stem cells, and whether purging of malignant cells from autologous stem cells is

184 Immunomagnetic purging of PBSC for autologous stem-cell transplantation

185 Analyses of genetic load reveal the purging of potentially high-effect insertion/deletion (i

186 raphic history on levels of accumulation and purging of putatively deleterious mutations that likely

187 n together, our findings are consistent with purging of recessive non-synonymous mutations exposed to

188 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

189 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

190 Arabidopsis suggest frequent integration and purging of retrotransposons within the TR regions of cen

191 ous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from

192 of minimal residual disease through in-vivo purging of stem cells may translate into more durable re

193 ystems of pinch valves and suction pumps for purging of sweat as a reset mechanism to coincide with h

194 ature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN)

195 With this technique, rigorous physical purging of the bowel was not necessary before structural

196 resistance to CDC, probably by facilitating purging of the C5b-9 complexes by endocytosis and exo-ve

197 s simplex virus thymidine kinase), to enable purging of the cells when desired, and a bioluminescence

198 Third, some purging of the deleterious recessive alleles that underp

199 g a stirred aqueous solution with continuous purging of the headspace above the solution.

200 d, yet their gradual decline resulted in the purging of the most deleterious genetic variation.

201 ction of remission involved selective T-cell purging of the pancreas and draining pancreatic lymph no

202 With Argon purging of the sulfoxide sample before photolysis, the m

203 Purging of tumor cells and selection of stem cells are k

204 , better ablative regimens, more efficacious purging of tumor cells from autografts, and enhancement

205 Thus, in this approach, purging of tumor cells from the graft is key to the prev

206 Lymph node purging of tumor cells was possible even in virus-immune

207 to dilute selection, which would inhibit the purging of variation and prevent the emergence of an opt

208 ic induction, achieved either by neutral gas purging or by sulfur deprivation of the cultures.

209 al (OS) was not improved by either rituximab purging or maintenance.

210 Infrequent binge eating or purging or overeating without a loss of control were rep

211 prove outcome, perhaps because of incomplete purging or residual tumour in patients.

212 signed using a factorial design to rituximab purging (P+; 375 mg/m(2) once per week for 4 weeks) or o

213 ncestral inbreeding coefficients) as well as purging parameters (purged inbreeding, and opportunity o

214 For purging, PBSC were mixed with carbonyl iron and phagocyt

215 ed under different storage conditions (argon purging, pH variation) using Conjugated Dienes and Thiob

216 immune privilege of the anterior chamber by purging potential inflammatory cells.

217 ne, and is in agreement with the theoretical purging predictions.

218 ed enzyme-based oxygen scavenging systems or purging procedures.

219 Treatment with photodynamic cell purging process (PDP) inhibited antihost responses measu

220 nd other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy

221 In contrast, the purging protocol did not affect the number or type of co

222 Improved marrow purging protocols are needed in autologous bone marrow t

223 developed diarrhea but with a lower average purging rate than required for the model.

224 e evolution of male haploidy by facilitating purging recessive deleterious mutations.

225 Genetic purging reduces inbreeding depression by removing these

226 not occur when groups reproduced via a cheat-purging regime.

227 Then, efficacy of purging (removal of CD138(-)20(+) and CD138(+) cells) wa

228 Also, after "purging," RNA for neuroblastoma cell markers (tyrosine h

229 that the extension is evolving under relaxed purging selection, a pattern inconsistent with the conse

230 application of this approach to bone marrow purging, selective killing of human lymphoma U937 cells

231 lays a fundamental and unanticipated role in purging self-reactive immature and transitional B cells

232 en unable to purge the mutation burden; such purging should be a key target in future cassava breedin

233 , suggesting the existence of mechanisms for purging some such errors.

234 A subsequent purging step was employed to remove contaminating WBCs t

235 ized operational sequences incorporating gas purging steps, rinses, and HV application.

236 l of the TALL-104 cell line in future marrow purging strategies against lysis-susceptible and -resist

237 Purging strategies that are able to remove these contami

238 dly neutralizing antibodies in HIV-reservoir-purging strategies.

239 ed to assess the in vivo efficacy of latency-purging strategies.

240 vant in vivo models that can be used to test purging strategies.

241 Here we report a sequential purging strategy targeting mature and immature clonogeni

242 We used our ex vivo purging strategy to treat frozen aphereses from 16 patie

243 is of anorexia nervosa (restricting or binge-purging subtype) and a demonstrated history of chronicit

244 individuals (i.e., anorexia nervosa bingeing/purging subtype; AN-BP).

245 inbreeding, alongside high levels of genetic purging, suggests adaptation to this long-term low N(e)

246 A modified gas-purging technique was used for the determination of Henr

247 was more effective in relieving binging and purging than psychoanalytic psychotherapy and was genera

248 tness correlations facilitate stress-induced purging that increases the average fitness of survivors

249 r species that should be ascribed to genetic purging, that is, to the increased opportunities of sele

250 Thus, by purging the acetate primer units that otherwise dominate

251 ns aimed at modulating immune activation and purging the HIV reservoir.

252 ellular miRNAs could be a novel approach for purging the HIV-1 reservoir.

253 l reservoir is one of the major obstacles in purging the immune system of HIV.

254 Current approaches to purging the latent reservoir involve pharmacologic induc

255 need to be answered to adopt strategies for purging the latent viral reservoirs.

256 filaggrin through passage 10 were induced by purging the monolayer cultures of growth factors, then a

257 n to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cel

258 frequencies that decreased upon irradiation, purging the population of subclonal variants.

259 iting, apoptosis and anergy in normal mice - purging the repertoire of autoreactive cells.

260 ur study is that ML approaches are better at purging the sampling space from deleterious mutations.

261 solution between normal atmosphere and after purging the solution with nitrogen gas.

262 igands lacking the thioether group, however, purging the solutions of the thioether-containing adduct

263 , in terms of survival benefit, the value of purging, the presence of graft-versus-leukemia effect, a

264 stratification by risk factors, the value of purging, the role of radiotherapy after transplantation,

265 to the actual population size tend to reduce purging, the search for a compromise between these strat

266 rs, allowing to contextualize inbreeding and purging these results in terms of the population demogra

267 to critical value, [Formula: see text], the purging threshold, which approximately equals the mean f

268 bing solution, volume of combustion igniter, purging time with oxygen, and the use of successive comb

269 th complete abstinence from binge eating and purging to cognitive behavioral therapy.

270 g's sarcoma was shown by real-time PCR, with purging to PCR negativity at levels of contamination of

271 stem cell harvests use positive selection or purging to provide a product that will engraft only norm

272 photodynamic action is a novel approach for purging tumor cells from autologous remission bone marro

273 ia nervosa or anorexia nervosa, binge eating/purging type);14 with anorexia nervosa, restricting type

274 who met DSM-IV criteria for bulimia nervosa, purging type, were assigned to single-blind treatment wi

275 nce on the evolutionary relevance of genetic purging under certain demographic conditions.

276 reement with the notion that drift overcomes purging under fast inbreeding, nor in G. dorcas (N(e) =

277 ion of the inbreeding load can be removed by purging under slow inbreeding in moderately large popula

278 g of stress affects ID and the potential for purging using inbred and outbred Drosophila melanogaster

279 n of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematic

280 scence nitric oxide analyzer with a standard purging vessel.

281 Purging was accomplished using immunomagnetic-based depl

282 Among low-grade NHL patients, the use of purging was associated with significantly better disease

283 However, some focal evidence of allele purging was detected including a suggestive QTL for litt

284 in 14 populations and a significant trend of purging was found across populations.

285 Purging was found to be significant in 14 populations an

286 No in vitro purging was used.

287 he evolution of inbreeding depression (i.e., purging), we need quantitative genetic interpretations o

288 Self-reported binge eating and/or purging were used to indicate presence of DEB.

289 osa (they had no episodes of binge eating or purging, were at normal weight, and had regular menstrua

290 in ID are consistent with intragenerational purging, whereas for abiotic stressors, there appeared t

291 itness recovery is due to 'intragenerational purging' whereby fitness correlations facilitate stress-

292 he nonpurgeable DBPs enriched with SPE after purging, while contributions of both fractions to bacter

293 emoved from the aqueous reaction mixture via purging with an inert gas, allowing for the preparation

294 ppa(1)-N(O)SR), which reversibly loses NO on purging with an inert gas.

295 mpletely reversible when CO(2) is removed by purging with argon.

296 ll malignancies, we found that immunological purging with complement-mediated lysis eradicated PCR-de

297 ffered from low efficiencies while requiring purging with inert gases, use of additives, and irradiat

298 , investigational strategies such as in vivo purging with rituximab and the use of radioimmunotherapy

299 irst complete remission, the role of in vivo purging with rituximab, the utility of radioimmunotherap

300 f 10(6) CFU, 14 of 15 volunteers experienced purging, with a geometric mean stool volume of 5,621 g.