ライフサイエンスコーパス: pustular

1 EGFR/MEK inhibitor-induced rashes are often pustular and folliculocentric, this mechanism provides j

2 Treatment with spesolimab led to more rapid pustular and skin clearance versus treatment with placeb

3 ements of two distinct mat types (smooth and pustular) at a millimeter scale were undertaken in the p

4 eceptor antibody, resulted in rapid skin and pustular clearance in patients presenting with GPP flare

5 We describe a case of pustular dermatitis in a 15-year-old girl who had just r

6 rom the Poxviridae family, causes contagious pustular dermatitis in small ruminants.

7 nfection, immunobullous disorders, and other pustular dermatoses were considered.

8 Erosive pustular dermatosis (EPD) is a rare condition that typic

9 Erosive pustular dermatosis of the scalp (EPDS) is an inflammato

10 Vesicular and pustular disorders are common in the neonatal period.

11 enter with localized erythema, swelling, and pustular drainage at the right neck incision site approx

12 e reported localized erythema, swelling, and pustular drainage at the right neck incision site.

13 r psoriasis, acute generalized exanthematous pustular eruption), whereas hypomorphic mutations were i

14 llopeau, and acute generalized exanthematous pustular eruption.

15 ts are frequently asked to see patients with pustular eruptions caused by EGFR mAbs or tyrosine kinas

16 derlie the pathogenesis of psoriasis-related pustular eruptions including generalized pustular psoria

17 y affects smokers and manifests with painful pustular eruptions on the palms and soles.

18 pecific types of psoriasis flares, including pustular, erythrodermic, and worsening plaque stage psor

19 By investigating pustular forms of psoriasis, we show that human neutroph

20 everal phenotypes and research has separated pustular from chronic plaque forms.

21 ochemical properties of two mats (smooth and pustular) from Shark Bay, Australia.

22 inoculation or when they developed a painful pustular lesion (days 7-14).

23 were biopsied after they developed a painful pustular lesion or were followed until disease resolved.

24 The pustular lesion was characterized by blister at the lowe

25 ion observed histopathologically and for the pustular lesions observed clinically.

26 laboratory confirmation of vaccinia virus in pustular lesions of a healthy adult vaccinee by use of a

27 Pustular mats were enriched with Halobacteria and Parvar

28 archaeal community structures of smooth and pustular mats were significantly different (global R = 1

29 d was up to seven-fold higher in smooth than pustular mats.

30 re up to four times higher in smooth than in pustular mats.

31 proteobacteria dominated the lower layers of pustular mats.

32 cussed: erythema toxicum, transient neonatal pustular melanosis, miliaria, neonatal acne, eosinophili

33 uous pustular pavements that extend >10 m2 ("pustular"), nonlaminated and nonnucleated masses with pe

34 lmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, de

35 inically difficult to differentiate from non-pustular palmoplantar psoriasis (palmPP) and dyshidrotic

36 ucleating center ("domed-plate"), continuous pustular pavements that extend >10 m2 ("pustular"), nonl

37 PPP, and AGEP, which is consistent with the pustular phenotypes.

38 er disease alleles in one subject with acral pustular psoriasis (c.2031-2A>C;c.2031-2A>C) and in two

39 arities, the distinction between generalized pustular psoriasis (GPP) and acute generalized exanthema

40 e studies, little is known about generalized pustular psoriasis (GPP) flares.

41 lonal antibody approved to treat generalised pustular psoriasis (GPP) flares.

42 analysis of 105 individuals with generalized pustular psoriasis (GPP) identified a low-frequency vari

43 Generalized pustular psoriasis (GPP) is a chronic, orphan disease wi

44 Generalized pustular psoriasis (GPP) is a rare and yet potentially l

45 Generalized pustular psoriasis (GPP) is a severe multi-systemic infl

46 Generalized pustular psoriasis (GPP) is a severe subtype of psoriasi

47 Generalized pustular psoriasis (GPP) lacks internationally accepted

48 itially focused our attention on generalized pustular psoriasis (GPP), a clinical variant associated

49 ere, we focused our attention on generalized pustular psoriasis (GPP), a potentially life-threatening

50 resembled acute exacerbations of generalised pustular psoriasis (GPP), a rare form of psoriasis that

51 severe, psoriasis-like disorder, generalized pustular psoriasis (GPP), is linked to loss-of-function

52 is of 3 pustular skin disorders: generalized pustular psoriasis (GPP), palmoplantar pustulosis (PPP),

53 IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations at

54 key role in the pathogenesis of generalized pustular psoriasis (GPP).

55 =159), erythrodermic psoriasis (n=23), acral pustular psoriasis (n=100), or sporadic PRP (n=29).

56 ndent effect on age of onset in all forms of pustular psoriasis (P = .003).

57 Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar

58 ris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmopla

59 zes several human cutaneous diseases such as pustular psoriasis and acute generalized exanthematous p

60 These findings identify pustular psoriasis as an autoinflammatory phenotype caus

61 Although generalized pustular psoriasis can be treated with IL-36R inhibitors

62 ysis of CARD14 mutations could help stratify pustular psoriasis cohorts but would be mostly uninforma

63 s and 6.50 (95% CI, 4.60-9.23; P < .001) for pustular psoriasis compared with conventional treatment.

64 y, in patients presenting with a generalized pustular psoriasis flare.

65 hroderma) among all flares reported, with no pustular psoriasis flares identified (0.07%; 95% CI, 0.0

66 athologic events associated with generalized pustular psoriasis flares.

67 The term pustular psoriasis indicates a group of severe skin diso

68 Generalized pustular psoriasis is a potentially life-threatening ski

69 Generalized pustular psoriasis is a rare, chronic disease without st

70 Generalized pustular psoriasis is a severe psoriatic subtype charact

71 Generalized pustular psoriasis is a severe skin disease characterize

72 nal definition established was, "Generalized Pustular Psoriasis is a systemic inflammatory disease ch

73 Pustular psoriasis is an inflammatory skin disease with

74 on, especially loss-of-function mutations in pustular psoriasis subtypes.

75 y of these genetic mutations in familial and pustular psoriasis suggests new links between cytokine-i

76 cterize the clinical and genetic features of pustular psoriasis through the analysis of an extended p

77 Generalized pustular psoriasis von Zumbusch type (GPP) is the most s

78 not the case when patients with palmoplantar pustular psoriasis were not included in the analysis.

79 ls was elevated in patients with generalized pustular psoriasis with disease-contributing variants co

80 will show their contribution to generalized pustular psoriasis's pathogenesis and indicate whether f

81 s issue by investigating the pathogenesis of pustular psoriasis, a model of autoinflammatory disorder

82 generalized pustular psoriasis, palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau

83 e identified in both localized (palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau

84 with severe clinical phenotypes (generalized pustular psoriasis, acute generalized exanthematous pust

85 In pustular psoriasis, neutrophil-derived IL-26 drives the

86 ted pustular eruptions including generalized pustular psoriasis, palmoplantar pustular psoriasis, acr

87 effector cells were increased in generalized pustular psoriasis, whereas the frequencies of naive CD4

88 d a self-sustaining autoinflammation loop in pustular psoriasis.

89 Mendelian hair and skin disorders, including pustular psoriasis.

90 fsX29) in patients with familial generalized pustular psoriasis.

91 lso implicated CARD14 in the pathogenesis of pustular psoriasis.

92 vere autoinflammatory skin disorder known as pustular psoriasis.

93 hild with sporadic, early-onset, generalized pustular psoriasis.

94 ype of psoriasis, nonpustular psoriasis, and pustular psoriasis.

95 ustular psoriasis, and 909 patient-years for pustular psoriasis.

96 c.425A>G [p.Glu142Gly]) and the generalized-pustular-psoriasis mutation, c.413A>C (p.Glu138Ala); the

97 AAND-recurrent episodes of maculopapular and pustular rash, gastrointestinal involvement resembling i

98 ease in which the main clinical features are pustular rash, marked osteopenia, lytic bone lesions, re

99 difficult to distinguish smallpox from other pustular rashes by description alone.

100 Together, the irregular micritic grains from pustular sheet mats and gelatinous pavement mats make up

101 in unlithified to weakly lithified microbial pustular sheet mats, which erode to release irregular pe

102 The molecular basis of most pustular skin conditions has remained unknown.

103 ngs identify MPO as a genetic determinant of pustular skin disease and neutrophil abundance.

104 Pustular skin disorders are a category of difficult-to-t

105 Transcriptomic changes in 3 pustular skin disorders, GPP, PPP, and AGEP, converged o

106 ught to investigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis

107 unimmunized animals developed more than 500 pustular skin lesions and became gravely ill or died, wh

108 He later developed cyclical fevers, diffuse pustular skin lesions, and thrombus formation.

109 itor," combined with the terms "psoriasis," "pustular," "skin," "rash," and "palmoplantar." All relev

110 Thus, experimental infection to the pustular stage of disease does not provide protective im

111 on with neutrophils and in the dermis at the pustular stage of disease in the human model of infectio

112 s seen as early as 48 h and persisted at the pustular stage of disease.

113 the ability of H. ducreyi to progress to the pustular stage of disease.

114 the ability of H. ducreyi to progress to the pustular stage of disease.

115 n experimental infection with 35000HP to the pustular stage of disease.

116 ucreyi recruits CD4 cells to the skin at the pustular stage of disease.

117 with wild-type H. ducreyi progressed to the pustular stage, compared to 0 of 30 sites inoculated wit

118 . ducreyi replicates between the papular and pustular stages of disease.

119 ANTES was present throughout the papular and pustular stages of experimental infection, but not prese

120 oriasis constituted the most events, whereas pustular types of psoriasis had the highest relative ris

121 psoriasis increased for both nonpustular and pustular types of psoriasis in TFNi-treated patients, th

122 dermis of psoriasis patients, especially the pustular variants resistant to treatments.