ライフサイエンスコーパス: putative

1 The Arabidopsis DMR6 gene encodes a putative 2-oxoglutarate Fe(II)-dependent oxygenase (2OGO

2 ta imply a new function for TWD1 acting as a putative activator of ABCB-mediated auxin transport by c

3 a total synthesis of (-)-myrocin G (4), the putative active form of the metabolite myrocin C (1), th

4 Loss- and gain-of-function mutations of the putative active site residues correspondingly altered co

5 l segments and a hydrophobic interface, with putative active sites within the membrane region.

6 tory dynamics and functional significance of putative aging-related heterogeneity are also unknown.

7 in, sesamin, fargesin, and delta-sanshool as putative agonists of PPARG, along with previously identi

8 Our finding points to putative allostatic changes that affect the functioning

9 Our data also suggest the presence of a putative allosteric substrate-binding site in a hydropho

10 Cross-coupling of the putative alpha-amino radical with nitrosopyridine leads

11 ns, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78.

12 phase and thus limited larval dispersal) and putative anthropogenic transport of specimens.

13 ch mass spectrometry revealed Drebrin as the putative antigen.

14 The presence of fox genes tracks with a putative antioxidant OsmC family peroxiredoxin, an indic

15 ly and slow-moving, making identification of putative ASD risk genes with existing data vital.

16 20, and treatment failure, n = 20), showing putative association of polymorphisms rs13900(C/T) and r

17 We provide evidence of these putative associations retrieved from the DNN model with

18 synaptic and perisynaptic GluD1 labeling at putative axo-dendritic and axo-spinous glutamatergic syn

19 nome-assembled genomes we identified over 90 putative bacterial and archaeal genomic families and nea

20 ogues are encoded in previously unidentified putative bacterial exopolysaccharide biosynthetic operon

21 hondrial genome complexity and might cause a putative barcoding paradox across 81 plant species.

22 , while caloric restriction and fasting have putative benefits for disease prevention and longevity.

23 stabilizing the receptor inactive state, the putative binding site of Mg(2+) on the MOP receptor, as

24 we found that overexpressed RUNX1 could bind putative binding sites in the HSV-1 genome, repress nume

25 ity prediction and applies it to uncover the putative bioactivity of food compounds.

26 uman cancer RNA-Seq, where we identify novel putative biomarker genes in different tumors, and microa

27 uced translational approach identified novel putative biomarkers for early pancreatic islet aberratio

28 We identified subsets of putative biomarkers for proliferation and involution as

29 ion and involution as well as a small set of putative biomarkers for propranolol's mechanism of actio

30 bosomal protein subunit RPS11, 16, and 18 as putative biomarkers for response to TOP2 poisons.

31 icle screening technique (DEST), we measured putative biomarkers of malignancy (MUC1, MUC2, MUC4, MUC

32 Our work provides a comprehensive set of putative biomarkers that advance understanding of PARPi

33 tive social bacterium, Myxococcus xanthus, a putative C-terminal sorting tag (MYXO-CTERM) is predicte

34 In entorhinal cortex layer 2, putative CA1-projecting pyramidal cells, but not putativ

35 The putative CAM-specific genes were predominantly involved

36 enomics studies have identified thousands of putative cancer driver genes(1).

37 Eight putative candidate genes were identified for three QTLs

38 G protein-coupled receptor (GPR) 55 is a putative cannabinoid receptor, and l-alpha-lysophosphati

39 The cytoplasmic domain of BRI1 contains five putative canonical surface-exposed Tyr-based endocytic m

40 dsRNA2 ORF sequence showed homology with the putative capsid proteins (CPs) of mycoviruses.

41 PR3 forms a compact structure built of three putative carbohydrate-binding modules (M1, M2 and LysM3)

42 donovani heat shock protein 78 (LdHSP78), a putative caseinolytic protease, as important for parasit

43 sferase or phosphatase, despite containing a putative catalytic site.

44 of the Collaborative Cross mice to identify putative causal genes that contribute to the risk of fra

45 It highlighted putative causal pathways to diabetes mediated by BMI for

46 tion and fine-mapping of that locus reveal a putative causal variant in a cardiac muscle specific reg

47 SNP in the second intron of the CDH1, as the putative causal variant.

48 eral clinical subtypes, pathogenic genes and putative causative environmental agents.

49 Each such group of cells corresponds to a putative cell type or state, characterized by the featur

50 es a droplet formation model to authenticate putative cell types discovered from a scRNA-seq dataset.

51 a method for the automated identification of putative cell types from single-cell RNA sequencing (scR

52 aled more than 100 clusters corresponding to putative cell types.

53 l immunofluorescence analyses and evaluating putative cell-cell communication based on spatial proxim

54 ion of a new phage, carrying gene encoding a putative cell-surface protein.

55 Brain regions populated with putative cells of origin for glioma, neural stem cells a

56 Identification of putative centromeres in closely related Candida sojae, C

57 in-dependent motor, myosin XI (a,b), and the putative chitin receptor Lyk5 (a,b,c).

58 Removing the putative client-binding loop altered the secondary struc

59 es of traumatic encephalopathy syndrome, the putative clinical syndrome associated with chronic traum

60 ified the Clp complex composition as well as putative Clp substrates.

61 Putative clusters were identified using maximum-likeliho

62 ng algorithms, such as MB versus MF RL, with putative cognitive processes.

63 ithin the vocal motor nucleus (VMN), forming putative contacts on those cells.

64 sed to provide a better understanding of the putative correlates of protection against EBOV.

65 lts evaluate novel biomarkers of EpSCC and a putative correlation between the expression of biomarker

66 on-mediated gene replacement resulted in two putative CpRbp1-null mutants and genotype analyses ident

67 xpression clustering, we identified over 100 putative CREs (pCREs) that predicted -Fe-induced gene ex

68 complex patterns of ancestral admixture and putative-damaging and novel variation, both within and b

69 o evaluate the burden of rare variants in 56 putative DCM genes in 1040 patients with DCM and 912 hea

70 Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deac

71 mputationally predict a diverse set of other putative defense genes that remain to be characterized.

72 ed a computational framework for identifying putative deleterious germline variants (pDGVs) from WES

73 tive CA1-projecting pyramidal cells, but not putative dentate gyrus/CA3-projecting stellate cells, re

74 ce has cast doubt on the validity of several putative dependencies that are currently being targeted

75 alpha-hydroxylation of C(19)-GAs and harbors putative desaturating activity of C(20)-GAs.

76 Use of the LIPS assay to identify putative "diagnostic" proteins would be a valuable asset

77 Mutations of CXCR4 residues located at a putative dimerization interface result in monomerization

78 indings were recently challenged by a failed putative direct replication attempt [M.

79 Approximately 60% of patients carry a putative disease-causing genetic variant, but interpreta

80 of genetically correlated traits to identify putative disorder-specific SNP associations.

81 number variation of TdDof, a gene encoding a putative DNA binding with one finger protein, controls t

82 hat leads to structural reorientation of the putative DNA-binding surface and extends the substrate-b

83 he human condensin II complex, revealing two putative DNA-entrapment sites.

84 sing local optogenetic excitations to oppose putative DNQX-induced inhibitions.

85 ructural analysis revealed that 3 of these 6 putative dominant negative missense variants localized t

86 ice showed that many VTA neurons, among them putative dopamine neurons, are excited by footshocks, an

87 ses reveal a functional organization wherein putative dorsal areas show specialization for visual mot

88 lective modulation of SST interneurons and a putative downstream circuit mechanism as an effective me

89 f TNBC subtypes and exhibit a diverse set of putative driver mutations, thus providing a unique patie

90 between vaccine uptake and a large range of putative drivers of uptake, including vaccine confidence

91 n interactomes, that can be used to identify putative drug-target interactions without resorting to 3

92 y, we analyzed the editing patterns of three putative dual-coding genes, ribosomal protein S12 (RPS12

93 m formation correlated with mutations in the putative E. faecium capsular polysaccharide (cps) biosyn

94 Here, we examine a putative ecdysteroid glycosyltransferase, Hba_07292 (Hb-

95 Parkinson's disease risk locus, identifying putative ectopic regulatory interactions in neurons that

96 SNPs were classified based on their putative effect on annotated genes and KOG analysis was

97 owever, it is unknown what might mediate its putative effect on mortality.

98 dentified a subset of sequences representing putative effectors.

99 We aimed to explore the putative effects of inorganic nitrate and nitrite on mit

100 analyses of the PRT data to investigate the putative effects of KOR antagonism on anhedonic behavior

101 sity, larger presynaptic terminals, and more putative efferent filopodial contacts onto inhibitory ne

102 associated with type 2 diabetes overlap with putative endocrine pancreatic enhancers, suggesting that

103 These findings identify a putative endogenous immune signaling axis that drives ne

104 es have shown many variants are found within putative enhancer elements.

105 low Amazon tropical forest: in the Andes, a putative enhancer in HAND2-AS1 (heart and neural crest d

106 nding of TCF/LEF factors to the promoter and putative enhancer regions of CSF3R.

107 cessibility with transcriptomics to identify putative enhancer-gene linkages and transcription factor

108 Myt1 binds putative enhancers of Atf4 and Hsps, whose overexpressio

109 rom backbone cleavages exclusively along the putative epitope regions of HA in the presence of the an

110 This cluster also shows strong homology to a putative ET cluster in human temporal cortex, but with a

111 Adult height is one of the earliest putative examples of polygenic adaptation in humans.

112 with larger synaptic terminals, providing a putative explanation for functional divergence.

113 based molecular sensors for detection of two putative fatty acid receptors, G protein-coupled recepto

114 However, the putative FcgammaR-dependent mechanisms of ADE overlap wi

115 Here, we investigated 19 types of putative feature selective lobula columnar (LC) neurons

116 Several researchers have described putative fracture planes in mesosaur caudal vertebrae -

117 pendium of M. truncatula SSP candidates with putative function and family annotations; (2) a large-sc

118 Although the putative function of circRNA is through miRNA sponging,

119 gene networks that provide information about putative function.

120 rent metabolites across our samples revealed putative functional connections.

121 The putative functional genes and variants identified could

122 r biochemical pathways, here we examined the putative functional relationship between Coq10 and Coq11

123 es of genetic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5' and

124 Most putative G/U base pairs were experimentally supported by

125 he deep mutational scan scores identified 40 putative gain-of-function and 33 putative loss-of-functi

126 A number of deletion alleles, as well as a putative gain-of-function mutant, of PEZO-1 caused a sev

127 s, one of which at Asn-126 was adjacent to a putative GalNAc transfer motif.

128 most other organisms M. tuberculosis has six putative genes for epoxide hydrolases (EH) of the alpha/

129 ished cancer pathways, and the INCM-inferred putative genetic interactions are correlated with patien

130 study we have identified two genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marinus

131 an immunoreactive antigen that was lost in a putative glycosyltransferase mutant, suggesting that thi

132 undary, enabling growth of neurites over the putative graft/host interface.

133 Here, we demonstrate the existence of a putative high-level face processing network in marmosets

134 Here, we show that the putative HSP-90 co-chaperone CHP-1 acts as a regulator o

135 that encode known (HvCslF6 and HvCslH1) and putative (HvCslF3 and HvCslF9) (1,3;1,4)-beta-glucan syn

136 We exploited putative hypomorphic and EOfAD-like mutations in the zeb

137 A screen for putative IL-10 elicitors revealed that IL-2, IL-4, IL-27

138 epitopes actually dominate viral epitopes in putative immunogenicity and plausibly drive immune respo

139 s were identified, and there was evidence of putative in-home (enrolled siblings) and outpatient clin

140 Two novel and more highly potent putative inhibitors of sChoK, MN58b and RSM-932A, were c

141 connections between neurons, as well as map putative inhibitory and excitatory inputs.

142 rtion), size accuracy, and genotype for 1235 putative insertions and deletions sampled from different

143 Indeed, disrupting the putative interaction between a highly conserved Trp/Glu

144 r way to further define the mechanism of the putative intestinal resistance.

145 lieu-Laroche et al. (2020) describe TACAN, a putative ion channel that mediates mechanical pain in mi

146 , alongside with dihydrodaidzein (DHD) and a putative isomer of DHD.

147 e role of the PD familial genes PTEN-induced putative kinase 1 (PINK1) and parkin (PRKN) in mediating

148 fied and include those encoding PTEN-induced putative kinase 1 (PINK1) and parkin.

149 t encodes a tandem kinase protein (TKP) with putative kinase-pseudokinase domains, designated WHEAT T

150 ng two distinct types in the skin: branched, putative Langerhans cells, and amoeboid cells.

151 cy of methyl salicylate and verbenone to two putative laurel wilt vectors in avocado, Xyleborus volvu

152 oriented perpendicularly to the NBDs and its putative ligand-binding sites face the transporter to li

153 ls and investigated the binding to different putative ligands (acetylated BSA [AcBSA], zymosan, manna

154 cell activity and, therefore, strengthen the putative link between grid cells and behaviour along wit

155 As IDOL is a putative lipid-lowering drug target, we investigated the

156 ve the transcription of the IL10 promoter or putative local enhancer constructs.

157 strate how the timing, size, and duration of putative local transmission chains were constrained by n

158 Putative loci that were coincident with previously repor

159 to exercise caution in the interpretation of putative LoF variants susceptible to induce in-frame spl

160 we identified a micropeptide produced from a putative long noncoding RNA (lncRNAs) that is important

161 Here, by manual curation of putative loss-of-function (pLoF) variants in haploinsuff

162 In addition to autism, individuals with putative loss-of-function variants in DYRK1A exhibit mic

163 ung male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7

164 entified 40 putative gain-of-function and 33 putative loss-of-function variants.

165 binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.

166 METTL4, a putative mammalian methyltransferase, can mediate mtDNA

167 Since SMI-32 antibody is considered to be a putative marker for Y cells forming a motion processing

168 Perceived facial attractiveness, a putative marker of high biological fitness, is costly to

169 -injected mice contained increased levels of putative markers for several inflammatory diseases, whic

170 and B-hydroxybutyrate could be considered as putative markers of inflammation with different pattern

171 than risk scores created using a set of five putative MDD biomarkers, genome-wide SNP data, and 27 cl

172 endent between frequency bands, suggesting a putative mechanism for malleable frequency-specific FC t

173 ntly of PRC1 catalytic activity, providing a putative mechanism for Polycomb target site selection.

174 Putative mechanisms of suboptimal efficacy of DARA inclu

175 al note on the discovery of ketamine and its putative mechanisms.

176 gable small molecules in silico and selected putative MEIS inhibitors (MEISi) with no predicted cytot

177 333.1) consists of a single exon, encoding a putative membrane protein of 127 amino acids.

178 We further showed that the putative membrane-binding domain also affected the nucle

179 or hippocampus granularity during windows of putative memory stabilization was associated with long-t

180 MS based metabolomics approach revealed that putative metabolites other than flavonoids may significa

181 Putative methylators were dominated by hgcA sequences di

182 Here we constructed and validated a putative Michaelis complex in silico and used it to eluc

183 TIMP3 and CPEB3 are putative miR targets in chondrocytes Identification of m

184 TIMP3 and CPEB3 are putative miR targets in chondrocytes.

185 However, the existence and nature of this putative modulation have never been physiologically demo

186 The putative mumiRs were related to other food legumes indic

187 y EPR features akin to those observed in the putative N(2) complex.

188 onomic nervous system function - contain two putative N-glycosylation sites within the large N-termin

189 One of these, the putative NAD(P)H nitroreductase YfkO, has been reported

190 zation, enabling more sensitive discovery of putative neoantigens.

191 vel insights into the genetic substrates and putative neurobiological mechanisms of impulsivity with

192 udy of compassion is burgeoning, however the putative neurophysiological markers of programs which ac

193 non-human primate stroke models, hundreds of putative neuroprotectants have been evaluated in preclin

194 ain containing soluble guanylate cyclases as putative NO/nitrite/nitrate sensors.

195 In this study, we manipulated three putative nuclear localization (NLS1 to -3) and two poten

196 rted by the synthesis and kinetic study of a putative off-cycle Pd complex.

197 al, including Pdx1, Ptf1a and p53, which are putative Ogt targets.

198 notochordal differentiation, TBXT acts as a putative oncogene.

199 riba by merging, filtering, and prioritizing putative oncogenic fusions across large cancer datasets,

200 and its condition-dependent activity uncover putative or recently discovered roles for at least five

201 nd relevant disease models and discuss their putative origin.

202 gene from A. officinalis, AoCYP94B1, and its putative ortholog in Arabidopsis (Arabidopsis thaliana),

203 Putative pacemaker-specific REs were identified up to 1

204 th implications for phenotypic variation and putative paradigms of mammalian epigenetic inheritance.

205 sociates with F-actin and is, along with its putative paralog SINE2, expressed in guard cells.

206 horough dendrophenotypic characterisation of putative parents, we assessed sex-specific relationships

207 tudies to show that the aggregated effect of putative passengers, including undetected weak drivers,

208 scretization of data into networks provide a putative path to predicting emergent shape from underlyi

209 coming more variable at higher layers of the putative pathway, and this variability is largely indepe

210 However, a functional understanding of the putative PC-1/PC-2 polycystin complex is lacking due to

211 targeting signals (PTS1/PTS2) identified 51 putative peroxisomal matrix proteins.

212 trate to the recipient lipid A molecule by a putative 'ping-pong' trade-off.

213 Mutation of the putative PKA phosphorylation sites did not change the in

214 sing speed), clinical disease severity and a putative plasma biomarker of disease activity, making th

215 tuberculosis D. discoideum cells lacking the putative polyphosphate receptor GrlD had reduced sensiti

216 including distinct second hits in SMARCA4, a putative predisposition gene for neuroblastoma.

217 The putative priming loop that is important for the initiati

218 Mechanistically, we identified PTEN as a putative PRL2 substrate and demonstrated that PRL2 down-

219 and interferon signaling, and it upregulates putative pro-viral genes (e.g., DYNLL1 and HSPA5), nomin

220 The distinct characteristics of these putative processes suggest dissociable underlying mechan

221 ciation between maize and Dyella japonica, a putative producer abundant in crop microbiomes.

222 hybridum (genome composition DDSS), and its putative progenitors, Brachypodium distachyon (DD) and B

223 ed the induction of antibody responses and a putative protective signature.

224 We demonstrate that this putative protein kinase undergoes autophosphorylation on

225 in ligase FBXW7 ensures stabilization of its putative protein substrate IFN-gamma receptor 1 (IFNGR1)

226 Genes encoding putative pseudoalterin-like proteins are found in many o

227 adult female mice to monitor the activity of putative pyramidal and inhibitory neurons located in dee

228 emotherapy, and the use of TRT with known or putative radiosensitizers such as poly(adenosine diphosp

229 simulations showing that the lifetime of the putative reactive NO(2) dimer on the surface of pure wat

230 ese heterobivalent ligands interact with the putative receptor complex.

231 the molecular interaction of BTNL2 with its putative receptor could provide strategies to restore im

232 intracellular concentrations of Cygb and its putative reducing systems and examined their roles in th

233 tic clusters, the presence of genes encoding putative reductive dehalogenases throughout the phylum e

234 of the mutant DISC1 model and understand the putative regional properties of astrocyte DISC1, we asse

235 Putative regulators described here add information to th

236 uction and highlights the genomic context of putative regulators of cyanobacterial sigma factors.

237 ing multiple GRNs within a species to detect putative regulators of important plant pathways and prov

238 DGKepsilon lacks a putative regulatory domain and has recently been reporte

239 testing using tissue- or cell-type-specific putative regulatory information.

240 loci and identify novel genes by determining putative regulatory regions for these and other tissues

241 The putative representation of skin folds coincides with blo

242 genomic data from one of the last remaining putative representatives of the Tupi coastal branch, a s

243 ricle-like cells and identified thousands of putative REs specific for either human cell type.

244 new compounds that can potentially mitigate putative resistance in target species and declines of no

245 Being a putative ribosyltransferase, the catalytic activity of H

246 Available treatments target the putative risk factors of pregnancy loss, although the ef

247 teracts with glycosylated proteins and has a putative role in facilitating viral infection.

248 B, its conformational fluctuations and their putative role in function are largely unknown.

249 ently localizes to mitochondria suggesting a putative role in mitochondrial metabolism.

250 ment of a functional renal system, and has a putative role in the pathogenesis of Hirschsprung diseas

251 sition of the tumor microenvironment and its putative role in tumorigenesis.

252 in humans), is potently obesogenic and plays putative roles governing certain evolutionary behaviours

253 We coexpressed the putative SBP genes (oppA1(Ct) , oppA2(Ct) , oppA3(Ct) )

254 r with an associated eip locus which encodes putative secreted ETT2 effectors as well as eilA, a gene

255 to the symbiosis plasmids, with mutations in putative signaling genes.

256 Furthermore, putative single-cell oscillators in the SFO and OVLT are

257 mplexes in a membrane environment, revealing putative sites for conformational switching.

258 Using this motif, we identified over 70 putative SNX-BAR ligands, many of which play critical ro

259 xymethylcytosine and overlap with subsets of putative somatic enhancers that are methylated in ESCs a

260 n economically important insect Asia II 7, a putative species of the Bemisia tabaci whitefly complex

261 ylation element-binding (CPEB) protein, is a putative substrate of long-lasting memories.

262 the HMPREF0389_00796 gene that encodes for a putative superoxide reductase (SOR) enzyme.

263 synaptic machinery immunostaining can define putative synaptic connections between neurons, as well a

264 nvolved in volatile detection) and HmGr56 (a putative synephrine-related receptor) emerge as strong c

265 We have recently reported that the putative T. gondii CGL gene encodes a functional enzyme.

266 ually opposite genomic signatures, and their putative target genes play an important role regulating

267 gulatory elements (cCREs) and linked them to putative target genes.

268 monstrate that eRNAs can be used to identify putative target genes.

269 Foxf2 occupancy at many of these putative target loci, including Fgf18, in the developing

270 98, but this had no obvious effects on their putative target mRNA levels.

271 g neurons in the ventrolateral thalamus, and putative target of DMFC in the caudate.

272 miRNA target site Selection) that can screen putative target sites of miRNA-target binding.

273 ylation proteomics strategy, we identify 200 putative targets of LC3-dependent secretion.

274 atasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cel

275 uding more than a dozen E3 ligases and their putative targets.

276 R 6 are regulated by TCP15 and often contain putative TCP recognition motifs in their promoters.

277 stimuli and analysis techniques, that these putative temporal processing deficits are not apparent i

278 nce, we identify new therapeutic targets and putative therapeutic approaches aimed at resolving detri

279 This study demonstrates the putative therapeutic interest of the administration of A

280 ferior to doxorubicin, rendering pazopanib a putative therapeutic option in the first-line treatment

281 eral blood precursor datasets identified two putative thymus seeding progenitors that varied in expre

282 covered, by documenting its biogeography and putative tissue tropism.

283 rePAAR, a conserved motif found in over 6000 putative TMD-containing effectors encoded predominantly

284 iption factor MYB125 (Potri.003G114100) as a putative trans-regulator of the majority of genes in the

285 quantify donor strain, EcoFJ1(pRP4-gfp), and putative transconjugants over time.

286 S-CoV-2 infection outcome, the data point to putative transcriptional genetic markers of susceptibili

287 effectors as well as eilA, a gene encoding a putative transcriptional regulator of ETT2 associated ge

288 ERF12 is a putative transcriptional repressor and genetically oppos

289 layed-rectifier (DR) potassium currents, two putative transcriptional targets of Foxp2, were not affe

290 ar to most members of MFS, PIC30 contains 12 putative transmembrane domains, and PIC30-GFP fusion pro

291 t adaptive emerging sequences tend to encode putative transmembrane domains, and that thymine-rich in

292 therapeutic potential of this factor in the putative treatment of inflammatory and autoimmune disord

293 at also contains genes predicted to encode a putative tripartite tricarboxylate transporter (TTT).

294 We validate the clinical relevance of new putative tumor suppressors by showing these are frequent

295 Putative tumor-promoting genes and lncRNAs defined using

296 protein-drug-disease links and evidence that putative viral interaction partners such as MARK3 affect

297 Putative virulence factors in K. aerogenes may account f

298 le genome sequencing revealed differences in putative virulence genes encoding aggregative adherence

299 s unique to K. aerogenes isolates, including putative virulence genes involved in iron acquisition (n

300 are consistent with the hypothesis that the putative zymogens of many trypsin-like proteases are act