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1 inhibitors (IC(50)s decrease 10-20-fold with putrescine).
2 oline and citrulline, and polyamines such as putrescine.
3 cued in culture by the addition of exogenous putrescine.
4 c activity and concentration of its product, putrescine.
5 d slightly decreased levels of intracellular putrescine.
6 ogether synthesize rhizoferrin without using putrescine.
7 increase in synthesis of polyamines such as putrescine.
8 etyl-3-aminopropanaldehyde and spermidine or putrescine.
9 ells was inhibited by high concentrations of putrescine.
10 ese acidic residues modulates the effects of putrescine.
11 hibition by high exogenous concentrations of putrescine.
12 ecause it was prevented by administration of putrescine.
13 involved in the conversion of agmatine into putrescine.
14 i by the short-chain diamines cadaverine and putrescine.
15 defect were only observed with the polyamine putrescine.
16 esence of alpha-difluoromethylornithine plus putrescine.
17 which was reversed by addition of exogenous putrescine.
18 he lowest measured concentration of 1mg/L of putrescine.
19 in xylem even when plants were treated with putrescine.
20 onversion of spermidine and spermine back to putrescine.
21 n plant foods by the external application of putrescine.
22 , leucine, spermidine, and spermine, but not putrescine.
23 acid (0.1-7.5), cis-ChA (1.1-2.2), caffeoyl putrescine (0.6-2.5), sinapoyl hexose (0.1-1.8), N(1),N(
25 e (2.9-fold), N-acetylputrescine (1.8-fold), putrescine (2.7-fold) and cadaverine (28-fold), which de
28 duct of putrescine catabolism and shows that putrescine accumulates in puuA, puuB, and puuC mutants b
29 novo and therefore obligatorily relies upon putrescine acquisition from the host to meet its nutriti
30 the putrescine binding site, suggesting that putrescine activates the enzyme through electrostatic ef
31 f the enzyme, congruent with the role of the putrescine activator of the mammalian AdoMet decarboxyla
32 hown to encode a hydroxycinnamoyl-coenzyme A:putrescine acyltransferase responsible for caffeoylputre
38 contributing factors include high levels of putrescine and acetylated polyamines, a 50% reduction in
42 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential class of meta
43 h-affinity transporters that recognized both putrescine and cadaverine but not spermidine or spermine
46 ved in the presence of the reaction products putrescine and cadaverine to 1.7 and 2.15A, respectively
47 were detected in the 300MPa treatments, but putrescine and cadaverine were detected in the control a
50 nly carried by two small aliphatic diamines, putrescine and cadaverine, which are generated by bacter
54 a, CO2, and ATP while converting agmatine to putrescine and is proposed to augment the acid resistanc
55 ulation of the GP pathway shows induction by putrescine and not by a product of putrescine catabolism
56 al, but not plasma, levels of the polyamines putrescine and spermidine as well as the collagen breakd
57 of hydroxycinnamic acids and two polyamines, putrescine and spermidine, is regulated by this transcri
58 1 to be a high affinity transporter for both putrescine and spermidine, whereas expression of LmPOT1
60 utants were expressed and dialyzed to remove putrescine and studied biochemically using X-ray crystal
61 al structure of the mutants with and without putrescine and their complexes with S-adenosylmethionine
62 ermented with caraway (and concentrations of putrescine and tryptamine in the sauerkraut fermented wi
63 ine) when compared to FD (from 1mgkg(-1) for putrescine and tyramine to 4mgkg(-1) for histamine); MS/
64 gmatine serves as the precursor compound for putrescine (and hence spermidine and spermine), which wa
65 els of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens, and risk of CR
66 up-regulation of polyamines (spermidine and putrescine) and potassium may mitigate oxidative stress
70 ine, tyramine, phenylethylamine, tryptamine, putrescine, and cadaverine) and two polyamines (spermidi
73 d levels of dephosphocoenzyme A, spermidine, putrescine, and phosphatidylethanolamines and elevated a
75 es and enzymes from the GABA-glutamate, GABA-putrescine, and the glyoxylate pathways significantly in
76 tly decreased the levels of inosine, lysine, putrescine, and xanthine at the gingivitis sites as earl
77 s of DFMO, RS1-Reg mutants, the ODC1 product putrescine, and/or glucose on SGLT1 expressed in oocytes
81 access to host spermidine pools, while host putrescine appears to be unavailable for salvage by the
82 ggest that polyamine metabolism and secreted putrescine are linked to host cell adherence and cytotox
85 level of biofilm correlated to the level of putrescine as measured by high-performance liquid chroma
93 d was observed, with histamine, tyramine and putrescine being the most abundant in Pignoletto wines.
95 e residues that link the active site and the putrescine binding site, suggesting that putrescine acti
96 sible for the majority of the activity ([14C]putrescine-binding assay) in whole brain and liver homog
98 vidence for coupling between residues in the putrescine-binding site and the active site, consistent
99 suggests that this inhibitor binds both the putrescine-binding site and the active site, providing e
102 the active site, providing evidence that the putrescine-binding site of the T. cruzi enzyme has broad
105 at swarming in response to the cues required putrescine biosynthesis and pathways involved in amino a
106 n TRV-infected plants and that impairment of putrescine biosynthesis promoted virus multiplication.
108 or L. pneumophila, Francisella species lack putrescine biosynthetic pathways because of genomic deca
110 osed of two citric acid residues linked by a putrescine bridge and thus is identical in structure to
111 tic enzyme ornithine decarboxylase, depleted putrescine but did not produce synergistic cell killing.
112 The oxidative deamination of methylated putrescine by a diamine oxidase activity (DAO) is an imp
113 of the triamine spermidine from the diamine putrescine by fusion enzymes from beta-proteobacterium D
115 riamide-44 partially inhibited the uptake of putrescine by PlaP and decreased both putrescine stimula
117 nopropyl group donor to form spermidine from putrescine by the key enzymes S-adenosylmethionine decar
121 e detection of various biogenic amines (i.e. putrescine, cadaverine) and in the monitoring of spoilag
122 ogenic amines (tryptamine, phenylethylamine, putrescine, cadaverine, histamine, serotonine, tyramine,
125 cally active molecules which have aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic
127 (GP) pathway but instead induces genes for a putrescine catabolic pathway that starts with a transami
128 termine if dual control regulates a complete putrescine catabolic pathway, we examined expression of
130 uction by putrescine and not by a product of putrescine catabolism and shows that putrescine accumula
133 from cells resistant to growth inhibition by putrescine compared with transport in inverted vesicles
134 biosensors could be used in determination of putrescine concentration in meat samples but improvement
137 SFM)-II, as well as in a defined serum-free, putrescine-containing medium for at least 9 passages (27
139 Finally, we showed that increments in the putrescine content in TRV-infected plants correlated wit
140 , antioxidant activity, nitrogen, folate and putrescine content were found for small scale beers.
141 d disA, that restored swarming motility to a putrescine-deficient speA mutant of Proteus mirabilis.
143 Extracellular spermine, spermidine, and putrescine directly activated TRPV1 in a charge-dependen
144 yamines that directly modulate ion channels, putrescine exerted its effect by altering the balance of
145 rotozoal parasite Trypanosoma cruzi requires putrescine for maximal enzyme activity, but not for proc
149 n does not induce genes of this glutamylated putrescine (GP) pathway but instead induces genes for a
150 on of flagellar rotation and accumulation of putrescine have been proposed to be sensory mechanisms.
151 factory receptors that detect cadaverine and putrescine have not been identified in any species so fa
153 significantly correlated with their sum were putrescine, histamine and tyramine, even if reached leve
154 yramine was the prevalent amine, followed by putrescine, histamine, phenylethylamine and cadaverine.
155 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, phenylethylamine, cadav
156 a macrocyclic dimer of N-hydroxy-N-succinyl-putrescine (HSP) and is structurally related to desferri
161 transporter capable of exporting the diamine putrescine in the Chinese hamster ovary (CHO) cells sele
163 g enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in
165 found that spermidine remained unchanged and putrescine increased by 2.5-fold after 15 h and then dec
171 ediated by an atypical pathway that converts putrescine into GABA, which then activates presynaptic G
175 n animal cells and indicate that the diamine putrescine is exported by an arginine transporter contai
176 yamines avidly, with a marked preference for putrescine (Kd=10 nM) over spermidine (Kd=430 nM), but t
177 tor substrate, especially for spermidine and putrescine (Km values of 33 mum and 3.9 mm, respectively
179 These findings suggest that spermidine and putrescine levels could be useful markers of postoperati
181 We observed that decreasing ODC activity and putrescine levels in Tsc2-RG mice worsened many of the n
182 4-hydroxytamoxifen (4OHT), ODC activity and putrescine levels were dramatically increased in the epi
183 putrescine-treated plants, so the exogenous putrescine likely accelerated disease indirectly by affe
184 e underlying type of infection, showing that putrescine, lysoPCaC18:0 and SM C16:1 are associated wit
185 addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule.
189 the JA-responsive genes is NtPMT1a, encoding putrescine N-methyl transferase, a key regulatory enzyme
191 ed transcription of NtPMT1a, a gene encoding putrescine N-methyltransferase, the first committed step
194 of ornithine or micromolar concentrations of putrescine or by complementation with either glycosomal
197 matic oxidation to 4-aminobutyraldehyde with putrescine oxidase or diamine oxidase as catalysts.
199 with greatly reduced levels of intracellular putrescine, plaP was required for the putrescine-depende
201 ic mice, prostatic N(1)-acetylspermidine and putrescine pools were remarkably increased relative to T
203 etabolic routes rose upon desiccation, while putrescine, proline and a variety of sugars rose in wint
204 roxyproline, glycine, leucine+isoleucine and putrescine proved to be useful for differentiating Canno
205 pauA5 was found to be inducible by diamines putrescine (PUT) and cadaverine (CAD) but not by diamino
206 rations increased with time, tyramine (TYR), putrescine (PUT) and cadaverine (CAD) were the most abun
208 e-harvest foliar spraying of grapevines with putrescine (Put) and spermidine (Spd) (0, 1, 2mM) was ev
209 mended with a single PA model compound, i.e. putrescine (PUT) or spermidine (SPD), or with no additio
212 Organic broccoli showed higher levels of putrescine (Put), and cooking resulted in lowering the o
213 d by B. dendrobatidis SPD and its precursor, putrescine (PUT), are the major polyamines detected, and
214 polyamines, including diaminopropane (DAP), putrescine (Put), cadaverine (Cad), and spermidine (Spd)
215 amines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemical investigation of th
216 Copper amine oxidases oxidize the polyamine putrescine (Put), producing an aldehyde, ammonia, and hy
217 studies have involved three biogenic amines: putrescine (Put), spermidine (Spd) and spermine (Spm), a
219 se and racemase coupled with SpuC, the major putrescine-pyruvate transaminase, were key components to
223 ted cells in media devoid of l-ornithine and putrescine, resulting in mixed populations stably expres
227 pplication of two polyamines, Spermidine and Putrescine (SPD-PUT), was tested in multiple combination
229 Oaz1, regulates synthesis of the polyamines putrescine, spermidine and spermine by controlling stabi
232 to the sequential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and sperm
237 ompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutant infloresc
238 n processes, with intracellular depletion of putrescine, spermidine, and spermine resulting in cellul
239 e studied the ability of natural polyamines (putrescine, spermidine, and spermine) and a series of th
244 ferase (vPAT), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine p
245 Thus, interactions of natural polyamines (putrescine, spermidine, spermine) and polyamine-like pot
246 d) because of the following: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not
249 es (cadaverine, histamine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamin
250 ake of putrescine by PlaP and decreased both putrescine stimulated swarming and urothelial cell invas
254 e identified residues that are important for putrescine stimulation of activity (F7 and T245), while
255 nteract with the distal primary amine in the putrescine substrate as well as the internal and distal
257 Serum-free media for CHO-K1 cells require putrescine supplementation, because these cells lack the
258 We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarbox
259 egrade arginine and ornithine, precursors of putrescine synthesis, are activated by either regulators
261 ffect of increased ODC activity and elevated putrescine that modify the phenotype in this development
263 t was grown in the presence of extracellular putrescine, the intracellular levels of putrescine were
267 fects of DFMO were reversible with exogenous putrescine, thus indicating that they are specifically m
268 tive Cdk5 abolishes the ability of dbcAMP or putrescine to enhance neurite outgrowth in the presence
269 speC mutant required >/= 15 microM exogenous putrescine to grow and could not grow alone in xylem eve
272 synthase (SPDSYN), the enzyme that converts putrescine to spermidine, was created by double-targeted
274 ndent sets of enzymes can completely degrade putrescine to succinate and that their relative importan
278 Interestingly, ATP13A3 complemented the putrescine transport deficiency and MGBG resistance of C
280 em putrescine concentration was unchanged in putrescine-treated plants, so the exogenous putrescine l
282 ing short hairpin RNA, caused an increase in putrescine uptake and a decrease in arginine uptake acti
284 n of LmPOT1 in Trypanosoma brucei stimulated putrescine uptake that was sensitive to inhibition by pe
288 capable of robust growth only when exogenous putrescine was supplied in the culture medium, confirmin
291 erformance of the two polyamines (spermidine/putrescine) was enhanced by ratio with CSF Abeta42 (ROC
293 inine catabolites citrulline, ornithine, and putrescine were detected in supernatants, indicating act
294 ular putrescine, the intracellular levels of putrescine were greatly reduced compared with the speA m
296 spermidine and diamine oxidase specific for putrescine, were co-immobilized onto a novel chitosan/co
297 the levels of the polyamines, spermidine and putrescine, were found to be increased which is an indic
298 ed at average concentrations <10mg/L, except putrescine which reached 20.5 +/- 10.2mg/L in Cannonau w
299 he aguBA operon that metabolizes agmatine to putrescine, which can be subsequently converted into oth
300 monas aeruginosa in response to agmatine and putrescine with an emphasis in polyamine catabolism.