ライフサイエンスコーパス: pyridoxal

1 In S. enterica, 2AA inactivates a number of pyridoxal 5'-phosephate(PLP)-dependent enzymes, some of

2 antile spasms (onset 5 months) responsive to pyridoxal 5'-phosphate (n = 1); and (iii) patients with

3 s with neonatal onset seizures responding to pyridoxal 5'-phosphate (n = 6); (ii) a patient with infa

4 sample preparation procedure for quantifying pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4PA)

5 In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enz

6 aeruginosa PAO1 in complex with the cofactor pyridoxal 5'-phosphate (PLP) and product UDP-GlcNAc(3NH(

7 corated with the vitamin B(6) cofactors like pyridoxal 5'-phosphate (PLP) and pyridoxal (Py) by formi

8 Pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phospha

9 ian HAD phosphatase known to dephosphorylate pyridoxal 5'-phosphate (PLP) and serine/threonine-phosph

10 Low plasma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transpl

11 In this study, we characterized the pyridoxal 5'-phosphate (PLP) biosynthesis pathway in Str

12 CBS contains a pyridoxal 5'-phosphate (PLP) cofactor which catalyzes th

13 no longer makes a Schiff base linkage to the pyridoxal 5'-phosphate (PLP) cofactor, and instead the c

14 tion from an adenosylcobalamin (AdoCbl) to a pyridoxal 5'-phosphate (PLP) cofactor.

15 bstrate on the internal aldimine form of the pyridoxal 5'-phosphate (PLP) cofactor.

16 PNPO activity was quantified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS bef

17 decreased erythrocyte PDXK activity and low pyridoxal 5'-phosphate (PLP) concentrations.

18 BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase,

19 DDC is a pyridoxal 5'-phosphate (PLP) dependent enzyme.

20 Both of these enzymes are pyridoxal 5'-phosphate (PLP) dependent, and their three-

21 CBS uses coenzyme pyridoxal 5'-phosphate (PLP) for catalysis, and S-adenos

22 le-enzyme biosynthetic pathway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-ph

23 sma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with r

24 ired for synthesis of the essential cofactor pyridoxal 5'-phosphate (PLP) in Escherichia coli Surpris

25 Vitamin B-6 status is routinely measured as pyridoxal 5'-phosphate (PLP) in plasma.

26 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunc

27 nic modulation in aspartate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor f

28 ine and erythrocytes, and among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

29 Pyridoxal 5'-phosphate (PLP) is the active vitamer of vi

30 tonation and H-bonded states of the cofactor pyridoxal 5'-phosphate (PLP) linked as an internal aldim

31 uced during the regeneration of the cofactor pyridoxal 5'-phosphate (PLP) of OAT by an unamplified mo

32 , the dimeric SufS protein uses the cofactor pyridoxal 5'-phosphate (PLP) to abstract sulfur from fre

33 semialdehyde with concomitant conversion of pyridoxal 5'-phosphate (PLP) to pyridoxamine 5'-phosphat

34 t was formed from SADTA covalently linked to pyridoxal 5'-phosphate (PLP) while the other adduct was

35 The enzyme activity was dependent on pyridoxal 5'-phosphate (PLP), and C18-S-ACP was the pref

36 en plasma folate, vitamin B-6 in the form of pyridoxal 5'-phosphate (PLP), and total B-12 with serum

37 The most common status marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammat

38 s in vitamin B(6) salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vit

39 Pyridoxal 5'-phosphate (PLP), the active form of vitamin

40 me in converting dietary vitamin B6 (VB6) to pyridoxal 5'-phosphate (PLP), the biologically active fo

41 In Escherichia coli, the synthesis of pyridoxal 5'-phosphate (PLP), the catalytically active f

42 ogy of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B

43 and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the major active form of v

44 An insufficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form

45 YggS/Ybl036c/PLPBP family includes conserved pyridoxal 5'-phosphate (PLP)-binding proteins that play

46 lix DNA-binding domain and a long C-terminal pyridoxal 5'-phosphate (PLP)-binding putative aminotrans

47 A) accumulates and inactivates at least some pyridoxal 5'-phosphate (PLP)-containing enzymes in Salmo

48 due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

49 rst step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible re

50 Radiation of the plant pyridoxal 5'-phosphate (PLP)-dependent aromatic l-amino

51 Pyridoxal 5'-phosphate (PLP)-dependent basic amino acid

52 S cluster assembly complex is a low-activity pyridoxal 5'-phosphate (PLP)-dependent cysteine desulfur

53 eme-synthesizing organisms, results from the pyridoxal 5'-phosphate (PLP)-dependent enzymatic condens

54 h features a two-enzyme catalytic cascade, a pyridoxal 5'-phosphate (PLP)-dependent enzyme (Fub7), an

55 Glycine decarboxylase, or P-protein, is a pyridoxal 5'-phosphate (PLP)-dependent enzyme in one-car

56 thionine beta-synthase (CBS) is an essential pyridoxal 5'-phosphate (PLP)-dependent enzyme of the tra

57 Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

58 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

59 butyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degra

60 ystathionine beta-synthase (CBS) is a unique pyridoxal 5'-phosphate (PLP)-dependent enzyme that has a

61 olevulinate synthase (EC 2.3.1.37) (ALAS), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes

62 rine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present i

63 biotin biosynthesis is performed by BioA, a pyridoxal 5'-phosphate (PLP)-dependent enzyme.

64 Pyridoxal 5'-phosphate (PLP)-dependent enzymes utilize t

65 e and serine to their other chiral form in a pyridoxal 5'-phosphate (PLP)-dependent manner.

66 The pyridoxal 5'-phosphate (PLP)-dependent S-selective trans

67 focused on the dehydration of serine by the pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

68 re generated as mechanistic intermediates of pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

69 Herein it is demonstrated that AbmH is a pyridoxal 5'-phosphate (PLP)-dependent transaldolase tha

70 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA

71 ct distribution generated upon reaction with pyridoxal 5'-phosphate (PLP).

72 ms, most notable among which is the cofactor pyridoxal 5'-phosphate (PLP).

73 e kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes.

74 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin

75 valuated the relation between plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active for

76 Pyridoxal 5'-phosphate (PLP; vitamin B(6))-catalyzed rea

77 an essential enzyme (pdxB) in production of pyridoxal 5'-phosphate (the active form of Vitamin B6),

78 ase, an enzyme involved in the catabolism of pyridoxal 5'-phosphate (vitamin B 6).

79 the active form of vitamin B6 (also known as pyridoxal 5'-phosphate [PLP]), in complex with artesunat

80 mutation that prevented covalent binding of pyridoxal 5'-phosphate abolished the ability of DdlR to

81 at the minor allele is destabilized and that pyridoxal 5'-phosphate and aminooxyacetic acid binding s

82 We also examine the effect of known ligands pyridoxal 5'-phosphate and aminooxyacetic acid on stabil

83 involved in binding flavin mononucleotide or pyridoxal 5'-phosphate and many of them showed residual

84 n a novel metabolic pathway for synthesis of pyridoxal 5'-phosphate and the existing metabolic networ

85 The dependence of the enzyme on pyridoxal 5'-phosphate and the production of 3H4P with t

86 smitter gamma-aminobutyric acid (GABA) using pyridoxal 5'-phosphate as a cofactor.

87 for HMP-P biosynthesis as well as the use of pyridoxal 5'-phosphate as a substrate rather than as a c

88 The enzyme activity requires pyridoxal 5'-phosphate but not alpha-keto acid; therefor

89 Cysteine lyase contains haem and pyridoxal 5'-phosphate co-factors and converts cysteine

90 formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and provides a rationale

91 termediates by masking the absorption of the pyridoxal 5'-phosphate cofactor.

92 plays a role in modulating the pK(a) of the pyridoxal 5'-phosphate complexes during catalysis.

93 nobutyric acid aminotransferase (GABA-AT), a pyridoxal 5'-phosphate dependent enzyme, catalyzes the d

94 NSALP substrates inorganic pyrophosphate and pyridoxal 5'-phosphate diminished.

95 beta-synthase (CBS), a novel heme-containing pyridoxal 5'-phosphate enzyme, catalyzes the condensatio

96 the newly discovered enzyme does not require pyridoxal 5'-phosphate for its activity.

97 own genes involved in the salvage pathway of pyridoxal 5'-phosphate in plants.

98 own homologs of the previously characterized pyridoxal 5'-phosphate or pyruvoyl-dependent arginine de

99 Enzymes that utilize the cofactor pyridoxal 5'-phosphate play essential roles in amino aci

100 ional change that releases strain in the Lys pyridoxal 5'-phosphate Schiff base and increases the pK(

101 Along with pyridoxal 5'-phosphate synthases and aryl nitroreductase

102 gher levels of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate than the wild type, reflected in

103 C) impairs binding of the essential cofactor pyridoxal 5'-phosphate to ALAS2, resulting in destabiliz

104 Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many

105 tanx is a product containing L-methylfolate, pyridoxal 5'-phosphate, and methylcobalamin for manageme

106 cysteine, folate and vitamin B6 (active form pyridoxal 5'-phosphate, PLP), we conducted a meta-analys

107 significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyridoxamine 5

108 rspermidine in CANSDC, form a Schiff base to pyridoxal 5'-phosphate, suggesting that the product comp

109 the oxidation of pyridoxine 5'-phosphate to pyridoxal 5'-phosphate, the active cofactor form of vita

110 6 phosphorylation, producing the active form pyridoxal 5'-phosphate, which regulates two key metaboli

111 MP) form of BCATm (PMP-BCATm) but not to the pyridoxal 5'-phosphate-BCATm and other metabolon protein

112 The enzyme is composed of a pyridoxal 5'-phosphate-binding catalytic domain, flanked

113 n the C-terminal domain, catalytic loop, and pyridoxal 5'-phosphate-binding domain that drives struct

114 pe proteins that have aminotransferase-like, pyridoxal 5'-phosphate-binding domains.

115 two genes, At2g20340 and At4g28680, encoding pyridoxal 5'-phosphate-dependent AADCs with high homolog

116 primary sequence analysis, MppP and MppQ are pyridoxal 5'-phosphate-dependent aminotransferases; MppR

117 5-Aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine

118 In the ISC pathway, the pyridoxal 5'-phosphate-dependent cysteine desulfurase en

119 mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinat

120 SelA, a member of the fold-type-I pyridoxal 5'-phosphate-dependent enzyme superfamily, has

121 Kynureninase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

122 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

123 SHMT is a pyridoxal 5'-phosphate-dependent enzyme that converts l-

124 ition of ornithine aminotransferase (OAT), a pyridoxal 5'-phosphate-dependent enzyme, has been implic

125 Human ornithine aminotransferase (hOAT), a pyridoxal 5'-phosphate-dependent enzyme, plays a critica

126 Here, by comparing the inventory of pyridoxal 5'-phosphate-dependent enzymes in different am

127 duced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert am

128 s structural features with other fold-type-I pyridoxal 5'-phosphate-dependent enzymes with native dim

129 ctive enamine intermediate generated by some pyridoxal 5'-phosphate-dependent enzymes, accumulates in

130 t mutational routes between the functions of pyridoxal 5'-phosphate-dependent enzymes, regardless of

131 mix between periplasmic binding proteins and pyridoxal 5'-phosphate-dependent enzymes.

132 th (13)C-labeled precursors indicated that a pyridoxal 5'-phosphate-dependent mechanism is involved i

133 reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (

134 The enzyme is pyridoxal 5'-phosphate-dependent, but unlike most of the

135 of the serine/threonine-specific protein and pyridoxal 5'-phosphate-directed HAD phosphatase chronoph

136 yjgF mutants, suggests that intermediates of pyridoxal 5'-phosphate-mediated reactions may have metab

137 ity of seizures in response to pyridoxine or pyridoxal 5'-phosphate.

138 h pyridoxine but responded to treatment with pyridoxal 5'-phosphate.

139 g of symptoms on changing from pyridoxine to pyridoxal 5'-phosphate.

140 all organisms, notably as the coenzyme form pyridoxal 5'-phosphate.

141 suramin (a general P2 receptor antagonist), pyridoxal 5'-phosphonucleotide derivative (a specific P2

142 d to assess HTPO inhibition as a function of pyridoxal 5-phosphate (PLP) concentration.

143 Pyridoxal 5-phosphate (PLP), the phosphorylated and the

144 I reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes.

145 This pyridoxal 5-phosphate (PLP)-dependent reaction is mediat

146 y evaluated plasma concentrations of folate, pyridoxal 5-phosphate (PLP; the principal active form of

147 This is the first instance in which one pyridoxal 5-phosphate enzyme has been crystallized with

148 Both substrates form external aldemines with pyridoxal 5-phosphate in the structures.

149 and those with lower plasma concentration of pyridoxal-5'-phosphate (P-interaction <= 0.01 for both).

150 erase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promo

151 the cofactors adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) and the substrate into prox

152 ino acid and nucleotide metabolism, and uses pyridoxal-5'-phosphate (PLP) as a cofactor.

153 es of serum carotenoids, retinyl esters, and pyridoxal-5'-phosphate (PLP) by using high-pressure liqu

154 al clinical observation of isolated cases of pyridoxal-5'-phosphate (PLP) deficiency, this prospectiv

155 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung can

156 Two routes for the de novo biosynthesis of pyridoxal-5'-phosphate (PLP) have been discovered and re

157 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimet

158 Vitamin B-6 as pyridoxal-5'-phosphate (PLP) is required as the coenzyme

159 Pyridoxal-5'-phosphate (PLP) is the biologically active

160 nents of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

161 The protein LpThi5 is a dimer that binds pyridoxal-5'-phosphate (PLP), apparently without a solve

162 This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine pal

163 spartate 4-carboxylyase, E.C. 4.1.1.12) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

164 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme, which fun

165 acid-base chemistry that drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been

166 transformations of amino acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

167 f 5,6-LAM are 5'-deoxyadenosylcobalamin- and pyridoxal-5'-phosphate (PLP)-dependent.

168 , vitamin B6 [whose main circulating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocyst

169 Pyridoxal-5'-phosphate (vitamin B(6) ) is an essential c

170 Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes t

171 Pyrococcus horikoshii was transaminated with pyridoxal-5'-phosphate to produce a ketone-bearing prote

172 nine with the help of three cofactors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

173 vealed this transformation is dependent upon pyridoxal-5'-phosphate, the enzyme has no activity with

174 on of P2 and glutamate receptor antagonists (pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

175 Application of the ATP receptor antagonists pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

176 roton-consuming acid resistance system has a pyridoxal-5'-phosphate-dependent amino acid decarboxylas

177 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes t

178 f the indoline quinonoid intermediate in the pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

179 In the 143 kDa pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

180 It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-c

181 beta-synthase (CBS) is a heme-dependent and pyridoxal-5'-phosphate-dependent protein that controls t

182 e reported low circulating concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipient

183 The pyridoxal-5-phosphate (PLP) molecule bonded tightly to L

184 s PNPO variant had a low cerebrospinal fluid pyridoxal-5-phosphate level.

185 f enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-ly

186 It is the only known pyridoxal-5-phosphate-dependent decarboxylase that catal

187 purine nucleotides (AMP and GMP), a vitamin (pyridoxal-5P), and a cofactor (heme) in both the acute a

188 1,3,5-naphthalenetrisulfonic acid), MRS2159 (pyridoxal-alpha5-phosphate-6-phenylazo-4'-carboxylic aci

189 at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only the Bolus dos

190 and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts, which are s

191 We evaluated the vitamin B-6 biomarkers PLP, pyridoxal, and pyridoxic acid (PA) and the pyridoxic aci

192 rals lowered concentrations of nicotinamide, pyridoxal, and vitamin B-12.

193 With pyridoxal as the aldehyde component, furo[2,3-c]pyridine

194 ly-modified cellulosic paper strips with the pyridoxal conjugated BSA-AuNCs for detecting Hg(2+) ion

195 oxal phosphate (PLP) > pyridoxic acid (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP >

196 her endogenous small molecules (for example, pyridoxal, folinic acid, ATP, and AMP) also convert the

197 (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP > PA > pyridoxamine).

198 oung rabbits and sharks were pretreated with pyridoxal hydrochloride and copper ions before CXL.

199 Pretreatment with pyridoxal hydrochloride resulted in significantly higher

200 g binding of artemisinins with the substrate pyridoxal inhibits PLP biosynthesis as demonstrated by k

201 d ligands, namely the aroylhydrazone (1)(4)C-pyridoxal isonicotinoyl hydrazone ((1)(4)C-PIH) and the

202 whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class can restri

203 In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B(6) salvage pat

204 report on the characterization of T. brucei pyridoxal kinase (PdxK), an enzyme required for the salv

205 al structure of the central metabolic enzyme pyridoxal kinase (PDXK), which catalyzes the production

206 ts, which are subsequently phosphorylated by pyridoxal kinase (PdxK).

207 We recently identified a pyridoxal kinase (SaPLK) as a target of the natural prod

208 These findings suggest that pyridoxal kinase is an essential and druggable target th

209 a recent study, Chen et al. demonstrate that pyridoxal kinase promotes vitamin B6 phosphorylation, pr

210 doxine/pyridoxamine 5'-phosphate oxidase and pyridoxal kinase, respectively, are the only known genes

211 nomutase, an adenosylcobalamin (AdoCbl)- and pyridoxal L-phosphate (PLP)-dependent enzyme that cataly

212 6.0) mug; Control: 3.4 (2.9, 4.0) mug], and pyridoxal [milk: Bolus: 90.5 (82.8, 98.9) mug . min-1 .

213 13 mU mg(-1) and a K(m)(app) with respect to pyridoxal of 29.6 +/- 3.9 microM.

214 functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative

215 e vitamin B-6 vitamer composition of plasma [pyridoxal phosphate (PLP) > pyridoxic acid (PA) > pyrido

216 I reflect on my research on pyridoxal phosphate (PLP) enzymes over fifty-five years

217 and identified PDXK-an enzyme that produces pyridoxal phosphate (PLP) from vitamin B6-as an acute my

218 their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid

219 Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flav

220 CAS and the Gm-CAS K95A mutant with a linked pyridoxal phosphate (PLP)-Cys molecule in the active sit

221 Cysteine desulfurases perform pyridoxal phosphate (PLP)-dependent desulfuration of cys

222 t: (i) the bioinformatics analysis reveals a pyridoxal phosphate (PLP)-dependent domain, we termed cy

223 Pyridoxal phosphate (PLP)-dependent enzymes can catalyze

224 Pyridoxal phosphate (PLP)-dependent enzymes catalyze man

225 l therapies for inherited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including p

226 oacrylate (2AA), an enamine produced by some pyridoxal phosphate (PLP)-dependent enzymes.

227 ase (PanD), the enzyme in M. jannaschii is a pyridoxal phosphate (PLP)-dependent l-aspartate decarbox

228 amin pyrimidine is formed from histidine and pyridoxal phosphate (PLP).

229 ecies (ROS) detoxification and production of pyridoxal phosphate (PLP).

230 two enzymes of the biosynthetic pathway for pyridoxal phosphate (SerC and PdxA), we have found that

231 nd the nonselective P2 receptor antagonists, pyridoxal phosphate 6-azophenyl-2',4'-disulfonic acid an

232 s of very slow biological reactions, notably pyridoxal phosphate and the ceric ion, are shown to meet

233 DhpH is a multidomain protein, in which a pyridoxal phosphate binding domain is fused to an N-acet

234 lyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-d-erythronate

235 e provides information on the binding of the pyridoxal phosphate cofactor as well as on amino acid re

236 ases via reactions of the compounds with the pyridoxal phosphate cofactor forming an irreversible add

237 PtaA is homodimeric and contains a pyridoxal phosphate cofactor.

238 rnal aldimine form of NtdA with the cofactor pyridoxal phosphate covalently attached to Lys-247.

239 The pyridoxal phosphate dependent alanine racemase catalyzes

240 which belong to two different fold types of pyridoxal phosphate enzymes: an aspartate aminotransfera

241 plants, the pathway for de novo synthesis of pyridoxal phosphate has been well characterized, however

242 Pyridoxal phosphate is the cofactor for the enzyme histi

243 and formation of the external aldimine with pyridoxal phosphate required for early steps in SufS cat

244 Fasting plasma concentration of pyridoxal phosphate was inversely associated with myocar

245 Plasma levels of pyridoxal phosphate were inversely associated with risk

246 Vitamin B6 (pyridoxal phosphate) is an essential cofactor in enzymat

247 en fasting plasma levels of vitamin B(6), as pyridoxal phosphate, and subsequent myocardial infarctio

248 ervation that the active form of vitamin B6 (pyridoxal phosphate, P5P) modulates the self-assembly of

249 referred to as Pat) that, in the presence of pyridoxal phosphate, transfers the primary amino group o

250 Pyridoxal phosphate, which binds at the intersubunit act

251 ythroidine and reduced by the P2X antagonist pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid (

252 r ATP, and by blocking P2 purinoceptors with pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) t

253 PPADS [pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid)],

254 Hindlimb intra-arterial infusion of pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (PPA

255 for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function.

256 We recently discovered that the pyridoxal phosphate-containing enzyme PvdN is responsibl

257 e enzyme binds the substrate cysteine in the pyridoxal phosphate-containing site, and a persulfide is

258 ucose-6-phosphate 3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:

259 ylacetaldehyde (4-HPAA), Rhodiola contains a pyridoxal phosphate-dependent 4-HPAA synthase that direc

260 The S-signal was generated by the pyridoxal phosphate-dependent aminotransferase ScrA; sig

261 Sequence homology identified the pyridoxal phosphate-dependent decarboxylase-like protein

262 nzymological source of the amine moiety as a pyridoxal phosphate-dependent decarboxylating enzyme tha

263 The catalytic effects of perdeuterating the pyridoxal phosphate-dependent enzyme alanine racemase fr

264 S. cerevisiae FKF had been reported to be a pyridoxal phosphate-dependent enzyme encoded by BNA3.

265 Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the

266 te, which is converted to Ala(P) by a second pyridoxal phosphate-dependent enzyme, DhpD.

267 site of cystathionine beta-synthase (CBS), a pyridoxal phosphate-dependent enzyme.

268 a sugar aminotransferase that catalyzes the pyridoxal phosphate-dependent equatorial transamination

269 vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec)

270 y Sep-tRNA:Cys-tRNA synthase (SepCysS) via a pyridoxal phosphate-dependent mechanism.

271 Among them, we identified the L136 gene as a pyridoxal phosphate-dependent sugar aminotransferase.

272 Conversion of l-dopa to dopamine by a pyridoxal phosphate-dependent tyrosine decarboxylase fro

273 by catalyzing incorporation of its cofactor, pyridoxal phosphate.

274 Unexpectedly, the double bond linking the pyridoxal-phosphate and benzoate moieties was reduced by

275 y X-rays to create a covalent linkage of the pyridoxal-phosphate moiety to lysine 120 in the binding

276 adult rats show that bilateral injections of pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS

277 blocked by P2Y receptor antagonists suramin, pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS

278 blocked by the broad P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

279 blocked by the broad P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

280 ed to MA; (iii) the P2X receptor antagonist, pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

281 e or no effect on sensitivity to suramin and pyridoxal-phosphate-6-azophenyl-2,4-disulfonate in chime

282 r, which is inhibited by NF449, suramin, and pyridoxal-phosphate-6-azophenyl-2,4-disulfonate, with re

283 e and that AGXT2L1 and AGXT2L2 catalyzed the pyridoxal-phosphate-dependent breakdown of phosphoethano

284 1 and AGXT2L2, two closely related, putative pyridoxal-phosphate-dependent enzymes encoded by vertebr

285 a salvage pathway that phosphorylates either pyridoxal (PL) or its related vitamers, pyridoxine (PN)

286 sue distribution or increased catabolism via pyridoxal (PL) to pyridoxic acid (PA).

287 The bioavailability of the pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM) f

288 pyridoxic acid (PA) and the pyridoxic acid:(pyridoxal + PLP) ratio (PAr), a proposed marker of vitam

289 ndex, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 cataboli

290 actors like pyridoxal 5'-phosphate (PLP) and pyridoxal (Py) by forming host-guest inclusion complexat

291 n B6, with significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyr

292 yme has equivalent catalytic efficiency with pyridoxal, pyridoxamine and pyridoxine, and that ginkgot

293 PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and

294 ell characterized, however only two enzymes, pyridoxal (pyridoxine, pyridoxamine) kinase (SOS4) and p

295 A putative pyridoxal reductase (PLR1) was identified in Arabidopsis

296 oding region in a yeast mutant deficient for pyridoxal reductase confirmed that the enzyme catalyzes

297 This is the first report of a pyridoxal reductase in the vitamin B6 salvage pathway in

298 me catalyzes the NADPH-mediated reduction of pyridoxal to pyridoxine.

299 the biosynthesis of thiamin (vitamin B1) and pyridoxal (vitamin B6).

300 The vitamin B6 cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs