ライフサイエンスコーパス: pyrin domain

1 t, similar to FMF patients, retains the full PYRIN domain.

2 Their N termini vary, but most have a pyrin domain.

3 90-amino-acid N-terminal sequence called the PYRIN domain.

4 pha2-alpha3 loop is not a general feature of pyrin domains.

5 two zebrafish caspases containing N-terminal pyrin domains.

6 does not directly interact with inflammasome pyrin domains.

7 gomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation in podocy

8 nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted mann

9 zation domain (NOD)-like receptor containing pyrin domain 3 (NLRP3) inflammasome is involved in the C

10 diated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) inflammasome, although exactly ho

11 oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) inflammasome, assembly of stress

12 and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome.

13 gomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasomes and induces the rel

14 delayed activation of the cytosolic PRR NLR pyrin domain 3 (NLRP3) that would otherwise amplify the

15 he absence of Nod-like receptor containing a pyrin domain 3 and absent in melanoma 2.

16 elanoma 2 and Nod-like receptor containing a pyrin domain 3 are partially required for caspase-1 acti

17 otide-binding domain and leucine-rich repeat pyrin domain 3 are simultaneously present in the same in

18 lood leukocytes and encodes a protein with a pyrin domain, a nucleotide-binding site (NBS, NACHT subf

19 BRCA1 (aa 502-802) interacted with the IFI16 Pyrin domain (aa 1-130).

20 sist of three functional domains including a pyrin domain, an NACHT domain, and a leucine-rich repeat

21 amily member that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/olig

22 N-terminal region that contains a predicted pyrin domain and a putative nuclear localization signal.

23 d ability to bind Sp1 require the N-terminal pyrin domain and nuclear localization of IFI16, but not

24 ein containing a caspase recruitment domain) pyrin domain and the IFI16-double stranded DNA complex h

25 unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence lin

26 Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome

27 Pyrin, a protein of 781 aa with pyrin domain at the N-terminal, negatively regulates inf

28 this response by interacting with the IFI16 pyrin domain, blocking its oligomerization upon DNA sens

29 200 domain of AIM2 binds to DNA, whereas the pyrin domain (but not that of the other PYHIN family mem

30 ing dsDNA, only the Aim2 protein through its pyrin domain can form an inflammasome to activate caspas

31 gomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide

32 these sensors, including NLRP1 (NLR family, pyrin domain containing 1), are described to form an inf

33 ng the NOD-like receptor NLRP10 (NLR family, pyrin domain containing 10); however, the mechanism by w

34 merization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective r

35 One NLR gene, NLRP12 (NLR family, pyrin domain containing 12)/Monarch-1, has emerged as an

36 yrin domain containing 3 (NLRP3), NLR family pyrin domain containing 2 (NLRP2), AIM2 (absent in melan

37 ucine-rich repeat containing protein family, pyrin domain containing 3 (NLRP3) (cryopyrin or NALP3) a

38 uble deficiency of Nod like receptor family, pyrin domain containing 3 (NLRP3) and caspase 8 inPstpip

39 n mutations in the NOD-like receptor family, pyrin domain containing 3 (NLRP3) gene, which cause unco

40 merization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) gene.

41 egion of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated w

42 ts are mediated by NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activatio

43 In this context, NLR family pyrin domain containing 3 (NLRP3) inflammasome activatio

44 turn, decreases TXNIP-stimulated NLR family pyrin domain containing 3 (NLRP3) inflammasome activatio

45 oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity

46 ound octanal, which activates the NLR family pyrin domain containing 3 (NLRP3) inflammasome and induc

47 ence suggesting the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome as a key

48 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome as an ess

49 ding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome complex a

50 nt of the canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome complex.

51 cell sensor leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome controls

52 ortant role of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome for media

53 NLR family pyrin domain containing 3 (NLRP3) inflammasome has been

54 is a key to induce NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in macrop

55 itin, activate the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in primed

56 oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome into a ma

57 Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involv

58 NLR family pyrin domain containing 3 (NLRP3) inflammasome mediates

59 leucine-rich repeat containing gene family, pyrin domain containing 3 (NLRP3) inflammasome to induce

60 r activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome to trigge

61 r activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome to trigge

62 oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome via lysos

63 The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, a multip

64 easures of senescence, the nod like receptor pyrin domain containing 3 (NLRP3) inflammasome, and micr

65 ntestinal tissue, implicating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which co

66 oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent

67 oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated

68 the absent in melanoma (AIM2) and NLR family pyrin domain containing 3 (NLRP3) inflammasomes in macro

69 of Tat in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in micro

70 ammasome system, mediated by the NLR family, pyrin domain containing 3 (NLRP3) initiating protein, wa

71 leotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key component of

72 NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is a key compo

73 rm depended on the NOD-like receptor family, pyrin domain containing 3 (NLRP3) sensor and the apoptos

74 components of the NOD-like receptor family, pyrin domain containing 3 (NLRP3), and absent in melanom

75 de-binding domain, leucine rich family (NLR) pyrin domain containing 3 (NLRP3), NLR family pyrin doma

76 ive oxygen species production and NLR family pyrin domain containing 3 (NLRP3)-dependent inflammasome

77 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3).

78 Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome

79 gomerization domain, leucine-rich repeat and pyrin domain containing 3 (NRLP3) inflammasome members (

80 erization domain (NOD)-like receptor family, pyrin domain containing 3 activation in the inflammasome

81 tightly regulating NOD-like receptor family, pyrin domain containing 3 activation.

82 rich repeat-containing-like receptor family, pyrin domain containing 3 and autophagosome-associated m

83 rvention targeting NOD-like receptor family, pyrin domain containing 3 inflammasome activity induces

84 he key role of the NOD-like receptor family, pyrin domain containing 3 inflammasome during acute pneu

85 n regulate hepatic steatosis; the NLR family pyrin domain containing 3 inflammasome is critically inv

86 he activity of the NOD-like receptor family, pyrin domain containing 3 inflammasome when compared wit

87 ypoxia activate the NOD-like receptor family pyrin domain containing 3 inflammasome.

88 IL-1beta-producing NOD-like receptor family pyrin domain containing 3 inflammasome.

89 otide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammasome.

90 oligomerization domain-like receptor family pyrin domain containing 3 pathway by nanoparticles.

91 innate immune-sensing complex known as "NLR-Pyrin domain containing 3" (NLRP3) inflammasome, also kn

92 omain leucine-rich repeat containing family, pyrin domain containing 3) inflammasome complex, assembl

93 The NLRP3 (NLR family pyrin domain containing 3) inflammasome has a key role i

94 Administration of the NLRP3 (NLR family pyrin domain containing 3) inflammasome inhibitor MCC950

95 The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotei

96 flammasomes, and that the NLRP3 (NLR family, pyrin domain containing 3) inflammasome is not involved

97 oligomerization domain]-like receptor family pyrin domain containing 3) inflammasome via IsoLG format

98 ar level, HIV-1 primes the NLRP3 (NLR family pyrin domain containing 3) inflammasome, leading to an i

99 OD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in the patho

100 rting a novel Cdx2-TRIM31-NLRP3 (NLR family, pyrin domain containing 3) signaling pathway, which may

101 also causes NLRP3 (NOD-like receptor family pyrin domain containing 3) translocation from endoplasmi

102 e-recruitment domain) and NLRP3 (NLR family, pyrin domain containing 3), which are essential for casp

103 spase-1, and NLRP3 (NOD-Like Receptor family Pyrin domain containing 3).

104 eased expression of inflammatory (NLR family pyrin domain containing 3, interleukins 1beta and 6, and

105 rich repeat-containing-like receptor family, pyrin domain containing 3-associated inflammasomes and i

106 e-1/Caspase-4- and NOD-like receptor family, pyrin domain containing 3-dependent inflammatory cell de

107 hibits nuclear factor kappaB- and NLR family pyrin domain containing 3-dependent proinflammatory sign

108 ce deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome feature e

109 NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome is requir

110 NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin

111 Notably, NOD-like receptor family pyrin domain containing 6 (NLRP6) was the only NLR requi

112 g oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are a

113 salivary levels of nod-like receptor family pyrin domain containing protein (NLRP) 3, apoptosis-asso

114 tide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which for

115 The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome i

116 leotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome.

117 te the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome.

118 LR [NACHT, LRR {leucine rich repeat}] family pyrin domain containing protein 3) inhibitor, NP3-361, f

119 (ATG5), ATG7 and ATG16L1 but not NLR family, pyrin domain containing-3 (NALP3).We show that NOD2-medi

120 tly demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal i

121 nding domain leucine-rich repeat containing, Pyrin domain containing-3 and for absent in melanoma 2 i

122 nding domain leucine-rich repeat containing, Pyrin domain containing-3 inflammasome, and caspase-4 ph

123 ting a role for the NOD-like receptor family pyrin domain containing-3 inflammasome.

124 otide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflamma

125 e nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella

126 Functional roles for NLR family, pyrin domain-containing (NLRP) 3 inflammasome and T2 cyt

127 omerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) complex in the developmen

128 lterations in NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) inflammasome-related g

129 NLRP1 (NLR family, pyrin domain-containing 1) is a contributor to innate im

130 de-Binding Domain Leucine-Rich Repeat Family Pyrin Domain-Containing 1.

131 se 1), and NLRP12 (NOD-like receptor family, pyrin domain-containing 12)-PANoptosome activation and P

132 nt NOD-like receptor (NLR) genes, NLR family pyrin domain-containing 2 and 7 (NLRP2, NLRP7).

133 me components, we found that both NLR family pyrin domain-containing 3 (Nlrp3) and apoptosis-associat

134 -1beta dependent on NOD-like receptor family pyrin domain-containing 3 (NLRP3) and ASC due to the sec

135 ndings support redundant roles of NLR family pyrin domain-containing 3 (NLRP3) and caspase-1 with cas

136 mutations in NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) cause neonatal-onset m

137 IL-1beta, a main effector of NLR family pyrin domain-containing 3 (NLRP3) inflammasome activatio

138 oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activatio

139 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and conco

140 main, leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome as well a

141 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives ma

142 Activation of the NLR-family pyrin domain-containing 3 (NLRP3) inflammasome has been

143 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been

144 tion domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome in human

145 The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is a casp

146 The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a crit

147 The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is a mega

148 binding oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is activa

149 omain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is now no

150 g oligomerization domain-like receptor (NLR) pyrin domain-containing 3 (Nlrp3) inflammasome is though

151 leucine-rich repeat containing family (NLR), pyrin domain-containing 3 (NLRP3) inflammasome plays a k

152 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays an

153 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome, a compon

154 studies of its regulation of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome.

155 oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome.

156 tion domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome.

157 cleotide-binding domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome.

158 In this study, we showed that NLR family pyrin domain-containing 3 (Nlrp3) is required to induce

159 n (ASC) inflammasomes, including NLR family, pyrin domain-containing 3 (NLRP3), but not NLR family, c

160 ts, including NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), NLRP1, NLR family CAR

161 ng and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3), simultaneously and di

162 direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activatio

163 otide-binding oligomerization domain family, pyrin domain-containing 3 inflammasome activation upon H

164 is detected by the NOD-like receptor family, pyrin domain-containing 3 inflammasome and can trigger a

165 tor 4 and prime the nod-like receptor family pyrin domain-containing 3 inflammasome in naive neutroph

166 ream mediators (eg, nod-like receptor family pyrin domain-containing 3 inflammasome, interleukin-1bet

167 oligomerization domain-like receptor family, pyrin domain-containing 3 inflammasome.

168 and activates the NOD-like receptor family, pyrin domain-containing 3 inflammasome.

169 ncluding increased expression of NLR family, pyrin domain-containing 3 protein (NLRP3) and constituti

170 ation of the NLRP3 (Nod Like Receptor Family Pyrin Domain-Containing 3) inflammasome and associated s

171 ation of the NLRP3 (Nod Like Receptor Family Pyrin Domain-Containing 3) inflammasome and associated s

172 main, leucine-rich repeat containing family, pyrin domain-containing 3) inflammasome by inhibiting ph

173 main, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates product

174 merization domain-, leucine-rich repeat- and pyrin domain-containing 3) inflammasome protects articul

175 LR4 (Toll-like receptor 4)-NLRP3 (NLR family pyrin domain-containing 3)-IL (interleukin)-1beta signal

176 mediators, such as NOD-like receptor family pyrin domain-containing 3, intercellular adhesion molecu

177 cleotide-binding domain, leucine-rich repeat/pyrin domain-containing 3.

178 Host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates innate immun

179 cruitment domain-containing 4 or NLR family, pyrin domain-containing 6, are required for triggering t

180 rodent NLRP1B (NACHT leucine-rich repeat and pyrin domain-containing protein 1B).

181 erization domain (NOD)-like receptor family, pyrin domain-containing protein 3 (Nlrp3) expression was

182 sed on the role of nod-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome a

183 The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome h

184 The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome i

185 The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome i

186 The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome i

187 The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome i

188 A1 (ANXA1) and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome p

189 f components of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome s

190 ory biomarkers [NF-kappaB, STAT3, NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome],

191 binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes

192 osolic contact, and activation of NLR family pyrin domain-containing protein 3 (NLRP3) inflammasomes

193 The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical

194 The NACHT-, leucine-rich-repeat- (LRR), and pyrin domain-containing protein 3 (NLRP3) is emerging to

195 marrow from donors deficient in NOD, LRR and pyrin domain-containing protein 3 (NLRP3), absent in mel

196 gomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3), disrupts infl

197 NLR family pyrin domain-containing protein 3 (NLRP3), once activate

198 ide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-med

199 a programmed death ligand 1/NOD-, LRR-, and pyrin domain-containing protein 3 (PD-L1/NLRP3) inflamma

200 omerization domain, leucine rich repeat, and pyrin domain-containing protein 3 inflammasome inhibitio

201 dendritic cells and inhibits NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome.

202 l dysfunction, activation of NOD-, LRR-, and pyrin domain-containing protein 3 inflammasomes, and inc

203 inding oligomerization-like receptor family, pyrin domain-containing protein 3) activation, either by

204 fic inhibition of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome as a CF

205 critical role for the NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome in infla

206 ways leading from the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome to IL-1

207 s that assembles an NLRP3 (NOD-like receptor pyrin domain-containing protein 3) inflammasome via a Ra

208 and activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome.

209 d MCC950, a selective NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inhibitor, into a sub

210 NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular s

211 ion domain]-' LRR [leucine-rich repeat]- and pyrin domain-containing protein 3) significantly decreas

212 flammasome components Nalp3 (NACHT, LRR, and pyrin domain-containing protein 3), ASC (apoptosis-assoc

213 l cycle inhibitor p16, NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3), IL-1alpha, and IL-be

214 NOD-, LRR- and pyrin domain-containing protein 3-inflammasome protein w

215 with a specific inhibitor of NOD-, LRR-, and pyrin domain-containing protein 3.

216 The SREBP-induced NOD-like receptor family pyrin domain-containing protein inflammasome and its ins

217 e activation of the NOD-like receptor family pyrin domain-containing protein inflammasome in macropha

218 The myxoma virus (MYXV)-encoded pyrin domain-containing protein M013 coregulates inflamm

219 Nod-like receptor family pyrin domain-containing protein-3 (NLRP3) complex inflam

220 t nucleotide-binding leucine-rich repeat and pyrin domain-containing receptor 12 (NLRP12) impedes alt

221 domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors.

222 ding domain, leucine-rich containing family, pyrin domain-containing-3 (NLRP3) inflammasome activatio

223 ding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome controls

224 ding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3 (Nlrp3) inflammasome plays an

225 ding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp

226 ding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome components.

227 ding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may pro

228 ding domain, leucine-rich-containing family, pyrin domain-containing-3).

229 ding domain, leucine-rich-containing family, pyrin domain-containing-3, and downstream mitogen-activa

230 ding domain, leucine-rich-containing family, pyrin domain-containing-3, and p38/extracellular signal-

231 ding domain, leucine-rich-containing family, pyrin domain-containing-3; hypoxia-inducible factor 1/2a

232 e-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pa

233 ucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome in human

234 The NOD-like receptor (NLR) family pyrin-domain-containing 3 (NLRP3) inflammasome, an essen

235 merization drug AP20187, suggesting that the PYRIN domain functions as an oligomerization domain, whe

236 mmasome trigger, and molecules targeting the pyrin domain have shown promise in inhibiting NLRP3 acti

237 gy include the elucidation of the N-terminal PYRIN domain in protein-protein interactions, the descri

238 8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome

239 LP1, is unlikely to be a common attribute of pyrin domain interactions.

240 The PYRIN domain is a recently identified protein-protein in

241 We show here that the pyrin domain of AIM2 (AIM2(PYD)) drives both filament fo

242 VHHASC leaves the Pyrin domain of ASC functional and stabilizes a filament

243 on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammas

244 Substitution of the PYRIN domain of ASC with an inducible FKBP12 oligomeriza

245 and leucine-rich repeat regions, but not the pyrin domain of CIAS1, are responsible for this inhibiti

246 weak affinity, and it is the non-DNA-binding pyrin domain of IFI16 that drives the cooperative filame

247 the structure and dynamics of the N-terminal pyrin domain of NLRP12 (NLRP12 PYD) determined using NMR

248 A-mediated) dephosphorylation of Ser5 in the pyrin domain of NLRP3.

249 the structure and dynamics of the N-terminal pyrin domain of NLRP7 (NLRP7 PYD) obtained by NMR spectr

250 protein that interacts selectively with the PYRIN domain of PYPAF1.

251 The pyrin domains of both Caspy and zAsc were required for t

252 ty, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits in

253 irus, M013 is a viral homologue of the viral pyrin domain-only protein (vPOP) family.

254 cent developments in elucidating the role of PYRIN domain-only proteins (POPs) and the related CARD-o

255 Pyrin domain-only proteins (POPs) are recently evolved,

256 teins that regulate the inflammasome, namely pyrin domain-only proteins (POPs), caspase activation re

257 DED, caspase recruitment domain or CARD, and pyrin domain or PYD).

258 Mutations in another PYRIN domain protein, termed cryopyrin, are responsible

259 tate, the NOD-like receptor (NLR)-containing pyrin domain (PYD) (NLRP)1 inflammasome is maintained in

260 It is composed of an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment

261 omain structure, consisting of an N-terminal pyrin domain (PYD) and a C-terminal caspase-recruitment

262 e to intramolecular interactions between its pyrin domain (PYD) and B-box.

263 hich consists of two domains, the N-terminal pyrin domain (PYD) and the C-terminal CARD.

264 izing double-stranded DNA and its N-terminal pyrin domain (PYD) for eliciting downstream effects thro

265 ary inflammasome complexes, achieved through pyrin domain (PYD) interactions between sensors and ASC

266 otein ASC and initiate polymerization of its pyrin domain (PYD) into filaments.

267 on dsDNA engagement, the AIM2 amino-terminal pyrin domain (PYD) is responsible for downstream signali

268 rk of highly intercrossed filaments, whereas pyrin domain (PYD) or caspase activation and recruitment

269 Pyrin domain (PYD) proteins have recently emerged as imp

270 Many pyrin domain (PYD) proteins modulate NF-kappaB activity

271 recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domai

272 three-dimensional homology model of the M013 pyrin domain (PYD) was built based on similarities to kn

273 Key domains in pyrin include a pyrin domain (PYD), a linker region, and a B30.2 domain.

274 ng studies on human growth hormone (hGH) and pyrin domain (PYD), and the results show how mutations a

275 uman NLRP1, mouse NLRP1b lacks an N-terminal pyrin domain (PYD), indicating that the assembly of the

276 ession of NLRP11, but not NLRP11 lacking the PYRIN domain (PYD), restored inflammasome activation.

277 Inflammasome assembly requires the PYRIN domain (PYD)-containing adaptor ASC, and depends o

278 main (NOD)-, leucine-rich repeat (LRR)-, and pyrin domain (PYD)-containing protein 3 (NLRP3) form an

279 , and NACHT-, leucine-rich repeat (LRR)- and pyrin domain (PYD)-containing protein 3 (NLRP3) is an in

280 Pyrin domain (PYD)-containing proteins are key component

281 Here we identified the PYRIN domain (PYD)-only protein POP3, which competes wit

282 sent cryo-EM and crystal structures of NLRP6 pyrin domain (PYD).

283 tion is controlled by phosphorylation of its pyrin domain (PYD).

284 2 in the region between its NACHT domain and pyrin domain (PYD); removal of the NLRP12 PYD abrogated

285 eracting filamentous oligomers involving the pyrin domains (PYD) of important inflammasome components

286 RD (caspase activation and recruitment), and pyrin domains (PyD).

287 or domains, caspase recruitment domains, and pyrin domains (PYD).

288 nd targets the assembly of upstream receptor pyrin-domain (PYD) filaments such as those of AIM2, IFI1

289 Inflammasome assembly is mediated by pyrin domains (PYDs) and caspase recruitment domains, wh

290 ns of caspase recruitment domains (CARDs) or PYRIN domains (PYDs).

291 ntain caspase recruitment domains (CARDs) or pyrin domains (PYDs).

292 , which harbor essential N-terminal CARD and PYRIN domains, respectively.

293 ld together by LRR-LRR interactions with the pyrin domains shielded within the assembly to avoid prem

294 MNDA and related proteins contain the pyrin domain that functions in signaling associated with

295 The surface residues on the pyrin domain that mediate the cooperative DNA binding ar

296 ts HINa domain and to RIG-I protein with its PYRIN domain, thus promoting IAV-induced K63-linked poly

297 -like protein containing a CARD) through its pyrin domain to activate caspase-1.

298 We also show here that PAN1 binds via its PYRIN domain to ASC, an adapter protein involved in casp

299 The pyrin domain was identified recently in multiple protein

300 ull-length ASC, but not its isolated CARD or PYRIN domain, with procaspase-1 induced activation of pr