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1 te fate, including lactate dehydrogenase and pyruvate dehydrogenase kinase.
2 of histone deacetylase, cyclooxygenase, and pyruvate dehydrogenase kinase.
3 he hyperthyroid heart in vivo is mediated by pyruvate dehydrogenase kinase.
4 dehydrogenase complex through inhibition of pyruvate dehydrogenase kinase.
5 imately 37% amino acid identity to mammalian pyruvate dehydrogenase kinases.
6 d motifs that are proposed to be specific to pyruvate dehydrogenase kinases.
8 K1 acts as a protein kinase to phosphorylate pyruvate dehydrogenase kinase 1 (PDHK1) at T338, which a
9 lysis in part due to increased expression of pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehyd
12 tochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inac
13 ycolysis, which were paralleled by increased pyruvate dehydrogenase kinase 1 (PDK1) protein levels an
14 Our analysis highlights multiple targets of pyruvate dehydrogenase kinase 1 (PDK1), a regulator of m
15 genes, particularly that of the gatekeeper, pyruvate dehydrogenase kinase 1 (Pdk1), decreasing lacta
16 result in the induction of the gene encoding pyruvate dehydrogenase kinase 1 (PDK1), which inhibits p
23 n HP [1-(13)C]lactate was likely mediated by pyruvate dehydrogenase kinase 1 up-regulation in activat
24 athways and dephosphorylates and inactivates pyruvate dehydrogenase kinase 1, Akt, Raf, mitogen-activ
25 catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruv
26 nsporter Glut1, phospho-fructose kinase, and pyruvate dehydrogenase kinase 1, which interrupted pyruv
29 HIF-1alpha increased glycolytic enzymes and pyruvate dehydrogenase kinase-1 (PDK-1), which reduces m
30 inhibition occurs via enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1), which results i
31 lucose transporters, glycolytic enzymes, and pyruvate dehydrogenase kinase-1 were increased in their
32 ctivity, because specific inhibition of Akt, pyruvate dehydrogenase kinase-1, or its downstream targe
33 led to the upregulation of the HIF1 target, pyruvate dehydrogenase kinase-1, which inhibits PDH acti
42 f PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasi
43 cle glucose metabolism in awake mice lacking pyruvate dehydrogenase kinase 2 and 4 [double knockout (
44 Wild-type p53 expression decreased levels of pyruvate dehydrogenase kinase-2 (Pdk2) and the product o
45 vates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and
47 DH inhibitory phosphorylation, expression of pyruvate dehydrogenase kinase-3, and levels of hypoxia i
48 mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy chain (MHC
49 ibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylati
52 sion and uncovered an enhanced expression of pyruvate dehydrogenase kinase 4 (PDK4) in the Glyco(Hi)
54 had decreased Akt1 and 2 phosphorylation and pyruvate dehydrogenase kinase 4 (Pdk4) mRNA and increase
57 d 2.5- and 5-fold, respectively, whereas the pyruvate dehydrogenase kinase 4 (PDK4) was upregulated 4
58 ubule of the kidney, we explored the role of pyruvate dehydrogenase kinase 4 (PDK4), a mitochondrial
59 le coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4), a negative regul
60 tin-like 4 (ANGPTL4)-induced upregulation of pyruvate dehydrogenase kinase 4 (PDK4), an inhibitor of
61 for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolp
62 e palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that wou
63 hanism centers around robust upregulation of pyruvate dehydrogenase kinase 4 (PDK4), resulting from h
65 itochondrial-specific protein degradation of pyruvate dehydrogenase kinase 4 (PDK4, inhibitor of PDH)
66 ubunits, and dramatic increases in mRNAs for pyruvate dehydrogenase kinase 4 and glutamine synthase,
67 thalamic expression of four genes, including pyruvate dehydrogenase kinase 4 and glycerol 3-phosphate
68 HLpL0 hearts had decreased expression of pyruvate dehydrogenase kinase 4 and increased cardiomyoc
69 ceptor substrate 2 was increased and that of pyruvate dehydrogenase kinase 4 and insulin receptor sub
70 activated receptor-gamma coactivator-1alpha, pyruvate dehydrogenase kinase 4 and mitochondrial transc
71 ate dehydrogenase (E1), and the induction of pyruvate dehydrogenase kinase 4 and pyruvate dehydrogena
73 ose oxidation was mediated by a reduction in pyruvate dehydrogenase kinase 4 expression, enabling pyr
74 on an ERRalpha-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac
76 d protein (2-fold, P < 0.05) expression, and pyruvate dehydrogenase kinase 4 mRNA (15-fold, P < 0.001
77 protein and glycogen content, and increased pyruvate dehydrogenase kinase 4 mRNA abundance in the he
79 pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and t
81 1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor
82 nes (medium chain acyl-CoA dehydrogenase and pyruvate dehydrogenase kinase 4), and caused substrate s
83 blastoma protein-E2F-induced upregulation of pyruvate dehydrogenase kinase 4, and targeting these pat
84 lucose transporter 1, glucose transporter 4, pyruvate dehydrogenase kinase 4, peroxisome proliferator
85 ulation and starvation-induced regulation of pyruvate-dehydrogenase kinase 4 and uncoupling protein 3
86 of several lipid regulatory genes, including pyruvate-dehydrogenase kinase 4 and uncoupling protein 3
87 array were shown to induce the expression of pyruvate dehydrogenase kinase-4 (PDK4) and uncoupling pr
89 protein O1 (FOXO1) mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) gene transcriptio
91 as CD36, Ly-6D, Rbp7, monoglyceride lipase, pyruvate dehydrogenase kinase-4, and C3f, that have been
92 insulin treatment of diabetic rats decreased pyruvate dehydrogenase kinase activity and also reversed
93 ti-PDK1 antibodies immunoprecipitated 75% of pyruvate dehydrogenase kinase activity from a maize mito
94 ion and diabetes induce a stable increase in pyruvate dehydrogenase kinase activity in skeletal muscl
95 PPAR-alpha), also induced large increases in pyruvate dehydrogenase kinase activity, PDK4 protein, an
97 es PDHc activity by altering the affinity of pyruvate dehydrogenase kinase, an inhibitor of the enzym
98 ctivity still remains its ability to inhibit pyruvate dehydrogenase kinase and force mitochondrial ox
99 calization of the aerobic glycolysis enzymes pyruvate dehydrogenase kinase and lactate dehydrogenase
101 id not activate the classic hypoxia targets (pyruvate dehydrogenase kinase and vascular endothelial g
103 O1-mediated transcriptional upregulation of pyruvate dehydrogenase kinase), and glutaminolysis (refl
104 enzyme biosynthesis and iron metabolism, the pyruvate dehydrogenase kinase, and a type 2C protein pho
105 ied housekeeping genes include Pdk, encoding pyruvate dehydrogenase kinase, and GdcH, encoding glycin
106 tal RVH and can be achieved by inhibition of pyruvate dehydrogenase kinase, fatty acid oxidation, or
107 ed residues positioned in the active site of pyruvate dehydrogenase kinase, Glu-243 and His-239.
108 ous HPCs was partially rescued by inhibiting pyruvate dehydrogenase kinase, highlighting a relationsh
109 n of pyruvate dehydrogenase by inhibition of pyruvate dehydrogenase kinases, induces epithelial-to-me
112 ry subsequent to postischemic, intracoronary pyruvate dehydrogenase kinase inhibition with dichloroac
113 roduction, as glycolytic inhibition with the pyruvate dehydrogenase kinase inhibitor dichloroacetate
114 cardiac Mtch mutants with dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, reduced lactate
116 g water containing no supplement or the PDK (pyruvate dehydrogenase kinase) inhibitor dichloroacetate
117 rease in the expression of PDK4, one of four pyruvate dehydrogenase kinase isoenzymes expressed in ma
118 e complete absence of K+ and phosphate (Pi), pyruvate dehydrogenase kinase isoform 2 (PDHK2) was cata
119 Deltaex3/Bnip3FL isoform ratio by inhibiting pyruvate dehydrogenase kinase isoform 2 (PDK2) in Panc-1
123 he Warburg effect through down-regulation of pyruvate dehydrogenase kinase isozyme 1 (PDK1) mediated
124 ivation of phosphoinositide 3-kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mamm
125 crystal structure reported here reveals that pyruvate dehydrogenase kinase isozyme 2 has two domains
127 report that genes for pancreatic lipase and pyruvate dehydrogenase kinase isozyme 4 are up-regulated
129 This is in contrast to the related mammalian pyruvate dehydrogenase kinase isozymes that occur as hom
130 esults indicate that BCKD kinase, similar to pyruvate dehydrogenase kinase isozymes, belongs to the s
131 y oxidative mitochondrial enzymes, including pyruvate dehydrogenase kinase, medium-chain length fatty
134 roxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that s
137 at insulin has a profound effect to suppress pyruvate dehydrogenase kinase (PDK) 4 expression in rat
138 phosphorylation caused in part by increased pyruvate dehydrogenase kinase (PDK) activity due to incr
140 ylation activates and inhibits mitochondrial pyruvate dehydrogenase kinase (PDK) and phosphatase (PDP
141 acilitates markedly enhanced function of the pyruvate dehydrogenase kinase (PDK) and pyruvate dehydro
143 od development, we used the dedicated kinase pyruvate dehydrogenase kinase (PDK) for the in vitro ass
146 Treatment of endometriosis HPMCs with the pyruvate dehydrogenase kinase (PDK) inhibitor/PDH activa
153 s with antibodies raised against recombinant pyruvate dehydrogenase kinase (PDK) isoforms PDK2 and PD
154 yltransferase (E2) has an enormous impact on pyruvate dehydrogenase kinase (PDK) phosphorylation of t
155 acetic acids are developed for inhibition of pyruvate dehydrogenase kinase (PDK), an enzyme responsib
156 by inhibiting a key enzyme in cancer cells, pyruvate dehydrogenase kinase (PDK), that is required fo
162 rpose of this study was to determine whether pyruvate dehydrogenase kinase (PDK)4 was expressed in ad
164 phorylation of pyruvate dehydrogenase by the pyruvate dehydrogenase kinases (PDK) inhibits pyruvate d
165 ToMI analysis revealed AKT and mitochondrial pyruvate dehydrogenase kinase PDK1 and PDK4 as kinase ta
166 report that hypoxia drives expression of the pyruvate dehydrogenase kinase (PDK1) and EGFR along with
169 pyruvate dehydrogenase (PDH) complex by the pyruvate dehydrogenase kinase PDK4 enables the heart to
171 f these antibodies to PDH activity using the pyruvate dehydrogenase kinase-specific inhibitor dichlor
172 thyroidism increases the ex vivo activity of pyruvate dehydrogenase kinase, thereby inhibiting glucos
173 gulation of the gene expression response for pyruvate dehydrogenase kinase to pressure overload.