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1 ing tRNA, it influences decoding of the UAGA quadruplet.
2 activated concomitantly by spike triplets or quadruplets.
3 dual log likelihoods of composing amino acid quadruplets.
4 allow decoding of complementary 5'-CAAA(-3') quadruplets.
5 higher-order relations, such as triplets and quadruplets.
6  as interactions between finger triplets and quadruplets.
7 2 +/- 0.01 s vs. -0.07 +/- 0.04 s, P < 0.05; quadruplets: -0.01 +/- 0.01 s vs. -0.09 +/- 0.09 s, P <
8 +/- 1.2 mmHg vs. 3.4 +/- 2.1 mmHg, P < 0.05; quadruplets: 3.0 +/- 1.0 mmHg vs. 5.5 +/- 3.7 mmHg, P <
9 ngletons, 88 of twins, 22 of triplets, 10 of quadruplets, 5 of quintuplets, and 2 of sextuplets.
10 oup of 83 women carrying twins, triplets, or quadruplets (aged 20-46 y) was recruited from 2011 to 20
11                                          New quadruplet and triplet combinations, including proteasom
12                     Open time for co-channel quadruplets and quintuplets tends to be relatively long
13 s the codon immediately 5' of the first UAGA quadruplet, and release factor 1 is partially inactivate
14 We suggest that, rather than engineering the quadruplet anticodon-codon pairing scheme at the ribosom
15 e twenty aminoacyl tRNA synthetases tolerate quadruplet anticodons.
16       As part of a study of the potential of quadruplets as codons, the decoding of tandem UAGA quadr
17 plets as codons, the decoding of tandem UAGA quadruplets by an engineered tRNA(Leu) with an eight-bas
18 chemical alphabet available to a nascent all-quadruplet code.
19  it is simpler and sufficient, not because a quadruplet codon code is unachievable.
20 cal amino acids into proteins in live cells, quadruplet codon decoding has potential to enable a grea
21 we discuss methodologies and applications of quadruplet codon decoding in genetic code expansion both
22  predominant form of genetic code in nature, quadruplet codon decoding often displays limited efficie
23     Inducing tRNA +1 frameshifting to read a quadruplet codon has the potential to incorporate a non-
24     Inducing tRNA +1 frameshifting to read a quadruplet codon has the potential to incorporate a non-
25 ted to the anticodon loop for pairing with a quadruplet codon in the aminoacyl-tRNA binding (A) site
26 engineered Escherichia coli tRNAs supporting quadruplet codon translation by first developing a libra
27 ng tRNA evolution (qtRNA-PACE) that improved quadruplet codon translation efficiencies up to 80-fold.
28                           However, efficient quadruplet codon translation often requires multiple tRN
29 g future developments towards an exclusively quadruplet codon translation system.
30 non-canonical amino acids in response to the quadruplet codon UAGA.
31  amino acid into proteins in response to the quadruplet codon, AGGA.
32 iring in the 0-frame to initially decode the quadruplet codon, but subsequently shifts to the +1-fram
33 sal adoption of a triplet codon, rather than quadruplet codon, genetic code?
34  library-cross-library selection to nominate quadruplet codon-anticodon pairs.
35 dons to all four bases of the complementary, quadruplet codon.
36 frameshift sequence) in the A site, and this quadruplet "codon-anticodon" helix is translocated to th
37                             We also designed quadruplet-codon codes that should ensure all single poi
38 or (YFFS) tRNAs that recognize two different quadruplet codons (CGGG and GGGU) in vivo.
39 ibo-Q1) that efficiently decodes a series of quadruplet codons and the amber codon, providing several
40           Here we investigate translation of quadruplet codons by a +1-frameshifting tRNA, SufB2, tha
41 he multiplexed decoding of up to four unique quadruplet codons by their corresponding qtRNAs in a sin
42  the amber codon, have been widely employed, quadruplet codons have attracted attention for the poten
43 ly encoded in response to unique triplet and quadruplet codons including fluorescent, photoreactive a
44   Here, we introduce a system for the use of quadruplet codons to direct incorporation of non-canonic
45                  While genome recoding using quadruplet codons to incorporate non-proteinogenic amino
46 ral amino acids into proteins in response to quadruplet codons, and the creation of an orthogonal tra
47 dology for incorporating UAAs in response to quadruplet codons, but currently, it is mostly limited t
48  engineered, evolved, and combined to decode quadruplet codons, portending future developments toward
49 As ribo-Q1 independently decodes a series of quadruplet codons, this work provides foundational techn
50      Developments include strategies to read quadruplet codons, use non-natural DNA base pairs, synth
51 cused on reassigning termination or decoding quadruplet codons.
52 le fragment (ScFv), in response to amber and quadruplet codons.
53 tion of unnatural amino acids in response to quadruplet codons.
54  single protein in response to four distinct quadruplet codons.
55 te a broad repertoire of ncAAs at orthogonal quadruplet codons.
56 nd enable processive translation of adjacent quadruplet codons.
57 ependence and improves ncAA incorporation at quadruplet codons.
58                                  The optimal quadruplet combination, and whether this obviates the ne
59                                         Each quadruplet composition was characterized by a single des
60 scoring function (log likelihoods of residue quadruplet compositions) is derived by the analysis of a
61 reover, while tRNAs were largely amenable to quadruplet conversion, only nine of the twenty aminoacyl
62 oach will facilitate the routine adoption of quadruplet decoding for genetic code expansion in eukary
63 n facilitated by the evolution of orthogonal quadruplet decoding ribosomes and the discovery of mutua
64         We demonstrate the efficiency of the quadruplet decoding system by incorporating photocaged a
65 nt efforts on genetic code expansion through quadruplet decoding.
66 anslation system that uses amber and evolved quadruplet-decoding transfer RNAs to encode numerous pai
67 e-assisted continuous evolution strategy for quadruplet-decoding tRNA evolution (qtRNA-PACE) that imp
68 lity that distinguishes individuals within a quadruplet despite their genetic similarity.
69 etween sequence pairs, but between triplets, quadruplets, etc., is proposed to strengthen the proper
70 c biologists to deliberately engineer an all-quadruplet expanded genetic code.
71 ction of interfacial nearest neighbor atomic quadruplets for each complex.
72 non-bursts [singlets, doublets, triplets and quadruplet (four or more)] and mean blood pressure and R
73 ic mutagenesis of both suprabranch guanosine quadruplets (G(4)) revealed a key role of central G resi
74                                              Quadruplets have become the new standard in transplantat
75 alators to DNA structure associated with the quadruplet helix and Holliday junction.
76 ed feasibility of an intensive strategy with quadruplet induction and consolidation plus tandem trans
77 tity of the codon immediately 5' of the UAGA quadruplet influences the efficiency of quadruplet trans
78  TFs and interacting TF pairs, triplets, and quadruplets involved in CYP3A4 expression.
79 , and we identified two frequently occurring quadruplet marks 'K9me1K23acK27me2K36me2' and 'K9me3K23a
80 plet motif (PQM) and the inverted processing quadruplet motif (iPQM).
81 re than 10 years ago, include the processing quadruplet motif (PQM) and the inverted processing quadr
82 nteractions between the lowest crystal-field quadruplet of Np(4+) ions induce a primary noncollinear
83 ntation defines all sets of nearest neighbor quadruplets of amino acids.
84 d from medical students while they diagnosed quadruplets of heartbeat cycles.
85 blood transcriptome of five wild monozygotic quadruplets over time to explore the influence of develo
86 cells prevents it from frameshifting using a quadruplet-pairing mechanism such that it preferentially
87  the m1G37 modification in the controversial quadruplet-pairing model of tRNA frameshift suppressors.
88 te of the 4-AzHBA probe was localized to the quadruplet Phe(90)-Met(91)-Val(92)-Phe(93) using ESI LC-
89        The therapeutic success of first-line quadruplet (QUAD) induction therapy and autologous stem
90 genetic code expansion using a non-canonical quadruplet reading frame.
91 d multiple myeloma, induction therapy with a quadruplet regimen before autologous transplant is the s
92 wly diagnosed multiple myeloma (NDMM) with a quadruplet regimen consisting of a monoclonal antibody,
93 epeat, whereas the DM2 expansion is an rCCUG quadruplet repeat.
94  stages of rediploidization were identified: quadruplets retaining their ancestral tetraploid conditi
95 l inactivation of release factor 1, the UAGA quadruplet specifies a leucine residue with an efficienc
96      Frontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated i
97 g their ancestral tetraploid condition, semi-quadruplets still reflecting the ancestral tetraploidy w
98 ing histone singlets, doublets, triplets and quadruplets, the latter comprising the four core histone
99                             For triplets and quadruplets, the most nonequilibrium interactions are be
100                                   Triplet or quadruplet therapies incorporating proteasome inhibitors
101  in the contemporary era of novel triplet or quadruplet therapies.
102             The present study supports D-VRd quadruplet therapy as a new standard of care for transpl
103  3' closely matched codon, the efficiency of quadruplet translation at UAGA is reduced.
104 UAGA quadruplet influences the efficiency of quadruplet translation via the properties of its cognate
105  previous model that suppressor tRNAs induce quadruplet translocation now appears incorrect for most,
106 eptor classes can be converted to functional quadruplet tRNAs (qtRNAs).
107                         The potential of the quadruplet UAGA in Escherichia coli to specify a single
108 ited a new approach to significantly improve quadruplet UAGN and AGGN (N = A, U, G, C) codon decoding

 
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