ライフサイエンスコーパス: quantal size

1 7 Hz elevated the amount released per event (quantal size).

2 ts of transmitter per vesicle (i.e., reduced quantal size).

3 quantal size and are potential regulators of quantal size.

4 by decreases in both release probability and quantal size.

5 pa, a catecholamine precursor that increases quantal size.

6 amplitude miniature IPSCs and larger BC-->GC quantal size.

7 reas occupancy levels were only dependent on quantal size.

8 ion with pHoenix only slightly increased the quantal size.

9 ause a small, but reproducible, reduction in quantal size.

10 tamate and GABA in synaptic vesicles reduces quantal size.

11 mechanism of release controls both rate and quantal size.

12 subunit (inhibiting PKA activity) increases quantal size.

13 vation results in a compensatory increase in quantal size.

14 of a receptor-mediated mechanism that alters quantal size.

15 ave an estimate of histogram peak spacing or quantal size.

16 an increase and a decrease, respectively, in quantal size.

17 synaptic vesicles (SV) and thereby regulate quantal size.

18 ation influences the SV content and synaptic quantal size.

19 ncentration and thus controlled postsynaptic quantal size.

20 ine reduces synaptic vesicle transmitter and quantal size.

21 ent with a change in quantal content but not quantal size.

22 eases in release probability or postsynaptic quantal size.

23 oorly understood but are key determinants of quantal size.

24 ontent and a PKC-independent increase of the quantal size.

25 distinct, presynaptic mechanism to regulate quantal size.

26 uestions about the presynaptic regulation of quantal size.

27 esicle filling also contribute to changes in quantal size.

28 t this synapse, involves a reduction in EPSC quantal size.

29 pontaneous quantal release with no change in quantal size.

30 that intracellular Ca2+ stores can regulate quantal size.

31 role of postsynaptic activity in controlling quantal size.

32 PC12 cells produced a unimodal population of quantal sizes.

33 pe vs CaSR(-/-) pairs) with little change in quantal size (23 +/- 4 pA vs 22 +/- 4 pA) or number of r

34 asticity expression components, reduction in quantal size (a postsynaptic property) contributing to L

35 examined the mechanism underlying increased quantal size after block of synaptic activity at the mam

36 it appears likely that the site of increased quantal size after chronic block of activity is presynap

37 rometric spike half-widths without change in quantal size after either myosin II inhibition or actin

38 % increase) of elementary synaptic currents (quantal size) after kindling results directly from a 75%

39 An important assumption has been that quantal size (amount of transmitter released per vesicle

40 However, the quantal size (amplitude of miniature end-plate currents)

41 ry synapses, in terms of larger postsynaptic quantal size amplitudes, in part because they likely con

42 TRPM7 affects EPSP quantal size, an intrinsic property of synaptic vesicle

43 logical analysis demonstrated an increase in quantal size and a concomitant decrease in quantal conte

44 unction (NMJ): a PKA-dependent modulation of quantal size and a retrograde regulation of presynaptic

45 ns suggest that RYRs are essential to normal quantal size and are potential regulators of quantal siz

46 nfirmed by estimates of release probability, quantal size and contact number at the AOB-to-ACP synaps

47 osities, which displayed both 2-fold greater quantal size and frequency of quantal release.

48 on in small synaptic vesicles increased both quantal size and frequency, consistent with the recruitm

49 that incorporated both spatial variation in quantal size and non-uniform release probability.

50 tic transmission as a result of both reduced quantal size and quantal content.

51 ase in striatal slices and reductions in the quantal size and release frequency of catecholamine in d

52 These data demonstrate that ACh controls the quantal size and release frequency of glutamate at haben

53 The quantal size and shape characteristics of amperometric e

54 transient shift was accompanied by increased quantal size and suprathreshold excitability in CTs, wit

55 ocytosis modes and their roles in regulating quantal size and synaptic strength, generating synaptic

56 sary for the developmental increase in AMPAR quantal size and that metabotropic glutamate receptor ac

57 in synaptic vesicles determines postsynaptic quantal size and thus the strength of synaptic transmiss

58 spiny and interneuron synapses have similar quantal sizes and baseline release probabilities.

59 From these quantal sizes and the EPSP mean amplitudes we calculated

60 increases in either total receptor number or quantal size, and differences between the variability of

61 learance and little delayed release, a large quantal size, and fast AMPA-type glutamate receptors.

62 f functional release sites, relatively large quantal size, and unusual dynamics of transmitter releas

63 y nerve synapses had reduced EPSC amplitude, quantal size, and vesicle release probability (P (r)).

64 We show that decrease and increase in quantal size are associated with a respective decrease a

65 olecular determinants of vesicle filling and quantal size are regulated by neuronal activity in an op

66 t the receptor subunit composition regulates quantal size, Argiotoxin sensitivity, and receptor desen

67 Postsynaptically, the quantal size as well as number and size of GluA1 puncta

68 However, quantal size at basket cell-to-granule cell synapses was

69 ncy which demonstrates a process that meters quantal size at moment of release.

70 onsolidation resulting in a normalization of quantal size at the few remaining functional synapses.

71 propose that presynaptic activity modulates quantal size at the neuromuscular junction by modulating

72 that postsynaptic activity does not regulate quantal size at the neuromuscular junction.

73 The distribution of quantal sizes at the junction usually does not follow a

74 We observed no differences in quantal size between control and occluded mice.

75 lls, in which VMAT2 expression increased the quantal size but not the number of release events.

76 whereas for mGluR-LTD there was no change in quantal size, but a large decrease in the frequency of e

77 tely 50-fold, in part through an increase in quantal size, but primarily through an increase in the n

78 Changes in synaptic activity alter quantal size, but the relative roles of presynaptic and

79 bility fluctuation analysis revealed similar quantal sizes, but 4-times more functional release sites

80 turation in turn makes it possible to modify quantal size by altering the flux of transmitter through

81 e activity by approximately 50% also reduced quantal size by approximately 50%.

82 changes in transporter expression that alter quantal size can affect behavior.

83 ion of a putative VAChT and demonstrate that quantal size can be regulated by changes in vesicular tr

84 s established that, for dense-core granules, quantal size can be varied by stimulation frequency, cha

85 ionally, extracellular osmolarity influences quantal size, causing quantal size increases under hypot

86 itional quantal analysis that attributes the quantal size change to a postsynaptic mechanism, the pre

87 ytosis affects short-term plasticity through quantal size changes.

88 and show a dramatic increase in presynaptic quantal size consistent with defects in synaptic vesicle

89 Spermidine did not affect quantal size, consistent with a presynaptic mechanism of

90 nt GABAergic neurons show reduced inhibitory quantal size, consistent with a presynaptic reduction in

91 Here, we reveal how individual quantal-sized corticothalamic EPSPs propagate within tha

92 Consistent with previous findings, the quantal size did not change during paired-pulse facilita

93 The quantal size distribution was modulated by treatment wit

94 when the combined variances of the noise and quantal-size distributions were reduced, increasing the

95 lysis of miniature EPSCs revealed that AMPAR quantal size doubled over time in vitro whereas NMDAR qu

96 analysis revealed a gradual augmentation in quantal size during trains of EPSCs, and application of

97 roM) reduced both the evoked current and the quantal size (estimated with MPF analysis) to a similar

98 The mean quantal size, estimated from the miniature EPSCs (MEPSCs

99 sed on large numbers of trials, and that the quantal size estimates from the binomial method with N h

100 Analyses of quantal size, FM1-43 loading, and dynamin function furth

101 auses a transient reduction in AMPA receptor quantal size followed by synaptic consolidation resultin

102 ssion, expressed as a compensatory change in quantal size following chronic activity perturbation, is

103 of the mean peak spacing, and hence the mean quantal size, for each histogram.

104 a2+ produces a reduction in the postsynaptic quantal size in addition to its known effect on release

105 uired for homeostatic synaptic plasticity of quantal size in central neurons.

106 examined the mechanism underlying increased quantal size in ClC mice and found that it also appeared

107 basal synaptic transmission, except a larger quantal size in CR-expressing synapses.

108 The ability to increase quantal size in vesicles that were already competent for

109 e fusion, parallels PTP, suggesting that the quantal size increase also contributes to the PTP genera

110 These data suggest that the quantal size increase contributes to the enhancement of

111 We conclude that an activity-dependent quantal size increase contributes to the enhancement of

112 Furthermore, it is unclear whether the quantal size increase is also mediated by PKC.

113 e of our previous studies, suggests that the quantal size increase is caused by a presynaptic mechani

114 osmolarity influences quantal size, causing quantal size increases under hypotonic conditions, presu

115 to enhanced transmitter release and a larger quantal size, indicating enhanced responsiveness to indi

116 along axons had a distribution with the same quantal size, indicating that a vesicle releases all the

117 c K(+) at a glutamatergic synapse influenced quantal size, indicating that synaptic vesicle K(+)/H(+)

118 Quantal size is a fundamental parameter controlling the

119 The PKA-dependent reduction in quantal size is accompanied developmentally by an increa

120 sicle volume, our results indicate that when quantal size is altered via the vesicular monoamine tran

121 Presynaptic regulation of quantal size is an appealing mechanism for changing syna

122 ecent studies suggest that the modulation of quantal size is associated with corresponding changes in

123 At central synapses, quantal size is generally regarded as fluctuating around

124 DGluRIIA, since PKA-dependent modulation of quantal size is lost in homozygous viable DGluRIIA- muta

125 the calcium-dependent effect on postsynaptic quantal size is mediated by group 1 metabotropic glutama

126 Quantal size is the postsynaptic response to the release

127 Moreover, although elevated K+ can increase quantal size it acts by a pathway that does not involve

128 tentiates dopamine (DA) release by elevating quantal size, longer term exposure to L-DOPA (48 hr) pro

129 Quantal size measurements were fitted to one and to two

130 lease (quantal content), without a change in quantal size (mEPSC amplitude), compensates for altered

131 In contrast, neither the quantal size nor the kinetics of AMPA EPSC was altered b

132 one could produce an appreciable increase in quantal size, normally attributed to either the presence

133 s release, yielded distributions with a mean quantal size of 0.55 +/- 0.01 nS and a CV of 0.37 +/- 0.

134 transport is the limiting factor determining quantal size of 5-HT and histamine release, intragranula

135 ion of alphaCaMKII(1-290)-EGFP increased the quantal size of AMPAR-mediated responses.

136 oading into synaptic vesicles, and increased quantal size of asynchronous released vesicles but did n

137 ms: an increase in the frequency but not the quantal size of Ca2+ syntillas, which are brief, focal C

138 expression of VNUT drastically increases the quantal size of exocytotic events.

139 inopyridine caused a significant increase in quantal size of NMDA EPSC.

140 f dendritic spines causes an increase in the quantal size of NMDA synaptic current.

141 2.4 times larger than in relay neurons, and quantal size of RTN EPSCs was 2.6 times greater.

142 The quantal size of secreted catecholamines, measured by amp

143 al analysis--the same mechanism controls the quantal size of spontaneous and evoked release.

144 f AMPAR miniature events and compromised the quantal sizes of both AMPAR and NMDAR currents evoked at

145 ed appear to be below those needed to affect quantal size or output.

146 ntent of the TS-eEPSCs without affecting the quantal size or release probability, suggesting a reduct

147 r monoamine transport blocker that decreases quantal size, or l-dopa, a catecholamine precursor that

148 This study reports how quantal size, or the quantity of chemical messengers wit

149 the recorded EPSP amplitudes for changes in quantal size over time.

150 creased amplitude reflects a decrease in the quantal size per mf-CA3 synapse and in the number of act

151 with postsynaptic changes that maintain the quantal size per release site.

152 analysis to compare the release probability, quantal size (q) and number of release sites (n) at moss

153 r of release sites (N) kept constant but the quantal size (Q) and the release probability (Pr) allowe

154 number of functional release sites (N) and a quantal size (q) of 0.5 +/- 0.03 nS (n = 6).

155 rom an average of 19 release sites (N) and a quantal size (q) of 34.0 +/- 4.7 pA.

156 bility of neurotransmitter release (Pr), the quantal size (q), and the so-called potency, which is de

157 Release probability (P(r)) and quantal size (Q), as measured at the somatic recording s

158 of neurotransmitter release (Pr), and large quantal size (Q).

159 between 0.33 and 0.46, and the corresponding quantal sizes ranged between 260 and 657 microV.

160 Quantal sizes ranged from 93 to 285 microV, with a mean

161 , then, likely a reflection of the increased quantal size rather than any direct effect on exocytosis

162 Ag stimulation and is characterized by large quantal size release events.

163 hand, the presynaptic factors that determine quantal size remain poorly understood.

164 ize doubled over time in vitro whereas NMDAR quantal size remained constant.

165 ction potential-evoked release of glutamate, quantal size remained unchanged.

166 The PKA-dependent modulation of quantal size requires the presence of the muscle-specifi

167 With increased stimulation, quantal size rose continuously, not abruptly, suggesting

168 At a single set of synapses, the increase in quantal size seen with long-term potentiation was comple

169 n in which the anion was aspartate increased quantal size similar to gluconate.

170 CIH also produced no changes in TS-eEPSC quantal size, since the amplitudes of both low calcium-e

171 oic acid (NPPB) antagonized the increases in quantal size, so it seems likely that Cl(-) follows H(+)

172 naptic transmission as a result of increased quantal size, suggesting that the loss of Caz in animals

173 synaptic currents at any synapse and a large quantal size that facilitates the resolution of spontane

174 VGLUT in motoneurons leads to an increase in quantal size that is accompanied by an increase in synap

175 When these treatments increased quantal size the mean 20-80 % rise time of MEPPs recorde

176 While elevated VGLUT expression increases quantal size, the minimum number of transporters require

177 of all AP-3 produces a dramatic increase in quantal size; these changes were correlated with alterat

178 perometric events, indicating an increase in quantal size: this reflects either an increase in vesicu

179 The regulation of quantal size through pre- rather than postsynaptic mecha

180 However, determination of the unitary, quantal size underlying such putatively multiquantal eve

181 , suggesting that [Glu]v is a main source of quantal size variation.

182 Quantal size varies at most synapses.

183 to provide an activity-dependent scaling of quantal size via a presynaptic mechanism.

184 The reduced quantal size was blocked by the D2 antagonist sulpiride

185 Surprisingly, quantal size was increased in ClC mice before block of s

186 ver, previous measurements showed that after quantal size was increased the vesicles in the terminal

187 letely blocked in both control and ClC mice, quantal size was large in both groups despite the higher

188 Quantal size was measured directly by comparing unitary

189 amine was quantal and calcium-dependent, but quantal size was much less than expected for large dense

190 When elimination was underway, AMPA-R quantal size was much reduced for the weakest terminals.

191 Quantal size was not altered following SNAT2 induction o

192 Moreover, quantal size was not an invariant parameter in CNS neuro

193 The increase in AMPAR quantal size was prevented by TTX and ionotropic glutama

194 m granules in VMAT2(+/-) cells revealed 5-HT quantal size was reduced more than that of histamine.

195 lease probability sharply increased, whereas quantal size was unaltered.

196 ring DSI, quantal content of eIPSCs, but not quantal size, was significantly reduced.

197 By using miniature IPSC amplitudes to infer quantal size, we estimated that unitary IPSCs associated

198 the correction procedure is that changes in quantal size were a major factor in obscuring peaks in h

199 influx, readily releasable SV pool size, and quantal size were unaltered, the reduced synaptic streng

200 otransmitter content of individual vesicles (quantal size), whereas deletion of all AP-3 produces a d

201 ic strength onto PNs as a result of a larger quantal size, whereas autaptic and heterosynaptic PV-PV

202 ively active PKA catalytic subunit decreases quantal size, whereas overexpression of a mutant PKA reg

203 d, exocytosis of compound vesicles increases quantal size, which increases synaptic strength and cont

204 Lowering clathrin levels also reduces quantal size, which occurs concomitantly with a decrease

205 there was a significant decrease in unitary quantal size, which was not due to postsynaptic receptor

206 y to acetylcholine neurotransmitter (reduced quantal size) while simultaneously enhancing evoked tran

207 one dimensions correlate with an increase in quantal size without a change in presynaptic vesicle siz

208 econd, GDNF elicited a small increase in the quantal size, without affecting the average rise and dec