ライフサイエンスコーパス: quaternary structure

1 e accounting for the complete folded protein quaternary structure.

2 ion while retaining overall protein fold and quaternary structure.

3 , to address key questions regarding laminin quaternary structure.

4 revealing its unique integrated tertiary and quaternary structure.

5 e to complexity in their domain assembly and quaternary structure.

6 ignificantly different void volumes in their quaternary structure.

7 Both classes exhibit a dimeric quaternary structure.

8 ng the possible preservation of the original quaternary structure.

9 idase to chaperone involves changes in their quaternary structure.

10 ed without impact on secondary, tertiary, or quaternary structure.

11 oth regarding ligand binding and the protein quaternary structure.

12 e the same functional properties within each quaternary structure.

13 the equilibrium toward an amyloid-resistant quaternary structure.

14 C, slow chromophore formation and obligatory quaternary structure.

15 tive manner, which most likely is due to its quaternary structure.

16 guous domain assignments and reveal a linear quaternary structure.

17 s a-g), which combine to form a 24-mer (4x6) quaternary structure.

18 However, SInv displays an unusual quaternary structure.

19 transcriptional regulation by regulating its quaternary structure.

20 rystallography can provide insight on native quaternary structure.

21 dence for assembly blockade of the RRM1-RRM2 quaternary structure.

22 change in tertiary but not net secondary or quaternary structure.

23 Da) and which constitute the doughnut-shaped quaternary structure.

24 bling the polypeptide chains into the native quaternary structure.

25 this superfamily (CAX(CK31)) and analyze its quaternary structure.

26 wo days, and is therefore uncoupled from the quaternary structure.

27 e bond results in a loss of peptide fold and quaternary structure.

28 ne residues enriched with (13)C to probe its quaternary structure.

29 ese sera mainly recognize native molecule or quaternary structure.

30 bled accurate design of protein tertiary and quaternary structure.

31 ins depends on their assembly into a defined quaternary structure.

32 led me to propose a structural model for its quaternary structure.

33 rs to be separable from the alteration in gB quaternary structure.

34 sidues that are critical for stabilizing the quaternary structure.

35 ities, including targeting of polysaccharide quaternary structure.

36 o probe internal chromophores as a marker of quaternary structure.

37 well as for predicting protein function and quaternary structure.

38 uence to secondary, tertiary, and ultimately quaternary structure.

39 roteins assemble into complexes with diverse quaternary structures.

40 y of the D3 receptor and possibly other GPCR quaternary structures.

41 een proteins constitute the basis of protein quaternary structures.

42 h native dimer or tetramer (dimer-of-dimers) quaternary structures.

43 mbling into 2D lattices and other prescribed quaternary structures.

44 the same fast and slow rates in both R and T quaternary structures.

45 nce in hemoglobin oxygen affinity of the two quaternary structures.

46 ween more reactive (R) and less reactive (T) quaternary structures.

47 n contacts, indicating similar secondary and quaternary structures.

48 stable signaling machines with well-defined quaternary structures.

49 q reflects the equilibrium between different quaternary structures.

50 are the most regular feature of tertiary and quaternary structures.

51 h to the creation of complex abiotic peptide quaternary structures.

52 principles involving secondary, tertiary and quaternary structures.

53 The quaternary structure, allosteric regulation, and propert

54 cture ofSdGluc5_26A adopts a stable trimeric quaternary structure also observable in solution.

55 Quaternary structure analysis of other members of the st

56 ein complexes into smaller substructures for quaternary structure analysis.

57 to 10 A, HAP18 caused only minor changes in quaternary structure and actually decreased the capsid d

58 s, we generated alpha-syn standards of known quaternary structure and conformational properties and c

59 xplored the impact of phosphorylation on the quaternary structure and dynamics of Hsp27.

60 The quaternary structure and dynamics of the human small hea

61 ategies, however, are limited by adiponectin quaternary structure and effective concentrations in cir

62 guingly, one subfamily retained a multimeric quaternary structure and has small insertions and deleti

63 ential to test the hypothesized link between quaternary structure and heme heterogeneity in wild-type

64 sylation of CCH, FLH, and KLH disrupts their quaternary structure and impairs their immunogenic effec

65 l role in promoting the stability of protein quaternary structure and in the assembly of large macrom

66 The rod adopts a helical quaternary structure and is thought to play essential ro

67 resentative structures revealed that loss of quaternary structure and large deletions or insertions a

68 According to the proposed model, spectrin's quaternary structure and mechanism of extension is simil

69 1) provide tunable coupling between protein quaternary structure and metal coordination, 2) enable t

70 The quaternary structure and substrate preferences of MERS-C

71 The SAXS data capture the enzyme's quaternary structure and suggest a conformational rearra

72 TET2 dodecameric particle displayed the same quaternary structure and thermal stability as the wild-t

73 oth kinds of homodimers adopt a head-to-tail quaternary structure and thus do not contain direct knob

74 SP that forms large, dynamic oligomers whose quaternary structures and chaperone activities depend on

75 two sHsps are strikingly different in their quaternary structures and chaperone properties, defining

76 crete protein-like bundles possessing unique quaternary structures and exceptional thermodynamic stab

77 meric glycoproteins with complex dodecameric quaternary structures and heterogeneous glycosylation pa

78 The recent achievements concerning tertiary/quaternary structures and the self-assembling foldameric

79 differences in intracellular concentration, quaternary structure, and distinct active site architect

80 timate relationships among protein assembly, quaternary structure, and evolution and demonstrate on a

81 cterized by more conserved binding sites and quaternary structure, and qualitatively different allost

82 n domain architecture, oligomeric state, and quaternary structure, and these variations represent dif

83 mulate the evolution and assembly of protein quaternary structure, and to provide a tractable way to

84 uaternary structure to the nonpolymerizing R quaternary structure are now being developed.

85 servations suggest that small disruptions of quaternary structure are sufficient for fast desensitiza

86 f flavin-binding proteins with a dodecameric quaternary structure, are able to incorporate two flavin

87 s that DnaB adopts a closed spiral staircase quaternary structure around an A-form ssDNA with each C-

88 ommonly assemble into complexes with diverse quaternary structure arrangements.

89 or increased thermostability and had similar quaternary structure as compared to the wild type.

90 nterface rather than generating all putative quaternary structures as accomplished by PISA or EPPIC,

91 nalysis of primary, secondary, tertiary, and quaternary structures as well as the dynamics that accom

92 Thus, a dimeric quaternary structure, as opposed to two cooperative acti

93 ear is whether XEEL and hIntL-1 have similar quaternary structures, as XEEL lacks the corresponding c

94 ctron microscopy, revealing the tertiary and quaternary structure at sufficient resolution to clearly

95 ed changes in protein higher order (tertiary/quaternary) structure at the picogram level, which is un

96 receptor-induced conformational changes, and quaternary structure-based strategies for immune evasion

97 transcarbamoylase exists in an intermediate quaternary structure between the canonical T and R struc

98 We observed that SpAhpD formed a dimeric quaternary structure both in the crystal and in solution

99 pportive evidences that the space of protein quaternary structures can be represented by the combinat

100 The spectra establish that quaternary structure change in the gel takes a week or m

101 hysical characterization indicates that this quaternary structure change is not accompanied by substa

102 Archaeal DHNA shows a unique secondary and quaternary structure compared with bacterial and plant D

103 t in subunit orientation leads to a peculiar quaternary structure compared with that of its ortholog

104 mn using the bNAb PGT145, which recognizes a quaternary structure-dependent epitope at the trimer ape

105 nd KNH1144 T162A, did not present the glycan/quaternary structure-dependent epitope for PGT145 bindin

106 s; cleaved, SOSIP-stabilized trimers express quaternary structure-dependent epitopes, whereas uncleav

107 at the intra-dimer interface, and the virus quaternary structure-dependent inter-dimer and inter-raf

108 Quaternary structure determination for transmembrane/sol

109 incorporating geometry restraints in aiding quaternary structure determination, we introduce two new

110 triphosphate, MnCl2, and tartrate, but their quaternary structure did not conform to the canonical pa

111 acetate decarboxylase, though the respective quaternary structures differ markedly and structural dif

112 of a class I terpenoid cyclase, its dimeric quaternary structure differs from that previously observ

113 This intermediate has a quaternary structure distinct from the native protein.

114 n implemented, including SALIGN, modeling of quaternary structures, DOPE scores, disulfide bond model

115 hese results indicate that aberrant myocilin quaternary structure drives Grp94 recognition, rather th

116 topes, whereas alloimmunogens lacking native quaternary structure elicited antibodies to shared alpha

117 temperature, concentration, and primary and quaternary structure, employing an instrument of our own

118 cines induced type-specific nAbs directed to quaternary structure envelope epitopes known to be targe

119 proteolysis at different rates, dependent on quaternary structure environment, while particle stabili

120 5D bridges the capsid of B19 by binding to a quaternary structure epitope formed by residues from thr

121 The structure shows a quaternary structure epitope formed by three VP2 protein

122 tralize DENV infection by binding a complex, quaternary structure epitope that is expressed only when

123 neutralize ZIKV and DENVs recognize complex quaternary structure epitopes displayed on E-homo-dimers

124 duce recombinant E protein dimers displaying quaternary structure epitopes is an important advance wi

125 Both antibodies bound to quaternary structure epitopes near the hinge region betw

126 the antigens tested do not display critical quaternary structure epitopes present on Zika E protein

127 ralizing antibodies that have been mapped to quaternary-structure epitopes displayed on the viral sur

128 ed were mainly monomers that did not display quaternary-structure epitopes found on E dimers and high

129 oteins is found to be useful for identifying quaternary-structure errors in published crystal structu

130 t these mutants retain the same tertiary and quaternary structures, establishing that the reduced act

131 of holoenzyme complexes can create distinct quaternary structures even though the R(1):C(1) heterodi

132 show that SAA1.1 and SAA2.2 differ in their quaternary structure, fibrillation kinetics, prefibrilla

133 ind that hemoglobin must be in the T (tense) quaternary structure for nucleation, but the presence of

134 oligomers, although the significance of such quaternary structures for signaling or receptor traffick

135 c disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pocke

136 oteins in any case when cofactor assembly or quaternary structure formation occurs after transport.

137 dification are well established, controlling quaternary structure formation remains a significant cha

138 We find that these proteins range in quaternary structure from monomers to tetramers, with 6

139 er revealed how the active-site residues and quaternary structure govern regioselectivity.

140 In their model, each quaternary structure has a single reactivity.

141 but the atomic details of TRIM tertiary and quaternary structure have not been fully understood.

142 However, the tertiary and quaternary structures have been elusive.

143 rogen-bonded imidazole-imidazolium histidine quaternary structures have been proposed, based on cryst

144 -ssDNA complex reported here shows a compact quaternary structure held together by a four-way interfa

145 t lie next to bulky domains or are masked by quaternary structures.Importin alpha3 facilitates the nu

146 ional clustering while utilizing the protein quaternary structure in 3D space.

147 fferent CpAMs and find that they also affect quaternary structure in different ways.

148 ts allowed us to test the importance of Hmg2 quaternary structure in mallostery: a nonresponsive Hmg2

149 lexes that must assemble into a well-defined quaternary structure in order to function.

150 es (UGDHDelta132) to investigate the role of quaternary structure in regulation of the enzyme.

151 , and in vivo data support the importance of quaternary structure in RNA-mediated regulation of targe

152 porting the hypothesis that the evolution of quaternary structure in SBS homomers is significantly in

153 Y tetramerization, a conserved and essential quaternary structure in vitro and likely also in vivo Fu

154 sistent with the D3 receptor also assuming a quaternary structure in which two transmembrane domain I

155 rotein dimers, existing in several different quaternary structures in infected hepatocytes, participa

156 epresentations to include dynamic aspects of quaternary structure, including conformational changes u

157 transvascularly deliver proteins of complex quaternary structures, including alpha-synuclein preform

158 comprise a protein family that forms diverse quaternary structures, including pentamers and 60-subuni

159 /T19C and N21C/A22C) converged onto the same quaternary structure, indicating that the disulphide-cro

160 ges were correlated with changes in the GMPR quaternary structure, induced by the binding of GMP, GTP

161 to monitor dynamic changes in peroxiredoxin quaternary structure inside the crowded environment of l

162 However, difficulties in engineering protein quaternary structure into stable and well-ordered shapes

163 The characterization of a unique ACAD quaternary structure involved in sterol metabolism that

164 the AQP family, the signature homotetrameric quaternary structure is conserved.

165 proteins assemble into dodecamers and their quaternary structure is entirely critical to their funct

166 Determining membrane protein quaternary structure is extremely challenging, especiall

167 y are generally dimers or tetramers, and the quaternary structure is linked to substrate affinity.

168 bits nucleus formation even when the correct quaternary structure is present.

169 AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recrui

170 it has been found that the space of protein quaternary structures is highly degenerate due to the pa

171 The self-assembly of proteins into protein quaternary structures is of fundamental importance to ma

172 with its analogous epitope, a discontinuous quaternary structure located at the surface of the viral

173 The H-tube's highly repetitive primary and quaternary structures made it amenable to a genetic anal

174 onships between E(app) distributions and the quaternary structure models that underlie them.

175 The evolution of quaternary structure occurs via changes in self-assembly

176 terface and to predict the three-dimensional quaternary structure of a protein-protein complex in sol

177 and dimers, morin affected the tertiary and quaternary structure of Abeta, even at low concentration

178 nance can help to gain new insights into the quaternary structure of active, membrane-embedded Bax ol

179 observations suggest that disruption of the quaternary structure of alpha1A/B-AR:CXCR4 heteromeric c

180 y targeted alloepitopes that depended on the quaternary structure of alpha345NC1 hexamers.

181 ectron microscopy (cryo-EM) to determine the quaternary structure of an active complex of DNA-bound E

182 Ms and is a direct consequence of the unique quaternary structure of Aspergillus UGM.

183 The new QUAFIT method for determining the quaternary structure of biological macromolecular assemb

184 Furthermore, the quaternary structure of both mutants, normally hexameric

185 Thus, the quaternary structure of BRAF complexes is shaped by its

186 ethods for determining the stoichiometry and quaternary structure of complexes of macromolecules in l

187 The bulky quaternary structure of cpPNPase compared with RNR1 coul

188 Because the quaternary structure of ENaC is yet undetermined, the ba

189 The quaternary structure of Filamin A (FLNa) 16-23 was recen

190 The quaternary structure of GabR is a head-to-tail domain-sw

191 We discuss the effect of Gal3 on the quaternary structure of Gal80 in light of the evidence p

192 Previous studies point to an oligomeric quaternary structure of hDAT; however, the exact stoichi

193 ins in S. coelicolor possesses a dodecameric quaternary structure of high stability.

194 incorporate additional flexibility into the quaternary structure of highly populated multienzyme com

195 polymorphism has an intriguing effect on the quaternary structure of Hp.

196 ial role in modulating both the tertiary and quaternary structure of Hsp27, which is pivotal to its f

197 The quaternary structure of human MBL is built from oligomer

198 f a given TNKS-binding peptide motif and the quaternary structure of individual binding partners play

199 The quaternary structure of MIBS is nonetheless similar in s

200 by-products from CP are able to disrupt the quaternary structure of noncrosslinked collagen.

201 to the N-terminal motif does not affect the quaternary structure of NUBP1.

202 We suggest that the quaternary structure of protein aggregates, especially s

203 r structural biology, helping to unravel the quaternary structure of protein complexes.

204 of potential differences in the tertiary and quaternary structure of protein reference standards is a

205 ationally derived models of the tertiary and quaternary structure of Purbeta.

206 design of novel GR ligands and redefine the quaternary structure of steroid receptors.

207 Deciphering the quaternary structure of such protein complexes is an ard

208 er are distinct, supporting a model in which quaternary structure of the 2:2 ChpT-CtrA complex enforc

209 In this work, we have characterized the quaternary structure of the ABCD1 and ABCD2 proteins in

210 utational approaches to not only address the quaternary structure of the beta subunits within the PhK

211 Regarding the quaternary structure of the beta subunits, they were dir

212 The most probable quaternary structure of the complex is identified from t

213 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demons

214 g site, the DNA-binding domain of GR and the quaternary structure of the dimeric complex.

215 BH4 binding result in drastic changes in the quaternary structure of the enzyme, leading to a more co

216 at unique positions required to maintain the quaternary structure of the gp160 trimer, as well as con

217 rmally induced structural transitions of the quaternary structure of the hemoglobin tetramer (human)

218 and that signals by changing the location or quaternary structure of the kinase domain.

219 although they have major differences in the quaternary structure of the ligand-binding domain.

220 , our data suggest how tetramers, the native quaternary structure of the mammalian CBS enzymes, are f

221 ollision cross sections and confirm that the quaternary structure of the mutants mirrored the wild ty

222 Our results establish the quaternary structure of the p73 DNA-binding domain requi

223 FimA, assemble into the filamentous, helical quaternary structure of the pilus rod via a mechanism te

224 The quaternary structure of the RIIbeta tetramer differs app

225 of immunoediting, in which modulation of the quaternary structure of the secreted tumor-specific anti

226 terminus is an important determinant of the quaternary structure of the SERCA regulatory complex.

227 ium distribution in tertiary features and/or quaternary structure of the sHsp ensembles.

228 derive a detailed, experimentally-supported quaternary structure of the spectrin heterotetramer.

229 a liposomal preparation strongly support the quaternary structure of the transmembrane helical bundle

230 tional changes in gp120 and gp41, changes in quaternary structure of the trimer have only recently be

231 elected AKAP79 complexes have determined the quaternary structure of these signaling complexes.

232 ayed by electrostatic interactions vis-a-vis quaternary structure of this high-pI protein.

233 Thus, the dissociating quaternary structure of TyrRS(Mini) regulates two opposi

234 nding on their interaction with the distinct quaternary structures of core protein.

235 cate that while the secondary, tertiary, and quaternary structures of CsoR and RcnR are quite similar

236 Here we determine the oligomeric states and quaternary structures of four bacterial P5CDHs using a c

237 Trapping quaternary structures of hemoglobin in single crystals o

238 s the potential of utilizing IM-SID to study quaternary structures of protein complexes and provides

239 nanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for

240 The secondary, tertiary, and quaternary structures of squid hemocyanin (Hc) were char

241 ciation pathway that we link directly to the quaternary structures of the precursor ions selected.

242 ans by which alterations in the tertiary and quaternary structures of the WCC can lead to its distinc

243 relative abundance of the supramolecular (or quaternary) structures of associating macromolecules.

244 he protomers within protein complexes (i.e., quaternary structure) of membrane receptors and transpor

245 and patterns suggest frequent recognition of quaternary structures on the surface of viral particles.

246 SPOUT enzymes, Trm10 does not share the same quaternary structure or key sequences with other members

247 tanding of the general principles underlying quaternary structure organization in protein complexes.

248 ciples that control symmetric and asymmetric quaternary structure organization.

249 sults of binding-interface determination and quaternary structure prediction highlight the effectiven

250 hese results have important implications for quaternary structure prediction, modeling, and engineeri

251 ent protein interactions in terms of protein quaternary structure, protein-protein and protein-ligand

252 ns among beta-sheets occur widely in protein quaternary structure, protein-protein interaction, and p

253 Therefore, determining protein quaternary structures provide critical insights for unde

254 Quaternary structure regulates the virus-neutralizing po

255 and suggests the possibility of dissociating quaternary structures regulating novel functions of othe

256 c proteins fold and assemble into functional quaternary structures remains unclear.

257 Their quaternary structure results from the self-assembly of s

258 The different quaternary structure results in an incompletely formed s

259 Recent studies on NR quaternary structure reveal novel mechanisms of receptor

260 An analysis of AChBP quaternary structure shows that cooperative ligand bindi

261 tal structure of IdaA shows its tertiary and quaternary structures similar to those of glycine oxidas

262 vestigate the very different explorations of quaternary structure space that have occurred in differe

263 Quaternary structure-specific antibodies appear to targe

264 Such quaternary structure-specific antibodies have diverse ne

265 ment (Fab) of PGT145, a broadly neutralizing quaternary-structure-specific antibody.

266 SID can be very useful for quaternary structure studies of large noncovalent protei

267 zymes are known to have similar tertiary and quaternary structure, subtle differences in structure, a

268 rotein misfolding and toxicity via different quaternary structures, suggesting a means to generate mo

269 small-molecule inhibitor (JNJ525) induces a quaternary structure switch of TNFalpha that inhibits th

270 cidating general mechanisms that explain how quaternary structure tends to evolve.

271 n solution adopts a stable tertiary fold and quaternary structure that is consistent with previously

272 se of P. denitrificans by a hitherto unknown quaternary structure that was first modeled here by stru

273 ein characterized by a variety of infectious quaternary structures that can propagate stably and fait

274 ts that delivery vehicles based on synthetic quaternary structures that exhibit higher-order architec

275 an important feature of protein tertiary and quaternary structures that has been associated with prot

276 Within each quaternary structure, the evolving nu(FeHis) frequencies

277 ral and functional properties, including the quaternary structure, the tertiary structure, and the li

278 ubunits, intermolecular interactions lead to quaternary structure--the ordered aggregation of separat

279 at they resemble LigD POL in their monomeric quaternary structures, their ability to add templated an

280 Highly repetitive in primary and quaternary structure, they are amenable to structure-fun

281 ein monooxygenase and is similar in fold and quaternary structure to MtmOIV and OxyS, which are enzym

282 operidol, resulted in re-organization of D3R quaternary structure to promote monomerization.

283 aternary equilibrium from the polymerizing T quaternary structure to the nonpolymerizing R quaternary

284 ructure, and the Polyomino model for protein quaternary structure-to a simple random null model that

285 We found that laforin adopts a dimeric quaternary structure, topologically similar to the proto

286 curately predict the expected frequencies of quaternary structure topologies, including those not yet

287 haustively enumerate a large set of possible quaternary structure topologies.

288 momeric complexes with cyclic and asymmetric quaternary structure topologies.

289 hexameric ring destabilization, and discrete quaternary structure transitions.

290 Their quaternary structure was also established using light sc

291 dumbbell-shaped, zipper-like and multi-loop quaternary structures were formed selectively.

292 processes ranging from acquisition of native quaternary structure (where the association is tightly c

293 HA, have disparate secondary, tertiary, and quaternary structures, where some regions are displaced

294 of B. thailandensis DNase II shows a dimeric quaternary structure which appears capable of binding do

295 r racemic crystallography can capture native quaternary structure, which could be disrupted by hetero

296 The quaternary structure, which has been conserved through e

297 uperfamily, has an exceptional homodecameric quaternary structure with a molecular mass of about 500k

298 nal analysis of E1E2 secondary, tertiary and quaternary structure with functional and immunological m

299 The sheath has a quaternary structure with handedness opposite that of co

300 we study the formation of preferred protein quaternary structures within such rapidly evaporating na