ライフサイエンスコーパス: question as to

1 Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution.

2 As such, these fossils pose major questions as to growth patterns, functional morphology,

3 RNase E and RNase G orthologues, raising the question as to how 16S rRNA processing occurs in these o

4 However, this raises the question as to how an agent's uncertainty may relate to

5 ent absence of physiological cues raises the question as to how and why MYRF is processed.

6 This poses the critical question as to how DNA replication can progress through

7 These findings have raised the question as to how E-proteins exert these different acti

8 is not significantly amplified, raising the question as to how ErbB3 overexpression is achieved.

9 for GATA-1 in megakaryopoiesis and raise the question as to how GATA-1 influences megakaryocyte matur

10 metazoans and plants raises the fundamental question as to how IRE1 is connected to organismal growt

11 This prompts the question as to how macrophages infiltrate obese adipose

12 zymes and biosynthetic routes underscore the question as to how major jumps in the biosynthetic route

13 then to form dorsal appendages, raising the question as to how Notch activity is spatially and tempo

14 e commentaries, concerning in particular the question as to how our account relates to the phenomenol

15 h narrow constrictions at one end, leaving a question as to how protons enter the channel.

16 HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a

17 carefully regulated spiking times poses the question as to how spike timing-based dynamics may suppo

18 highlighted role of T cells in IRI raises a question as to how T lymphocytes interact with the innat

19 tion occurs in a Cdc42-dependent manner, the question as to how the beta cell utilized RhoGDI for dif

20 This raises the question as to how the DNA gets into the central channel

21 This study addresses a long-standing question as to how the most abundant serine/threonine pr

22 insertion and extraction, raising a critical question as to how the SEI interactively responds to and

23 f biochemical network motifs, and raises the question as to how these effects are managed in real bio

24 extent of a visual scene - which raises the question as to how these features might be computed.

25 t) behavioral responses in vivo, raising the question as to how these growth factors affect individua

26 ld strength transmission lines prompting the question as to how these high levels of exposure affect

27 This raises the question as to how these Ints bind their DNA substrates,

28 This raises the fundamental question as to how these PDZ domains discriminate ligand

29 This poses a crucial question as to how these restrictions can be alleviated

30 ntal cortex in the case of value, raises the question as to how they are integrated during human deci

31 , multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real

32 However, the question as to how to achieve timely introduction of pea

33 It remains an unanswered evolutionary question as to how yeast repairs 3meC, particularly in s

34 Referring physicians were questioned as to how the additional information provided

35 They also raise questions as to how a dimeric receptor functions when on

36 neurons is controversial, leaving unanswered questions as to how and where Parkin-mediated mitophagy

37 he findings in animal models now raise major questions as to how B cells and Abs carry out these func

38 aureus and Bo. burgdorferi CoADRs, but leave questions as to how BACoADR can interact with both pyrid

39 This central role of cells frames the basic questions as to how cells work and how cells come to be

40 the backbone of mismatched DNA, raising new questions as to how clamp domains enhance mismatch recog

41 e genetic nature of these experiments leaves questions as to how direct may be their contribution to

42 These recent findings raise intriguing questions as to how enduring changes at synapses are acc

43 e onerous nature of section 7 but also raise questions as to how federal agencies could apply this to

44 list of undruggable targets, but also raise questions as to how FR achieves its therapeutic effect.

45 reactions with several hemoproteins, raising questions as to how free NO can signal in hemoprotein-ri

46 These observations raise questions as to how homeostasis of ribosomal proteins is

47 d respiratory substrate and as a toxin raise questions as to how it is cleared when the electron tran

48 63) pore (approximately 12 angstroms) raises questions as to how large molecules such as LF and EF ca

49 ed stimulus presentations raises provocative questions as to how noncoincidence is detected and repre

50 These recent findings raise exciting questions as to how proteasomal activity can regulate sy

51 me end-protection capability, raised crucial questions as to how rDNA tracts 'jump' to eroding chromo

52 pe is crucial in these cases, there are open questions as to how shape is represented for object reco

53 ve to environmental conditions, which raises questions as to how studies in dilute buffer relate to t

54 a common phosphorylation site motif, raising questions as to how substrate specificity is achieved.

55 been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated

56 ty of viruses promises to answer fundamental questions as to how the activity and recruitment of the

57 es are increasing across the planet, raising questions as to how the biosphere will respond.

58 aged humans, there are still many unanswered questions as to how the genetic pathways that regulate a

59 ernative roles in cells, raising interesting questions as to how the responses to the interferons int

60 nearly every single cell of the body raises questions as to how this gives rise to rhythmic physiolo

61 s strongly associated with asthma, there are questions as to how this relates to asthma symptoms.

62 These observations raise serious questions as to how to achieve the rational design of a

63 This raises questions as to how to elucidate the mechanism of these

64 pora inhabits nitrogen-fixing nodules raised questions as to its potential ecological role.

65 multiple effects on cell functions, raising questions as to its suitability for this purpose.

66 This architecture raises a question as to the degree to which, when devising a plan

67 This poses a question as to the exact role of different amygdala nucl

68 (PHD) enzymes as oxygen sensors raises a key question as to the existence and nature of non-HIF subst

69 and, if it is nitrogen as nitride, raises a question as to the existence of a family of molecular ir

70 further light on another open and important question as to the fundamental working principles of org

71 These and other recent reports raise the question as to the metabolic role of glutamate in gastri

72 These findings raise the question as to the potential mechanisms of JNK1 activati

73 ead higher ALT might reduce BMI, raising the question as to the role of ALT in body composition.

74 unction architectures and answers a critical question as to the role of the anion and excess organic

75 of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the mammal

76 This perspective begs the question as to the sources of self-derived nucleic acids

77 hilic or electrophilic addition, raising the question as to the timing and mechanism of proton loss f

78 This raises the question as to the translatome remodelers that titrate p

79 new cases are still being reported, raising questions as to the ability to identify patients likely

80 eukaryotic N-glycosylation pathways, raising questions as to the basic architecture and detailed func

81 tor-expressing cells directly but leave open questions as to the basis for the recruitment of central

82 These differences raise questions as to the certainty of T/F HCV genome inferenc

83 s with postacute sequelae, raising important questions as to the contribution of emerging autoreactiv

84 (MMPs) are structurally homologous, raising questions as to the degree of distinction, or overlap, i

85 ecent studies, there remain many outstanding questions as to the enzymatic mechanism and structure of

86 the substrate specificity of ZK896.9 raises questions as to the evolutionary ancestry of this group

87 decreases in total translation, which raises questions as to the evolutionary expression of GEF compl

88 s and 4% of endemic (African) cases, raising questions as to the exact role EBV in the disease.

89 f an intriguing regulatory network and poses questions as to the functional compatibility and specifi

90 enetic mark of repressed chromatin and raise questions as to the functional distinctiveness of differ

91 venoms from insects and snakes, which raises questions as to the fundamental differences between prot

92 olubilised under some conditions have raised questions as to the generality of this phenomenon and th

93 This work poses intriguing questions as to the genetic and molecular nature of the

94 These findings raise questions as to the importance of fibrosis as a therapeu

95 ne and cytoplasmic domains in cubilin raises questions as to the means by which it can mediate endocy

96 om Tyr194 in the glycogenin structure raises questions as to the mechanism for the attachment of the

97 ]3 homotrimer has not been detected, raising questions as to the mechanism of chain assembly and why

98 ic MHC Ags is weak in rodent livers, raising questions as to the mechanisms that might control respon

99 The problem raises fundamental questions as to the nature and interrelation of pathways

100 is and hypertriglyceridemia in mice, raising questions as to the net effects of these compounds on th

101 These data raise fundamental questions as to the origin and evolution of tyrosine pho

102 review highlights, there are common research questions as to the origin and spread of the viruses, th

103 ot been isolated from healthy sites, raising questions as to the origin of these putative pathogens.

104 bstitution sites can be separated has raised questions as to the physical basis for their separation.

105 sure to apoptosis-inducing stresses, raising questions as to the physiological significance and under

106 Our findings raise important questions as to the possible roles of divalent metals in

107 onship of this symbiont to R. montana raised questions as to the potential origin of pathogenic SFG r

108 Unanswered questions as to the regulatory mechanisms and routes rem

109 stinguishable from dopamine neurons, raising questions as to the reliability of past findings.

110 he bulge cycle abnormally, raising important questions as to the role of 14-3-3sigma in the bulge.

111 before apoptosis induction raise interesting questions as to the role of BCL-xL in conferring apoptos

112 ate and not always present, which raises new questions as to the role of cellular inflammation in ear

113 from human and mouse studies together raise questions as to the role of microglia in disorders of br

114 xpressed in Prochlorococcus, raising further questions as to the role of phycobilins in the host and

115 uring obesity, starvation and exercise raise questions as to the role of stearoyl-coenzyme A desatura

116 New questions as to the safety and effectiveness of a laparo

117 osition via precipitation worldwide, raising questions as to the sources of high Arctic Hg loading.

118 Furthermore they raise interesting questions as to the spatial organization of protein degr

119 However, there are questions as to the stability of this procedure over mul

120 kpoint inhibitor (ICI) survival curves-raise questions as to the suitability of Cox proportional haza

121 lt in substantial amino acid changes raising questions as to their biological consequence.

122 nctions as independent polypeptides, raising questions as to their evolutionary derivation.

123 rgans but are abundant in the liver, raising questions as to their function in immune responses to in

124 not in its central catalytic domain raising questions as to their impact.

125 Co-occurring CH raises questions as to their origin, selection, and impact.

126 ms ranging from prokaryotes to humans raises questions as to their structural and evolutionary relati

127 on of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performanc

128 ID in gene expression raises the fundamental question as to what extent, if any, TAF1 contributes to

129 However, it still remains an open question as to what kind of cellular communication media

130 The question as to what proportion of this complexity is tru

131 ired for their initiation, but it is an open question as to what the sources of those inhomogeneities

132 lution at room temperature, which raises the question as to what the spectrum of a single OH oscillat

133 The question as to what triggers stomatal closure during lea

134 ements in cellular infrastructure raises the question as to what ultimately limits the level of molec

135 Our data raise intriguing questions as to what drove the loss of both Mx1 and Mx2

136 These findings open new questions as to what is the true aetiology for FSHD, the

137 e important for weight regulation but raises questions as to what self-reported sleep duration is mea

138 ts is often a contiguous helix, thus raising questions as to what the linker contributes and what def

139 ellular to multicellular organisms poses the question as to when genes that regulate cell-cell intera

140 We have addressed the question as to where this equilibrium is established for

141 This raises questions as to where the pathology in HD begins and als

142 These studies have also raised the question as to whether 'catch up' growth following early

143 lamellar vesicles (SUV), they leave open the question as to whether a similar pattern is followed by

144 This raises the intriguing question as to whether a single administration of cocain

145 ons associated with this procedure raise the question as to whether all low-risk patients need a comp

146 alian aging, however, and it remains an open question as to whether and to what extent the pathways t

147 In particular, question as to whether animal movement is predominantly

148 This raises the question as to whether arthropods do not express specifi

149 The question as to whether chromosomal DNA replication also

150 We pose the question as to whether clinical trials could be modified

151 sordered protein complex and leaves open the question as to whether completely disordered dimers (or

152 This raises a fundamental question as to whether delayed relaxation and/or stiffen

153 y times in ferric and ferrous Mbs raises the question as to whether electron transfer may also be ope

154 This variability raises the question as to whether estimates of the time taken for (

155 The question as to whether FA heterozygotes are at increased

156 merase and repair enzymes in vitro raise the question as to whether Fapy.dG elicits similar effects i

157 These results raise a significant question as to whether fatty acids differentially modula

158 d surfaces via the adhesin FimH, raising the question as to whether FimH forms catch bonds that are s

159 to G6Pase in vitro is disputed, raising the question as to whether G6P is a physiologically importan

160 It is still an open question as to whether genome size (GS) variation is sha

161 t directly impact health directly raises the question as to whether global measures of genomic variat

162 tter metrics in humans, leaving open the key question as to whether gray or white matter microstructu

163 tion.SIGNIFICANCE STATEMENT There is an open question as to whether human amygdala function tracks th

164 uinidine, a selective I(K) blocker, raises a question as to whether I(K) consists of two components t

165 ole in retinal progenitor cells, raising the question as to whether Ikaros/Hunchback proteins could b

166 ing emergent cases, their use has raised the question as to whether imaging carries additional progno

167 However, this raises the question as to whether individuals with sensitive feet b

168 It remains an open but important question as to whether innate restriction factors such a

169 on euarthropod relationships centers on the question as to whether insects, crustaceans, and myriapo

170 This raises the question as to whether it is possible to build a safer g

171 lf is not located in mitochondria raises the question as to whether LFG in the ER participates in Fas

172 It also addresses the question as to whether long-term smell loss might increa

173 nsistent with memory precursors, raising the question as to whether loss of Id2 impairs the different

174 ansformations of main-group species pose the question as to whether metal catalysts could be avoided

175 membrane interaction, posing an interesting question as to whether modifying the tips of tubes may h

176 This begs the question as to whether mosquito feeding assays should be

177 We therefore raised the question as to whether myeloid cell-mediated T cell supp

178 fect on G6PC2 RNA splicing, which raises the question as to whether nonsynonymous SNPs with a major i

179 This raises a question as to whether or not the entire I(K) passes thr

180 ity of the complex, it is still an unsettled question as to whether or not these continuum solvation

181 rferon and NF-kappaB signalling, raising the question as to whether other host factors participate in

182 phenomenology of experience in time, and the question as to whether our dichotomy between temporal re

183 RNA synthesis by HCV polymerase, raising the question as to whether our phosphoramidate ProTide appro

184 Although it remains an open question as to whether oxidative stress is a causative f

185 oviding CD28 costimulation, which raises the question as to whether p110delta activity plays a role i

186 Thus, it remains an open and important question as to whether p53 inhibits HIF-1alpha-mediated

187 ts of a possible genetic predisposition, the question as to whether patients with tardive dystonia ha

188 ation and in clinical disorders, raising the question as to whether perceptual accuracy and its subje

189 The presence of this maximum raises the question as to whether plants regulate transpiration thr

190 ion to the infectious form, thus raising the question as to whether proteasome inhibitors might facil

191 rotein tyrosine kinase 2 (Pyk2), raising the question as to whether Pyk2 also participates in driving

192 These opposing inputs raise the key question as to whether reduced Sac3 protein levels and/o

193 The question as to whether RNA viruses produce bona fide mic

194 Thus, we examined the question as to whether Rrn3 functions catalytically or s

195 4 is still unknown, even regarding the basic question as to whether S4 is close to the pore domain.

196 eories of affective disorders and raises the question as to whether SERT and NET exhibit a functional

197 irable satellite droplets and also raise the question as to whether similar dynamical transitions ari

198 present in all aerobic organisms raises the question as to whether SOD is absolutely required for an

199 This raised an intriguing question as to whether sphingolipids are involved in pat

200 hown in a few mammalian species, raising the question as to whether such a high-level function may be

201 rs of the MAPK pathway prompts the important question as to whether such inhibitors might be therapeu

202 plete responses of up to 25% have raised the question as to whether surgery can be avoided in a selec

203 ased on our results, we pose the provocative question as to whether the 40 kDa nanomolecule PEG carri

204 ne materials, the NMR solution data pose the question as to whether the absence of solvent shifts ind

205 It has been a long-standing question as to whether the activation of Notch by its li

206 But this raises the question as to whether the brain activity changes as a f

207 This discrepancy poses a question as to whether the chosen treatment should depen

208 ifiable into four major syndromes, raise the question as to whether the deficiencies are primary or s

209 This raises the question as to whether the enhanced excitability produce

210 ., insulin), the present study addressed the question as to whether the enhancing effect of sleep on

211 However, the question as to whether the full-length type I IL-1 recep

212 a1 with p53, the present study addressed the question as to whether the functions of h-TRbeta1 could

213 These findings from early studies raised the question as to whether the ghrelin system is an essentia

214 logues found in human gut bacteria raise the question as to whether the indole-3-acetic acid degradat

215 sive mitral valve surgery to help answer the question as to whether the minimally invasive approach s

216 bation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obes

217 An important nutritional question as to whether the ratio of omega-6 (n-6) to ome

218 approximately GapLength, and thus raises the question as to whether the read length (as opposed to Ga

219 This finding raises the question as to whether the reduction in cytotoxicity and

220 between NUP98/NSD1 and FLT3/ITD, raising the question as to whether the reported poor outcome is due

221 ression of the huntingtin protein raises the question as to whether the selective vulnerability of th

222 This raises the question as to whether the telomerase subunit was presen

223 To address the question as to whether the UVM response is accompanied b

224 gions of the human genome, thus inviting the question as to whether the virus has evolved mechanisms

225 ns can occur in a single tubulin allele, the question as to whether the wild-type and mutant transcri

226 f coiling, twisting and linking, raising the question as to whether their topological complexity (con

227 typic profile(4,5), it remains a fundamental question as to whether there are common cellular defects

228 This finding raises the question as to whether there are uncharted opportunities

229 ure and prevented renal lesions, raising the question as to whether these beneficial effects of insul

230 us-specific plasmablast responses raises the question as to whether these cells might have a role in

231 This raises the question as to whether these essential RNA processing fu

232 embrane-bound phagosomes, there remains some question as to whether these phagosomes fuse with macrop

233 Here, we addressed the question as to whether these renoprotective purines are

234 s populate the meninges, raising the central question as to whether these structures relate to the B

235 ter activity in B cells, there has been some question as to whether these two octamer-binding factors

236 ary progressive multiple sclerosis raise the question as to whether they actually represent separate

237 expressed within the same cells, raising the question as to whether they also interact in cis.

238 ing of the T cell repertoire have raised the question as to whether they are produced intrathymically

239 elerators are experiencing is now posing the question as to whether they could be included in the des

240 ols and bipolar subjects, which raises a key question as to whether this alteration represents an ada

241 This reactivity raised the question as to whether this class of chelate is redox-ac

242 of GP IIIa and coronary syndromes raise the question as to whether this inherited variation may cont

243 steinyl-tRNA synthetase (CysRS), raising the question as to whether this latter aminoacyl-tRNA synthe

244 Antigen specificity of RTL raises the question as to whether this treatment would be successfu

245 back regulator of muscle mass and raises the question as to whether this type of chalone mechanism is

246 Dispensary employees were questioned as to whether marijuana was recommended and w

247 It has been questioned as to whether polyplexes in the cytoplasm can

248 It has been rarely questioned as to whether the enrichment of specific bact

249 The results raise further questions as to whether abasic lesions are noninstructiv

250 This raises questions as to whether and to what degree currently ava

251 Although these results raise questions as to whether cellular transformations derive

252 Our findings also do only raise questions as to whether cholesterol-induced condensation

253 The review raises questions as to whether elderly patients entered on clin

254 erations that accompany tumour genesis raise questions as to whether experimental cancer-promoting mu

255 s a bona fide transcription factor and raise questions as to whether HSP2 serves as a functional prom

256 metabolism originates in the gut, it raises questions as to whether impaired sulfide clearance in th

257 is listed as a provisional entity because of questions as to whether it is truly a disease or just an

258 rk with 8-chloro-cAMP (8-Cl-cAMP) has raised questions as to whether it works as a cAMP analogue or a

259 These observations raise questions as to whether multiple TGFbeta isoforms partic

260 Here, we address questions as to whether novelty-induced PRPs are able to

261 duced neutralization against variants raises questions as to whether other antibody functions are sim

262 ls cost and higher efficiency, but there are questions as to whether the intrinsic stability of mater

263 carcinogenesis remain obscure, and there are questions as to whether the methylation changes are a ca

264 hesis, and raise important but controversial questions as to whether the same mechanisms could also r

265 s with several mumps virus MNVTs have raised questions as to whether the test can reliably discrimina

266 ility of tip links to acoustic trauma raises questions as to whether these fragile structures can be

267 in a majority of clinical cancers has led to questions as to whether these observations are causally

268 ever, different lines of investigation raise questions as to whether these views are fully correct.

269 n tetraploid complementation assays, raising questions as to whether they are sufficiently potent to

270 dely and, in some cases, are absent, raising questions as to whether they define a universal, or even

271 n a large number of different sHsps, raising questions as to whether they function redundantly or are

272 This situation raised questions as to whether this shift in technique was appr

273 This observation raises questions as to whether this suppression results from a

274 cytoplasmic compartment of the cell, raising questions as to whether vaccinia virus has access to nuc

275 There is a long-standing question as to which factors regulate these events.

276 These structures raise questions as to which form may exist in solution and wha

277 ere defects than do FN-null embryos, raising questions as to which integrin(s) are the key FN recepto

278 have clarified less and in fact raised more questions as to which mode of FGF2 dimerization, if any,

279 encoding during working memory, raising the question as to why mnemonic encoding is observed during

280 This raises an important question as to why mutagenesis studies indicate that an

281 xtreme ornamentation but left unresolved the question as to why parents show the preference.

282 These observations raise the question as to why Q(1) does not spontaneously undergo i

283 vely slow, which is part of the more general question as to why rearrangements of intermediates occur

284 comparative enzymology, but also raises the question as to why so many different solutions to the sa

285 high prevalence of HHV-8 in PBMC raises the question as to why there is no evidence for bloodborne v

286 Such an extent of conservation raises the question as to why, in contrast to all other shuttle pro

287 m, is currently of great interest and raises questions as to why HSC subtypes exist, how they are gen

288 he known speed of sound in proteins, raising questions as to why it is not apparent in computational